• Journal of Pharmaceutical Investigation
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• v.40 no.6
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• pp.367-372
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• 2010

Rabeprazole sodium (RPN) is known to be very unstable at acidic condition or some acidic pharmaceutical excipients such as acrylic acid polymer (carbomer 934) with carboxylic acids. Thus, degradation mechanism of binary blends of rabeprazole with pharmaceutical excipients in a solid state without using solvents at three different ratios (3:1, 1:1 and 1:3) was investigated using Fourier transform infrad (FTIR) spectroscopy. Alkalizer (MgO), neutral hydroxypropymethylcellulose (HPMC 4000) were also tested for comparison. The binary blends were stored under accelerated conditions ($40^{\circ}C$/75% relative humidity) for two weeks. The concentration of thioether rabeprazole from the binary blends with acidic carbomer 934 increased as the rabeprazole concentration decreased. In addition, the degradation half-life of rabeprazole as well as the relative peak area ratios obtained from FTIR spectra of S=O stretching at $1094.1\;cm^{-1}$ decreased consistently as the fraction of carbomer 934 increased due to its sensitivity between the basic benzimidazole nitrogen and carboxylic acid group of carbomer 934. The physical appearance also turned into strong brown color in the presence of carbomer 934. In contrast, there were no significant changes in the degradation kinetics of rabeprazole with MgO and HPMC 4000 in a solid state. This present study demonstrated that the solid-state compatibility test with the aid of HPLC chromatographic and FTIR spectral analyses could offer a valuable methodology to select suitable pharmaceutical excipients and to elucidate the degradation mechanism of RPN for drug formulations at the early formulation stages.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.38 no.3
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• pp.197-209
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• 2020

Signboards are installed in different types and sizes depending on the shop characteristics. However, the local government is having difficulty managing signboards with frequent opening and closing of stores and insufficient management personnel. In this study, a methodology was proposed to standardize and efficiently manage signboard information. To this end, the signboard display method of the enforcement ordinance related to outdoor advertising was analyzed to define the attribute elements of standard signboard data. In addition, physical information of signboards was obtained through signboard recognition technology, which is a prior study, and attribute elements of signboard standard data were defined through information that can be read with the naked eye, building integration information of the Ministry of the Interior and Safety, and street name address. In order to standardize the signboard information by spatial characteristics, data product specifications and metadata were defined according to the national spatial information standard. Lastly, standard data for signboards were produced in XML (Extensible Markup Language) format for compatibility, and XSD (XML Schema Definition) was defined for XML integrity so that data validity could be verified. Through this, a standard data model for the informatization of signboards was designed.

• Korean Journal of Materials Research
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• v.33 no.7
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• pp.285-294
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• 2023

Porous ceramics are used in various industrial applications based on their physical properties, including isolation, storage, and thermal barrier properties. However, traditional manufacturing environments require additional steps to control artificial pores and limit deformities, because they rely on limited molding methods. To overcome this drawback, many studies have recently focused on fabricating porous structures using additive manufacturing techniques. In particular, the binder jet technology enables high porosity and various types of designs, and avoids the limitations of existing manufacturing processes. In this study, we investigated process optimization for manufacturing porous ceramic filters using the binder jet technology. In binder jet technology, the flowability of the powder used as the base material is an important factor, as well as compatibility with the binder in the process and for the final print. Flow agents and secondary binders were used to optimize the flowability and compatibility of the powders. In addition, the effects of the amount of added glass frit, and changes in sintering temperature on the microstructure, porosity and mechanical properties of the final printed product were investigated.

