• The Korean Journal of Physiology and Pharmacology
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• 제21권5호
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• pp.555-563
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• 2017

Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted FB filter for artifact subtraction. From the extracted retinae of rd1 mice, we recorded RGC spikes with $8{\times}8$ multielectrode array (MEA). The recorded signals were classified into four groups by distances between the stimulation and recording electrodes on MEA (200-400, 400-600, 600-800, $800-1000{\mu}m$). Fifty cathodic phase-$1^{st}$ biphasic current pulses (duration $500{\mu}s$, intensity 5, 10, 20, 30, 40, 50, $60{\mu}A$) were applied at every 1 sec. We compared false positive error and false negative error in FB filter and TP-adopted FB filter. By implementing TP-adopted FB filter, short-latency spike can be detected better regarding sensitivity and specificity for detecting spikes regardless of the strength of stimulus and the distance between stimulus and recording electrodes.

• 대한전자공학회논문지TC
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• 제43권10호
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• pp.46-54
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• 2006

본 논문에서는 기존의 아날로그 트랜시버가 가지고 있는 단점을 극복하기 위한 디지털 트랜시버를 제안한다. 제안된 트랜시버는 불연속적인 협대역 채널들로 구성된 환경에서 사용된다고 가정하였다. 그리고 어느 정도의 보안성을 가지며 개인 대(對) 개인뿐만 아니라, 개인 대(對) 그룹, 그룹 대(對) 그룹의 음성 및 데이터 통신이 가능하여야 하며, 음성과 데이터를 동시에 전송할 경우 1 Mbps의 데이터 율을 가져야 한다고 가정하였다. 주파수 대역의 제한 때문에 FH-SS(Frequency Hopping-Spread Spectrum) 방식을, 구현의 복잡성 때문에 D8PSK(Differential 8 Phase Shift Keying) 방식을 채택하였다. 반송파와 심볼 타이밍 복원을 위해 IEEE 802.11 FHSS 프레임 구조를 바탕으로 새로운 프리앰블 구조를 제안하여 검출 확률을 높였다. 전산 모의 실험과 전력 계산을 통하여 제안된 시스템은 아날로그 워키토키와 같은 간단한 무선 통신에 사용될 수 있음을 보였다.

• 비파괴검사학회지
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• 제28권1호
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• pp.9-15
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• 2008

증기발생기 전열관에 생성되는 투자율변화에 의해 야기되는 신호왜곡 문제를 해결하기 위한 새로운 탐촉자를 개발하였다. 고리 1 호기 폐전열관에 생성된 자성상을 분리하여 자기이력곡선을 측정하였으며, 자성상이 생성되는 원인을 규명하기 위하여 고온 인장 시험을 수행하였다. 전산모사를 이용하여 탐촉자의 자정상 탐지조건을 결정하였으며, 디지털 신호전송을 위하여 신호처리용 전자회로를 소형화하여 탐촉자 속에 삽입하였다. 본 연구에서 개발된 신형 탐촉자를 이용하여 PVC 신호와 니켈 슬리빙 부위의 결함을 측정하였다. 신형 탐촉자는 보빈 탐촉자와 같이 고속으로 결함을 측정 할 수 있으며, 증기발생기 전열관의 탐상속도와 결함 탐지의 신뢰성을 증진시킬 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5131-5136
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• 2012

Cancer is one of the major health problems worldwide and its current treatments have a number of undesired adverse side effects. Natural compounds may reduce these. Currently, a few plant products are being used to treat cancer. In this study, goniothalamin, a natural occurring styryl-lactone extracted from Goniothalamus macrophyllus, was investigated for cytotoxic properties against cervical cancer (HeLa), breast carcinoma (MCF-7) and colon cancer (HT29) cells as well as normal mouse fibroblast (3T3) using MTT assay. Fluorescence microscopy showed that GTN is able to induce apoptosis in HeLa cells in a time dependent manner. Flow cytometry further revealed HeLa cells treated with GTN to be arrested in the S phase. Phosphatidyl serine properties present during apoptosis enable early detection of the apoptosis in the cells. Using annexin V/PI double staining it could be shown that GTN induces early apoptosis on HeLa cells after 24, 48 and 72 h. It could be concluded that goniothalamin showing a promising cytotoxicity effect against several cancer cell lines including cervical cancer cells (HeLa) with apoptosis as the mode of cell death induced on HeLa cells by Goniothalamin was.

