• 동의생리병리학회지
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• 제23권4호
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• pp.925-932
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• 2009

The purpose of this study is to evaluate factors that have correlation with improvement of Cerebrovascular accidents(C.V.A) and to decide ranking of influence about improvement of C.V.A. This observation was made on 153 subjects of C.V.A. that were diagnosed through brain MRI or brain CT. They were hospitalized in the Semyung University Oriental Medicine Hospital from the January 1st 2006 to December 31th 2007. The subjects of this study are divided into two groups. The one group has slight motor disturbance, and the other group has severer motor disturbance. Based on medical treatment chart, we analyze differences of many factors like past history, family history, drinking, smoking, several symptoms with C.V.A., etc between two groups. As a result, The past history of cerebrovascular disease and past history of hypertension are the most influencing factors in improvement of C.V.A.

• 자연과학논문집
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• 제15권1호
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• pp.79-88
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• 2005

효모에는 여러 가지 종류의 thiol peroxid se 동위 효소들인 cytoplasmic TPx I, cTPx II, cTPx III, mitochodrial TPx (mTPx), 및 nuclear TPx (nTPx)가 존재하고 있다. 특히 cTPx II는 다른 효모TPx와 비교해 볼 때 매우 낮은 peroxidase 활성을 보이나, cTPx II를 제거한 cTPx II mutant균주는 심하게 성장이 저해되는 특징을 보인다. 본 연구에서는 효모에서의 cTPx II의 생리학적 기능을 밝히는 연구의 첫 과정으로 cTPx II와 상호 작용하는 단백질을 탐색하였다. Sacchromyces cerevisiae genomic DNA library에서 yeast two-hybrid system을 이용하여 cTPx II와 상호 결합하는 단백질을 탐색하여 그 단백질들의 기능을 연구하여, 궁극적으로 cTPx II의 생리기능을 밝히는데 이 연구의 목적을 두었다.

• 동의생리병리학회지
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• 제25권1호
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• pp.122-131
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• 2011

The object of this study was to evaluate the single dose toxicity of Yukmijihwangtanggamibang (YMJHTGMB), a polyherbal formula have been traditionally used as prevention or treatment agent for various lung diseases including chronic obstructive pulmonary disease (COPD), in male and female mice. Aqueous extracts of YMJHTGMB (Yield = 16.33%) wasadministered to female and male ICR mice as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 12 principle organs were examined. As results, we could not find any mortality, clinical signs, and changesin the body and organ weight except for soft feces restricted to YMJHTGMB 2,000 mg/kg treated two male mice (2/5; 40%) at 1 day after administration. In addition, no YMJHTGMB-treatment related abnormal gross findings and changes in histopathology of principle organs were detected except for some sporadic accidental findings. The results obtained in this study suggest that the 50% lethal dose and approximate lethal dose of YMJHTGMB aqueous extracts in both female and male mice were considered as over 2,000 mg/kg, the limited highest dosage recommended by KFDA Guidelines.

• 동의생리병리학회지
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• 제26권5호
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• pp.788-792
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• 2012

The purpose of this report was to show that the oriental medical treatment is effective on recurrent bell's palsy. We investigated 1 patient with recurrent bell's palsy who was a case of recurrent ipsilateral bell's palsy with four distinct episodes over the past 11 years. As a treatment, Ligigepung-san(Liqiqufeng-san), Acupuncture, and Moxa were tried upon the patient for 40 days in order to relieve the symptom of palsy. In terms of observing the changes of symptoms, the progress of patient's condition was evaluated periodically by using the House-Brackamnn's grading system. In accordance with the observation under House-Brackamann's grading system, the patient's facial nerve palsy had gradually improved throughout the treatment. Therefore, this report suggests that Ligigepung-san (Liqiqufeng-sa n), Acupuncture, and Moxa are probably effective in the treatment of recurrent Bell's palsy.

• Biomolecules & Therapeutics
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• 제26권1호
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• pp.39-44
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• 2018

In 1923, Dr. Warburg had observed that tumors acidified the Ringer solution when 13 mM glucose was added, which was identified as being due to lactate. When glucose is the only source of nutrient, it can serve for both biosynthesis and energy production. However, a series of studies revealed that the cancer cell consumes glucose for biosynthesis through fermentation, not for energy supply, under physiological conditions. Recently, a new observation was made that there is a metabolic symbiosis in which glycolytic and oxidative tumor cells mutually regulate their energy metabolism. Hypoxic cancer cells use glucose for glycolytic metabolism and release lactate which is used by oxygenated cancer cells. This study challenged the Warburg effect, because Warburg claimed that fermentation by irreversible damaging of mitochondria is a fundamental cause of cancer. However, recent studies revealed that mitochondria in cancer cell show active function of oxidative phosphorylation although TCA cycle is stalled. It was also shown that blocking cytosolic NADH production by aldehyde dehydrogenase inhibition, combined with oxidative phosphorylation inhibition, resulted in up to 80% decrease of ATP production, which resulted in a significant regression of tumor growth in the NSCLC model. This suggests a new theory that NADH production in the cytosol plays a key role of ATP production through the mitochondrial electron transport chain in cancer cells, while NADH production is mostly occupied inside mitochondria in normal cells.

