• 대한간호학회지
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• 제36권1호
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• pp.15-24
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• 2006

Purpose: This study was to examine the effects of foot reflexion massage on sleep disturbance, depression disorder, and the physiological index of the elderly in nursing homes. Method: The research design was a non-equivalent control group pretest-posttest quasi-experimental study. The subjects in this study were 50 elderly people who resided in two different nursing homes in the same region. An experimental group and a control group were organized with 25 subjects respectively, and foot reflexion massage was provided for 12 sessions, 30 minutes per session. The selected dependent variables were sleep disturbance, depression disorder, and physiological indices(blood plasma serotonin, serum cortisol), which were all measured before and after foot reflexion massage was offered. Data analysis included $x^{2}$-test, t-test, paired t-test, and ANCOVA, using the SPSS program package. Result: 1. The experimental group improved sleep quality more than the control group. 2. The experimental group had less depression disorder than the control group. 3. The experimental group had higher serotonin levels than the control group. Conclusion: It's necessary to give foot reflexion massage as a successful nursing intervention to elderly who undergo a change in sleep, and suffer from a depression disorder due to a deterioration in sleep.

• 한국간호교육학회지
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• 제22권3호
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• pp.345-354
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• 2016

Purpose: The purpose of this study was to determine the effects of a low intensity exercise program with telephone coaching on the physical fitness and physiological index of elderly women who are receiving home visiting health program. Methods: This study was conducted using a non-equivalent control group pretest-posttest design. The participants were 53 senior citizens. The subjects (15) in experimental group 1 performed only a low-intensity exercise program and the subjects (16) in experimental group 2 performed a low intensity exercise program with telephone coaching for 16 weeks. The low intensity exercise program consisted of muscle strength band exercise, stretching, and hand exercise using balls. Results: There were statistical differences in the right grip strength (p=.030), left grip strength (p=.035), raising behind of right arm (p=.046), raising behind of left arm (p=.045), postprandial blood sugar (p=.021), body mass index (p=.029). Conclusion: The low intensity exercise program with telephone coaching is recommended as a physical fitness and physiological index for elderly women in a home visiting health program.

• 성인간호학회지
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• 제16권2호
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• pp.276-287
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• 2004

Purpose: This study was undertaken to investigate the effects of foot reflexo-massage on physical, psychological, and physiological parameters in patients with osteoarthritis of the knee. Method: This study was employed non-equivalent control group pretest-posttest time series experimental design. The subjects of this study were 47 elderly patients with osteoarthritis of the knee from two different nursing homes in Deajeon. The patients were divided into two groups; 26 patients in experimental group, the rest in control group. Each patient in experimental group received the 30-minute foot reflexo-massage, 3 times per week for 4 weeks. The dependent variables of each patient were measured before treatment, after 2 weeks and after 4 weeks during the treatment session. The collected data was analyzed using the Social Package Social Science(version 10.0) software program. Result: There were significant differences in the flexion angle of both knees; the flexion and extension muscle strength of both knees; systolic blood pressure; POMS; plantaris skin temperature and blood velocity of dorsalis pedis artery between the two groups over different the three measurement times. Conclusion: The results suggest that foot reflexo-massage could be an effective intervention to improve physical, psychological and physiological parameters for patients with knee osteoarthritis.

• 한국식품과학회지
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• 제30권3호
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• pp.581-589
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• 1998

$5{\sim}10\;kGy$ 범위의 감마선 조사는 한방약재에 오염된 유기체를 완전사멸 시켜 저장중 미생물학적 품질 안전성을 가져왔으며, 한방약재의 유효성분 추출율을 약 $5{\sim}25%$ 증대시킬 뿐만 아니라 추출시간의 단축효과도 나타냈다. 또한 살균 및 유효성분의 추출율이 증대된 조사선량에서 한방약재의 몇 가지 생리적 활성(항산화력, 항보체능력, 아질산염 소거능, 전자공여능)은 비조사군과 차이를 보이지 않았다.

• 감성과학
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• 제2권2호
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• pp.37-42
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• 1999

Long-term exposure to loud noise affects performance since it changes arousal level, distracts attention, and also is able to evoke subjective stress accompanied by negative emotional states. The purpose of the study was to analyze dynamics of subjective and physiological variables during a relatively long-lasting (30 min) exposure to white noise (85 dB[A]). Physiological signals were recorded on 15 college students during 30 min of intense auditory stimulation. Autonomic variables, namely skin conductance level , non-specific SCR number, inter-best intervals in ECG, heart rate variability index (HF/LF ratio of HRV), skin temperature, as well as respiration rate were analyzed on 5 min epoch basis. Psychological assessment (subjective rating of stress level) was also repeated every 5 min. Statistical analysis was employed to trace the time course of the dynamics of subjective and autonomic physiological variables and their relationships. Results showed that the intense noise evoked subjective stress as well as associated autonomic nervous system responses. However it was shown that physiological variables endured specific changes in the process of exposure to the loud white noise. Discussed were probable psychophysiological mechanisms mediating reactivity to long-term auditory stimulation of high intensity, namely short-term activation, followed by transient adaptation (with relatively stable autonomic balance) and then a subsequent wave of arousal due to tonic sympathetic dominance.

