• Title/Summary/Keyword: Phase II study

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Changes in the Gait Pattern of Hemiparetic Patients with Subacute Basal Ganglia Stroke: a Retrospective Study (아급성 기저핵 뇌졸중 후 편마비 환자의 보행양상의 변화 : 후향적 연구)

  • Hong, Hae-jin;Kim, Cheol-hyun;Sung, Kang-kyung;Lee, Sang-kwan
    • The Journal of Internal Korean Medicine
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    • v.37 no.6
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    • pp.990-997
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    • 2016
  • Objectives: This study observed changes in gait pattern according to the motor grade of the paretic lower limb in patients with basal ganglia stroke who are in the subacute phase. Methods: We used the Manual Muscle Test (MMT) to evaluate the motor grade of the paretic lower limb of 21 patients with subacute basal ganglia stroke and then divided them into two groups based on the MMT results. Stroke patients with a motor grade above Gr. III were put in group I (15 people) and those with a grade less than Gr. III in group II (6 people). We also estimated spatiotemporal factors using treadmill gait analysis equipment. The values were gait velocity, step length, step time, double support phase, and cadence. The first measure was conducted during the early period of admission and the second was between four and five weeks after admission. Results: In Group I, the gait velocity and step length of both legs significantly increased. In Group II, the step length and step time of the paretic side and the gait velocity tended to decrease, but not significantly. The step length of the paretic side in Group II was significantly longer than that in Group I at the first measure. The step time of the paretic side in Group I was significantly shorter than that in Group II and gait velocity and cadence in Group I were significantly higher than in Group II at the second measure. Conclusions: The gait parameters of all stroke patients improved in terms of time. In addition, the changes in gait pattern were different depending on the motor grade of the paretic lower limb.

Key Methodologies to Effective Site-specific Accessment in Contaminated Soils : A Review (오염토양의 효과적 현장조사에 대한 주요 방법론의 검토)

  • Chung, Doug-Young
    • Korean Journal of Soil Science and Fertilizer
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    • v.32 no.4
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    • pp.383-397
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    • 1999
  • For sites to be investigated, the results of such an investigation can be used in determining foals for cleanup, quantifying risks, determining acceptable and unacceptable risk, and developing cleanup plans t hat do not cause unnecessary delays in the redevelopment and reuse of the property. To do this, it is essential that an appropriately detailed study of the site be performed to identify the cause, nature, and extent of contamination and the possible threats to the environment or to any people living or working nearby through the analysis of samples of soil and soil gas, groundwater, surface water, and sediment. The migration pathways of contaminants also are examined during this phase. Key aspects of cost-effective site assessment to help standardize and accelerate the evaluation of contaminated soils at sites are to provide a simple step-by-step methodology for environmental science/engineering professionals to calculate risk-based, site-specific soil levels for contaminants in soil. Its use may significantly reduce the time it takes to complete soil investigations and cleanup actions at some sites, as well as improve the consistency of these actions across the nation. To achieve the effective site assessment, it requires the criteria for choosing the type of standard and setting the magnitude of the standard come from different sources, depending on many factors including the nature of the contamination. A general scheme for site-specific assessment consists of sequential Phase I, II, and III, which is defined by workplan and soil screening levels. Phase I are conducted to identify and confirm a site's recognized environmental conditions resulting from past actions. If a Phase 1 identifies potential hazardous substances, a Phase II is usually conducted to confirm the absence, or presence and extent, of contamination. Phase II involve the collection and analysis of samples. And Phase III is to remediate the contaminated soils determined by Phase I and Phase II. However, important factors in determining whether a assessment standard is site-specific and suitable are (1) the spatial extent of the sampling and the size of the sample area; (2) the number of samples taken: (3) the strategy of taking samples: and (4) the way the data are analyzed. Although selected methods are recommended, application of quantitative methods is directed by users having prior training or experience for the dynamic site investigation process.

