• Journal of Environmental Health Sciences
• /
• v.43 no.1
• /
• pp.77-86
• /
• 2017

Objectives: The purpose of this study was to compare permeation characteristics in three skin types using oil-soluble benzoic acid and water-soluble caffeine after method condition optimization based on OECD guideline 428. Methods: A Franz diffusion cell, a reliable alternative method for skin permeation, was used. One-milliliter samples were taken and immediately replaced with fresh solution in the receptor chamber at regular time intervals (1, 2, 4, 7, 10 and 24 hr). The amount of test substances was measured by LC-MS/MS. Results: The permeation rate increased dose-dependently, and the permeation orders were $KeraSkin^{TM}$ > hairless mouse full skin > human cadaver epidermis for skin types, and benzoic acid solution > caffeine solution > benzoic acid cream > caffeine cream for type of test materials. Conclusion: According to the definitions of Marzulli, benzoic acid and caffeine would be classified as 'fast' and 'moderate' compared with the permeation of other chemical species. The setting conditions and permeation characteristics performed in this study are expected to contribute to future permeation studies.

• Korean Membrane Journal
• /
• v.8 no.1
• /
• pp.21-30
• /
• 2006

A faujasite NaY zeolite membrane was prepared on a tubular ${\alpha}-Al_2O_3$ support by the secondary growth process, and effects of permeation test conditions on the $CO_2/N_2$ separation were investigated. A NaY zeolite membrane with good $CO_2/N_2$ separation was successfully synthesized by using the hydrothermal solution ($Al_2O_3:SiO_2:Na_2O:H_2O$ = 1:6:14:840 in a molar base): at a permeation temperature of $30^{\circ}C$, its $CO_2$ permeance and $CO_2/N_2$ separation factor were $2.5{\times}10^{-7}mol/m^2secPa$ and 34, respectively. The $CO_2$ and $N_2$ permeations were highly dependent on permeation test conditions (feed composition, feeding rate, feed pressure, He sweeping rate and permeation temperature). The results indicated that (i) $CO_2$ and $N_2$ permeations through NaY zeolite membrane are governed by surface and micropore diffusions, respectively, (ii) the preparation of NaY zeolite membrane with a large permeating area is one of the most difficult hurdles for its real applications, and (iii) the retardation of $N_2$ permeation is an effective key to improve $CO_2/N_2$ separation factor in NaY zeolite membrane.

• Journal of Pharmaceutical Investigation
• /
• v.30 no.1
• /
• pp.27-32
• /
• 2000

Various release test methods have been applied for the evaluation of nicotine release in vitro from commercial patches. However, whether and how the release data reflect the permeation of nicotine across the skin, is not fully elucidated. To predict in vivo bioavailability from in vitro release tests, correlation between in vitro release and in vitro skin permeation was assessed in the present study. Release of nicotine from three commercial patches was measured for 24 hours under nine experimental conditions which were classified depending on the apparatus (i.e., paddle over disk, cylinder and reciprocating holder) and dissolution media (i.e., phosphate buffer pH 7.4, water and the 1 % phosphoric acid pH 1.5). In vitro permeation of nicotine from the patches across the human cadaver skin was also measured using a diffusion cell. The release of nicotine was better explained by the Higuchi's equation rather than by the first order rate equation. Correlation between the release rate and the in vitro skin permeation differed among the patches. However, in general, the cylinder method, in which water is used as a dissolution medium, showed the highest correlation among the nine release test conditions.

• Journal of Pharmaceutical Investigation
• /
• v.25 no.1
• /
• pp.47-54
• /
• 1995

Transdermal patch formulations of estradiol to treat post-menopausal symptoms and prevent osteoporosis in women were developed and evaluated for the permeation characteristics through the excised hairless mouse abdorminal skin and the uterotropic effect on the ovariectomized rabbits. The design of patch formulations was optimized by varying several formulation parameters, such as type of enhancers, amount of enhancers, amount of drug loading and coating thickness. Compared to a commercially available transdermal product, several patch formulations showed the similar skin permeation profiles (following zero-order kinetics), but their skin permeation rates were lasted for the longer period (a week). In one-week uterotropic efficacy test in the ovariectimized rabbits, the selected patch formulations showed the positive effect in atrophy of the urogenital epithelium. The mean values of uterus weight in rabbits after application of patches containing estradiol were much higher than those in control group (containing no drug).

• Korean Journal of Materials Research
• /
• v.28 no.7
• /
• pp.428-434
• /
• 2018

Hydrogen evolution on a steel surface and subsequent hydrogen diffusion into the steel matrix are evaluated using an electrochemical permeation test with no applied cathodic current on the hydrogen charging side. In particular, cyclic operation in the permeation test is also conducted to clarify the corrosion-induced hydrogen evolution behavior. In contrast to the conventional perception that the cathodic reduction reaction on the steel in neutral aqueous environments is an oxygen reduction reaction, this study demonstrates that atomic hydrogen may be generated on the steel surface by the corrosion reaction, even in a neutral environment. Although a much lower permeation current density and significant slower diffusion kinetics of hydrogen are observed compared to the results measured in acidic environments, they contribute to the increase in the embrittlement index. This study suggests that the research on hydrogen embrittlement in ultra-strong steels should be approached from the viewpoint of corrosion reactions on the steel surface and subsequent hydrogen evolution/diffusion behavior.