• Journal of Ecology and Environment
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• 제32권3호
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• pp.149-158
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• 2009

American sycamore seedlings were grown in chambers with two different ozone concentrations ($O_3$-free air and air with additional $O_3$) for 45 days. Both the control and the $O_3$ chambers included non-fertilized and fertilized plants. After 18 days of $O_3$ fumigation, seedlings were placed in a clean chamber for 27 days. Seedlings under ozone fumigation showed a significant decrease in pigment contents and photosynthetic activity, and a significant increase in lipid peroxidation. Fertilization enhanced physiological damage such as the inhibition of photosynthetic activity and the increase of lipid peroxidation under ozone fumigation. During the recovery phase, the physiological damage level of seedlings increased with ozone fumigation. In addition, physiological damage was observed in the fertilized seedlings. Superoxide dismutase (SOD) and glutathione reductase (GR) activities of $O_3$-treated seedlings increased up to 33.8% and 16.3% in the fertilized plants. The increase of SOD activity was higher in the fertilized plants than in the non-fertilized plants. Negative effects of ozone treatment were observed in the biomass of the leaves and the total dry weight of the fertilized sycamore seedlings. The $O_3$-treated seedlings decreased in stem, root and total dry weight, and the loss of biomass was statistically significant in the fertilized plants. In conclusion, physiological disturbance under normal nutrient conditions has an effect on growth response. In contrast, in conditions of energy shortage, although stress represents a physiological inhibition, it does not seem to affect the growth response.

• The Korean Journal of Physiology
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• 제3권1호
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• pp.51-54
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• 1969

The effects of saponin and histamine solution on the division of Saccharomyces cerevisiae were compared with the effects of ginseng on the division. 1. $10^{-2},\;10^{-3}%$ saponines were inhibitory on the division but $10^{-5}%$ saponin increased slightly the division, however its increasing rate was much less than that of ginseng. 2. 0.5% histamine was inhibitory on the division but $10^{-2}%$ histamine increased the division, however its increasing rate was higher than that of saponin and lower than that of ginseng. 3. Although some doses of saponin and histamine were inhibitory on the division, the increasing dose of saponin or histamine on the division could be recognized as shown in the case of the optimal dose of ginseng.

• 약학회지
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• 제47권2호
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• pp.104-109
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• 2003

The present paper reviews the notion and comparison of the Korea Food and Drug Administration(KFDA) general pharmacology and the International Conference on Harmonisation (ICH) safety pharmacology. General pharmacology or safety pharmacology is termed the study to determine the potential of a compound to induce adverse pharmacological effects. KFDA general pharmacology studies have been considered an important component in drug safety assessment and these were originally referred to those designed to examine effects other than the primary therapeutics effect of a drug candidate. The KFDA notified the Guideline for General Pharmacology in 1997. Safety pharmacology studies were focused on identifying adverse effects on physiological functions. In the ICH came into place S7A Safety Pharmacology Studies for Human Pharmaceuticals in 2001. A new chemical entity should be assessed for its side effects, initially in those physiological systems which are generally agreed to be the key systems that are essential for life; these "core system" include the central nervous system, cardiovascular system and respiratory system in safety pharmacology studies. These studies should be performed in compliance with Good Laboratory Practice (GLP).

• 한국식품영양학회지
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• 제21권2호
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• pp.115-120
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• 2008

To develop a new Gugija(Lycium chinensis Mill) product having increased value, the physiological functionality of various commercial Gugija products were investigated. In addition, an in vivo study was performed using spontaneous hypertensive rats(SHR) to examine the anti-hypertension effects of products. The results showed that antioxidant activity was highest in the methanol extract of Gugija leaf pickle(97.7%), and anti-hypertensive angiotensin I -converting enzyme(ACE) inhibitory activity was 80.4% in Gugija doenjang(soybean paste) water extract. Anti-cholesterolemia HMG-CoA reductase inhibitory activity was highest in the methanol extract of Gugija rice cake(66.1 %). However, SOD-like activity was below 30% in most products; and fibrinolytic activity was not detected or was very weak. Ultimately, we selected Gugija tea and Gugija wine as superior anti-hypertensive Gugija products, and subsequent in vivo testing was performed using SHR, comparing the tea and wine to Gugija fruit. Among them, the Gugija fruit demonstrated the best anti-hypertension effects in SHR.

• 대한간호학회지
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• 제34권1호
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• pp.123-131
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• 2004

Purpose: This study was aimed to identify the effects of a ten-week stretching exercise program on physiological, psychological functions, and activities of daily living(ADL) among elderly women. Methods: Using a quasi-experimental design, the experimental group received a ten-week stretching exercise program 3 times a week from March to May in 2002. They were divided into 22 persons in the experimental groups in 2 halls where the program was incorporated, and 22 persons in the control group in 2 halls, where the program wasnot incorporated. Data was analyzed with descriptive statistics, the chi-square test, Fisher's Exact test, and ANCOVA was considered significant as a 2-tailed test. Results: There was a significant improvement in diastolic blood pressure(P=0.023), total cholesterol (P=0.019), triglycerides (P=0.002), spine ROM(P=0.000), trunk and hip-joint ROM(P=0.000), percent of body fat(P=0.039) as physiological functions, depression(P=0.041) as a psychological function, and activities of daily living(P=0.001) in the experimental group compared to the control group. Conclusion: A stretching exercise program showed good effects on improving physiological functions, psychological functions and activities of daily living among the elderly women in a city. Therefore, we recommend this program be utilized as a health promoting program for the elderly in the community.