• Journal of Photoscience
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• v.8 no.2
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• pp.71-71
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• 2001

• Journal of Biomedical Engineering Research
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• v.37 no.4
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• pp.134-139
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• 2016

US Food and Drug Administration (FDA) approved as a innovative cure for cancer, 1996. The effect is death of cancer cells through necrosis, apoptosis. Mainly the Continuous Wave mode (CW) use for PDT Laser. It sting, the question including itch, and etc. Reportedly, the increase of temperature with the perforated edema, ulcer, necrosis. The Thermal relaxation time and Oxygen recovery time is necessary. To give a normal oxygen recovery time of the cell, used Pulse mode. Progress, it was Burst Pulse mode when easing the thermal wake, the simplicity was secured, the PDT effect is good. Excepted in control group CW, Pulse, Burst pulse mode were incubated with various concentrations of 5-aminolevulinic acid hydrochloride (ALA-5). The tumor size reduction CW mode (44%), Pulse mode (48%), Burst pulse mode (53%) at 4 week after PDT with 0.3, 0.3, 0.3 mg/ml of ALA-5. After 4 hours, investigation of 100, 100, $100J/cm^2$ laser irradiation. The pulse mode was superior in expirimental data analysis. And it was the Burst pulse mode edge head of a family effect.

• Journal of Photoscience
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• v.8 no.2
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• pp.70-73
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• 2001

The chlorin-bromine building block was constructed and applied to synthesize $\delta$-bromo compounds of methyl pyropheophorbide-a. The visible spectra of the title compounds were discussed.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.420.2-420.2
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• 2016

Various fields have been paid attention to upconversion nanoparticles (UCNPs) because of its unique optical properties. Moreover, to use the UC luminescent techniques through cell images for identified apoptosis/necrosis of cancer cells have been performed. They have been studied for a versatile biomedical application such as a biosensing tool, or delivery of active forms of medicines inside living cells. UCNPs have distinctive characteristics such as photoluminescence, special emission, low background fluorescence signal and good colloidal stability, which have many advantages compared with the organic dyes and quantum dots. UCNPs have not only a great potential for imaging (UC luminescence) but also therapies (photo-thermal therapy, PTT and photo-dynamic therapy, PDT) in cancer diagnostics. Therefore, we report the enhancement of upconversion red emission in NaYF4:Yb3+,Er3+ nanoparticles, synthesized via solid-state method with the thermal decomposition of trifluoroacetate as precursors and organic solvent at a high boiling point. The UCNPs have an emission in the field of near infrared wavelength, cubic shape and nano-size in length. In this study, we will further investigate it for cancer therapy with NIR optical detection onto the solid substrate.

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2008.10a
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• pp.131-132
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• 2008

Several squarylium dyes, derived from benzothiazole and indoles, were synthesized as a potential NIR dyes with absorption in the 700-900 nm region. These chromophores were induced much more bathochromic shift in the absorption maximum of the compound relative to the neutral parent squarylium dyes which we were described before. The squaryliums offer a convenient way of linking the dye to functional substrates and may be an advantage to be potential chromophores for NIR-absorbing, NIR-Cut-off filter, PDT(Photo Dynamic Therapy) materials.

• Journal of the Korean Society of Radiology
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• v.6 no.3
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• pp.207-215
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• 2012

As one of photo dynamic therapies, the existing LED photo irradiation method with 635 nm continuous wave has most frequently been used for acne treatment, it suffered from a low energy efficiency and generation of a large amount of heat in tissues requiring improvement measures. In this thesis, a LED photo irradiation system for acne treatment has been designed using PWM(Pulse Width Modulation) mode to enhance the energy efficiency and prevent thermal destruction in tissues. System configuration consisting largely of timer module, PWM module, and photo transfer device has been designed with the use of 1 W LED at a wavelength of 660 nm for the photo transfer device to increase skin penetration depth for treatment of acne. Frequency and wave form generated by using PWM control was verified along with confirmation of output energy of 660 nm LED and surface temperatures of tissues, followed by evaluation of stable energy outputs and stability of tissues. The results indicated that whereas power loss was high and thermal destruction in tissues was exhibited when C.W mode was used to obtain the optical energy of 1 W LED at a wavelength of 660 nm for acne treatment, realization of PWM mode allowed lowering of power consumption for LED through pulse width modulation, and no occurrence of thermal destruction in tissues, suggesting that PWM mode is safer and more effective for treatment of acne than C.W mode.