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AN ELECTROMYOGRAPHIC STUDY OF THE MUSCLE ACTIVITY IN ANGLE'S CLASS II DIV. 1 MALOCCLUSION AND NORMAL OCCLUSION (근전도를 이용한 Angle씨 II급 1류 부정교합자와 정상교합자의 근육활성도에 관한 연구)

  • Kim, Tae-Soo;Baik, Hyoung-Seon
    • The korean journal of orthodontics
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    • v.18 no.1 s.25
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    • pp.89-104
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    • 1988
  • This study was performed to investigate the relationships between the EMG activity of the masticatory muscles in Angle's Class II div. 1 malocclusion and normal occlusion. This study was ranged from age 12 to 14 year-old for 30 male subjects: 15 subjects were Angle's Class II div. 1 malocclusion, and 15 subjects were normal occlusion with acceptable profile. Their cephalometric measurement were analyzed, and the EMG recordings from the anterior temporal, posterior temporal, masseter, and orbicularis oris muscles were analyzed during rest position, mastication of peanuts, and swallowing. All data was recorded and statistically processed with the VAX-11/780 computer system. The results were as follows: 1. The activity of muscles at rest was highest in the posterior temporal muscle with normal occlusion, as well as in those with Class II div. 1 malocclusion, and the posterior temporal muscle activity of Class II div. 1 malocclusion was higher than that of normal occlusion. 2. During mastication, all muscle activities of Class II div. 1 malocclusion were recorded lower than those of normal occlusion, and the activity of the anterior temporal muscle was higher than that of the posterior temporal muscle in both types of occlusion. 3. As for the activity in orbicularis oris muscle, it was greater in opening phase than in closing phase during chewing cycle with both types of occlusion. 4. During swallowing, the activities of the anterior temporal, masseter, and orbicularis oris muscles of Class II div. 1 malocclusion were recorded lower than those of normal occlusion.

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Review of Clinical Cancer Research Methodology of Botanical Agents (한약 및 천연물의 항암 임상연구 방법론에 대한 고찰)

  • Oh, Hye Kyung;Lee, Jee Young;Ryu, Han Sung;Yoon, Seong Woo
    • Journal of Korean Traditional Oncology
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    • v.20 no.1
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    • pp.11-21
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    • 2015
  • Objectives : The cancer incidence and cancer burden is increasing. In addition, the use of botanical agents in cancer care is increasing. This article aims to review a research strategy for botanical agents. Methods : The clinical studies of anticancer botanical agents and the papers about clinical research methodology of botanical agents were reviewed. Results : In phase I study, safety confirmation, optimal dose determination and drug interaction study are important. Most botanical agents have low toxicity and some have non-monotone dose response. Therefore, dose-response curve must be evaluated separately from the dose-toxicity curve to determine optimal dose. Although anticancer botanical agents can't shrink tumor size rapidly, they do extend survival. So, in phase II study, response should be evaluated by the survival. Conclusions : Clinical research of botanical agents in cancer is different from traditional methods and strategies. Considering the characteristics of botanical agents and experimental mechanism is necessary in conducting botanical based clinical trials.

Ecological Studies on Heading of Rice Plant I. The Response to Photoperiod of Major Rice Varieties (수도의 출수생태에 관한 연구 제1보 주요수도 품종의 일장반응)

  • 최경구;장영남;이성춘
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.28 no.2
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    • pp.151-163
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    • 1983
  • This study was conducted to investigate the responses to photoperiod of some Korean rice cultivars at four levels of the day length, 10, 12, 14 and 16 hours. Generally the days to heading were reduced in the short day length. Japonica varieties seemed to have shorter basic vegetative growth phase and, were more sensitive to day length, while Japonica crossed Indica varieties showed longer basic vegetative growth phase and, were less sensitive to day length. All tested varieties could be classified into 19 ecotypes based on the periods of the basic vegetative growth phase and the sensitivity to day length.