• Textile Coloration and Finishing
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• v.35 no.3
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• pp.159-168
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• 2023

Polyolefin elastomer (POE) is widely used in a variety of applications, particularly in the manufacture of composites, due to its excellent mechanical properties, chemical resistance, and flexibility. However, POE has a high processing temperature, which causes damage to the fiber during the manufacturing process when impregnating the fiber. Therefore, ethylene vinylacetate (EVA), which has a low melting point and excellent adhesion properties, is blended with POE to reduce the processing temperature, and POE-g-MAH (Polyolefin elastomer-grafted-maleic anhydride) is used as a compatibilizer to further improve the POE/EVA blend properties. The compatibility of POE/EVA blends is observed by SEM, and the interaction between each polymer is confirmed by DSC and FT-IR. In addition, the effect of adding the compatibilizer is analyzed through mechanical properties such as tensile strength and elongation. The optimal content of compatibilizer for POE/EVA blends considering physical properties and moldability is sought, and 20 phr is determined to be the most appropriate.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1994.10a
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• pp.1-8
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• 1994

A variable-node-flat shell element designated as CLS which has variable mid-side nodes with drilling freedom has been presented in this paper. The shell element to be applied in finite element analysis has been developed by combining a membrane element named as CLM with drilling rotation d.o.f. and plate bending element. The combined shell element possess six degrees of freedom per node. By introducing the variable-node elements which have physical midside nodes, some difficulties associated with imposing displacement constraints on irregular nodes to enforce interelement compatibility in common adaptive h-refinement on quadrilateral mesh are easily overcome. Detailed numerical studies show the excellent performance of the new shell elements developed in this study.

• Ceramist
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• v.21 no.3
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• pp.216-232
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• 2018

The average life span is over 80 years of age, and various biomaterials have being studied. Many research institutes and companies around the world have been commercializing bioactive glass through R&D, however, there is not much research in Korea. Most bioactive glass is applied to bone regeneration in powder form due to its excellent bio-compatibility. Recently, new applications such as scaffolds for tissue engineering and nerve regeneration have been found in composite form. The global market size is not as large as US $ 556 million in 2019, but the growth rate is very high at a CAGR of 14.35 %. This field is waiting for the challenge of new researchers.

• Proceedings of the Korea Concrete Institute Conference
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• 1999.04a
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• pp.585-590
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• 1999

There is still a lack of knowledge and modelling relating to shear behaviour in reinforced concrete beams. The reason is that shear loading leads to complicated physical mecanisms, such as interlock action, dowel action, etc. Therefore, It is difficult that we make the ideal model of shear behaviour, while Truss model theory has been made good use of shear design because of simplicity and reasonableness. In this study, 6 T-type reinforced concrete beams were designed and made based on the two truss models, i.e, the plasticity truss model and the compatibility truss model, to observe shear strength of concrete and stress distribution of stirrups. 6 beams test pieces were tested with the following testing parameters. 1) specified concrete strength ; 270kg/$\textrm{cm}^2$, 400kg/$\textrm{cm}^2$ 2) with and without the steel fiber.

• Spatial Information Research
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• v.5 no.1
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• pp.61-75
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• 1997

National Geographic Information System(NGIS) should be designed on the assumption that geographic data collected by each national organization should be integrated into geographic database systemically. To achieve this object, NGIS database would be better connected to National Very High-Speed Communication Network. In the process of research, some problems related to Korean NGIS are found. These are standardization, compatibility, extension, issue of making and opening digital map, and issue related to land information. So, it is required that pilot project apply National Geographic Information System in terms of National Very High-Speed computer network project. This project is to contain two main theme building of physical network and special management of network which is related with NGIS.

• Proceedings of the Korean Fiber Society Conference
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• 1998.10a
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• pp.236-239
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• 1998

The in situ composites based on poly(ethylene 2,6-naphthalate) and thermotropic liquid crystalline polymer (LCP) have been an area of increasing interest and study, since LCP exhibits high chemical stabilities and excellent thermo mechanical properties such as high strength and modulus. In a binary, however, poor compatibility and interfacial adhesions between two phases frequently results in deteriorated mechanical properties. (omitted)

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.3 no.4
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• pp.81-87
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• 2004

The titanium has many superior characteristics such as specific strength, heat resistance, corrosion resistance, organism compatibility, non-magnetic and etc. and their quantity are abundant. This study performed turning operation of Ti-6Al-4V alloy using the TiAlN coated tool which was treated with PVD. Experimental works were also executed to measure cutting force, chip figuration and surface roughness for different cutting conditions. As a result of study, tool wear was serious at the condition over 100m/min of cutting speed. The excellent cutting condition of cutting depth was at 1.0mm.