• Title/Summary/Keyword: Phase I study

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Observational Studies on Evolved Stars Using KVN and KaVA/EAVN

  • Cho, Se-Hyung;Yun, Youngjoo;Imai, Hiroshi
    • The Bulletin of The Korean Astronomical Society
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    • v.44 no.2
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    • pp.51.1-51.1
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    • 2019
  • At the commissioning phase of KVN from 2009 to 2013, single-dish survey and monitoring observations were performed toward about 1000 evolved stars and about 60 relatively strong SiO and H2O maser sources respectively. Based on these single-dish results and VLBI feasibility test observations at K/Q/W/D bands in 2014, KVN Key Science Project (KSP) has started from 2015 and will be completed in 2019 as KSP phase I. Here we present the overview of observational studies on evolved stars using KVN. In KSP phase I, we have focused on nine KSP sources which show a successful astrometrically registered maps of SiO and H2O masers using the source frequency phase referencing method. We aim at investigating the spatial structure and dynamical effect from 43/42/86/129 GHz SiO to 22 GHz H2O maser regions associated with a stellar pulsation and development of asymmetry in circumstellar envelopes. Using the combined network KaVA (KVN+Japanese VLBI network VERA), KaVA Large Program titled on "Expanded Study on Stellar Masers: ESTEMA Phase I" was performed from 2015 to 2016. Based on ESTEMA Phase I, EAVN Large Program titled on "EAVN Synthesis of Stellar Maser Animations: ESTEMA Phase II" was also performed from 2018. The ESTEMA II project aims to publish composite animations of circumstellar H2O and SiO masers, which taken from up to 6 long-period variable stars with a variety of the pulsation periods (333-1000 days). The animations will exhibit the three-dimensional kinematics of the maser gas clumps with complexity caused by stellar pulsation-driven shock waves and anisotropy of clump ejections from the stellar surface. Adding three EAVN telescopes (Tianma 65m, Nanshan 26m and NRO 45m telescopes) with KaVA always secures the high quality of the maser image frames through the monitoring program.

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A Comparative Study on Output of Four Type Diagnostic X-ray Equipments (정류방식에 따른 진단용 X-선 장치의 출력비교)

  • Kim, Jung-Min
    • Journal of radiological science and technology
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    • v.20 no.2
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    • pp.34-43
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    • 1997
  • There are 4 types of equipment in diagnostic radiography. These are single phase, three phase, inverter type and condenser type X-ray generators. It is very confusing to make an adequate exposure factor and to know the usage of different type of X-ray generators. In this experiment, I explored a comparative study of outputs in 4 different type of X-ray units. I expect that this experiment could be helpful for manufacturer to make both the X-ray equipment better, In terms of Ideal exposure factors, thereby reducing the patient dose. Experimental results are as follow : 1) X-ray output The ratio of X-ray output of single, three phase and inverter type of X-ray generator was 1 : 1.6 : 2 without absorber and 1 : 2 : 2.6 with 20 mm aluminium absorber. 2) Beam quality The X-ray beam quality of single phase generator was proved to be softer than three phase and inverter type of generators by 0.4 mmAL and 0.55 mmAl HVL respectively. 3) Reproducibility Linearity of X-ray output Retroducibility of X-ray output met the regulation below CV 0.05 and linearity also met the regulation below 0.1 in 4 types of diagnostic X-ray generators. 4) The comparison of incident dose Three phase X-ray generator was 20% higher than two other X-ray generators in radiation dose to make same film density.

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A Study on the Polarity Discrimination Method of the Stator Windings for 3 Phase Induction Motors based on the Residual Magnetism and I Winding Connection (잔류자기와 I 결선에 의한 3상유도전동기 고정자 권선의 극성판별법에 대한 연구)

  • Choi, Soon-Man
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.64 no.1
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    • pp.72-77
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    • 2015
  • When connecting 6 lead wires from stator windings to the terminals of 3 phase induction motors for Y or ${\triangle}$ connection, it is feared that the polarities of windings could be reversed each other if the wire tags are lost or erased, resulting in inadmissibly high current to motors in case of starting. To protect motors against such situations, some test procedures are necessary during wire connection which need to be easy ways to electricians without particular tools except a general multi-tester and with less time-consuming in the field. This study focuses on a test measure to satisfy these requirements which is able to provide them a convenient procedure for winding polarity discrimination considering the field condition. Here, the proposed measure utilizes the residual magnetism of the rotor and checks the indication of voltage or current at windings which are induced by the residual flux of rotor when rotating it by hands with 3 stator windings connected in the form of I connection. Principle characteristics and experiment results for this method are analyzed in the view of the effectiveness and applicability for the winding polarity discrimination.

