• Genomics & Informatics
• /
• v.17 no.3
• /
• pp.23.1-23.6
• /
• 2019

The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data.

• Biomolecules & Therapeutics
• /
• v.31 no.4
• /
• pp.388-394
• /
• 2023

Nitric oxide (NO) is a signaling molecule that plays a crucial role in numerous cellular physiological processes. In the skin, NO is produced by keratinocytes, fibroblasts, endothelial cells, and immune cells and is involved in skin functions such as vasodilation, pigmentation, hair growth, wound healing, and immune responses. NO modulates both innate and adaptive immune responses. As a signaling molecule and cytotoxic effector, NO influences the function of immune cells and production of cytokines. NO is a key mediator that protects against or contributes to skin inflammation. Moreover, NO has been implicated in skin sensitization, a process underlying contact dermatitis. It modulates the function of dendritic cells and T cells, thereby affecting the immune response to allergens. NO also plays a role in contact dermatitis by inducing inflammation and tissue damage. NO-related chemicals, such as nitrofatty acids and nitric oxide synthase (NOS) inhibitors, have potential therapeutic applications in skin conditions, including allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). Further research is required to fully elucidate the therapeutic potential of NO-related chemicals and develop personalized treatment strategies for skin conditions.

• Journal of Korea Multimedia Society
• /
• v.19 no.11
• /
• pp.1878-1890
• /
• 2016

Web 2.0 has features produced the content through the user of the participation and share. The content production activities have became active since social network service appear. The social bookmark, one of social network service, is service that lets users to store useful content and share bookmarked contents between personal users. Unlike Internet search engines such as Google and Naver, the content stored on social bookmark is searched based on tag keyword information and unnecessary information can be excluded. Social bookmark can make users access to selected content. However, quick access to content that users want is difficult job because of the user of the participation and share. Our paper suggests a method recommending search word to be able to access quickly to content. A method is suggested by using Collaborative Filtering and Jaccard similarity coefficient. The performance of suggested system is verified with experiments that compare by 'Delicious' and "Feeltering' with our system.

• Journal of Fashion Business
• /
• v.23 no.6
• /
• pp.101-115
• /
• 2019

3D printing is attracting attention from all industries as it enables the development of personalized product design to meet consumer needs by establishing a mutual connection system between production, management and consumers. However, there are still limitations to applying them as apparel materials, and research on the recognition of 3D printing or the preference for fashion products is needed to actually commercialize 3D printing in the fashion industry. In this study on the development of various product designs using 3D printing technology in the fashion industry, an analysis of 255 questionnaires was conducted to determine the preferences and purchase intention trends of fashion product design using 3D printing for college students. Data analysis was performed with IBM SPSS Statistics (V.24). 'Fashion sensitive pursuit', 'Individuality & brand pursuit' and 'Functional convenience' was interested in fashion accessories using 3D printing technology and customized fashion apparel products using 3D printing. 'Functional Convenience-oriented' and 'Practical Purchasing-oriented' type showed that the functionality and durability of products made using 3D printing technology were important. And 'Individuality pursuit' type indicated that design and applied materials were important when producing products using 3D printing technology.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• v.9 no.2
• /
• pp.643-646
• /
• 2005

In this paper, we present a service model which serves multimedia contents to end consumer(End-user) that have various mobile communication terminals under a communication & broadcasting converged environment that broadcasting and communication networks are linked. A main feature of this service model is that it has a distribution structure that deliver to end consumer via adaptation of content from production of contents offering End to End (E2E) media QoS and personalized contents consumption. The proposed service model may be used as a reference model for distribution of multimedia content in communication & broadcasting converged environment in the future.

• Food Science and Industry
• /
• v.50 no.1
• /
• pp.16-25
• /
• 2017

There is no doubt that accumulation of big data using multi-omics technologies will be useful to solve human's long-standing problems such as development of personalized diet and medicine, overcoming diseases, and longevity. However, in the food industry, big data based on omics is scarcely accumulated. In particular, comprehensive analysis of molecular lipid metabolites directly associated with food quality, such as taste, flavor, and texture has been very limited. Moreover, most of food lipidomics studies are applied to analyze lipid components and discriminate authenticity and freshness of limited foods including vegetable and fish oil. However, if lipid big data through food lipidomics research of various foods and materials can be accumulated, lipidomics can be used in the optimization of food processing, production, delivery system, food safety, and storage as well as functional food.