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Numerical Study of Heat Transfer with Selective Phase Change in Two Different Phase Change Materials (이종 PCM의 선택적 상변화 시의 열전달 해석)

  • Kim, Hyung Kuk;Lee, Dong Gyu;Peck, Jong Hyeon;Kang, Chaedong
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.25 no.9
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    • pp.477-483
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    • 2013
  • A numerical analysis of solid-liquid phase change was performed on a heat transfer module which consisted of circulating water path (BRINE), heat transfer plate (HTP) and phase change material (PCM) layers, such as high temperature PCM (HPCM, $78{\sim}79^{\circ}C$) and low temperature PCM (LPCM, $28{\sim}29^{\circ}C$). There were five arrangements, consisting of BRINE, HTP, LPCM and HPCM layers in the heat transfer module. The time and heat transfer rate for melting/solidification was compared to their arrangements, against each other. As results, the numerical time without convection was longer than the experimental one for melting/solidification. Moreover, the melting/solidification with the BRINE I-LPCM-BRINE II-HPCM arrangement was faster(10 hours) than the others; HPCM-BRINE-LPCM, BRINE I-HPCM-LPCM-BRINE II one.

A Case Study of Sandplay Therapy for a Boy in an Elementary School with Social and Emotional Difficulties (사회성과 정서에 어려움이 있는 초등학생 남아의 모래놀이치료 사례연구)

  • Kim, Shin Hwa;Sim, Hee-og
    • Human Ecology Research
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    • v.56 no.6
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    • pp.589-601
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    • 2018
  • This study explored the internal world through sandplay therapy for an elementary school boy who had social and emotional difficulties of poor peer relations, anxiety and withdrawal. This study examined the changing processes of sandboxes, how a boy expressed his internal world by the content themes in sandplay according to Turner (2009) based on analytical psychology and sandplay theories. There were 72 sessions. The initial phase was 1-6 (The beginning of war) expressing confusing wars as the start of a long internal journey. The intermediate phase was 7-55 (Struggle), dividing by phase I 7-18 (Hero's fight I), phase II 19-36 (Hero's fight II), phase III 37-48 (Seeking for a male identity), and phase IV 49-55 (Centering). The client identified himself as a teenaged hero and expressed the conflict between good and bad, between death and rebirth and struggled for seeking treasures in the fight of heroes. He found identity as a male by finding a sense of existence, establishing order in the middle of confusion, and expressing strong and rational masculinity. The final phase was 56-72 (The winner of the struggle). In the fights repeating, he expressed an adventurous and positive male energy such as racing, speed contests and a union in the opposites of hero and heroine as well as the birth of a new conscious. This study provides a basic knowledge of educational guidance in school and counseling fields by expanding the understanding of a boy's unconsciousness.

Implantation Rate and Clinical Pregnancy Rate According to Dosage and Timing of Progesterone Administration for Secretory Endometrial Preparation in Frozen-Thawed Embryo Transfer Cycles (동결보존 배아이식에서 분비기 자궁내막 유도시 프로게스테론 투여 방법에 따른 착상율과 임신율의 비교)

  • Park, Chan-Woo;Hur, Kuol;Kim, Moon-Young;Song, Hyun-Jung;Kim, Hye-Ok;Yang, Kwang-Moon;Kim, Jin-Yeong;Song, In-Ok;Yoo, Keun-Jae;Cheon, Kang-Woo;Byun, Hye-Kyung;Koong, Mi-Kyoung;Kang, Inn-Soo
    • Clinical and Experimental Reproductive Medicine
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    • v.30 no.3
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    • pp.193-202
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    • 2003
  • Objective: To evaluate the difference of implantation rate (IR) and clinical pregnancy rate (CPR) between two protocols of endometrial preperation in women undergoing frozen-thawed embryo transfer (FET) cycles. Methods: This study was performed during the different time periods: A retrospective study from January 2000 to June 2001 (phase I) and a prospective study from July 2001 to March 2002 (phase II). All the patients received estradiol valerate (6 mg p.o. daily) starting from day 1 or 2 of the menstrual cycle without pituitary down regulation. Progesterone was administered around day 14 after sonographic confirmation of endometrial thickness $\geq$7 mm and no growing follicle. In Group A (n=88, 99 cycles) of phase I, progesterone was administered i.m. at a dose of 50 mg daily from one day prior to thawing of pronuclear (PN) stage frozen embryo or three days prior to thawing of 6-8 cell stage frozen embryo and then each stage embryos were trasnsferred 2 days or 1 day later after thawing. In Group B (n=246, 299 cycles) of phase I, patients recieved progesterone 100 mg i.m. from one day earlier than group A; two days prior to PN embryo thawing, four days prior to of 6-8 cell embryo thawing. During the phase II, to exclude any differences in embryo transfer procedures, in Group 1 (n=23, 28 cycles) of phase II embryo was transfered by one who have used the progesterone protocol since the phase I. In Group 2 (n=122, 139 cycles) of phase II embryo was transfered by one who use the progesterone protocol from the phase II. Results: When compared across the phase and group, there were no significant differences in the characteristics. During the phase I, there were significant increase in IR (14.4% vs 5.9%, p=0.001) and CPR (28.3% vs 14.5%, p=0.000) in group A. During the phases II, IR (11.8% vs 10.6%) and CPR (27.6% vs 27.3%) show no differences between two groups. Conclusions: In FET cycles, IR and CPR are increased significantly by the change of dosage and timing of progesterone administraton. And the timing is considered to be more important factor because the dosage of progesterone did not affect implantation window in previous studies. Therefore, we suggest that progesterone administration in FET cycle should begin from one day prior to PN stage embryo thawing and three days prior to 6-8 cell stage embryo thawing.

