• Archives of Pharmacal Research
• /
• 제24권2호
• /
• pp.114-118
• /
• 2001

The present study was undertaken to investigate whether or not the hepatoprotective activity of acetylbergenin was superior to bergenin in carbon tetrachloride ($CCl_4$)-intoxicated rat. Acetylbergenin was synthesized by acetylating bergenin, which was isolated from Mallotus japonicus. The hepatoprotective effects of acetylbergenin were examined against $CCl_4$-induced liver damage in rats by means of serum and liver biochemical Indices. Acetylbergenin was administered orally once daily for 7 successive days, then a 0.5 ${m/kg}$ mixture of $CCl_4$in olive oil (1:1) was intraperitoneally injected at 12 h and 36 h after the final administration of acetylbergenin. Pretreatment with acetylbergenin reduced the elevated serum enzymatic activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and $\gamma$-glutamyltransferase in a dose dependent fashion. Acetylbergenin also prevented the elevation of hepatic malondialdehyde formation and depletion of glutathione content dose dependently in $CCl_4$-intoxicates rats. In addition, the decreased activities of glutathione S-transferase and glutathione reductase were restored to almost normal levels. The results of this study strongly suggest that acetylbergenin n has potent hepatoprotective activity against $CCl_4$-induced hepatic damage in rats by glutathione-mediated detoxification as well as having free radical scavenging activity. In addition, acetylbergenin doses of 50 ${mg/kg}$showed almost the same levels of hepatoprotection activity as 100 ${mg/kg}$ of bergenin, indicating that lipophilic acetylbergenin is more active against the antihepatotoxic effects of $CCl_4$ than those of the much less lipophilic bergenin.

• 한국콘텐츠학회논문지
• /
• 제20권11호
• /
• pp.511-524
• /
• 2020

연구목적은 혈액투석환자를 위한 혈액투석 중 자전거운동과 걷기운동을 개발하여 적용하고, 혈액투석환자의 신체 활동량이 건강관련 삶의 질과 영양섭취에 미치는 영향을 확인하기 위함이다. 연구방법은 혈액투석환자에게 적용한 유산소 운동 프로그램의 효과를 확인하기 위한 비동등성 대조군 전·후 실험연구이다. 연구대상자는 중재군과 대조군에 각각 30명이 배정되어 총 60명이었다. 운동중재는 두 종류의 유산소 운동이 포함되어 있으며, 총 8주간 진행되었다. 첫 번째 운동은 일주일에 세 번씩 혈액투석 중 수행되는 자전거운동이었고 두 번째 운동은 일주일에 최대 7 일 동안 실시되는 걷기운동이었다. 통계분석은 기술통계, 독립표본 t-test, 𝑥2-test와 Mann-Whitney U test를 사용하였다. 영양섭취는 CAN-2.0을 사용하여 평가하였다. 연구결과는 중재군이 중재 후 신체활동량 점수가 유의하게 높았으며, 신체적 건강관련 삶의 질도 중재 후 유의하게 개선되었다. 그러나 영양섭취는 중재 전 후 유의한 차이가 없었다. 비록 그룹 간의 차이는 없었지만, 총 칼로리 섭취는 중재 후에 중재군이 대조군보다 높은 것으로 나타났다. 신체적 건강관련 삶의 질은 동물성 단백질, 망간, 셀레늄과 비타민 C와 유의한 상관관계가 있었다. 본 연구는 혈액투석 중 자전거운동과 걷기운동은 신체활동량과 신체적 건강관련 삶의 질을 향상시키는데 효과적인 것으로 나타났다. 따라서, 본 연구결과는 혈액투석환자의 운동증진을 위한 지침으로 사용될 수 있을 것이다.

