• 한국균학회소식:학술대회논문집
• /
• 한국균학회 2006년도 추계학술대회 및 정기총회
• /
• pp.19-23
• /
• 2006

Methods of lichen-derived culture were spore- and thallus-derived cultures. Spore-derived culture was modified and thallus-derived culture was established for our two decades. We maintained about 500 lichen-derived cultures by using both methods. In recent several years, we have investigated to screen various pharmacological activities in lichen-derived cultures for the first time and found some activities in our cultures.

• 약학회지
• /
• 제37권6호
• /
• pp.631-637
• /
• 1993

In the previous report, it was described that the butanol fraction of the root bark extract of Aralia elata had potent antigastritic and antiulcerative effects in rats, In this pharmacological profile, the fraction revealed low acute toxicities in mice and rats, no central nervous system activities, moderate analgesic action, weak inhibitory action in carrageenin edema of rats and no direct effects on isolated smooth muscles of rats and guinea-pigs. Slight lowering of blood pressure as given i.v. in rabbit was observed.

• 생약학회지
• /
• 제15권1호
• /
• pp.6-14
• /
• 1984

Pharmacological studies have been carried out with the methanol extract of the whole plant of Pseudostellaria palibiniana Ohwi (Caryophyllaceae). The results showed that it had stimulation effect on heart, hypotensive actions depending on extract contents, stimulation effect on respiration, contraction on excised intestines, enhancement of tension on excised uterus, antineoplastic activity on Ehrlich carcinoma, liver protective activity against $CCl_4$ intoxication, writhing and diuretic activities.

• Archives of Pharmacal Research
• /
• 제21권6호
• /
• pp.759-763
• /
• 1998

In connection with the development of new anticonvulsant agents with a broad spectrum, we found that N-Cbz-alpha-amino-alkylsuccinimides showed significant anticonvulsant activities, and the pharmacological activities of these compounds were dependent on their stereochemistry and N-substituted alkyl group. These results prompted us to define the effects of other functional group on the anticonvulsant activities of these compounds. Therefore a series of N-alkoxycarbonyl-alpha-amino-N-methylsuccinimide were prepared from N-Cbz-aspartic acid and were evaluated with their anticonvulsant activities againt the MES and PTZ tests, in order to define the effect of N-substituted alkoxy carbonyl group with the anticonvulsant activities. From these studies, it was found that all the tested N-alkoxycarbonyl-alpha-amino-N-methylsuccinimides exhibited significant anticonvulsant activities in the PTZ test and were not active in the MES test. The most active compound in the PTZ test was (S) N-ethoxycarbonyl-alpha-amino-N-methyl-succinimide. We found that the pharmacological activities in the PTZ test were dependent on their N-alkoxycarbonyl groups. They follow as such: The order of anticonvulsant activities for (R) series as evaluated by $ED_{50}$ was N-phenoxycarbonyl=N-4-nitrobenzyloxycarbonyl > N-ethoxycarbonyl > N-allyloxycarbonyl > N-tert. butoxycarbonyl compound: For the (S) series N-ethoxycarbonyl > N-phenoxycarbonyl > N-allyloxycarbonyl compound. From the above results, it was conceivable that N-substituted alkoxycarbonyl group had certain effects on the anticonvulsant activities of N-alkoxycarbonyl-${\alpha}$-amino-N-methylsuccinimides.

• 생약학회지
• /
• 제25권3호
• /
• pp.221-225
• /
• 1994

Pharmacological activities of two sesquiterpenes, curzerenone(I), and curcumenol(II) isolated from the rhizomes of Curcuma zedoaria being used as an aromatic stomachic in Chinese medicines were evaluated in rats and mice. Curzerenone (I), at 100mg/kg, p.o. showed a potent protective effect against HCl-ethanol induced gastric lesion in rats, and curcumenol(II), at the same dose level showed a CNS depressant action characterized by a potentiation of hexobarbital(HB)-induced narcosis. Both compounds showed a moderate analgesic action but did not exhibit a hypothermic action even at 200mg/kg dose level.

• 생약학회지
• /
• 제21권2호
• /
• pp.179-185
• /
• 1990

The acute and subacute toxicities and pharmacological actions of two preparations of Ssanghwa Tang prescriptions have been evaluated in mice, rats and rabbits. The two prescriptions were found to be safe drugs because those preparations exhibited almost no acute and subacute toxicities even at a high dosage level. The two prescriptions elicited CNS depressant activities characterized by potentiation of hexobarbital-induced narcosis, antipyretic activity in typhoid-vaccinated rabbits and a significant antifatigue effect against cold immobilized stress, the activities of prescription B being more potent.

• Advances in Traditional Medicine
• /
• 제9권3호
• /
• pp.207-216
• /
• 2009

Bauhinia variegata Linn (Mountain Ebony) is a medium-sized, deciduous tree, found throughout India, ascending to an altitude of 1,300 m in the Himalayas. The plant is widely used by the tribals throughout India and popular in various indigenous systems of medicine like Ayurveda, Unani and Homoeopathy. Following the various traditional claims on utility of this plant in curing number of diseases, considerable efforts have been made by researchers to verify its utility through pharmacological screenings. The notable biological activities reported are anthelmintic, antiulcer, antitumour, antimicrobial, anti-inflammatory, antigoitrogenic, hepatoprotective and haemagglutination. Industrially, the plant is widely used for the manufacture of wood wool board, production of tannin, oil, gum and fibre. The plant is also utilized for afforestation to conserve the nature. In this article, a comprehensive account of the cultivation, microscopy, phytochemical investigation, traditional and biologically evaluated medicinal uses of B variegata is presented.

• Natural Product Sciences
• /
• 제25권2호
• /
• pp.92-102
• /
• 2019

Centella asiatica (Linn.) Urban (Umbelliferae) which is also known as 'pegaga' is highly consumed and eaten raw as 'ulam' in Malaysia. C. asiatica is used in traditional medicines to treat various health conditions such as rheumatism, inflammation, syphilis, skin diseases and diarrhoea. Various reports exhibited that the crude extracts and isolated bioactive compounds of C. asiatica possessed a broad range of pharmacological activities such as anti-oxidant, anti-diabetic, anti-tumor, wound healing, anti-microbial, anti-inflammatory, immunomodulatory, hepatoprotective and memory enhancing properties. The pharmacological validation on anti-microbial and immunomodulatory of C. asiatica is very limited and several existence review papers related for this plant had not been focused for both activities. This review therefore attempts to combine the existing literature to offer immense scope for researchers engaged in validation of the traditional claims and bioactivities of this plant related with anti-microbial and immunomodulatory potential.

• 한국미생물생명공학회:학술대회논문집
• /
• 한국미생물생명공학회 2004년도 Annual Meeting BioExibition International Symposium
• /
• pp.316-320
• /
• 2004

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 춘계총회 및 학술대회
• /
• pp.109.3-110
• /
• 2000