• Fashion & Textile Research Journal
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• v.10 no.5
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• pp.668-675
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• 2008

The purpose of this study was to collect data of skin temperature and physiological responses which is useful for standardization of insulation measurement in various garments. And we investigated sex and season difference of physiological responses of 60's males and 60's females in hot and cold environment. Healthy ten 60's males and ten 60's females volunteered as subjects. The experiment was conducted three times; One for winter condition($5^{\circ}C$, 45%), another for summer condition($30^{\circ}C$, 65%) and the other for nude condition as control($30^{\circ}C$, 65%). The subjects were sitting for 1 hour with suitable ensemble on each experimental condition in climate chamber. We measured skin temperature, rectal temperature, heart rate, oxygen uptake, sweat rate, blood flow, blood pressure and subjective sensations. We found that skin temperature and most of physiological responses were higher in male subject, summer condition than in female subject, winter condition.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1347-1353
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• 2008

Pulse condition is the essential division for conducting pulse diagnosis which is one of the most fundamental and important diagnostics in traditional Korean/Chinese medicine. We studied the pulse condition referred to classics of traditional medicine for a full understanding in present time and come to a conclusion like below. The reference to pulse condition was concluded to 'twenty four pulse conditions' which is the fundamental conception generally accepted in present age since it had first mentioned in "Huangdi Neijing" and after it had passed through "Nanjing", "pulse pattern identification-chapter of normal pulse"of Zhang Zhongjing and reached "Maijing"of Wang Shuhe. Although medical partitioners had different views to some extent about pulse condition, there were no significant differences in the main theoretical frame. Even though there had been a diversity of opinions on the classification of pulse-condition between various medical practitioners, the method of Dae-dae and the method of systematic endeavored by Zhou Xueting and Zhou Xuehai who were medical scholars in the Ch'ing dynasty have been a criterion for the classification of pulse-condition up to date. We were able to recognize that the change of pulse condition caused by pathological situation should be compared to physiological pulse condition for detecting the deficiency and excess by researching the analyzing methods of pulse condition mentioned in the "Lingshu", and the book of Hua Shou and Zhou Xuehai). To sum up, first normal pulse which is the physiological pulse condition should be a standard for detecting physiological pulse condition. Secondly, Zhou Xueting insisted that relaxed pulse should be a standard pulse condition for detecting normal pulse.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1267-1272
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• 2009

The purpose of this study is to survey the importance of items for the physiological and pathological symptoms for estimating a health condition according to Sasang constitution to establish the SHI(Sasangin Health Index) which will reflect the concept of inherent vitality. We surveyed expert opinion with questionnaires from 20 Sasang constitution specialists. The questionnaire was composed of 57 items on physiological and pathological symptoms and specialist opinions. Each item was marked from A to E according to importance in evaluating health state in each constitution, and if the mean score of an item was over 3.0, the item was regarded as important. Important indexes among physiological symptoms were diet, digestion condition, perspiration condition, frequency of defecation, heat and cold response, and temperature of drinking water in Soeumin, pathologic perspiration and defecation condition in Soyangin, repast, perspiration condition, and the amount of drinking water in Taeeumin, and urination frequency in Taeyangin. Important indexes among pathological symptoms were sighing, indigestion, and abdominal pain in Soeumin, oral condition, chest distress, brash, and amnesia in Soyangin, eye condition, palpitation, and edema in Taeeumin, and vomiting and incapacity of the lower limbs in Taeyangin. There are different health evaluating index and priority order in it according to Sasang constitution.

• Science of Emotion and Sensibility
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• v.7 no.3
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• pp.27-35
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• 2004

This study has investigated a psychological status of optimal and pleasant driving condition by measuring various physiological signals using SCR(skin conductance response), PPG(peripheral plethysmograph), SKT(skin temperature) and HR(heart rate). The physiological response was measured during various simulated driving conditions. We developed a hardware and algorithm to measure and analyze the physiological response. The physiological signals has reflected the level of driver's tension or relaxation as well as the heart rate. The emotional responses of drivers were also measured and analyzed in this experiment. The result of the study can be used to design a system to enhance the driver's emotional satisfaction as well as to monitor the driver's safety and health condition.

