• Title/Summary/Keyword: Phase I and II

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A Computer Method for GT Plant Layout and Its Simulation Analysis (컴퓨터를 이용한 GT설비배치(設備配置)와 시뮬레이션에 의한 평가(評價))

  • Sin, Hyeon-Pyo
    • Journal of Korean Society for Quality Management
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    • v.12 no.1
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    • pp.17-30
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    • 1984
  • A computer method is developed for group technology layout and its simulation analysis. The method is composed of three phases: Phase I sorts the parts by its similar production routes and forms part families. Phase II plots the layout by machine cell and evaluates the group layout alternatives by the total process time analysis and the part travel distance evaluation analysis. Phase III also evaluates the alternatives by simulation analysis using SIMAN simulation software. All the computer programs are developed with BASIC except SIMAN simulation.

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Digital Control of a Single-Phase UPS Inverter for Robust AC-Voltage Tracking

  • Woo Young-Tae;Kim Young-Chol
    • International Journal of Control, Automation, and Systems
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    • v.3 no.4
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    • pp.620-630
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    • 2005
  • This paper presents a digital controller for a single phase UPS inverter under two main considerations: (i) the overall system shall keep very low AC-voltage tracking error as well as no phase delay over different load conditions, and (ii) the digital controller shall be employed at a fixed sampling time. We propose that the former can be achieved by the proposed controller using the error-state approach and the latter can be dealt with by the socalled characteristics ration assignment.

The Effects of Different Methionine and Lysine Levels in. 15% Iso-protein Diet on the Performance of Laying Hens (동일한 단백질 수준의 사료에서 Methionine과 Lysine수준이 산란계의 생산성에 미치는 영향)

  • 이상진;김삼수;정선부;곽종형;하정기;이규호
    • Korean Journal of Poultry Science
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    • v.18 no.1
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    • pp.9-31
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    • 1991
  • The purpose of this study was to investigate the effects of dietary methionine and lysine levels on laying hen performance. The level of protein was fixed 15% during whole experiment period, but the levels of methionine and lysine were 0.30% and 0.58% (Low), 0.32% and 0.64% (Medium), 0.35% and 0 70% (High), respectively. Total 288 laying pullets of 22 weeks age were reared from January 28, 1989 to March 23, 1990 for 60weeks. The results obtained were summarized as follows : 1. The e99 Productions were highest in medium treatment in phase I (22~42weeks of age), phase II (42~62 weeks of age) and phase III (62~82weeks of age) and especially, there was significant difference among treatments during phase II (P<0.05). 2. Egg weight was significantly increased as the levels of methionine and lysine were increased up to methionine and lysine were 0.32% and 0.64%, respectively(P<0.01). 3. Daily egg mass was highest when the levels of methionine and lysine were 0.32% and 0.64%, respectively and there were significant differences among treatments during phase I and phase II (P<0.01) 4. Daily feed intake was increased as the levels of methionine and lysine were increased, and there was significant difference among treatments during phase III (P<0.05). 5. Feed efficiency was best in medium treatment in phase I and phase II (P<0.01) 6, Viability was highest in medium treatment, but there was no significant difference among treatments. 7. Nutrient utilizability of experimental diets was not significantly different among treatments. 8. Eviscerated yield was highest and abdominal fat accumulation was lowest in medium treatment, but there was no significant difference among treatments. 9. Egg shell quality and chemical composition of egg content were not different among treatments. 10. The feed cost per kg egg mass was lowest in medium treatment and there were significant differences among treatments in phase I, phase II and whole egg laying period(P<0.05)

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Phase II two-stage single-arm clinical trials for testing toxicity levels

  • Kim, Seongho;Wong, Weng Kee
    • Communications for Statistical Applications and Methods
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    • v.26 no.2
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    • pp.163-173
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    • 2019
  • Simon's two-stage designs are frequently used in phase II single-arm trials for efficacy studies. A concern of safety studies is too many patients who experience an adverse event. We show that Simon's two-stage designs for efficacy studies can be similarly used to design a two-stage safety study by modifying some of the design parameters. Given the type I and II error rates and the proportion of adverse events experienced in the first stage cohort, we prescribe a procedure whether to terminate the trial or proceed with a stage 2 trial by recruiting additional patients. We study the relationship between a two-stage design with a safety endpoint and an efficacy endpoint as well as use simulation studies to ascertain their properties. We provide a real-life application and a free R package gen2stage to facilitate direct use of two-stage designs in a safety study.

