• 한국산림과학회지
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• 제34권1호
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• pp.47-56
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• 1977

I have investigated and compared the morphology of vascular bundle shown in the section of culm wall of bamboo trees growing on Mt. Jiri which were classified by Grosser and Liese with their methods of morphological classification. The results obtained were as follows: 1. It was shown that there are no b.g.i. types of bamboo classified by Grosser and Liese among the bamboo trees on Mt. Jiri (Phyllostachys and Sasa). 2. As for the thickness of the culm wall in the culm, it was shown that the culm wall of the Phyllostachys becomes thinner in proportion to its nearness to the upper part of the tree, but no distinctive difference appeared in the Sasa. 3. The c, d, and e types of Sasa were the same as those of the Phyllostachys, but there was a vascular bundle type of the a' type, which was quite different from that of the Phyllostachys. 4. It was shown that the a', d, and e types of Sasa were distributed in a zone less than 500m above sea level, but no a' type was distributed in the high mountain area except for the c, d and e types which ranged from 600m to 1000m above sea level. Such facts mean that the vascular bundle sheath has changed in quantity because of the height of mountain. 5. In general, as compared with the Phyllostachys, the Sasa (types a, c, d and e which included a new type a) have fewer vascular bundles. 6. Considering the above results, it is thought that not by the current Sasa classification method based on observation of the the study of Sasa form the outside, but by a new method of classification based on the aspect of the physiological construction as seen from the inside wall is advanced. I believe this new method of classification to be a first step towards an epoch-making methodological advance and encourage the further study of it.

• 대한본초학회지
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• 제31권6호
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• pp.63-71
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• 2016

Objective : To suggest a scientific evidence of Aconitum carmichaeli Debx. (Aconiti Lateralis Radix Preparata: ALRP) as one of cooling and heating medicines on the regulation of body temperature, we investigated the effects of ALRP water extract on hypothyroidism. Methods : Hypothyroidism was induced by intradermal injection with PTU for 4 weeks in SD rats. ALRP extract or L-thyroxine as a control drug was orally administrated for 2 weeks with PTU injection in rats. The physiological and serological parameters were measured in rats. The histological change of thyroid tissues was observed by H&E staining, and also the expression of thermo-regulating proteins was determined by Western blot in dorsal root ganglia and brain tissues of rats. Results : The administration of ALRP extract in PTU-induced hypothyroidism rats was significantly increased body temperature, but did not changes on body weight, food and water intake. ALRP extract did not effect on the levels of TSH and T4 in the hypothyroidism rats. ALRP extract significantly decreased the levels of GPT, glucose, HDL-cholesterol, LDL-cholesterol, and total cholesterol in the hypothyroidism rats. In histological observation, the enlarged epithelium and atrophic follicles with higher concentration of follicular cells on hypothyroidism were improved by ALRP extract. In addition, ALRP extract increased the expression of TRPV1 and TRPM8 ion channel proteins in hypothyroidism rats. Conclusion : These results indicate that ALRP extract can improve PTU-induced hypothyroidism through regulation of body temperature and lipid accumulation. The action mechanism of ALRP extract is related with body temperature control by thermoregulation with TRP ion channels.

• 동의생리병리학회지
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• 제33권5호
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• pp.295-301
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• 2019

The purpose of this study is to assess potential effects of the effects of Korean Medicine treatments on condyloma. Retrospective study of 194 patients with diagnosed condyloma in Saengki Korean Medicine Clinic from October 2013 to September 2018 was done. Patients were treated with Korean Medicine treatments such as herbal treatment, pharmacopuncture and moxibustion. The data has been analyzed by chi-squared distribution and t-test. A total of 194 patients were 148 males and 46 females. In the aspect of diagnosis, newly diagnosed patients were 96 and recurrent patients were 98. After the treatment, in the light of size complete clearances were 110 patients, partial clearances were 63 and non responses were 21. And in the light of number complete clearances were 110 patients, partial clearances were 68 and non responses were 16. In complete clearance group, the relation among the treatment period, sex, age, and the site of wart showed statistically significant. There were 3 recurrences of warts in the 6 months of follow-up observation for 110 of clearance group. No major side effects related to the treatment were found. As the result of t-test shows, the Korean Medicine treatment we had applied revealed as statistically effective on both number(t=11.471, p<.001) and size(t=11.951, p<.001) of the wart. The result of this study suggests that additional treatment of Korean medicine such as acupuncture and moxibustion treatment could be effective on condyloma patients.

