• 생약학회지
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• 제41권3호
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• pp.157-160
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• 2010

Chinese crude drug 'JeonHo (前胡)' has been used mainly cough and dyspnea in respiratory infections. To clarify the botanical origin of 'JeonHo' in Korean market, the anatomical characterization of Anthriscus sylvestris, Angelica decursiva and Peucedanum praeruptorum were studied. As a result, it was clarified that 'JeonHo' in Korean market was the root of Peucedanum praeruptorum.

• 생약학회지
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• 제43권4호
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• pp.291-296
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• 2012

The dried roots of Angelica decursiva and Peucedanum praeruptorum are registered as the official sources for the drug 'Junho' in Korean Herbal Pharmacopoeia. In this study the essential oils were extracted from the roots of the two plants by steam distillation. Their compositions and the biological activities were compared. As the results of GC and GC-MS analysis, forty one and thirty five compounds were identified in the essential oils of Angelica decursiva and Peucedanum praeruptorum, respectively. Both of the two essential oils contained ${\alpha}$-pinene as the most abundant component. They showed similar significant antioxidant activities in DPPH scavenging assay, and reducing power test. Their dose dependent inhibitions of the nitrosamine formation were identified in experiment using BHA as control. In MTT test of three cancer cell lines, HeLa, MCF-7 and SK-Hep-1, the essential oil from A. decursiva showed stronger activities than that of P. praeruptorum and their common main component, ${\alpha}$-pinene.

• Natural Product Sciences
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• 제22권3호
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• pp.162-167
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• 2016

Peucedani Radix is the root of Angelica decursiva Franchet et Savatier (=Peucedanum decursivum Maximowicz) or Peucedanum praeruptorum Dunn in several Asian countries. The coumarins contained in Peucedani Radix were quantitatively analyzed using HPLC-DAD to develop a simultaneous determination for the quality control of A. decursiva and P. praeruptorum. For quantitative analysis, four major coumarins contained in these medicinal plants were assessed. Nodakenin (1), nodakenetin (2), praeruptorin A (3), and praeruptorin B (4) were separated with a Phenomenex Luna C18 column ($5{\mu}m$, $4.6{\times}250mm$) under the gradient conditions using distilled water with 0.1% phosphoric acid and acetonitrile with 0.1% phosphoric acid as the mobile phase, at a flow rate of 1.0 ml/min and a detection wavelength of 330 nm. This method was fully validated for linearity, accuracy, precision, recovery, and limit of detection and quantification. As a result, A. decursiva and P. praeruptorum were clearly classified by the quantification of four major coumarins in extracts. Also, the pattern recognition analysis based on HPLC indicates that all of the samples were largely clustered into two groups. Therefore, it is possible to distinguish between A. decursiva and P. praeruptorum and contribute to quality control.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.660-671
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• 2003

A chemical investigation of Peucedanum praeruptorum has resulted in the isolation of 3 khellactone derivatives, which have inhibitory effects on melanogenesis in B16 mouse melanoma cell lines. The khellactone derivatives were isolated from the crude extract of the roots of Pecedanum praeruptorum by a combination of adsorption chromatography and HPLC. The structures of isolated compounds were identified as 3', 4'-diangeloyl-cis-khellactone, 3'-angeloyl-4'-senecioyl-cis-khellactone and, 3', 4'-disenecioyl-cis-khellactone by $^1$H NMR, $^{13}$ C NMR and mass spectral studies and by comparisons of spectral data with reported literatures. These khellactone derivatives can be a good candidate for new skin whitening agent due to its strong inhibitory activity and safety.

