• Journal of Periodontal and Implant Science
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• 제34권3호
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• pp.671-681
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• 2004

Genomic Project 이후로 다양한 질환에 있어서 유전적인 영향에 관한 연구가 진행되고 있다. 이 연구의 목적은 한국인 치주질환 환자에서 Fc ${\gamma}R$ 유전자의 유전자다형성과 치주질환 특성과의 관련성을 알아보는 것이다. 치주적으로 건강한 한국인 90명(대조군, 남자64명, 여자26명), 중도 만성 치주염환자 40명(severe chronic periodontitis patients; severe CP, 남자 24명, 여자 16명)을 대상으로 임상지수(치주낭 깊이, 입상부착소실, 치은지수, 치태지수, 탐침 후 출혈지수, 치조골소실)를 측정하였다. 또한 이들의 정맥혈에서 추출한 DNA를 PCR(Polymerase Chain Reaction)법, 전기영동법 등을 이용하여 Fc ${\gamma}RIIIa$ , Fc ${\gamma}RIIIb$의 대립유전자의 존재여부를 확인하였다. 이를 바탕으로 각 유전자의 다형성 및 Fc ${\gamma}R$ 복합유전자형 (Fc ${\gamma}R$ composite genotype)을 확인하여, 각 군 간을 비교하였다. 치주질환의 특성과 유전자 다형성과의 관련성을 알아보기 위하여 Fc ${\gamma}R$ 유전자에 대한 유전자다형성을 조사한 결과 다음과 같은 결과를 얻을 수 있었다. 1. Fc ${\gamma}RIIla$에 대한 유전자다형성 연구결과 대조군과 severe CP, AgP군 사이에서, severe CP와 AgP군 사이에서는 대립유전자분포가 서로 유의성 있는 차이를 나타내었지만(p<0.05), Fc ${\gamma}RIIlb$에서는 유의성 있는 차이를 보이지 않았다(p>0.05). 2. Fc ${\gamma}R$ 복합유전자형간의 비교에서 유의성 있는 차이를 발견할 수 없었다(p>0.05). 이와 같은 결과를 종합하여 볼 때 실험대상 한국인 치주염환자에서 Fc ${\gamma}R$ 유전자에 대한 다형성분석에서 Fc ${\gamma}RIIIa$ 대립유전자가 치주염에 대한 감수성과 관련되어 있다고 생각된다. 이 연구의 결과는 유전자의 차이가 치주질환의 감수성 판단의 자료로 활용할 수 있는 가능성을 보여주고 있다.

• 대한소아치과학회지
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• 제39권2호
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• pp.181-185
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• 2012

치내치는 치아 조직이 석회화되기 전에 법랑기가 치유두 내로 함입되어 형성된 발육성 기형이다. 가장 널리 통용되는 치내치의 분류법은 방사선 사진 상에서 함입(invagination)이 얼마나 치관에서 치근 쪽으로 연장되어 있는지에 따라 분류하는 Oehler's classification system이다. 그 중 Oehler's classification type III는 함입이 치근까지 연장되어 치주인대와 직접적으로 'pseudo foramen'을 통해 교통하는 경우를 말하며 대체로 치수와는 독립적으로 존재한다. Type III 함입을 통한 감염은 언제나 치주조직의 염증성 반응을 야기할 가능성이 있으며, 이처럼 'pseudo foramen' 주위로 염증성 병변이 발생한 경우 이를 'peri-invagination periodontitis'라 한다. 본 증례는 Oehler's type III 치내치를 갖는 상악 측절치의 'peri-invagination periodontitis'을 주소로 내원한 두 환자에게 각각 다른 치료적 접근을 통하여 양호한 결과를 얻었다. 치내치에 대한 처치 시 조기 진단과 예방적 치료를 통한 치수의 건강 유지가 매우 중요하나, 이미 치수까지 질환에 이환 되었을 경우 환아의 나이, 치근 성숙도, 함입의 종류, 염증의 치수 이환 여부 등을 고려하여 치료계획을 수립해야 한다.

• 대한소아치과학회지
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• 제27권1호
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• pp.146-150
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• 2000

장애인은 일반적으로 구강관리에 대한 인식과 수행능력의 부족으로 구강위생상태가 불량하며, 치과질환의 발생빈도가 높고 그 정도가심한 편이다. 장애인의 치과치료시 많은 어려움이 따르는 행동조절은 장애의 종류와 정도에 따라 심리적 물리적, 약물적 방법 및 전신마취 등을 선택할 수 있으나, 여러 가지 이유로 인하여 일반적인 방법으로 치료가 불가능할 경우 전신마취를 이용하게 된다. 장애인 환자에 있어서 보철치료는 정상인에서와 다를 바가 없으나 장애정도에 따라 치과의사의 세심한 주의가 필요하며, 수복후에도 철저한 구강위생관리를 위해 환자 스스로나 보호자의 각별한 노력이 요구된다. 본 증례는 경도의 장애를 가지고 있으나 치과치료에 대한 불안과 공포가 심하고, 다수치아의 수복을 위하여 장시간의 치과 치료가 요구된 경우로서 전신마취를 이용한 보존 외과적 처치 및 보철치료를 시행하여 비교적 양호한 결과를 얻었다.