• 대한수의학회지
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• 제47권4호
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• pp.417-423
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• 2007

Serological surveillance programs in animal populations are becoming increasingly important to estimate prevalence of a specific disease and subsequently to document disease-free status in a region or a country. For these purposes, the programs need to be based on both theoretical and economical aspects from the designing phase. From Aujeszky's disease (AD)-eradication program point of view, group of animals (aggregates, herds) not individual animal is the more important sampling unit of concern. In this study the authors therefore attempted to compute an appropriate sample size tailored to a current surveillance program against AD, assuming that the goal of this program is either herd-level prevalence estimation or documentation of AD-freedom. For prevalence estimation, assuming a finite population with imperfect sensitivity (Se) and specificity (Sp) of ELISA kit for AD diagnosis, the number of herds present, expected herd prevalence, and desired accuracy for a certain level of confidence, sample size was estimated at herd-level in the first stage and individual animal-level in the second stage. A two-stage sampling design was used to calculate a sample size to indicate AD-freedom. In this instance, the computation was based on the possible detection of a predetermined prevalence at a certain herd-level Se and Sp. This study indicated that the sample size varied with predetermined confidence, tolerance, Se and Sp at herd- and animal-level, and within- and among-herd prevalence. In general, smaller sample size was required to estimate AD prevalence than to document of AD-freedom. Compared to individual-based samples, two-stage sampling strategy requires a larger sample size to show disease-freedom. Statistical considerations including herd-level test characteristics when designing surveillance program also are further discussed.

• 한국재료학회지
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• 제23권5호
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• pp.281-285
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• 2013

In the present work, ZnO nanofibers were applied to electrode materials for the detection of cholesterol. ZnO nanofibers were synthesized using the electrospinning technique with zinc acetate as a precursor. Electrospinning-synthesized ZnO nanofibers were uniformly distributed by properly controlling the electrospinning parameters. After the calcination treatment, nanofibers of pure ZnO phase were synthesized. Then, these fibers were successfully placed on Au-coated glass substrates by dispersion of ZnO nanofibers in ethanol, dropping, and drying, in sequence. Cholesterol oxidase was then immobilized onto the surface of the ZnO nanofibers. To enhance the immobilization, Nafion was additionally applied. The sensing performances of the fabricated ZnO nanofibers-based sensors were analyzed by cyclic voltammetry in terms of cholesterol concentration ranging from 100 to 400 mg/dl. In the I-V curves, measured by cyclic voltammetry, the ZnO nanofiber-based sensor showed a proportional current behavior with cholesterol concentrations in phosphate buffered saline solution. The sensitivity was measured and found to be $30.7nA/mM{\cdot}cm^2$, which is comparable to the values reported in the literature. After not only optimizing the shape of the ZnO nanofibers but also improving the adhesion nature between the ZnO nanofibers and the Au conducting layer, these fibers can be a good candidate for electrode materials in devices used to detect low concentrations of cholesterol in blood.

• 한국산업보건학회지
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• 제28권2호
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• pp.144-150
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• 2018

Objectives: The purpose of this study is to analyze the trend for exceedance of the domestic permissible exposure limit of benzene based on a review of the previous literature. Materials and methods: From among 13 chemical substances regulated through a PEL (Permissible Exposure Limit) in the Occupational Safety and Health Act, the research object of this study is benzene. The information utilized is work environment measurement data from 2004 to 2013. The highest level among the concentration data measured at various workplaces was selected as a representative value through the data process. N.D. (Not Detected) data was considered as 1/2 of the LOD (limit of detection). Results: Among the work environment measurement data between 2004 and 2013, the highest number of exceeding workplaces and the excess rate (12 sites and 5.4%) was observed in the 2006 data when applying the current PEL for benzene. When compared with the action level, which means a level one-half of the PEL, 2005's data showed the highest number of exceeding workplaces and greatest excess rate (89 sites & 13.3%). The number of exceeding workplaces and excess rate relative to the PEL for benzene showed an increasing trend in 2004, but tended to decrease after 2007. Conclusions: Based on the results obtained from this study, the exposure level for benzene among domestic workers is not considered to be in a safe phase regardless of the year of work environment measurement. Thus, strict preventive management in workplaces should be provided for reducing exposure to benzene.

