• Title/Summary/Keyword: Pharmacognosy

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Hypoglycemic activity of diospyros peregrina fruits in diabetic rats

  • Dewanjee, Saikat;Maiti, Anup;Kundu, Mintu;Mandal, Subhash C
    • Advances in Traditional Medicine
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    • v.8 no.3
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    • pp.279-285
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    • 2008
  • Diospyros peregrina Gurke. (Ebenaceae) is a small middle sized tree grows luxuriantly in the plains of costal West Bengal, India. The objective of the study was to explore the antidiabetic activity of methanol extract of matured fruits of Diospyros peregrina to substantiate the folklore claim of traditional practitioners. It was also aimed to establish correlation with reduction of oxidative state associated with diabetes. Methanol extract of matured fruits of Diospyros peregrina was administered orally at doses of 150 and 300 mg/kg body weight for 12 consecutive days to normal and streptozotocin induced diabetic rats. Fasting blood glucose level was estimated in both normal and diabetic rats while serum lipid profiles, liver glycogen level and pancreatic thiobarbituric acid reactive substances (TBARS) were evaluated for diabetic rats. Initial and final changes in body weight were also recorded. Oral glucose tolerance test was performed during the course of study. Experimental findings showed significant antidiabetic potential of extract in term of reduction of fasting blood glucose level of both normal and diabetic rats. It was found that extract at the dose of 300 mg/kg body weight is more effective and percentage reduction (55.64) of elevated blood glucose level is comparable to that of standard drug glibenclamide (60.60) at a dose of 10 mg/kg body weight. Observed data found statistically significant in reduction of serum lipid and pancreatic TBARS levels whilst improvement was observed in liver glycogen level and body weight profiles in extract treated diabetic rats.

Quantitative Analysis of Taxifolin, (+)-Catechin and Procyanidin B1 from the Preparation of Pinus densiflora (PineXol®) (적송제제(PineXol®)로 부터 Taxifolin과 (+)-Catechin, Procyanidin B1의 함량분석)

  • Hwang, Yoon Jeong;Yin, Jun;Le, Thi Tam;Youn, Sung Hye;Ahn, Hye Shin;Kwon, Suk Hyung;Min, Bok Kee;Yun, Seong Ho;An, Yeoung Eun;Lee, Min Won
    • Korean Journal of Pharmacognosy
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    • v.47 no.3
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    • pp.246-250
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    • 2016
  • Pinus densiflora contained diverse phenol compounds like flavonoid, phenylpropanoid and tannin. PineXol$^{(R)}$ is nutraceutical preparation which was treated from bark of Pinus densiflora. Validation and contents determination of taxifolin, (+)-catechin and procyanidion B1 for the preparation of Pinus densiflora (PineXol$^{(R)}$) were confirmed using High-Performance Liquid Chromatography (HPLC). As a result, content of taxifolin, (+)-catechin and procyanidin B1 were, respectively 4.90%, 2.35% and 8.19%. These analysis method and results could be used as important basic data for the preparation of Pinus densiflora.

Naphthaquinones from some Boraginaceous Taxa-A Chemical Review

  • Khatoon, Sayyada;Mehrotra, Shanta
    • Natural Product Sciences
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    • v.2 no.2
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    • pp.75-85
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    • 1996
  • The naphthaquinones-isohexenylnaphthazarins-are mostly found in the ceratenchymatous cells of the roots of some boraginaceous taxa. A total of 34 naphthazarins and their derivatives have been isolated from these taxa till date.

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Anticancer Compound of Paulownia tomentosa

  • Moon, Hyung-In;Zee, Ok-Pyo
    • Natural Product Sciences
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    • v.7 no.1
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    • pp.21-22
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    • 2001
  • A cytotoxic compound was purified from the flowers (46 g) of Paulownia tomentosa by normal column chromatography. As a result of the structure analysis by spectroscopic methods, the compound was identified as isoatriplicolide tiglate, which shows in vitro cytotoxicity.

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Pharmacognostic Evaluation of the Roots of Berberis chitria Lindl.

  • Srivastava, Sharad Kumar;Rawat, Ajay Kumar Singh;Srivastava, Manjoosha;Mehrotra, Shanta
    • Natural Product Sciences
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    • v.12 no.1
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    • pp.19-23
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    • 2006
  • Berberis chitria (family Berberidaceae) has a close affinity with B. aristata, used in traditional systems of medicine as a drug 'Daruharidra' for skin disease, jaundice, affection of eyes, and rheumatism. Keeping this in view, in the present study attempts have been made to identify marker characters of B. chitria in order to differentiate the two species. Some of the diagnostic features of the root are patches of pericyclic fibre, pitted sclerieds and berberine containing cells and heterocyclic medullary rays. Besides, the physicochemical characters such as total ash; acid insoluble ash; alcohol and water soluble extractive; tannins; sugar and starch percentages has shown variations. The percentage of berberine as berberine hydrochloride was also calculated through HPTLC densitometric method and it was found little higher than B. aristata and B. asiatica i.e. 3.16%. Thus, this species can be utilized as a possible substitute to Daruharidra.

Pharmacognostic Evaluation of the Flower of Alcea rosea L.

  • Mehrotra, Shanta;Rawat, A.K.S.;Shome, Usha
    • Natural Product Sciences
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    • v.5 no.1
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    • pp.39-47
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    • 1999
  • The flowers of Alcea rosea L., Malvaceae, sold in the Indian market under the trade name 'Gulkhairo', are well known for their expectorant, cooling and diuretic properties and used in many indigenous cough mixtures in India. The present paper deals with the detailed pharmacognosy of the floral parts including morphological, anatomical, phytochemical and fluorescence characters. Some of the diagnostic features of the drug are : pedicel characterized by multicellular appendages, stellate hairs, rosette crystals of Ca-oxalate, starch sheath and large sized mucilage canals; sepals having distinctive multicellular appendages arranged in a semilunar fashion present adaxially at their base; monadelphous stamens, pollen grains pentaporate provided with dimorphic spines; placentation axile, ovules campylotropous; dark green fluorescence of the powder with nitrocellulose in amyl acetate and yellow fluorescence of trichomes under Fluorescence microscope.

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Anti-emetic Principles of Alpinia katsumadai Hayata

  • Yang, Ye;Kinoshita, Kaoru;Koyama, Kiyotaka;Takahashi, Kunio;Tai, Takaaki;Nunoura, Yoshiki;Watanabe, Kazuo
    • Natural Product Sciences
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    • v.5 no.1
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    • pp.20-24
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    • 1999
  • Bioassay-guided fractionation of anti-emetic constituents of Alpinia katsumadai Hayata was performed. Nine compounds including one novel compound, (3R,5S)-trans-3,5-dihydroxy-1,7-diphenyl-1-heptene (9) were isolated from it. Among these compounds, four diarylheptanoids, one sesquiterpenoid and one flavonoid showed anti-emetic activity on copper sulfate induced-emesis in young chicks.

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