• Science of Emotion and Sensibility
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• v.18 no.2
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• pp.37-44
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• 2015

LED lighting has an advantage of adjusting color temperature. This change of color temperature may derive change in behavioral and physiological responses of the visual perception for indoor environments. This research examined the changes of behavioral and physiological responses caused by the color temperature. The environment was configured that the indoor temperature was 20 degrees centigrade or less as the perceived uncomfortable environment in winter. Then, the comfortable sensation vote (CSV) and the results of 3-back working memory test were measured as behavioral responses. In addition, the Electrodermal Activity (EDA) and Electrocardiogram (ECG) were measured as the responses of autonomics nervous system (ANS) in the three conditions of color temperature (red: 3862K, white: 5052K, blue: 11,460K). As a result, behavioral responses were not significant by the condition of color temperature, but the tendency of occupants' physiological relaxation appeared in the blue color temperature condition compared with the white color temperature condition. Although the color temperature of LED lighting might be a small factor in terms of the characteristics of indoor environment, it suggests that the color temperature could have an impact on the physiological changes in the parasympathetic nervous system.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.3
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• pp.14-20
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• 2015

It is important to understand psychological and physiological responses of occupants who seated in a chair in order to shape a comfortable indoor official environment. So it is needed to find out optimal seated conditions. The purpose of this study was to explore optimal condition of seat air conditioning control based on psychological or subjective responses (perceived temperature and comfort sensation) and physiological responses (heartrate variability; HRV). To do this, experimental conditions were designed by the difference of indoor temperature and seat air conditioning temperature. In the experiment 1, seven experimental conditions were designed with one control condition which was not used seat air conditioning system, and six experimental conditions which the difference of indoor temperature and seat air conditioning temperature ($-1^{\circ}C{\sim}-6^{\circ}C$). In the experiment 2, four experimental conditions were designed with one control condition and three experimental conditions ($-3^{\circ}C{\sim}-5^{\circ}C$). In addition, participants' psychological or subjective response was measured by CSV (comfort sensation vote) and PTS (perceived temperature sensitivity) as a psychological or subjective response, and heartrate variability was measured as a physiological response. As a result, in the experiment 1, it was reported that the optimal conditions of seat air conditioning control based on participants' psychological or subjective comfort were from $-3^{\circ}C$ to $-5^{\circ}C$ experimental conditions. In addition, in the experiment 2, it was reported that the optimal condition of seat air conditioning control based on participants' physiological comfort was $-4^{\circ}C$ experimental condition. These results suggested that seat air conditioning could affected to comfort sensation of occupants in an appropriate range, rather than unconditionally.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.26 no.1
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• pp.22-29
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• 2003

The study was to evaluate psychological and physiological changes of simulator sickness in the controlled condition of driving a car (1 hr. at speed of 60 km/h) in a graphic simulator. Simulator sickness was measured and analyzed every 5 min using both subjective responses(i.e., Simulator Sickness Questionnaire) and Physiological signals(EEG, HRV, Skin Temperature, GSR). The results showed that there was significant differences in subjective response 10 min after the main experiment. From 10 min after the driving, the level of subjective simulator sickness increased significantly, relative one of the rest condition. There also was significant differences in physiological responses between the rest and the 5 min after from the start of driving : for EEG, $\delta$ and $\theta$ at Fz area increased, while $\alpha$ decreased; the averaged R-R interval and skin temperature decreased; LF/HF and GSR increased. The results indicated that simulator sickness was induced by activation of the autonomic nerves and inactivation of the central nerves.