• 대한치과의사협회지
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• 제56권1호
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• pp.42-48
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• 2018

INTRODUCTION The most commonly impacted tooth is the third molar. An impacted third molar can ultimately cause acute pain, infection, tumors, cysts, caries, periodontal disease, and loss of adjacent teeth. Local anesthesia is employed for removing the third molar. This study aimed to evaluate the efficacy and safety of 2% lidocaine with 1:80,000 or 1:200,000 epinephrine for surgical extraction of bilateral impacted mandibular third molars. METHODS Sixty-five healthy participants underwent surgical extraction of bilateral impacted mandibular third molars in two separate visits while under local anesthesia with 2% lidocaine with different epinephrine concentration (1:80,000 or 1:200,000) in a double-blind, randomized, crossover trial. Visual analogue scale pain scores obtained immediately after surgical extraction were primarily evaluated for the two groups receiving different epinephrine concentrations. Visual analogue scale pain scores obtained 2, 4, and 6 h after administering an anesthetic, onset and duration of analgesia, onset of pain, intraoperative bleeding, operator's and participant's overall satisfaction, drug dosage, and hemodynamic parameters were evaluated for the two groups. RESULTS There were no statistically significant differences between the two groups in any measurements except hemodynamic factors (P > .05). Changes in systolic blood pressure and heart rate following anesthetic administration were significantly greater in the group receiving 1:80,000 epinephrine than in that receiving 1:200,000 epinephrine ($P{\leq}01$). CONCLUSION The difference in epinephrine concentration between 1:80,000 and 1:200,000 in 2% lidocaine liquid does not affect the medical efficacy of the anesthetic. Furthermore, 2% lidocaine with 1:200,000 epinephrine has better safety with regard to hemodynamic parameters than 2% lidocaine with 1:80,000 epinephrine. Therefore, we suggest using 2% lidocaine with 1:200,000 epinephrine rather than 2% lidocaine with 1:80,000 epinephrine for surgical extraction of impacted mandibular third molars in hemodynamically unstable patients.

• International Journal of Oral Biology
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• 제45권3호
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• pp.134-142
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• 2020

Colon cancer is one of the most common malignant tumors, but there are still a few validated biomarkers of colon cancer. Exosome-mediated microRNAs (miRNAs) have been recognized as potential biomarkers in cancers, and miRNAs can regulate a variety of genes. Recently, Fusobacterium nucleatum was discovered in the tissues of human colon cancer patients. Its role in colon cancer was highlighted. F. nucleatum may contribute to the progression of colon cancer through the mechanism of exosome-mediated miRNAs transfer. However, the exosomal miRNAs regulation mechanism by F. nucleatum in colon cancer is not well known. Thus, we performed next-generation sequencing to investigate the overall pattern of exosomal miRNAs expression in the colon cancer cell culture supernatant. We have confirmed the alterations of various exosomal miRNAs. In addition, to investigate the function of exosomal miRNAs, a Kyoto Encyclopedia of Genes and Genomes analysis was performed on the target genes of changed miRNAs. Potential target genes were associated with a variety of signaling pathways, and one of these pathways was related to colorectal cancer. These findings suggested that F. nucleatum can alter exosomal miRNAs released from colorectal cancer cells. Furthermore, exosomal miRNAs altered by F. nucleatum could be potential biomarkers for the diagnosis and therapy of colon cancer.

• 구강회복응용과학지
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• 제33권3호
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• pp.216-222
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• 2017

지적장애는 정신 발육이 항구적으로 지체 되어 지적 능력의 발달이 불충분하고 불완전한 장애이며, 지적장애를 가지면 자신의 일을 처리하는 것과 사회생활에의 적응이 상당히 곤란하다. 그렇기 때문에 환자 스스로 구강상태를 위생적으로 관리하는 것이 쉽지 않아 다발적 우식이 쉽게 관찰되며 치주질환 이환율이 높다. 본 증례의 환자는 지적장애 1급을 판정받은 33세 여환으로 치아 및 치주 건강이 좋지 않아 식사에 어려움이 있다는 주소로 내원하였다. 초진 구내 검사 시 환자는 치주염과 다발성 우식으로 수직고경이 감소되고 구치부 교합이 붕괴되어 있었다. 이를 가철성 국소의치 이용하여 교합을 재구성함으로써 심미적, 기능적으로 만족할 만한 결과를 얻었기에 보고하는 바이다.

