• Journal of Pharmaceutical Investigation
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• v.34 no.4
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• pp.319-325
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• 2004

A bioequivalence of $Etodol^{TM}$ tablets (Yuhan corporation) and $Kuhnillodine^{TM}$ tablets (Kuhnil Pharm. Co., Ltd.) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 200 mg dose of etodolac of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a $2{\times}2$ crossover design. Concentrations of etodolac in human plasma were monitored by a high-performance liquid chromatography. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Etodol^{TM}/Kuhnillodine^{TM}$ were 1.01-1.10 and 0.87-1.06, respectively. This study demonstrated a bioequivalence of $Etodol^{TM}$ and $Kuhnillodine^{TM}$ with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.505-511
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• 2004

A bioequivalence study of $Bestidine^{TM}$ tablets (Choong Wae Pharma. Corp., Korea) to Dong-A $Gaster^{TM}$ (Dong-A Pharmaceutical Co., Ltd., Korea) tablets was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the famotidine dose of 40 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of famotidine were monitored by a high-performance liquid chromatography for over a period of 12 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the Cmax ratio for $Bestidine^{TM}/Gaster^{TM}$ were log 0.90-log 1.06 and log 0.98-log 1.20, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the bioequivalence of $Bestidine^{TM}$ and $Gaster^{TM}$ with respect to the rate and extent of absorption.

• Journal of Broadcast Engineering
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• v.10 no.3
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• pp.270-285
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• 2005

A joint design scheme is proposed to optimize the up/down scaler and the motion vector estimation module in the transcoder system. The proposed scheme first optimizes the resolution scaler for a fixed motion vector, and then a new motion vector is estimated for the fixed scaler. These two steps are iteratively repeated until they reach a local optimum solution. In the optimization of the scaler, we derive an adaptive version of a cubic convolution interpolator to enlarge or reduce digital images by arbitrary scaling factors. The adaptation is performed at each macroblock of an image. In order to estimate the optimal motion vector, a temporary motion vector is composed from the given motion vectors. Then the motion vector is refined over a narrow search range. It is well-known that this refinement scheme provides the comparable performance compared to the full search method. Simulation results show that a jointly optimized system based on the proposed algorithms outperforms the conventional systems. We can also see that the algorithms exhibit significant improvement in the minimization of information loss compared with other techniques.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.1
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• pp.81-88
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• 2020

Flight data recorder is a equipment that records data required for investigation of aircraft accidents and should be developed in compliance with the ED-112A standard. Unlike general data storage device, flight data recorder must be able to recover data after an aircraft accident, requiring a housing and a memory board to protect data in extreme environments. To attain this performance, we designed a housing that can withstand the test by analyzing the physical environment of the impact, shear/tensile, penetration resistance and static crush test of the crash survival test and minimized the size and weight compared to the existing one in consideration of the installation of the aircraft in this paper. Insulation material and thermal block material were applied to endure high and low temperature fire so that the internal temperature does not rise above 150℃ even in 260℃, 10 hour environment. In addition, the memory board is designed to minimize the size and we devise a hoping programming method to prevent continuous data loss of more than 16 seconds. Through this, Crash protected memory module that satisfies ED-112A was completed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.4
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• pp.1786-1795
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• 2011

The trajectory control for omni-directional mobile robot is not easy. Especially, the tracking control which system uncertainty problem is included is much more difficult. This paper develops trajectory controller of 3-wheels omni-directional mobile robot using fuzzy multi-layered algorithm. The fuzzy control method is able to solve the problems of classical adaptive controller and conventional fuzzy adaptive controllers. It explains the architecture of a fuzzy adaptive controller using the robust property of a fuzzy controller. The basic idea of new adaptive control scheme is that an adaptive controller can be constructed with parallel combination of robust controllers. This new adaptive controller uses a fuzzy multi-layered architecture which has several independent fuzzy controllers in parallel, each with different robust stability area. Out of several independent fuzzy controllers, the most suited one is selected by a system identifier which observes variations in the controlled system parameter. This paper proposes a design procedure which can be carried out mathematically and systematically from the model of a controlled system; related mathematical theorems and their proofs are also given. Finally, the good performance of the developed mobile robot is confirmed through live tests of path control task.

• Journal of KIISE:Computer Systems and Theory
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• v.30 no.5_6
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• pp.273-279
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• 2003

Hypercube multicomputers have been drawing considerable attention from many researchers due to their regular structure and short diameter. One of keys to the performance of Hypercube is the efficiency of communication among processors. Among several communication patterns, multicast is important, which is found in a variety of applications as data replication and signal processing. As the number of processors increases, the probability of occurrences of fault components also increases. So it would be desirable to design an efficient scheme that multicasts messages in the presence of faulty component. In fault-tolerant routing and multicast, there are local information based scheme, global information based scheme and limited information based scheme in terms of information. In general, limited information is easy to obtain and maintain by compressing information in a concise format. In this paper, we propose a new routing scheme and a new multicast scheme using recently proposed fully reachability information scheme and new local information scheme. The proposed multicast scheme increases multicast success possibility and reduce deroute cases. Experiments show that multicast success possibility can increase at least 15% compared to previous method.