• 동의생리병리학회지
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• 제32권6호
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• pp.418-421
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• 2018

The purpose of this study was to evaluate the changes of liver function test before and after treatment in patients admitted to Korean medicine hospital. We checked liver function test level (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, direct bilirubin) of 147 patient who admitted in Korean medicine hospital from July 1, 2015 to June 30, 2018. The subjects were selected those who took herbal medicine continuously during the admission period and who performed liver function test on admission and before discharge. And the subjects were excluded those who had a history of liver and biliary disease at the time of admission or who took hepatoprotectants. Aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase significantly decreased compared with the values of admission(p<0.05), but total bilirubin and direct bilirubin were not significantly changed(p>0.05). On admission 31 patients(21.1%) had abnormal liver function and 6 patients(4.1%) had liver injury while 19 patients(12.9%) had abnormal liver function and 6 patients(4.1%) showed liver injury before discharge. This study suggests that herbal medicine may not injure liver function.

• 셀메드
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• 제9권3호
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• pp.3.1-3.7
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• 2019

Recent researches on adipocytes in human and mice model have reported that the adipocytes are not only the fat depots but having role in maintenance of physiology and metabolism through adipokines released by them in accordance to their anatomical location. Ayurveda scholars too have mentioned different tissues like Vasa (inter muscular fat), Meda (visceral fat) and Majja (bone marrow) which are predominantly rich in adipocytes similar to adipose tissues, with a different sites, functions, compositions and pathological outcomes. The metabolic effect of Meda and Majja Dhatu on other tissues like muscle (Mamsa Dhatu), bone (Asthi Dhatu) and reproductive tissue (Shukra Dhatu) shows their functional interdependence. The detailed description of therapeutic indications of Vasa and Majja under Snehakarma (oleation therapy) illustrates that clinical physiology of these tissues have been elaborated rather than general physiology. This article is an attempt to comprehend the physiological aspect of Vasa, Meda and Majja retrospectively on the basis of their therapeutic indication for the management of variety of disorders, in the form of Sneha through different therapeutic procedures. An effort has been also taken to distinguish Vasa, Meda, Majja based on the functional peculiarities of adipocytes present in different sites of body like omentum, muscle and bone marrow. Critical observation of explanations of Vasa, Meda and Majja in Ayurveda compendia and advanced research in field of adipocytes reflected that Ayurveda scholars had deep insights regarding the various dimensions of adipocytes, most of which are in consistent with the advanced physiology and biomolecular studies of adipocytes.

• 동의생리병리학회지
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• 제35권1호
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• pp.36-41
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• 2021

Many prior studies on neck pain after a traffic accident (TA), but there is a lack of research on risk factors for post-TA neck pain in Korea. The purpose of this study was to examine the relationship between post-traffic neck pain and the demographic characteristics of TA patients and to find any factors affecting the neck pain after TA. In this study, 120 TA patients in a Korean medicine hosipital were analysized. The Korean version of the Neck disability Index (NDI) and Numeral Rating Scale (NRS) were used. Data were summarized by frequency(%) and mean(standard deviation). Pearson correlation test, Independent sample t-test, chi-squre test, one-way ANOVA and two-way ANOVA were performed. The IBM SPSS Advanced Statistics for window, version 20.0 was used for statistical processing. All p-values less than 0.05 were considered statistically significant. NDI and NRS were highly correlated. NRS and NDI showed higher scores for women, those in 30s, BMI≥25, and side collisions, but there were no statistically significant differences. For women, the direction of collision was observed to affect NDI. In this study, it was confirmed that the NDI and NRS had a high correlation. However, it was confirmed that sex, degree of obesity, direction of traffic accident collision are not factors that significantly affect the intensity of neck pain and the functional disorder by neck. It is necessary to conduct an additional study by larger scale.

• 동의생리병리학회지
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• 제36권4호
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• pp.143-146
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• 2022

This study aims to report a case of facial dermatitis herpetiformis with allergy diseases improved by administration of Mahaengeuigam-tang (Maxingyigan-tang). Multiple blisters appeared on the patient's face, Erythema, papules, and scales were also observed on the neck, back, and knee areas of the patient. The patient has had cough, sputum, and dyspnea symptoms since she was 5-6 months old. After diagnosing the patient's condition as dermatitis herpetiformis, atopic dermatitis, and bronchial asthma through history taking and symptom observation, Mahaengeuigam-tang (Maxingyigan-tang) was prescribed for about 30 days. As a result of evaluation through our own criteria, dermatitis herpetiformis symptoms improved from 18 to 2 points. Atopic dermatitis and asthma symptoms also decreased from 12 to 0 and 20 to 3 points, respectively. Since this study has proven the efficacy of Mahaengeuigam-tang (Maxingyigan-tang) for dermatitis herpetiformis patient, this prescription may be fully utilized as the treatment for other inflammatory skin diseases.