AVERAGE LIQUID LEVEL AND PRESSURE DROP FOR COUNTERCURRENT STRATIFIED TWO-PHASE FLOW

  • Kim, Yang-Seok;Yu, Seon-Oh;Chun, Moon-Hyun
    • Proceedings of the Korean Nuclear Society Conference
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    • 1996.11a
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    • pp.301-306
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    • 1996
  • To predict the average liquid level under the condition of the countercurrent stratified two-phase flow in a pipe, an analytical model has been suggested. This is made by introducing the interfacial level gradient into the liquid-phase and the gas-phase momentum equations. The analytical method for the gas-phase pressure drop calculation with f$_i$ $\neq$ f$_G$ has also been described using the liquid level prediction model developed in the present study.

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A Study on the Transformation Behaviors of a Multi-phase (Ferrite-Bainite-Martensite) in Ductile Cast Iron (구상흑연주철(球狀黑鉛鑄鐵)의 3상혼합조직(相混合組織)의 변태거동(變態擧動)에 관(關)한 연구(硏究))

  • Kim, Sug-Won;Kim, Dong-Keun;Yo, Seon-Kyung
    • Journal of Korea Foundry Society
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    • v.11 no.5
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    • pp.406-413
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    • 1991
  • Ductile cast iron(DCI) with a multi-phase(ferrite-bainite-martensite) structures was produced by various special heat treatment. Intercritical heat treatment(I. C.), intermediate heat treatment(I. M.) and step quenching(S. Q.) were used to strengthen and toughen the fracture initiation sites such as graphite-marix interfaces and eutectic cell boundaries in DCI. The purpose of this study was to investigate of DCI by the special heat treatment. (I. C., I. M., and S. Q.) At a result, bainite nucleation rate at higher temperature was higher than that of at lower temperature, and shapes of bainite and martensite became bar /spheroidal type with increase of isothermal transformation time.

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Phase-Resolved CARS Temperature Measurement in a Lean Premixed Gas Turbine Combustor (I) -Effect of Equivalence Ratio on Phase-Resolved Gas Temperature- (CARS를 이용한 희박 예혼합 가스터빈 연소기내 온도 측정 (I) -연료/공기 혼합정도가 위상별 온도에 미치는 영향-)

  • Lee Jong Ho;Jeon Chung Hwan;Park Chul Woong;Hahn Jae Won;Chang Young June
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.28 no.10
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    • pp.1184-1192
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    • 2004
  • Experimental investigations were carried out in an atmospheric pressure, optically accessible and laboratory-scale dump combustor operating on methane gas. The objective of this study was to obtain the phase-resolved gas temperatures at different phases of the oscillating pressure cycle during unstable combustion. CARS temperature measurements were made at several spatial locations under lean premixed conditions to get the information on temperature field within the combustor. Also the effect of incomplete fuel-air mixing on phase-resolved temperature fluctuation was investigated. Results including phase-resolved averaged temperature, normalized standard deviation and temperature probability distribution functions (PDFs) were provided in this paper. Temperature PDFs gave an insight on the flame behavior. And strong correlation between phase-resolved temperature profile and pressure cycle was observed. Results of the phase-resolved high temperature gave an additional information on the perturbation of equivalence ratio at flame as well as the effect of mixing quality on NOx emission characteristics.