• 생약학회지
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• 제33권4호통권131호
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• pp.395-398
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• 2002

A chemical investigation of Peucedanum praeruptorum has resulted in the isolation of 3 khellactone derivatives, which have inhibitory effects on melanogenesis in Bl6 mouse melanoma cell lines. The khellactone derivatives were isolated from the crude extract of the roots of Pecedanum praeruptorum by a combination of adsorption chromatography and HPLC. The structlues of isolated compounds were identified as 3',4'- diangeloyl-cis-khellactone, 3'-angeloyl- 4'- senecioyl-cis-khel- lactone and,3', 4'-disenecioyl-cis-khellactone by $^1H\;NMR$, $^{13}C\;NMR$ and mass spectral studies and by comparisons of spectral data with reported literatures.

• 대한본초학회지
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• 제27권3호
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• pp.15-21
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• 2012

Objective : This study aimed to compare the difference between $Angelica$ $decursiva$, Peucedanum $praeruptorum$ and $Anthriscus$ $sylvestris$ which have been used as herbal medicine, Jeonho (Angelicae Decursivae Radix) in Korea and provided the evidence to exclude $A.$ $sylvestris$ not to use as Joenho. Methods : The similarities of original medicinal herb with samples from local market were evaluated including morphological appearance and chromatographic fingerprint. In addition, relation between original medicinal herb and local samples were analyzed using statistical clustering methods. Results : $A.$ $decursiva$, $P.$ $praeruptorum$ and $A.$ $sylvestris$ represented different morphological appearances and chromatographic fingerprint. Several samples from China exhibited similar morphological and chromatographic appearance with $A.$ $decursiva$ or $P.$ $praeruptorum$. Eleven samples from Korea showed identical similarity to $A.$ $sylvestris$. Conclusions : Since $A.$ $sylvestris$ represented obvious differences compared to $A.$ $decursiva$ and $P.$ $praeruptorum$, it is required not to use $A.$ $sylvestris$ as medicinal herb, Jeonho. Additionally, exact identification and quality control must be applied to $A.$ $decursiva$ or $P.$ $praeruptorum$ from China in order to maintain therapeutical efficacy.

• 대한본초학회지
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• 제26권3호
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• pp.57-63
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• 2011

Objectives : Peucedani Radix ('Jeonho' in Korean) is the root of Peucedanum praeruptorum or Angelica decursiva. However, the root of Anthriscus sylvestris has usually been distributed as Jeonho. This study was performed to determine the discriminative criteria of Jeonho, focused on distribution in Korean markets. Methods : We have determined identification keys to discriminate each Jeonho samples, through observation of external morphology of original plants, and the research of external and internal morphological features of dried Jeonho herbs. Results : Because of identical to the Korean plant name 'Jeonho', Anthrisci Radix had been came into use as a substitute of Jeonho in Korea during the time of Japanese colonial rule. The original plants of Jeonho and its substitute are discriminated with shape of leaf, leaf margin and color of stem. External morphological features of the medicinal herbs of Jeonho are different in the color of cross-sections, pellucid dot, white powder. Internal morphological points, such as fiber bundle of xylem, seconadary mudullary ray and ray of xylem were also used as discriminative criteria for Jeonho. Further details(e.g. identificaion keys) are in the article. Conclusions : We think that these discriminative criteria will be meaningful in identifying the substitutes and adulterants of Jeonho.

• 생약학회지
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• 제45권3호
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• pp.187-193
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• 2014

To identify potential gastrointestinal prokinetic agents, water and 70% ethanol extracts and isolated compounds from 41 different traditional medicinal herbs were evaluated for the stimulation of gastrointestinal (GI) motility in vivo. Of the 41 water and 70% ethanol extracts, 12 extracts were found to enhance GI motility activity in mice by more than 10%. The 12 extracts are as follows: Atractylodes japonica (root), Crataegus pinnatifida (flower), Aucklandia lappa (root), Inula helenium (root), Cynanchum wilfordii (root), Chinese Liriope platyphylla (root), Codonopsis pilosula (root), Glehnia littoralis (root), Pinellia ternate (tuber), Agastache rugosa (aerial part), Angelica decursiva (whole plant), and Peucedanum praeruptorum (whole plant). In particular, the extracts from Atractylodes japonica (root), Cynanchum wilfordii (root) and Angelica decursiva (whole plant) have demonstrated the highest GI motility activity. In addition, 26 isolated compounds from the medicinal herbs were tested, and 8 isolated compounds were found to be active. They are ${\alpha}$-ionone, ${\beta}$-ionone, trans-caryophyllene, cedrol, methyl-3,5-di-O-E-caffeoyl-quinate, lobetyolin, oleoyllinoleoylolein and cis-jasmone. ${\beta}$-ionone from Aucklandia lappa (root) showed the most potent GI motility activity. The active traditional medicinal herbs and isolated compounds might be therapeutically advantageous in the treatment of GI motility disorders.