• 사상체질의학회지
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• 제35권1호
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• pp.14-24
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• 2023

Objectives This study was conducted to observe physiological changes when the function of spleen was extremely deteriorated, and to make an animal model with spleen deficiency. Methods The Normal group (Nr group) was not administered with Senna Folium extract. The SFE group(Senna Folium extract group) was administered with Senna Folium extract every day for the first 2 weeks and then every other day for another week. And the SFE_G group(Senna Folium extract_Ginseng group) was also administered with Senna Folium for 3weeks like the SFE group and fed with ginseng in the third week. Results The score of spleen deficiency was significantly higher in SFE group than in the Nr group and significantly lower in the SFE_G group than in the SFE group. The total weight gain was significantly lower in the SFE group than in the Nr group, and the average daily weight gain was significantly lower in the SFE group than in the Nr group. The difference in stool weight before and after the process of drying was significantly higher in the SFE group than in the Nr group, and significantly lower in the SFE-G group than the SFE group. There was no significant difference in the outcomes related to cold and heat among the three groups. Conclusions Through this study, the animal model with spleen deficiency was developed to prepare a stepping stone for animal tests to verify the efficacy and safety of constitutional prescriptions.

• 동의생리병리학회지
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• 제36권5호
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• pp.175-180
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• 2022

The seeds of Trichosanthes kirilowii (STK) used in traditional Oriental medicine for the treatment of dry cough and constipation have diverse pharmacological activities, including hypolipidemic, antioxidant, immunosuppressive, and anticancer effects. However, the effect of STK on angiogenesis has not been studied yet. In this study, we investigated whether the ethanolic extract of STK (ESTK) can regulate the migration and tube formation of human umbilical vein endothelial cells (HUVECs) and explored the underlying mechanism. Results of transwell assay showed that ESTK treatment dose-dependently suppressed the migration of HUVECs. The conditioned medium collected from H1299 human lung cancer cells was used as a chemoattractant. Our observation suggests that ESTK would inhibit the recruitment of endothelial cells into tumors. In addition, ESTK treatment significantly reduced the tube formation of HUVECs. As a molecular mechanism, we found that vascular endothelial growth factor (VEGF)-induced phosphorylation of VEGF receptor 2 (VEGFR2) was completely blocked by ESTK treatment. The expression of angiogenic factors, including VEGFA, fibroblast growth factor 2 (FGF2), angiopoietin, placental growth factor (PGF), platelet derived growth factor (PDGF), angiogenin, and tumor necrosis factor (TNF)-α, was commonly decreased by ESTK treatment in H1299 cells, indicating that ESTK would reduce the production of angiogenic factors from cancer cells. Taken together, our results clearly demonstrated that ESTK exhibited anti-angiogenic effects in HUVECs, which provides another possible mechanism underlying the anticancer activities of STK.

• 한국체육학회지인문사회과학편
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• 제56권6호
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• pp.541-559
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• 2017

본 연구는 라인댄스 프로그램에 참여한 유방암 생존자들을 대상으로 라인댄스 프로그램 참여 경험과 그 효과를 알아보는데 목적이 있다. 연구 참여자는 유목적 표집 방법에 따라 9명을 선정하였다. 자료는 심층면담과 참여관찰을 통해 수집하였으며, 참여 경험을 통한 효과에 대해 깊이 있는 의미를 도출하고자 현상학적 연구방법을 이용하였다. 본 연구의 분석 결과 프로그램 참여자가 경험한 라인댄스 프로그램의 효과로 신체적 효과 (생리적 변화, 소화 기능 향상, 수면의 질 향상, 신체의 유연성 증가, 인지 기능 향상), 심리적 효과 (재미와 즐거움, 활력, 평온, 자신감 향상, 자기만족), 사회적 효과 (가족 분위기 향상, 친밀도의 향상), 라인댄스 지속 효과(지속적 연습 및 스스로의 복습, 라인댄스 재미 발견, 참여의 지속 원함, 수업의 기대)로 범주화하였다. 마지막으로, 참여자들은 라인댄스에 참여하면서 서로에게 필요한 정보 공유 및 습득하였고, 프로그램에 참여하는 다른 유방암 환자들과 공감 하고 서로 위안이 되었다고 하였으며, 이로 인한 시너지 효과를 느끼는 것으로 나타났다. 따라서 그룹으로 이루어지는 라인댄스 프로그램은 향후 유방암 생존자들에게 적용될 수 있는 매우 안전하고 효과적인 운동프로그램 중 하나로 사료되어 진다.