Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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Identification of neoantigens derived from alternative splicing and RNA modification

  • Park, Jiyeon (Precision Medicine Research Center, College of Medicine, The Catholic University of Korea) ;
  • Chung, Yeun-Jun (Precision Medicine Research Center, College of Medicine, The Catholic University of Korea)
  • Received : 2019.04.23
  • Accepted : 2019.05.09
  • Published : 2019.09.30
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Abstract

The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data.

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References

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