• Journal of Power Electronics
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• 제16권6호
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• pp.2119-2128
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• 2016

Due to detection and control errors, some high-frequency harmonics with voltage-source characteristics cause circulating currents in modular inverters. Moreover, the circulating currents are usually affected by the output filters (OF) of each module due to their filter and resonance properties. The interaction among the circulating currents in the modules increase the power loss and reduce system stability and control precision. Therefore, this paper reports the results of a study on the SPWM high-frequency harmonics circulating currents for a double-module VSI. In the paper, an analysis of the circulating-current circuits is briefly described. Next, a mathematic model of the single-module output voltage based on the carrier frequency of SPWM is built. On this basis, through mathematic modeling of high-frequency harmonic circulating currents, the formation mechanism and distribution characteristics of circular currents and their influences are studied in detail. Finally, the influences of the OF on the circulating currents are studied by mainly taking an LC-type filter as an example. A theoretical analysis and experimental results demonstrate some important characteristics. First, the carrier phase shifting of the SPWM for each module is the major cause of the SPWM harmonic circulating currents, and the circulating currents are in an odd distribution around n-times the carrier frequency $n{\omega}_s$, where n = 1, 2, 3, ${\ldots}$. Second, the harmonic circular currents do not flow into the parallel system. Third, the OF can effectively suppress the non-circulating part of the high-frequency harmonic currents but is ineffective for the circulation part, and actually reduces system stability.

• 한국산학기술학회논문지
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• 제8권6호
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• pp.1458-1464
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• 2007

현재 국내 외 제조 산업은 기업 시스템의 노후화 등의 많은 문제들이 발생하고 있다. 현재의 자동차 부품공장에서의 불량품에 대한 처리방법은 제품의 생산이 완료된 후 테스트 단계를 거쳐 양품과 불량품을 분류하고 불량품이 발생하면 생산을 중단하고 생산라인의 상태를 점검하는 방식이다. 본 연구에서는 자동차 부품공장의 생산라인에서 불량품 생산을 줄이고 생산라인 가동시간의 지연을 줄이기 위한 생산성 향상을 위한 모니터링 솔루션에 대해 제안한다. 생산성 향상을 위한 모니터링 솔루션은 제품 조립의 각 단계마다 테스트를 통해 데이터를 수집하고, 수집한 데이터에서 불량이 예상되면 알람기능을 이용해서 경고를 하도록 설계하였다. 경고 메시지를 통해 불량이 예상되는 곳에 대해 조기에 조치하여 불량품이 나올 확률을 최소한으로 하고 제품의 생산지연 시간을 줄이는 것을 목표로 한다.

• 천문학회지
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• 제54권4호
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• pp.129-137
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• 2021

It has been established that the acoustic mode parameters of the Sun and Sun-like stars vary over activity cycles. Since the observed variations are not consistent with an activity-related origin, even Sun-like stars showing out-of-phase changes of mode frequencies and amplitudes need to be carefully studied using other observational quantities. In order to test whether the presumed relations between the global seismic parameters are a signature of the stellar activity cycle, we analyze the photometric light curve of HD 49933 for which the first direct detection of an asteroseismic signature for activity-induced variations in a Sun-like star was made, using observations by the CoRoT space telescope. We find that the amplitude of the envelope significantly anti-correlates with both the maximum frequency of the envelope and the width of the envelope unless superflare-like events completely contaminate the light curve. However, even though the photometric proxy for stellar magnetic activity appears to show relations with the global asteroseismic parameters, they are statistically insignificant. Therefore, we conclude that the global asteroseismic parameters can be utilized in cross-checking asteroseismic detections of activity-related variations in Sun-like stars, and that it is probably less secure and effective to construct a photometric magnetic activity proxy to indirectly correlate the global asteroseismic parameters. Finally, we seismically estimate the mass of HD 49933 based on our determination of the large separation of HD 49933 with evolutionary tracks computed by the MESA code and find a value of about 1.2M_☉ and a sub-solar metallicity of Z = 0.008, which agrees with the current consensus and with asteroseismic and non-asteroseismic data.