YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Determination of Mefenamic acid with ISEs Using Ternary Complex of Metal -phenanthroline -mefenamate as Ion-exchanger

이온교환체로서 금속 -페난드롤린 -메페남산 3원 작물을 이용한 메페남산의 정량

  • 허문회 (부산지방식품의약품안전청) ;
  • 김대병 (부산지방식품의약품안전청) ;
  • 남수자 (부산지방식품의약품안전청) ;
  • 문현숙 (경성대학교 약학대학) ;
  • 이미나 (경성대학교 약학대학) ;
  • 정문모 (경성대학교 약학대학) ;
  • 안문규 (경성대학교 약학대학)
  • Published : 2001.02.01
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Abstract

A method for the determination of anionic drug, mefenamate with ion-selective electrode using Fe(II)-1,10-phenanthroline chelate as a counter ion was developed. Benzyl nitrophenyl ether (BNPE) plasticized membrane was more selective and sensitive than the other tested membranes. This membrane electrode exhibits a linear response for 10$^{-2}$ M~5 $\times$ 10$^{-5}$ M of mefenamic acid with a slope of -61.4 mV/dec. in borate buffer solutions (pH 9.0). Potentiometric selectivity measurements revealed negligible interferences from various organic and ionorganic anions. Direct potentiometry and potentiometric titration method of mefenamic acid in capsule preparations are presented and compared.

Keywords

References

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