• Journal of the Korean Society of Safety
• /
• v.23 no.6
• /
• pp.62-69
• /
• 2008

As the concerns of dermal exposure of spray painters to isocyanates in the automobile industry, glove performance was examined like permeation rate and breakthrough time including fatigue test. Methylene chloride was used as the solvent for derivatization of the isocyanates with a 97.5% recovery. Ghost wipe pads were used to wipe the surface of the glove material after chemical penetration through the glove material placed under a disposable test cell. Several solvents were tested, such as thinner(xylene, toluene) and cleaning agent(acetone) by using a standard permeation test cell(AS/NZS standard 2161. part 10.3). Solvents accelerate chemical permeation through the gloves more quickly than pure HDI hardener products. The longest breakthrough times were from Nitrosolve gloves, not detected in 8 hours, compared with others like Latex, Neoprene, TNT and Dermo Plus. Therefore Nitrosolve gloves could be recommended as personal protective equipment in crash repair shops. In addition, revised exposure limit of korean regulation should be suggested for employee to minimize the risk of health symptoms.

• Journal of Auto-vehicle Safety Association
• /
• v.16 no.1
• /
• pp.49-54
• /
• 2024

This paper provides an analysis of the experimental procedures and results to ensure the reliability of the system manufactured for testing the hydrogen permeability of a 175 L compressed hydrogen container for a hydrogen bus. Based on the hydrogen permeability standard of 6 cc/(h·L), it was injected into the permeability test chamber at 10% intervals, and the permeated hydrogen concentration according to the injected amount was measured and compared with the actual amount of hydrogen permeated. As a result of the experiment, the measured value represented 96.34% of the actual permeation amount, which can be used as basic data for the hydrogen bus vessel permeability test system being built in Korea.

• Membrane Journal
• /
• v.14 no.3
• /
• pp.207-217
• /
• 2004

In this study, we prepared nanofiltration membrane by applying the interfacial polymerization method as a way of manufacturing composite membranes. We have examined the effects of various preparation factors such as monomer concentration and composition, thermal curing condition, post treatment condition. In addition to preparation conditions, we also monitored the effects of operation conditions such as feed solution concentration and operation pressure on the permeation properties of the resulting nanofiltration membrane. We intended to increase the permeation rate of nanofiltration membrane by the enlargement of effective surface area using additives during interfacial polymerization step. With increasing the monomer concentration, membrane permeation rate are decreased with maintaining almost constant rejection. With respect to curing condition, with increasing the curing temperature both permeation rate and rejection are decreased. With increasing the ratio of MPD in amino monomer composition, permeation rate decreased drastically with high rejection. With increasing the feed solution concentration, both permeation rate and rejection decreased. Both permeation rates and rejection increased with increasing the operating pressure. Nanofiltration membrane have higher surface roughness with increasing additive concentration in the case of using MPD contained amine composition than using piperazine alone. Permeation rates are much lower than the nanofiltration membrane prepared by piperazine.

• Economic and Environmental Geology
• /
• v.43 no.2
• /
• pp.177-184
• /
• 2010

When cement grout is used for waterproofing of grounds, important roles are played by fluidity, particle size and bleeding. The most important element which determines their characteristics is the water/cement ratio of grout. Moreover in order to improve the efficiency of soil permeation, micro cement with a smaller average diameter is used in addition to ordinary portland cement. Besides the mixing ratio and cement diameter, the condition of ground is also of fundamental importance in the efficiency of permeation. In order to evaluate grout in terms of permeation ability into ground, we need a field test of grounting, which is cost and time consuming. In this paper we present a laboratory test method in which the suitability and efficiency of grouts are simply and more practically tested. In Korea neither a test standard nor devices are available to simulate grouting in a laboratory. We devised a grout injection equipment in which grouting was reproduced in the same condition with different materials, and suggested a standard for the production of specimens. Our tests revealed that the efficiency of injection increases with the water/cement ratio. We also found that more efficiently injected is the grout with the order of decreasing size; MS8000, micro cement, and ultra fine cements, and colloidal super cement.

• Archives of Pharmacal Research
• /
• v.18 no.4
• /
• pp.231-236
• /
• 1995

Effects of sodium salts of various monovalent inorganic anions on transdermal permeation of salicylic acid were investigated. In in-vitro experiment using a Franz-type diffusion cell and excisicylic acid were investigated. In-vitro experiment using a Franze-type diffusion cell and excised mouse skin, the permeation-enhancing activities of the sodium salts of inoraganic anions were rougly proportional to lyotropic Hofmeister serlling abilities of the anions l F/sup -/