• 약학회지
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• 제45권1호
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• pp.29-33
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• 2001

A method for the determination of anionic drug, mefenamate with ion-selective electrode using Fe(II)-1,10-phenanthroline chelate as a counter ion was developed. Benzyl nitrophenyl ether (BNPE) plasticized membrane was more selective and sensitive than the other tested membranes. This membrane electrode exhibits a linear response for 10$^{-2}$ M~5 $\times$ 10$^{-5}$ M of mefenamic acid with a slope of -61.4 mV/dec. in borate buffer solutions (pH 9.0). Potentiometric selectivity measurements revealed negligible interferences from various organic and ionorganic anions. Direct potentiometry and potentiometric titration method of mefenamic acid in capsule preparations are presented and compared.

• Bulletin of the Korean Chemical Society
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• 제30권12호
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• pp.3061-3065
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• 2009

A series of mono- and 1,1'-bis(heteroaryl)-substituted ferrocenes were prepared by employing Frielander reaction of acetyl- and 1,1'-diacetylferrocene with a series of o-aminoaldehydes. Reactions of 1,1'-diacetylferrocene with two equivalents of 1-aminonaphthalene-2-carbaldehyde and 8-aminoquinoline-7-carbaldehyde afforded a mixture of mono- and 1,1'-bis(heteroaryl)-substituted ferrocenes in a ratio of 1 : 3.1 - 3.8, while the reaction with 4-aminoacridine-3-carbaldehyde did not provide any characterizable product presumably due to the redox instability of the product induced by low reduction potential of benzo[b]-1,10-phenanthroline. Structural and optical properties of the compounds prepared were described.

• Bulletin of the Korean Chemical Society
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• 제35권4호
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• pp.1087-1090
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• 2014

A simple and general method that selectively introduces metal binding sites into a protein can greatly increase the ability to design and biosynthesize artificial metalloproteins. Here, we report the incorporation of a phenanthroline-containing amino acid (Phen-Ala) into proteins in Escherichia coli by using the $tRNA{^{Tyr}}_{CUA}$ and tyrosyl aminoacyl-tRNA synthetase pair (BpyRS) from Methanococcus jannaschii, which was originally developed for a bipyridine-containing amino acid (Bpy-Ala). The incorporation efficiency of BpyRS for Phen-Ala was comparable to that for Bpy-Ala. Because of its high metal-binding ability and characteristic spectral properties, Phen-Ala can be a useful alternative to the existing metal-chelating amino acids for the design and synthesis of artificial metalloproteins.

• 약학회지
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• 제16권4호
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• pp.180-185
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• 1972

A new spectrophotometric method was established for the determination of undecylenic acid. The method is based on the solvent extraction into nitrobenzene of the ion pair formed between tris(1,10-phenanthroline)Fe(II) chelate and the anion of undecylenic acid. The maximum absorbance of the extract in the organic phase was at 518nm. A maximum extraction was obtained at pH 9-11, when excess of at least 50-fold(molar) of the phenanthroline-Fe(II) chelate to undecylenic acid was present. The color intensity of the extracted species remained constant at room temperature for the several hours after separation of the organic layer. A linear relationship was obtained over the tested range of 5-20${\gamma}$/ml of undecylenic acid. The effect of several other fungicids on this method was investigated. The method was applied to the determination of undecylenic acid in preparations and the results were in good agreement with those added amounts.

• 대한화학회지
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• 제39권9호
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• pp.705-714
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• 1995