• 대한지역사회영양학회지
• /
• 제8권6호
• /
• pp.822-830
• /
• 2003

Carotenoid-rich foods focus one's attention on the prevention age-related diseases. This study was conducted to investigate the carotenoid status and look into the factors that affect the bioavailability of carotenoid in 121 elderly nonsmoking Korean women. Carotenoids and lipids in plasma, and nutrient intakes including carotenoid were studied. The mean plasma total-cholesterol, HDL-cholesterol, LDL-cholesterol and triacylglycerol concentrations were 220.0 mg/dl 49.5mg/dl , 139.2mg/dl and 157.4mg/dl , respectively. Significantly positive correlations were found between the plasma lutein + zeaxanthin, lycopene and $\beta$-carotene concentrations and the intake of fruits (r=0.17, r=0.20, r=0.19). However, significantly negative correlations were found between the plasma zeaxanthin, and $\beta$-carotene concentrations that adjusted for carotenoid intakes and intakes of vegetables (r=-0.21, r=-0.19), and between plasma lutein＋zeaxanthin, lycopene and $\beta$-carotene concentrations that adjusted for carotenoid intakes and intakes of fruits (r= -0.21, r=-0.18, r=-0.24). After the adjustment for plasma lipids, there was no correlation between the plasma carotenoid concentrations and the carotenoid-rich foods. However, after adjustment for fiber intake, significantly strong positive correlations were found between the plasma carotenoid concentrations and carotenoid-rich foods. The plasma levels of carotenoid biomarkers (plasma carotenoid concentrations adjusted for dietary fiber intakes) decreased with age, and the plasma levels of lycopene biomarkers (plasma lycopene concentrations adjusted for dietary fiber intakes) increased with regular exercise. However alcohol drinking had no impact. These results suggested that age, physical activity, and dietary fiber intake affected the bioavailability of carotenoid. Therefore, when the elderly have carotenoid-rich foods, they should consider ways of increasing the bioavailability of carotenoid through cooking methods and Physical activity.

• Journal of Preventive Medicine and Public Health
• /
• 제52권2호
• /
• pp.101-108
• /
• 2019

Objectives: To objectively determine and compare the physical activity (PA) levels of adults newly diagnosed with type 2 diabetes (T2D) and adults without T2D in Vietnam using an accelerometer. Methods: A total of 120 participants with newly diagnosed T2D and 120 adults without T2D were recruited from a large hospital in Hanoi, the capital city of Vietnam. All participants wore an ActiGraph GT3X accelerometer for at least 5 days, including 1 weekend day. Freedson cut-off points were used to estimate different intensities of PA. In addition, comparisons between groups were made with respect to achieving the World Health Organization (WHO) and International Diabetes Federation (IDF) recommended PA guidelines. Results: Men with T2D had significantly lower levels of PA than men without T2D. The respective multivariable-adjusted mean values of daily step count, daily light-intensity, moderate-intensity, and moderate-to-vigorous-intensity PA were approximately 14%, 19%, and 22% lower in the men with T2D than in their non-T2D counterparts. However, women with T2D accumulated a greater number of steps per day than women without T2D. Only 59.2% of the adults with T2D met the minimum recommended level of PA (WHO and IDF), compared to 74.2% of adults without T2D (p<0.05). After adjusting for potential confounders, participants with T2D experienced 50.0% significantly lower odds of achieving PA recommendations. Conclusions: Vietnamese men with T2D were less physically active than those without T2D, and adults with T2D were less likely to meet PA guidelines. The results suggest a need for integrating PA into the self-management of this chronic condition.

• 대한통합의학회지
• /
• 제10권3호
• /
• pp.53-62
• /
• 2022

Purpose : This research is a descriptive study that aimed to identify the levels of health promotion behaviors, fatigue, and depression of nursing students and confirm the effect of health promotion behaviors on fatigue and depression. Methods : Data were collected from September 27 to October 15, 2021 through survey questionnaires on 178 nursing students of 2 universities in G-do who voluntarily agreed to participate. The collected data were analyzed using SPSS 23.0, the general characteristics of nursing students were analyzed by frequency and percentage, and the levels of their health promotion behaviors, fatigue, and depression of nursing students was analyzed by mean and standard deviation. The relationship among the health promotion behaviors, fatigue, and depression was analyzed by Pearson's Correlation Coefficient. Multiple regression analysis was performed for the effects of health promotion behaviors on fatigue and depression of nursing students. Results : The nursing students' health promotion behaviors averaged 2.25±.43 points out of 5, and for each sub-factor, interpersonal relationship was the highest at 2.66±.49 points and physical activity was the lowest at 2.01±.60 points. Fatigue was 4.89±1.02 points out of 7 and depression was 10.52±9.10 points out of 63. A statistically significant correlation was found among health promotion behaviors, fatigue, and depression. Health promotion behaviors that significantly affected fatigue were stress management (𝛽=-.263, p=.004) and physical activity (𝛽=-.208, p=.026), which showed 35 % explanatory power on fatigue. Health promotion behaviors that significantly affected depression were spiritual growth (𝛽=-.342, p=.002), and physical activity (𝛽=-.231, p=.016), which showed 31 % explanatory power for depression. Conclusion : This study is meaningful in that it provided basic data to develop an effective health promotion behavior program to prevent and manage nursing students' fatigue and depression, by identifying and analyzing the sub-factors of health promotion behaviors affecting their fatigue and depression.