• BMB Reports
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• 제48권7호
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• pp.367-368
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• 2015

It has long been thought that glucocorticoid receptor (GR) functions as a DNA-binding transcription factor in response to its ligand (a glucocorticoid) and thus regulates various cellular and physiological processes. It is also known that GR can bind not only to DNA but also to mRNA; this observation points to the possible role of GR in mRNA metabolism. Recent data revealed a molecular mechanism by which binding of GR to target mRNA elicits rapid mRNA degradation. GR binds to specific RNA sequences regardless of the presence of a ligand. In the presence of a ligand, however, the mRNA-associated GR can recruit PNRC2 and UPF1, both of which are specific factors involved in nonsense-mediated mRNA decay (NMD). PNRC2 then recruits the decapping complex, consequently promoting mRNA degradation. This mode of mRNA decay is termed "GR-mediated mRNA decay" (GMD). Further research demonstrated that GMD plays a critical role in chemotaxis of immune cells by targeting CCL2 mRNA. All these observations provide molecular insights into a previously unappreciated function of GR in posttranscriptional regulation of gene expression. [BMB Reports 2015; 48(7): 367-368]

• 동의생리병리학회지
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• 제28권1호
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• pp.53-58
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• 2014

The object of this study was to evaluate the single dose toxicity of Choweseuncheng-tang (CWS), a polyherbal formula have been traditionally used as prevention or treatment agent for various diseases as Tae-eumin prescription on Korean medicinal theory, Sasang-euihak, in male and female mice. Aqueous extracts of CWS (yield = 11.00%) was administered to female and male mice as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 14 principle organs were also examined. As results, we could not find any CWS treatment related mortality and clinical signs, changes in the body and organ weights, gross findings and changes in histopathology of principle organs, except for some dose-independent accidental findings. The results obtained in this study suggest that the 50% lethal dose and approximate lethal dose of CWS aqueous extracts in both female and male mice were considered as over 2,000 mg/kg, the limited highest dosage recommended by KFDA Guidelines, and can be safety used in clinics.

• 동의생리병리학회지
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• 제18권1호
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• pp.274-278
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• 2004

The prostatitis is characterized as relatively incurable, chronic and recurrent illness. Because of this property, we have a difficulty in treating this illness. The purpose of this study is evaluating the efficiency of herb medicine, acupuncture, and herbal acupuncture therapy to the prostatitis. A clinical observation was made on two patients with chronic prostatitis who had perineal pain, pubic pain, testicular pain, painful urination, frequency and dysuria. They were treated with herb medicine, acupuncture, and herbal acupuncture therapy for four weeks and symptoms were considerably decreased. This result suggests that oriental medical therapy is useful enough to treat the prostatic diseases. Therefore the further study of the approach and application of this treatment on prostatitis would be necessary.

• 동의생리병리학회지
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• 제19권3호
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• pp.586-589
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• 2005

To study on the assignment of the eight trigrams (八卦) for the process on intake, digestion, excretion of food. Being based BEOK-HEE's diagram of eight trigrams order(伏羲次序圖), provisional namely six entera are assigned eight trigrams(八卦). Eight trigrams(八卦) are attached to the air(GEON 乾), the month(TAE 兌), the stomach(LEE 離), the small intestine(JIN 震),the large intestine(SON 巽), the rectum(GAM 坎), the anus(GAN 艮), the excrements(GON 坤). The BEOK-HEE's diagram of eight trigrams order(伏羲次序圖) means immutable order naturally. The process of six entera's digestion is also unchangeable in region and program. Therefore we can set up the process of six entera's digestion as the category of observation on the basis of BEOK-HEE's diagram of eight trigrams order(伏羲次序圖), and then we can arrange eight trigrams(八卦) on the process of six entera's digestion.

• 동의생리병리학회지
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• 제25권4호
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• pp.658-662
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• 2011

This study was designed to investigate the effects of Gleditsiae Spina (GS) on polycystic ovary (PCO) induced by estradiol valerate in female rats. We investigated the effects of GS on changes in body weights and food and water uptake for 5 weeks. In addition, we also examined the effects on ovary weights. Finally, we observed histopathological changes in PCO rats. Treatment with GS did not affect body weights, amount of food and water uptake compared with non-treated control group. Administration group of GS restored body/ovary weight ratio to normal levels, which were lowered by induction of PCO. In histopathological observation, formation of cysts was suppressed in GS group compared with non-treated control group. These results suggest that GS can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.