• Journal of Periodontal and Implant Science
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• 제42권5호
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• pp.151-157
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• 2012

Purpose: Cyclooxygenase (COX) enzyme catalyzes the production of prostaglandins, which are important mediators of tissue destruction in periodontitis. Single nucleotide polymorphisms of $COX_2$ enzyme have been associated with increasing susceptibility to inflammatory diseases. The present study evaluates the association of two single nucleotide polymorphisms in $COX_2$ gene (-1195G>A and $8_{473}$C>T) with chronic periodontitis in North Indians. Methods: Both SNPs and their haplotypes were used to explore the associations between $COX_2$ polymorphisms and chronic periodontitis in 56 patients and 60 controls. Genotyping was done by polymerase chain reaction followed by restriction fragment length polymorphism. Chi-square test and logistic regression analysis were performed for association analysis. Results: By the individual genotype analysis, mutant genotypes (GA and AA) of $COX_2$-1195 showed more than a two fold risk (odds ratio [OR]>2) and $COX_2$ $8_{473}$ (TC and CC) showed a reduced risk for the disease, but the findings were not statistically significant. Haplotype analysis showed that the frequency of the haplotype AT was higher in the case group and a significant association was found for haplotype AT (OR, 1.79; 95% confidence interval, 1.03 to 3.11; P=0.0370) indicating an association between the AT haplotype of $COX_2$ gene SNPs and chronic periodontitis. Conclusions: Individual genotypes of both the SNPs were not associated while haplotype AT was found to be associated with chronic periodontitis in North Indians.

• 대한치과보철학회지
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• 제38권6호
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• pp.800-805
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• 2000

In an effort to facilitate fabrication procedure of all ceramic crowns, a novel preparation method for all ceramic crown using alumina tape was developed. The alumina tape having a uniform thickness was cast by using Doctor blade method. The physical properties of newly introduced alumina tape has biaxial flexure strength of $500\sim600MPa$. The value of toughness is $3.18\sim3,28MPa.m^{1/2}$ which corelates with fracture and the linear shrinkage rate of the alumina tape is 0.44% during core production. The marginal fitness of the alumina tape all-ceramic restoration with $90{!`}$shoulder margin had average marginal discrepancy at $78.3{\S}$ > and average marginal gap at $44.4{\S}$ >. At the marginal preparation of $135{!`}$deep chamfer, the average marginal discrepancy at $82.1{\S}$ > and the average marginal gap at $40.2{\S}$ > had been reported. This fabrication procedure of all ceramic crowns with alumina tapes is easier and less technical sensitive for dental technicians. After restoration with new all ceramic crowns we followed the patients 2 years later, there were no complications as porcelain fractures or periodontal disease. We had good esthetic clinical results with new all ceramic crowns.

• 한국치위생학회지
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• 제18권6호
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• pp.969-977
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• 2018

Objectives: The purpose of this study was to determine the importance of oral health care in the control of diabetes mellitus. Methods: The raw data of the National Health and Nutrition Examination Survey were utilized and 4,445 adults aged 19 and over were surveyed and examined. Complex samples crosstabs and general linear model analysis were carried out. Results: In total, 69.6 percent of the subjects were normal, 21.4 percent had impaired fasting glucose, and 9.0 percent had diabetes. By sex, 25.8 percent of the men had impaired fasting glucose and 10.8 percent had diabetes. Women with impaired fasting glucose accounted for 17.2 percent and 7.2 percent of women had diabetes. Impaired fasting glucose and diabetes were more common among men. Fasting glucose values were higher in the respondents who were male, were younger, whose monthly mean household income was lower, and who were less educated. Fasting glucose values were higher when the frequency of toothbrushing was lower and when dental floss and a dental brush were not in use. Fasting glucose was lower when there was no periodontal disease, when there was less difficulty in mastication, and when there were no implants in the upper and lower jaws. Conclusions: Oral health care workers should develop a variety of programs to motivate patients to take care of their own oral health actively and responsibly.

• 대한치과의사협회지
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• 제57권3호
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• pp.149-160
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• 2019

Atrophic alveolar ridge of maxillary anterior area is commonly observed after the extraction of teeth in patients with severely compromised periodontal disease, causing difficulties with implant placement. Successful esthetics and functional implant rehabilitation rely on sufficient bone volume, adequate bone contours, and ideal implant positioning and angulation. The present case report categorized the ridge augmentation techniques using guided bone regeneration (GBR) on the maxillary anterior site by Seibert classification. Case I patient presented for implant placement in the position of tooth #11. The alveolar ridge was considered a Seibert classification I ridge defect. Simultaneous implant placement and GBR were performed. Eight months after implantation, clinical and radiological examinations were performed. Case III patient presented with discomfort due to mobility of the upper maxillary anterior site. Due to severe destruction of alveolar bone, teeth #11 and #12 were extracted. After three months, the alveolar ridge was considered a Seibert classification III ridge defect. A GBR procedure was performed; implantation was performed 6 months later. Approximately 1-year after implantation, clinical and radiological examinations were performed. During the whole treatment period, healing was uneventful without membrane exposure, severe swelling, or infection in all cases. Radiographic and clinical examinations revealed that atrophic hard tissues and buccal bone contour were restored to the acceptable levels for implant placement and esthetic restoration. In conclusion, severely resorbed alveolar ridge of the maxillary anterior area can be reconstructed with ridge augmentation using the GBR procedure so that dental implants could be successfully placed.