Dispersion-Managed Optical Links Combined with Asymmetrical Optical Phase Conjugation for Compensating for Distorted WDM Signals

  • Lee, Seong-Real
    • Journal of information and communication convergence engineering
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    • v.14 no.2
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    • pp.71-77
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    • 2016
  • The combination of dispersion management (DM) and midway optical phase conjugation (OPC) is one of the promising techniques for compensating for optical signal distortion due to group velocity dispersion and nonlinear fiber effects. However, in this combination technique, midway OPC restricts the flexible optical link configuration. Therefore, the possibility of implementing the flexible optical link configuration with non-midway OPC applied to complete inline DM links is investigated in this study. It is confirmed that although the compensation using non-midway OPC for the distorted WDM channels is less effective than that using midway OPC, when non-midway OPC is placed at positions closer to the transmitters, the deployment of precompensation (i.e., the sequence of DCF + SMF)-OPC-postcompensation (i.e., the sequence of SMF + DCF) is more advantageous for the compensation. On the other hand, inverse deployment with respect to OPC (i.e., postcompensation-OPC-precompensation) is more advantageous when non-midway OPC is placed at positions closer to the receivers.

Estimation of Maximal Tolerated Dose in Sequential Phase I Clinical Trials

  • Park, In-Hye;Song, Hae-Hiang
    • Communications for Statistical Applications and Methods
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    • v.6 no.2
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    • pp.543-564
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    • 1999
  • The principal aim of a sequential phase I clinical trial in which the toxicity reponses of a group of patient(s) determine the dose level of the next patient(s) group is to estimate the maximal tolerated dose(MTD) of a new drug, In this paper we compared with a simulation study the performance of the MTD estimates that are determined by a stopping rule in a design and also those that are determined by analyzing the data after a clinical trial is terminated. To the latter belong the mean median mode and maximum likelihood estimates. For the Standard Methods the stopping rule MTD is quite inefficient but the median MTD has a best efficiency and is robust with respect to the three different toxicity curves. The problem of non-convergence of MLE MTD is severe. A more improved MTD estimate is produced by combining the advantages of the various MTD estimates and its efficiency is better than the single median MTD estimate especially for the toxicity curve of an unlucky choice of dose levels. The simulation results suggest that simple types of phase I designs can be combined with relatively standard analytic techniques to provide a more efficient MTD estimate.

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Maximum Tolerated Dose Estimate by Curve Fitting in Phase I Clinical Trial (제1상 임상시험에서 곡선적합을 이용한 MTD 추정법)

  • Heo, Eun-Ha;Kim, Dong-Jae
    • Communications for Statistical Applications and Methods
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    • v.18 no.2
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    • pp.179-187
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    • 2011
  • The purpose of a Phase I clinical trial is to estimate the maximum tolerated dose, MTD, of a new drug. In this paper, the MTD estimation method is suggested by curve fitting the dose-toxicity data to an S-shaped curve. The suggested MTD estimation method is compared with established MTD estimation procedures using a Monte Carlo simulation study.

Annexin I Stimulates Insulin Secretion through Regulation of Cytoskeleton and PKC Activity

  • Kang, Na-Na;Won, Jong-Hak;Park, Young-Min
    • Animal cells and systems
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    • v.13 no.1
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    • pp.17-23
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    • 2009
  • In previous studies, we found that Annexin I (Anx I) was co-secreted with insulin in response to glucose, and that extracellular Anx I stimulated the release of insulin via the Anx I binding site in rat pancreatic islets and the &-cell line. However, the role that Anx I plays in the insulin secretion was not established. Therefore, in this study, we evaluated the insulin secretion pattern in response to Anx I and the involvement of the cytoskeleton or PKC in Anx Istimulated insulin secretion in MIN6N8a cells. The peak time of insulin secretion in response to Anx I treatment corresponded with the second phase insulin secretion by glucose in the perifused pseudoislets. In addition, Anx I-stimulated insulin secretion was not affect by readily releasable pool depletion. Taken together, these findings indicate that Anx I treatment was associated with movement of the reserve pool of insulin. Furthermore, Anx I-stimulated insulin secretion was attenuated by treatment with a microfilament inhibitor, cytochalasin B, as well as by PKC down regulation. These results indicate that Anx I may be a regulator of second phase insulin secretion.