• The Korean Journal of Physiology
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• 제2권2호
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• pp.83-92
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• 1968

A study was planned to evaluate the effects of removal of the cingulate cortex upon the occurrence of any behavior commonly displayed by the rat, and to compare the effects of cingulectomy with those of removal of the parietal, parieto-occipital, or occipital regions. The subjects were 54 male albino rats (Holtzman strain, body weight $200{\sim}330\;gm$) including 14 rats in which the cingulate gyri between splenium and genu of the corpus callosum were bilaterally ablated by suction (cingulate group), 9 animals which had their parietal cortices (chiefly area 7) partially removed (parietal group), 9 rats whose parietal and occipital regions (chiefly areae 7 & 17), 13 animals in which the occipital cortices (chiefly area 17) were removed bilaterally (occipital group), and 9 normal rats (normal control group). Eighteen observation cages, each of which housed a subject and was provided with food and water ad lib., were arranged in 6 rows on a rack and the behavior of each subject was scanned by an observer at a distance of 1.5 m from the rack. The observer scanned the first and second rows 6 times in 1 min, then proceeded to the 3rd and 4th rows, scanning for another 1 min, and finally to the 5th and 6th rows. The speed of scanning was such that behavioral observations of all of the 18 rats were completed in 3 min, each subject receiving 6 observations. The scanning was repeated every 3 min for 18 min, which constituted one observation session and was followed by a 72 minutes' recess. The whole procedure was repeated through 24 hours so that a total of 576 behavioral observations were made on each subject in 16 observation sessions. Behaviors checked were sleeping, lying, lying and sniffing, standing, standing and sniffing, exploring, eating, drinking, grooming (included were washing, licking, and scratching), and others. Results obtained were as follows: 1. The cingulate group ate significantly more often than the normal control, the parietal, and the parieto-occipital groups. 2. Exploration was significantly less frequent in the cingulate group than in the normal control, the parietal, and the occipital groups. There was, in the case of the cingulate group, a significant negative correlation between the occurrence of eating and the exploratory activity. 3. The general activity, as judged from the value obtained by adding the occurrence of exploration, eating, drinking, grooming, and standing and sniffing, was significantly increased in the cingulate group compared with those of any other groups including the normal control. 4. Though statistically insignificant, the cingulate group slept least often among all the animal groups tested. 5. The parieto-occipital group tended to groom less, and the parietal group to eat less often than the normal control group did, but the difference was not significant. There were no significant differences among all the groups except the cingulate group as regards other behaviors analyzed. Based on the above results, it was inferred that the cingulate cortex exerts an inhibitory influence upon the occurrence of eating and general activity, while it tends to facilitate the occurrence of sleep.

• 디지털융복합연구
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• 제12권9호
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• pp.353-358
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• 2014

인터렉티브 아트는 관람객들과 상호 작용을 전제로 예술 작품을 구현하는 것으로 가상성, 몰입성, 상호작용성을 특징으로 한다. 그에 따라 관람객이 작품으로 몰입하게 하는 연구는 매우 중요하다. 현재까지 인터렉티브 아트분야에서, 몰입을 측정하기 위해서는 주로 설문지나 인터뷰, 정신 생리학적인 방법을 이용하였다. 그러나 이 방법들은 작품 관람 이후에 진행되어져서 정확한 몰입 측정이 어려우며 작품 관람에 방해를 줄 수 있다. 본 연구에서는 이를 개선하기 위해서 모바일 기기와 카메라를 이용하여 관람객들의 동선을 파악하고 관람시간을 중심으로 한 몰입 측정 방법을 제안한다. 본 논문은 작품의 몰입 정도를 파악하는데 도움을 제공한다.