• 대한물리치료과학회지
• /
• 제6권3호
• /
• pp.53-61
• /
• 1999

Prior studies have revealed that several stimulation to the muscle have released serum myoglobin into the blood vessel and increased aldolase activity. The present authors carried out a study which effect of electrical stimulation treatment (induced a isotonic wrist exerceise) on serum myoglobin(Mb) levels and aldolase(Al) activity were investigated in 6 healthy female. There were four groups of female: 1. no electrical stimulation control: 2. electrical stimulation 10min (EST10'); 3. electrical stimulation 20 min (EST20'); 4. electrical stimulation 30min (EST30'). Each groups is all the same one. Radioimmunoassay and Ultraviolet Spectrophotometry were performed to increased or decreased of serum myoglobin and aldolase. Serum myoglobin significantly increased in electrical stimulated groups[EST10' $(30.20{\pm}5.27ng/ml)$, EST20'$(31.65{\pm}3.96ng/ml)$, EST30'$(31.95{\pm}2.0ng/ml)$] to be compared with control group$(24.43{\pm}2.20ng/ml)$. Aldolase significantly increased in electrical stimulated groups [EST10' ($6.85{\pm}1.17$ Sigma U/mL), EST20'($6.70{\pm}1.46$ Sigma U/mL), EST30'($6.56{\pm}1.01$ Sigma U/mL)) to be compared with control group($5.03{\pm}1.86$ Sigma U/mL). The results of this study show that isotonic exercise result in electrical stimulation treatment increased serum myoglobin content and aldolase activity. In conclusion, our results support that stimulation release serum myoglobin and increase aldolase activity.

• 한국전문물리치료학회지
• /
• 제12권3호
• /
• pp.22-30
• /
• 2005

This study was designed to identify the effect of various decline boards and postures of lower extremities on surface electromyographic (EMG) activity of knee muscles during isometric single-leg decline squat exercises. The subjects were twenty young male adults who had not experienced any knee injury and their Q-angles were within a normal range. They were asked to perform single-leg decline squat exercises in five various conditions. The EMG activities of the gluteus maximus (GM), vastus lateralis (VL), vastus medialis (VMO), tibialis anterior (TA), and gastrocnemius (GCM) muscles were recorded in five various single-leg decline squat exercises by surface electrodes and normalized by maximal voluntary isometric contraction (MVIC) values. The normalized EMG activity levels were compared using one-way ANOVA with repeated measures. The results of this study were as follows: 1) Exercises 2 and 4 produced significantly greater EMG activity of VMO than did exercise 1 ($p_{adj}$<.05/10), 2) The VMO/VL ratio of EMG activity of exercise 4 was the highest, producing a significantly greater ratio than exercise 1 ($p_{adj}$<.05/10). These results show that single-leg lateral oblique decline squat exercise is the best exercise for selective strengthening of VMO, and the posture of the contralateral leg does also affect strengthening of VMO, but we'll need to research patellofemoral joint compression for clinical application of single-leg lateral oblique decline squat exercises.