Metabolic Responses of Activated Sludge to Pentachlorophenol in SBR Systems

  • ;Larry D. Benefield
    • Journal of Environmental Science International
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    • v.3 no.3
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    • pp.273-284
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    • 1994
  • The primary objective of this study was to examine the toxic effects of PCP on activated sludge and to analyze its metabolic responses while treating wastewater containing pentachlorophenol (PCP) in a sequencing batch reactor (SBR) system operating under different control strategies. This study was conducted in two phases 1 and 2 (8-hr and 12-hr cycles). Each phase was operated with two control strategies I and II. Strategy I (reactor 1) involved rapid addition (5 minutes to complete) of substrate to the reactor with continuous mixing but no aeration for 2 hours. Strategy ll (reactor 2) involved adding the feed continuously during the first 2 hours of the cycle when the system was mixed but not aerated. During both phases each reactor was operated at a sludge age of 15 days. The synthetic wastewater was used as a feed. The COD of the feed solution was about 380 mg/l. After the reference response for both reactors was established, the steady state response of each system was established for PCP feed concentrations of 0.1 mg/l, 1.0 mg/l, and 5.0 mg/l in SBR systems operating on both 8-hr and 12-hr cycles. Soluble COD removal was not inhibited at any feed PCP concentrations used. At 5.0 mg/l fined PCP concentration and in SBR systems operating on phase 2, the concentrations of MLVSS were decreased; selective pressure on the mixed biomass might be increased, narrowing the range of possible ecological responses; the settleability of activated sludge was poor; the SOURS were increased, showing that the systems were shocked. Nitrification was made to some extent at all concentrations of feed PCP in SBR systems operating on phase 2 whereas in SBR systems operating on phase 1 little nitrification was observed. Then, nitrification will be delayed as much as soluble COD removal is retarded due to PCP inhibition effects. Enhanced biological phosphorus removal occurring in the system operating with control strategy I during phase 1 of this work and in the presence of low concentrations of PCP was unreliable and might cease at anytime, whereas enhanced biological phosphorus removal occurring in the system operating with either control strategy I or II during phase 2 of this work and in the Presence of feed PCP concentrations up to 1.0 mg/l was reliable. When, however, such processes were exposed to 5.0 mg/l PCP dose, enhanced phosphorus removal ceased and never returned.

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Geological structure of the Ogcheon belt in the Buunnyeong area, Mungyeong, Korea (문경 부운령지역에서 옥천대의 지질구조)

  • ;原郁夫;宮本隆實
    • The Journal of the Petrological Society of Korea
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    • v.10 no.2
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    • pp.82-94
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    • 2001
  • The main geological structure of the Ogcheon belt in the Buunnyeong area, Mungyeong, which consists of three stratigraphic sequences, Joseon and Pyeongan Supergroups and Daedong Group, is characterized by the development of ESE-vergence structural unit (Dangok unit) and WNW-vergence structural units (Samsil and Bugongni units) onto an autochthonous unit (Buunnyeong unit). Three phases of deformation are recognized in this area. The lent phase of deformation coourred under the WNW-ESE compression, forming an upright-open fold (Buunnyeong-I fold) with NNE axial trend in the Buunnyeong unit. The second phase of deformation also under the WNW-ESE compression formed the Dangok, Samsil and Bugongni units, resulting in the further closing of the Buunnyeong-I open fold, the elongation of pebbles in the conglomerate rocks of a basal sequence of the Daedong Group, recumbent folds (Buunnyeong-II fold) and drag folds (Dangok fold) with NNE axial trend in the Buunnyeong and Dangok units, respectively. The third phase of deformation formed kink folds with its axis p1unging subvertically. The first and second phases of deformation took place before and after the deposition of the Daedong Group of the Upper Triassic -Lower Jurassic, respectively. These first two deformation events, which occurred under the same WNW-ESE compressional field, produced the regional NNE trend of geological structure in the Joseon and Pyeongan Supergroups of this area.

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A Case Study of Sandplay Therapy for a Boy in an Elementary School with Social and Emotional Difficulties (사회성과 정서에 어려움이 있는 초등학생 남아의 모래놀이치료 사례연구)

  • Kim, Shin Hwa;Sim, Hee-og
    • Human Ecology Research
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    • v.56 no.6
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    • pp.589-601
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    • 2018
  • This study explored the internal world through sandplay therapy for an elementary school boy who had social and emotional difficulties of poor peer relations, anxiety and withdrawal. This study examined the changing processes of sandboxes, how a boy expressed his internal world by the content themes in sandplay according to Turner (2009) based on analytical psychology and sandplay theories. There were 72 sessions. The initial phase was 1-6 (The beginning of war) expressing confusing wars as the start of a long internal journey. The intermediate phase was 7-55 (Struggle), dividing by phase I 7-18 (Hero's fight I), phase II 19-36 (Hero's fight II), phase III 37-48 (Seeking for a male identity), and phase IV 49-55 (Centering). The client identified himself as a teenaged hero and expressed the conflict between good and bad, between death and rebirth and struggled for seeking treasures in the fight of heroes. He found identity as a male by finding a sense of existence, establishing order in the middle of confusion, and expressing strong and rational masculinity. The final phase was 56-72 (The winner of the struggle). In the fights repeating, he expressed an adventurous and positive male energy such as racing, speed contests and a union in the opposites of hero and heroine as well as the birth of a new conscious. This study provides a basic knowledge of educational guidance in school and counseling fields by expanding the understanding of a boy's unconsciousness.