• 동의생리병리학회지
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• 제25권6호
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• pp.1044-1049
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• 2011

The purpose of this study was to study clinical characteristics of patients complained of tremor and to evaluate availability of oriental medical treatment. This observation was made on 36 cases that were hospitalized in the Semyung University Oriental Medicine Hospital and evaluated tremor using clinical rating tremor scale(CRTS). The ratio of patients were essential tremor(50%), parkinson's disease(13.9%), psychogenic tremor(13.9%), physiologic tremor(11.1%), cerebellar tremor(11.1%). CRTS score of essential tremor patients decreased significantly. Physiologic tremor patients's CRTS score were under 15 points. Every patient's scores decreased. Two patients's score decreased to 0 point. Every patient were treated with Bojungikki-tang-gamibang. CRTS scores of psychogenic tremor patients were various.(4~24 points) Two patients's scores decreased to 0 point. The CRTS scores of three cases among four patients with cerebellar tremor were not changed. Changes of CRTS score between oriental medication group and western-oriental combined medication group were statistically significant. Changes of CRTS score between over 15 points group and under 15 points group were statistically significant. Kejigayongolmoryo-tang was one of the most widely used herbal medication, which was diagnosed as ascendant hyperactivity of liver yang.

• 동의생리병리학회지
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• 제27권3호
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• pp.299-305
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• 2013

This study was to evaluate the single dose toxicity of Arecae Semen (AS) in male and female ICR mice. Aqueous extracts of AS (Yield = 13.15%) were administered as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 12 principle organs were examined. We could not find any mortality, clinical signs, and changes in the body and organ weight except for diarrhea. Diarrhea were observed in all three different dosage groups of male mice, and in 2000 mg/kg groups of female mice within 48hrs after administration. In addition, no AS extract related abnormal gross findings and changes in histopathology of principle organs were detected except for some sporadic accidental findings. Although the 50% lethal dose and approximate lethal dose of AS aqueous extracts in female and male mice were detected as over 2,000 mg/kg - the limited highest dosage recommended by KFDA guidelines. It should be carefully used in clinics because AS may be induced severe digestive tract disorders.

• 동의생리병리학회지
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• 제33권6호
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• pp.334-340
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• 2019

In order to promote scientification of Korean medicine, two hypothetical scenarios were proposed methodologically. Firstly, the scientification of Korean medicine requires a comprehensive understanding of the process and reality, and new logical procedures and the methods of observation and experiment. Secondly, transformation to revised Korean medicine is to replace traditional Korean medicine with biochemistry-based Western medicine, that is a method of reconstructing the recognition foundation describing symptoms and diseases using anatomical platforms and analytical tools. But there are areas of human training and practice that are not subject to scientification, and there are incommensurable parts as for the methodology between western medicine too. And additionally arbitrary rejection by uniform science with a political reason was done. So these various backgrounds and factors should be considered for the scientification of Korean medicine. And before that, reflection and agreement on the understanding and attitude of the method of scientification within the Korean medical community is necessary.

• 한국임상수의학회지
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• 제8권2호
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• pp.157-170
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• 1991

Effects of recombinant bovine somatotropln(${\gamma}$BST) on hematologie and blood chemical values were investigated in twenty-five multiparous Holstein dairy cows. Recombinant BST was administered by two different routes ; intramusculary(12.5mg and 25mg/day) and subcutaneously(500mg and 750mg) in sustained-release vehicle every 2 weeks beginning 4 weeks postpartum and continuing for 7 months. Whole blood and serum samples were collected 0, 1, 2, 3, 5, and 7 months after beginning of treatments from control and ${\gamma}$BST-administered groups. Hematologic values including RBC, PCV, HB, MCH, MCHC, WBC and differential counts of treatment groups receiving ${\gamma}$BST were similiar to those of control group. Blood chemical values observed were total protein, albumin, A/G ratio, glucose, cholesterol, Ca, Pi, Ca/pi ratio, total bilirubin, creatinine, BUN, alkaline phosphatase, lactate dehydrogenase, alanine aminotransferase and aspartate aminotransferase. There were no significant differences in blood chemical values of cows administered with ${\gamma}$BST from those of control. Although some blood chemical values were fluctuated at a certain observation period, they were remained within the normal physiological ranges. It is concluded from the observations of these experiments that the dose and dosage froms of ${\gamma}$BST employed in this work might not affect hematologic and blood chemical values in dairy cows under the normal sanitary condition and adequate nutritional balance.