• Bulletin of the Korean Chemical Society
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• v.30 no.10
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• pp.2318-2328
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• 2009

Massive deadenylation of adenine based-nucleosides induced by halogenated alkanes at the physiological condition have been observed. For the study of deadenylation effects by the different substituents and/or functionality in halogenated alkanes, diverse kinds of halogenated alkanes were incubated with adenine based-nucleosides (ddA, dA and adenosine) for 48 h at the physiological condition (pH 7.4, $37\;{^{\circ}C}$), which were analyzed by HPLC and further confirmed by LC-MS. Among the sixteen different halogenated alkanes, we observed massive deadenylation of nucleosides by 2-bromo-2-methylpropane, 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane. The order of deadenylation rate was highest in 2-bromo-2-methylpropane followed by 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane. In addition, time and dose response relationship of deadenylation in adenine based-nucleosides induced by 2-bromo-2-methylpropane, 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane at the physiological condition were investigated. In addition, deadenylation of calf thymus DNA induced by halogenated alkanes was also investigated. These results suggest that the toxic effect of certain halogenated alkanes might be from the depurination of nucleosides.

• Bulletin of the Korean Chemical Society
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• v.30 no.12
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• pp.2949-2958
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• 2009

Massive deguanylation of guanine based-nucleosides induced by halogenated alkanes at the physiological condition have been observed. For the study of deguanylation effects by the different substituents and/or functionality in halogenated alkanes, diverse kinds of halogenated alkanes were incubated with guanine based-nucleosides (ddG, dG and guanosine) for 48 h at the physiological condition (pH 7.4, 37$^{\circ}C$), which were analyzed by HPLC and further confirmed by LC-MS. Among the sixteen different halogenated alkanes, we observed massive deguanylation of nucleosides by 2-bromo-2-methylpropane, 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane. The order of deguanylation rate was highest in 2-bromo-2-methylpropane followed by 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane. In addition, time and dose response relationship of deguanylation in guanine basednucleosides induced by 2-bromo-2-methylpropane, 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane at the physiological condition were investigated. Deguanylation of calf thymus DNA induced by halogenated alkanes was also investigated. These results suggest that the toxic effect of certain halogenated alkanes might be from the depurination of nucleosides.

• Bulletin of the Korean Chemical Society
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• v.30 no.10
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• pp.2309-2317
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• 2009

Depurination, the release of purine bases from nucleic acids by hydrolysis of the N-glycosidic bond, gives rise to alterations of the cell genome. Though cells have evolved mechanisms to repair these lesions, unrepaired apurinic sites have been shown to have two biological consequences: lethality and base substitution errors. 2-Bromopropane (2-BP) is used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organics. In addition, 2-BP has been used as a replacement for chloroflurocarbons and 1,1,1-trichloroethane as a cleaning solvent in electronics industry. However, 2-BP was found to cause reproductive and hematopoietic disorders in local workers exposed to it. Owing to the toxicity of 2-BP, there has been a tendency to use 1-BP as an alternative cleaning solvent to 2-BP. However, 1-BP has also been reported to be neurotoxic in rats. Though $N^7$-guanine adduct of 2-BP has been reported previously, massive depurination of the nucleosides and calf thymus DNA was observed in this study. We incubated the nucleosides (ddG, dG, guanosine, ddA, dA and adenosine) with excess amount 2-BP at the physiological condition (pH 7.4, $37\;{^{\circ}C}$), which were analyzed by HPLC and LC-MS/MS. In addition, the time and dose response relationship of depurination in nucleosides induced by 2-bromopropane at the physiological condition was investigated. Similarly, incubation of calf-thymus DNA with the excess amount 2-BP at the physiological condition was also performed. In addition, the time and dose response relationship of depurination in calf-thymus DNA induced by 2-BP at the physiological condition was investigated. Those results suggest that the toxic effect of 2-BP could be both from the depurination of nucleosides and DNA adduct formation.