• 한국산업보건학회지
• /
• 제27권3호
• /
• pp.201-209
• /
• 2017

Objectives: This study was conducted to assess the association between level of physical activity and depressive symptoms among Korean male workers. Methods: A self-administered questionnaire was distributed and anthropometric measurements were conducted with 1,379 male workers during a general health check. From this data, we identified the general characteristics, levels of physical activity(IPAQ), and depressive symptoms(CES-D) of the study population. We conducted univariate logistic regression to verify the variables that affect depressive symptoms and multivariate logistic regression to calculate odds ratios. Results: Among the 1,379 male workers, 43.4% were in the insufficiently active group(IPAQ category 1) and 22.8% were in the depressive symptom group($CES-D{\geq}16$). The odds ratio(OR) for depressive symptoms was statistically higher in the insufficiently active group, workers aged over 30, the shift work group, and the unmarried group. Adjusted for those variables, the ORs for depressive symptoms were found to be 1.45(95% CI=1.25-2.11), 1.15(OR=1.15, 95% CI=1.08-1.99) and 1.75(95% CI=1.48-2.02), for the insufficiently active group, workers aged over 30, and the shift work group, respectively. Conclusions: We found physical inactivity, age, marital status, and shift work to be associated with depressive symptoms among male workers. This study supports the suggestion that physical activity can be helpful to reduce depressive symptoms among workers.

• 대한간호학회지
• /
• 제21권3호
• /
• pp.257-267
• /
• 1991

This study investigated the effects of nursing in formation given verbally and a booklet on the knowledge, Physical symptoms, anxiety and daily activities of patients recovering from open heart surgery from just before discharge to six weeks after discharge. The convenience sample was of patients who had undergone open heart surgery in Seoul National University Hospital. The first 25 patients who agreed to participate in the study became the control group. They did not receive the intentional information but the usual nursing care. The next 28 patients became the experimental group who received a booklet about their post-discharge care which was discussed with them by the researcher before discharge. This study used a non equivalent control group non - synchronized quasiexperimental design. The tools included a 30 item knowledge scale, a 9 item physical symptom scale, Spielberger's state anxiety scale, and a 28 item daily activity scale. The instruments were applied before discharge and at two and six weeks after discharge. For data analysis, frequency, t-test, Pearson's Correlational Coefficient and Cronbach's $\alpha$ were used. The results were as follows : 1. Information given through the booklet was effective in increasing the knowledge of patients recovering from open heart surgery. The experimental group's knowledge was higher at 2 weeks after discharge than prior to discharge (P＜0.05). 2. There was no significant difference in physical symptoms between the two groups at two and six weeks after discharge. 3. Information given through the booklet was effective in decreasing the State Anxiety two weeks after discharge (P＜0.001) but at six weeks after discharge, there was no significant difference in anxiety between the control and the experimental groups. 4. There was no significant difference in daily activity between the two groups at two and six weeks after discharge. 5. There was a negative correlation between knowledge at discharge and at 2 weeks and anxiety at 2 weeks after discharge. There was a positive correlation between knowledge at discharge and daily activity at 2 weeks after discharge. There was a negative correlation between knowledge at 2 weeks and Physical symptom at 6 weeks after discharge.

• Journal of Radiation Protection and Research
• /
• 제42권3호
• /
• pp.166-175
• /
• 2017

Background: This study presents food ingestion standards for radioactivity that can be applied in nuclear emergency exposure situations, and discusses the validity of the current domestic standards. Materials and Methods: This study derived food ingestion standards for radiocesium and radioiodine using domestic food intake rates and intervention levels, which serve as a basis for determining the necessity of public protective actions, and then compared them with the existing guidelines. Operational intervention levels were also derived using domestic food intake rates, and were compared with those of the International Atomic Energy Agency. Results and Discussion: The derived activity concentrations for food ingestion standards of radiocesium for infants were higher than those in the Act on Physical Protection and Radiological Emergency (APPRE) for all food categories, while for adults, the derived activity concentrations for drinking water and milk appeared to be slightly lower. The derived activity concentrations for vegetables, fruits, and grains were greater than those in the guidelines of the APPRE, while the derived activity concentrations for meat and seafood were similar to those in the APPRE. The derived activity concentrations for radioiodine were greater than both domestic and global standards. The calculated operational intervention levels (OILs) based on domestic food intake rates were greater than the IAEA's default OIL6 values for most radionuclides, except for a few ${\alpha}$-radionuclides. Conclusion: The current domestic guidelines turned out to be conservative overall, compared to the present results that were calculated using domestic food intake rates. It is recommended that the domestic guidelines should be revised and complemented transparently through an in-depth review by stakeholders on a solid scientific basis.