• Journal of KIISE:Software and Applications
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• v.26 no.11
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• pp.1359-1371
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• 1999

대규모 네트워크 상에서 동작하는 분산 시스템의 구현을 위해 제시된 방법 중의 하나인 이동 코드 개념은 네트워크 공유 자원에 접근할 수 있는 효과적인 방법을 제시하였고 이 개념을 지원하는 많은 언어들의 개발을 가져왔다. 개발된 언어들이 가지고 있는 이동 코드를 지원하기 위한 언어 구문과 적용하려는 문제 영역의 특성을 반영한 언어 구문은 네트워크 프로그래밍을 하는데 있어서 효율과 문제 중심의 프로그램의 두 가지를 모두 가능하게 하고 있다. 본 논문에서는 현재 분산 컴퓨팅 환경에서 가장 많이 사용되고 있는 클라이언트-서버 모델을 확장하여 서버의 자원에 접근할 수 있는 또 다른 방법을 가진 모델을 제시하고, 이 모델을 표현할 수 있는 언어를 설계하였다. 설계된 언어는 이동 코드의 개념을 지원함으로써 대규모 네트워크에서 수행되는 프로그램의 작성을 가능하게 하고, 분산 범위 규칙을 채택함으로써 이동 코드의 기술을 일반 함수를 기술하듯 명확한 관점에서 할 수 있도록 하였다. 또한 네트워크 관련 자원들을 언어 구문으로 채택하여 네트워크 프로그래밍을 언어 수준에서 할 수 있도록 하였다. 언어의 이론적인 설계에 그치지 않고 설계된 언어를 수행할 수 있는 실행 시간 지원 시스템을 구현하였다. 실행 시간 지원 시스템은 언어를 해석하고 실행하는 코드 해석기와 이동 코드를 지원하는 네트워크 감독으로 구성되며 설계된 언어를 사용하여 실제로 네트워크 응용 프로그램을 작성하고 테스트 해 볼 수 있다.Abstract Some studies bring up a concept of code mobility as an innovative way to access network resources in order to develop distributed systems working on a large scale network. After that, many languages are suggested to support this concept. In these languages, language constructors for their particular application domains and mobile codes provide both problem-oriented views to the programmer and reasonable performance to the system. In this thesis, we extend the client-server model that is the most popular model in developing distributed systems these days. We propose a model to have another method to access server's resources and extend the C language to implement the proposed model for the large scale network. The new language has capability to build a software working on a large scale network by supporting mobile code and gives a consistent network programming view to the programmer by adapting distributed semantics. The language also makes network programming easy by providing network primitives at the language level. We implement a prototype of run-time system to support this language. The run-time system is composed of two major parts: code-interpreter that interprets and executes the language and network-daemon that supports mobile codes.

• Journal of the Earthquake Engineering Society of Korea
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• v.12 no.4
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• pp.1-10
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• 2008

Shear wave velocity($V_S$), which can be obtained using various seismic tests, has been emphasized as representative geotechnical dynamic characteristic mainly for seismic design and seismic performance evaluation in the engineering field. For the application of conventional geotechnical site investigation techniques to geotechnical earthquake engineering, standard penetration tests(SPT) and piezocone penetration tests(CPTu) together with a variety of borehole seismic tests were performed at many sites in Korea. Through statistical modeling of the in-situ testing data, in this study, the correlations between $V_S$ and geotechnical in-situ penetrating data such as blow counts(N value) from SPT and piezocone penetrating data such as tip resistance ($q_t$), sleevefriction($f_s$), and pore pressure ratio($B_q$) were deduced and were suggested as an empirical method to determine $V_S$. Despite the incompatible strain levels of the conventional geotechnical penetration tests and the borehole seismic tests, it is shown that the suggested correlations in this study are applicable to the preliminary estimation of $V_S$ for Korean soil layers.

• Korean Journal of Construction Engineering and Management
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• v.19 no.5
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• pp.61-69
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• 2018

Construction projects consist of long-term on-site production, and most disciplines are featured by outdoor works. Therefore, when a process plan is established, non-working days are calculated and reflected in a process schedule to comply with the planned construction period. However, necessary information and working methods are different in the course of the work, so the method of calculation varies depending on persons even for the same site, and the result is also very different. Therefore, scientific and quantitative understanding of business information is needed. This study reconstructed non-working day estimation process by collecting and organizing the information necessary for non-working day estimation, and designed the demonstration screen based on the reconstructed process and verified through expert interview at each stage. As a result, it showed about 69% reduction of work time and reliability of 92% work information matrix, and 80% of the experts evaluated the systemization of the relevant work. This study is expected to improve the understanding of work and increase the efficiency of work performance, and the study on systemization in the future should be continued.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.12
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• pp.2293-2300
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• 2008

In ad-hoc sensor network, AODV routing information is disclosed to other nodes because AODV protocol doesn't have any security mechanisms. The problem of AODV is that an attacker can falsify the routing information in RREQ packet. If an attacker broadcasts the falsified packet, other nodes will update routing table based on the falsified one so that the path passing through the attacker itself can be considered as a shortest path. In this paper, we design the routing-information-spoofing attack such as falsifying source sequence number and hop count fields in RREQ packet. And we suggest an efficient scheme for detecting the attackers and isolating those nodes from the network without extra security modules. The proposed scheme doesn't employ cryptographic algorithm and authentication to reduce network overhead. We used NS-2 simulation to evaluate the network performance. And we analyzed the simulation results on three cases such as an existing normal AODV, AODV under the attack and proposed AODV. Simulation results using NS2 show that the AODV using proposed scheme can protect the routing-information-spoofing attack and the total n umber of received packets for destination node is almost same as the existing norm at AODV.