란탄이온의 특성 발광선 세기가 Nylon Membrane상에서 증폭되는 현상을 이용하여 $Eu^{+3}$과 $Tb^{+3}$이온에 대한 고감도의 미량분석법에 대하여 연구아였다. 수용액(혹은 에탄올 용액) 상태에서의 $Eu^{+3}$과 $Tb^{+3}$두이온의 발광선의 세기에 비하여 주어진 용액 시료를 Nylon Membrane에 점적하면 이온의 방출선의 세기가 매우증가하였으며 특히 점적된 이온에 o-phenanthroline을 추가로 점적하면 방출선의 세기가 더욱 증가하는 증폭현상을 이용하여 $Eu6{+3}$과 $Tb^{+3}$이온의 검출한계를 용액 시료에 비하여 $10_7$배 이상 개선하였으며 이때의 검정곡선은 검출한계 근처에서 2-3 order의 선형범위(dynamic range)와 상관계수가 0.99 이상인 직선성을 나타냈으며 또한 TLC 방법에 비하여 10배정도의 검출한계 개선효과를 얻었다. 한편 o-phenanthroline의 변화에 따른 선세기의 변화를 관찰한 결과 -4몰비 정도에 최대의 선세기를 보였으며 그 이상에서는 일정한 선세기를 나타내었는데 이런한 발광증폭의 이론적인 배경으로 착물내의 리간드와 란탄이온 사이의 energytransfer mechanism을 설명하였다.

• 대한화학회지
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• 제56권1호
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• pp.164-168
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• 2012

• 대한화학회지
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• 제51권6호
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• pp.595-599
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• 2007

• 대한화학회지
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• 제39권4호
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• pp.318-322
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• 1995

• Korean Chemical Engineering Research
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• 제54권4호
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• pp.555-559
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• 2016

본 연구에서는 2,2'-bispyrimidine (bpim), 2,2'-bipyridine (bpy), 5,5'-dimethyl-2,2'-bipyridine (5,5-mebpy), 5'-bromo-2,2'-bipyridine (5-brbpy), 5,5'-dibromo-2,2'-bipyridine (5,5-brbpy), 4,4'-dimethyl-2,2'-bipyridine (4,4-mebpy), 4,4'-dihexyl-2,2'-Bipyridine (4,4-hebpy), 1,10'-Phenanthroline (phen), 3,4,7,8'-tetramethyl-1,10'-Phenanthroline (3,4,7,8-phen)을 사용하여 단핵 Platinum착체를 합성하였다. 합성되어진 Platinum착체의 화학적 구조를 결정하기 위해서 $^1H(^{13}C)$-NMR, FT-IR을 사용하였으며, 광 물리학적 특성에 대한 측정은 UV-vis, PL을 통하여 측정하였다. 합성한 Platinum착체는 356 nm~421 nm영역에서 발광파장이 확인되었으며, DMSO용액에서 내부양자효율이 0.05~0.46으로 나타났다.

• Bulletin of the Korean Chemical Society
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• 제24권12호
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• pp.1775-1780
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• 2003

A continuous flow system has been developed to determine trace Cu(II), Mn(II), Ni(II) and Zn(II) in a large volume of water samples by a solvent sublation technique. The mixed solution of 1,10-phenanthroline(phen) and thiocyanate ion was used as ligands for the formation of their ternary complexes. The continuous system was constructed in this laboratory with a peristaltic pump, a mini shaker, three mixing bottles and a flotation cell by connecting each part with a polyethylene tube. The flotation conditions such as the flow rate of sample solution and the injection rates of ligand, buffer and surfactant solutions have been investigated to obtain the best sublation efficiencies. Each solution flowed into the flotation cell through each polyethylene tube by the peristaltic pumps. The ternary complexes were floated and extracted into MIBK in a flotation cell of 2 L by bubbling a nitrogen gas. The absorbances of extracted analytes in MIBK were directly measured by graphite furnace-AAS. The concentrations of 1,10-phenanthroline and thiocyanate ion were $2.6\;{\times}\;10^{-3}$ M and $2.3\;{\times}\;10^{-2}$ M in the mixed solution, respectively. The pH of sample solution was adjusted to 5.0 with a buffer solution and 1%(m/v) sodium lauryl sulphate solution was added as a surfactant to support the effective flotation of the complexes. The $N_2$ gas was bubbled at 30 mL/min for 90 minutes for 20 L of sample. Reproducible results of less than 10% RSD and recoveries of 80-120% could be obtained in real samples.