• International Journal of Internet, Broadcasting and Communication
• /
• v.14 no.3
• /
• pp.91-100
• /
• 2022

Major developed countries are seriously considering smart factories to increase their manufacturing competitiveness. Smart factory is a customized factory that incorporates ICT in the entire process from product planning to design, distribution and sales. This can reduce production costs and respond flexibly to the consumer market. The smart factory converts physical signals into digital signals, connects machines, parts, factories, manufacturing processes, people, and supply chain partners in the factory to each other, and uses the collected data to enable the smart factory platform to operate intelligently. Enhancing personalized value is the key. Therefore, it can be said that the success or failure of a smart factory depends on whether big data is secured and utilized. Standardized communication and collaboration are required to smoothly acquire big data inside and outside the factory in the smart factory, and the use of big data can be maximized through big data analysis. This study examines big data analysis and standardization in smart factory. Manufacturing innovation by country, smart factory construction framework, smart factory implementation key elements, big data analysis and visualization, etc. will be reviewed first. Through this, we propose services such as big data infrastructure construction process, big data platform components, big data modeling, big data quality management components, big data standardization, and big data implementation consulting that can be suggested when building big data infrastructure in smart factories. It is expected that this proposal can be a guide for building big data infrastructure for companies that want to introduce a smart factory.

• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.8 no.2
• /
• pp.139-150
• /
• 2022

Theranostics, a composite word of therapy and diagnosis, is known as personalized medicine and the concept of diagnosis and treatment at the same time. In nuclear medicine, it means performing both therapeutic and diagnostic radioisotope therapy using the same target molecule. The increased production and utilization of ⁶⁴Cu opens a new era of theranostics. The studies introduced here have shown that ⁶⁴CuCl₂ and various compounds or biomolecules labeled with ⁶⁴Cu are unique radiopharmaceuticals with physiological properties suitable for use as diagnostic and therapeutic agents. So far, these two abilities have been described only for radioactive iodine. Although ⁶⁴Cu has complex chemical properties compared to other PET radioisotopes such as ⁶⁸Ga, it has an appropriate half-life and enables high-quality PET images similar to ¹⁸F, which is an advantage in terms of diagnosis. In addition, since it also has therapeutic properties through the release of β^- particles and Auger electrons by electron capture, radiopharmaceuticals using ⁶⁴Cu stand for innovative radiopharmaceuticals for theranostic purposes. Therefore, based on the initial results obtained using ⁶⁴Cu as a therapeutic agent, it is expected that additional research on the application of ⁶⁴Cu will lead to a new era in the theranostics field.

• Food Science of Animal Resources
• /
• v.44 no.2
• /
• pp.225-238
• /
• 2024

3D printing technology enables the production of creative and personalized food products that meet consumer needs, such as an attractive visual appearance, fortification of specific nutrients, and modified textures. To popularize and diversify 3D-printed foods, an evaluation of the printing feasibility of various food pastes, including materials that cannot be printed natively, is necessary. Most animal resources, such as meat, milk, and eggs, are not inherently printable; therefore, the rheological properties governing printability should be improved through pre-/post-processing or adding appropriate additives. This review provides the latest progress in extrusion-based 3D printing of animal resource-based inks. In addition, this review discusses the effects of ink composition, printing conditions, and post-processing on the printing performance and characteristics of printed constructs. Further research is required to enhance the sensory quality and nutritional and textural properties of animal resource-based printed foods.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.10 no.1
• /
• pp.167-174
• /
• 2015

This study examines the Personalized Oriented Customized and services in smart environments. In addition to The structure of industry is currently smart environment shifting from the manufacturing industry focusing on goods production to service industry merging and combining service and marketing. The companies are placing a higher value on the customer needs to gain a competitive edge with creation of new business model. The key dilemma in mass customization and service, though, is how product customization can be realized without increasing production cost significantly. The purpose of this study is to explore new product development strategies that facilitate mass customization and service. Specifically, we propose Crowdsourcing marketing, Digital experience technology, Recommender Systems, 3D printing technology, Flexible manufacturing systems and UX based PSS(Product-Service Systems) in new product development processes as enabling strategies for mass customization and service in smart environments.