Separation and Elution Behaviors of Some Metal-2-hydroxyarylazopyrazolone Chelates by Reversed Phase High Performance Liquid Chromatography (I) (역상 액체 크로마토그래피에 의한 금속-2-hydroxyarylazopyrazolone 유도체 킬레이트의 용리거동 및 동시분리에 관한 연구 (I))

  • Lee, Chang-Heon;Kang, Chang-Hee;Kim, Eun-Kyung;Lee, Won
    • Analytical Science and Technology
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    • v.7 no.1
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    • pp.103-114
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    • 1994
  • The elution behaviors of Ni(II), Cu(II), Co(II), and Cr(II) in 1-phenyl-3-methyl-4(2-hydroxy-5-X-phenylazo)-5-pyrazolone, [Pm(2-OH)(5-X)PaPz](X=H, $CH_3$, $NO_2$, Cl) chelates have been studied by reversed phase HPLC. Thirteen metal-[Pm(2-OH)(5-X)PaPz] chelates were prepared and characterized by UV, IR, MS, and ICP spectroscopic methods. These metal-2-hydroxyarylazopyrazolone chelates were successfully separated on Novapak-$C_{18}$ column using methanol/water mixtures as a mobile phases. It was found that the chelates were eluted properly in an acceptable range of the capacity factor value($0{\leq}log\;k^{\prime}{\leq}1$). The dependence of the capacity factor(log k') on the volume fraction of water in the binary mobile phase showed a good linearity. Also, there was a good linear dependence of the capacity factor on the liquid-liquid extraction distribution ratio($D_c$) in methanol-water/n-pentadecane extraction system by the batch method. It suggested that the retention of the chelates in the reverse phase liquid chromatographic system be largely due to the solvophobic effect.

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The opening of Gyeongbu high-speed railway project phase II (between Daegu and Busan) (기획특집: 경부고속철도 2단계사업 (대구~부산)개통)

  • Rim, Hyoung-Gyu
    • Journal of the Korean Professional Engineers Association
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    • v.43 no.6
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    • pp.27-30
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    • 2010
  • Gyeongbu high-speed railway project which comprises the construction of the new line with 417.5km between Seoul and Busan is one of the biggest national projects with approx. 20-trillion-won project cost. The construction was started in June 1992 and afterward phase I (between Seoul and Daegu) was opened in April 2004 and phase II (between Daegu and Busan, 169.5km) is scheduled for opening in the end of October 2010. It is assured that the opening of the entire sections of Gyeongbu high-speed railway will significantly increase productivity and efficiency by improving the land utilization with the promotion of personal and material exchanges induced by the reduction of travel time between regions. Especially, Gyeongbu high-speed railway will be the opportunity to boost speed-up of Korea railway.

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Development of Site Characterization Technologies for Crystalline Rocks at Mizunami Underground Research Laboratory (MIU) - Surface-based Investigation Phase - (미즈나미 지하처분연구시설 결정질암에 대한 부지 특성규명 기술 개발 -지표기반 조사단계-)

  • Hama, Katsuhiro
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.11 no.2
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    • pp.115-131
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    • 2013
  • The Mizunami Underground Laboratory (MIU) Project is a comprehensive research project investigating the deep underground environment within crystalline rock being conducted by Japan Atomic Energy Agency. The MIU Project has three overlapping phases: Surface-based Investigation phase (Phase I), Construction phase (Phase II), and Operation phase (Phase III), with a total duration of 20 years. The overall project goals of the MIU Project from Phase I through to Phase III are: 1) to establish techniques for investigation, analysis and assessment of the deep geological environment, and 2) to develop a range of engineering for deep underground application. For the overall project goals 1), the Phase I goals were set to construct models of the geological environment from all surface-based investigation results that describe the geological environment prior to excavation and predict excavation response. For the overall project goals 2), the Phase I goals were set to formulate detailed design concepts and a construction plan for the underground facilities. This paper introduces geosynthesis procedures for the investigation and assessment of the hydrochemistry of groundwater in crystalline rock.