Study on the Phase II Qualification Test for Fuel Cell of Rotorcraft (회전익항공기용 연료셀 Phase II 인증시험에 대한 고찰)

  • Kim, Hyun-Gi;Kim, Sung Chan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.3
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    • pp.1054-1060
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    • 2013
  • Fuel tank of a rotorcraft has a great influence on the survivability of crews. For a long time, US army has tried to develop the proper material for fuel cell of a military rotorcraft. As a result, the design specification of fuel cell, MIL-T-27422A, was issued for the first time on 1961. Through a few revisions, it has been developed to ML-DTL-27422D in 2007. It should be assured that fuel cell satisfies the requirement defined in MIL-DTL-27422D. The qualification test of this specification is classified into Phase I test for material and Phase II for fuel cell itself. This paper studies test conditions and procedures of slosh & vibration, gunfire resistance and crash impact test. They are considered as the most important tests which have a high possibility of failure. The rational consideration of this paper can improve the ability for estimating not only the validity of test procedure and test condition but test result. Based on the rational consideration, it is expected that the ability of the systematic development can be improved.

Preconcentration of Iron(III), Lead(II), Cobalt(II) and Chromium(III) on Amberlite XAD-1180 Resin Loaded with 4-(2-Pyridylazo)-resorcinol (PAR) and Their Determination by FAAS

  • Tokalloglu, Serife;Kartal, Senol
    • Bulletin of the Korean Chemical Society
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    • v.27 no.9
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    • pp.1293-1296
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    • 2006
  • In this study, a solid phase extraction method has been developed for the preconcentration and separation of the elements Cr(III), Fe(III), Co(II) and Pb(II) at trace levels by using a column packed with Amberlite XAD-1180 resin loaded with 4-(2-pyridylazo)-resorcinol (PAR) reagent. After preconcentrating, the metals retained on the column were eluted with 20 mL of 3 mol/L $HNO_3$ and then determined by flame atomic absorption spectrometry (FAAS). The factors affecting the recovery of the elements, such as pH, type and concentration of eluent, volume of sample and elution solution, and matrix components, were also ascertained. The recoveries of Cr(III), Fe(III), Co(II) and Pb(II) were found to be $99\;{\pm}\;4,\;97\;{\pm}\;3,\;95\;{\pm}\;3$ and $98\;{\pm}\;4$%, respectively, under the optimum conditions at 95% confidence level and the relative standard deviations found by analyzing of nine replicates were $\leq4.4$%. The preconcentration factors for Cr(III), Fe(III), Co(II) and Pb(II) were found as 75, 125, 50 and 75 respectively. The detection limits (DL, 3s/b) were 3.0 $\mu g/L$ for Cr(III), 1.25 $\mu g/L$ for Fe(III), 3.3 $\mu g/L$ for Co(II), and 7.2 $\mu g/L$ for Pb(II). The recoveries achieved by adding of metals at known concentrations to samples and the analysis results of Buffalo river sediment (RM 8704) show that the described method has a good accuracy. The proposed method was applied to tap water, stream water, salt and street dust samples.