• 지역사회간호학회지
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• 제27권3호
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• pp.242-253
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• 2016

Purpose: This research aims to understand the perceptions of nursing homes from the perspective of the elderly, explores the themes of such perception and provides supporting evidence for developing nursing intervention that focuses on the subjects of care within nursing homes. Methods: This research is based on qualitative research in a phenomenological methodology. The research participants included elders aged 67~83 living at home in Jeonnam, Jeonbuk Provinces and G City. Data collection methodologies included in-depth interviews and observation of participants. The data were analyzed in the phenomenological methodology by Colaizzi. Results: As a result of the research, it was found that all significant statements about the Korean elders' perception of nursing homes fell within 3 categories with 9 major themes and 23 minor themes. The three observed categories for the Korean elders' perception on nursing homes were: 'places they do not like to be in', 'places they have to be in' and 'places that makes them feel fortunate as they have a place to go'. Conclusion: This research provides foundational tools that will provide a steer for changes in nursing environment, physiological support, programs and education so that the needs of the elderly can be met more sufficiently.

• 동의생리병리학회지
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• 제27권6호
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• pp.842-846
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• 2013

The purpose of this study was to report one clinical case of spinocerebellar ataxia(SCA) type 1 improved by herbal medicine and oriental medical treatment. As a treatment, Yukmijihwang-tang(Liuweidihuangtang)-gamibang, acupuncture, and moxa were tried upon the patient for 21 days in order to relieve the symptoms. In terms of observing the changes of symptoms, the progress of patient's condition was evaluated periodically by using the Korean-mini mental state examination(K-MMSE), Modified Barthel Index(MBI), Functional Independence Measure(FIM). In accordance with the observation under K-MMSE, MBI, FIM, the patient's symptoms had gradually improved throughout the treatment. Therefore, this report suggests that Yukmijihwang-tang(Liuweidihuangtang)-gamibang, acupuncture and moxa were probably effective in the treatment of SCA type 1.

• 한국식품영양과학회지
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• 제28권5호
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• pp.1180-1186
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• 1999

A wide ranges of chemicals released into the environment have potential to interfere with physiological and development process by disrupting endocrine pathways. Endocrine system embraces a multitude of mechanisms of action, including effect on growth, behavior, reproduction and immune function. These environmental endocrine disruptors are present in environment and pose potential health consequences to human and wildlife. The best known form in endocrine distruptors involves substances which mimic or block the action of natural hormone in the body. Endocrine disruptor have been variously defined as exogenous agents that interfere with the synthesis, secretion, transport, metabolism, binding action or elimination of the natural hormones in the body which are responsible for the maintenance of homeostasis, reproduction developmental and/or behavior. Many compounds polluted into the environment by human activity are capable of disrupting the endocrine system of animals, including fish, wildlife, and humans. Among these chemicals are pesticides, industrial chemicals, and other anthropogenic products. It has been alleged that several adverse effects on human health are linked with exposure to chemicals which are claimed to be endocrine disrupters, that is, increased incidence of testicular, prostate and female breast cancer, time dependent reductions in sperm quality and quantity, increased incidence of cryptorchidism (undescended testicles) and hypospadias(malformation of the penis), altered physical and mental de velopment in children. This observation is currently the only example of chemically mediated endocrine disruption which has resulted in a clear effect at the population level.

• 동의생리병리학회지
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• 제23권5호
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• pp.1183-1187
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• 2009

We presented an ataxia patient who was difficult to diagnose and treated her by oriental medical treatment. We applied various methods of oriental medicine including herb medicine, acupunture, moxibustion and so on. After that, we checked the extent of dysarthria, pruritus, finger to nose and rapid alternative movement and measured the progress of general condition with Modified Barthel Index(MBI). After the oriental medical treatment was applied to her, ataxia, dysarthria, pruritus, finger to nose and rapid alternative movement were improved. The score of MBI was improved from 45 to 71, too. Even though there is no exact pattern identification about ataxia in oriental medicine, the oriental medicine can have an effect on the ataxia patient. In addition, more clinical study and observation should be needed.