• 한방안이비인후피부과학회지
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• 제32권2호
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• pp.1-10
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• 2019

Objectives : The objective of present study is to evaluate anti-inflammatory and anti-allergic effects of Perilla(Perilla frutescens; Labiatae, PF), the roots of Peucedanum praeruptorum(PP) and the root of Scutellaria baicalensis(SB) in vitro and anti-asthmatic effects of mixture of PF, PP and SB(PS) on ovalbumin (OVA)-induced asthma in BALB/c mice. Methods : Anti-inflammatory and anti-allergic effects were observed on the lipopolysaccharide(LPS) treated RAW 264.7 cells through Nitric Oxide(NO) production and RBL-2H3 cells through ${\beta}$-hexosaminidase. Anti-asthmatic effects were observed on the number of inflammatory cells in bronchoalveolar lavage fluid(BALF) and the level of IgE in serum on OVA-induced BALB/c mice. Results : The treatment of PF, PP and SB(12.5, 25, 50, $100{\mu}g/m{\ell}$) resulted in a significant inhibition of NO production in RAW 264.7 cells and mast cell degranulation in RBL-2H3 cells. Oral administration of PS(400mg/kg/day) resulted in a significant reduction in the numbers of eosinophils in BALF and level of IgE in serum. Conclusion : The oral administration of PS is effective in ameliorating the eosinophilic infiltration in vivo and thus can be a good therapeutic candidate for allergic asthma.

• 대한본초학회지
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• 제37권6호
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• pp.29-36
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• 2022

Objectives : The objective of this study was to investigate the possibility for the treatment of hypertension of herbal medicines belong to Umbelliferae family. Methods : Domestic and international articles about Herbology were investigated. A review was performed via the database (DB) search engines such as Pubmed, Korean studies Information Service System (KISS), KoreaScience, and Google Scholar. Hypertension-related terms including "vasorelaxation", "vasorelaxant", "vasodilation", "vasodilatory", "vasodilative", "hypotension", and "hypotensive" were performed as search terms. Results : A list was made about herbal medicines and origin plants belonging to the Umbelliferae family in Korean Pharmacopoeia 12 and Korean Herbal Pharmacopoeia. 14 herbal medicine and 22 origin plants were searched. Ostericum koreanum root and rhizome, Notopterygium incisum root and rhizome, N. forbesii root and rhizome, Ligusticum tenuissimum root and rhizome, L. jeholense root and rhizome, Angelica gigas root, A. dahurica root, A. dahurica var. formosana root, Bupleurum falcatum root, Peucedanum japonicum root, P. praeruptorum root, A. decursiva root, Cnidium officinale rhizome, L. chuanxiong rhizome, Foeniculum vulgare fruit, and Ferula assa-foetida resin and stem showed significant vasorelaxant or hypotensive effects. Conclusion : These review results showed that Osterici seu Notopterygii Radix et Rhizoma, Ligustici Tenuissimi Rhizoma et Radix, Angelicae Gigantis Radix, Angelicae Dahuricae Radix, Bupleuri Radix, Peucedani Japonici Radix, Peucedani Radix, Cnidii Rhizoma, Foeniculi Fructus, and Ferulae Resina had vasorelaxant or hypotensive effects. The results are expected as basic data in clinical trials and experimental researches for the treatment of hypertension of herbal medicines.