• Proceedings of the KSEEG Conference
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• 2002.04a
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• pp.8-10
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• 2002

POPs in sediments and soil in the PRD are comparable to or much higher than those reported in other regions. Some sites may be classified as POPs- polluted with high ecological risks. Large-scale land transform in the process of regional urbanization may facilitate the transfer of POPs in the soil to the sedimentary system by enhancing the soil run-off. Urban atmospheric PCBs in PRD are found to be less than some of the North American or European urbans, but PAHs are significantly higher. The center of the PRD has been the major source area of PAHs and organochlorine pesticides in the PRD. The northern part of the PRD serves as a regional sink for the air particulates and affiliated POPs.

• BMB Reports
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• v.40 no.1
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• pp.72-81
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• 2007

In order to screen the aging related proteins in human normal colon epithelia, the comparative proteomics analysis was applied to get the two-dimensional electrophoresis (2-DE) profiles with high resolution and reproducibility from normal colon epithelial tissues of young and aged people. Differential proteins between the colon epithelia of two age groups were found with PDQuest software. The thirty five differential protein-spots were identified by peptide mass fingerprint (PMF) based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) and database searching. Among them there are sixteen proteins which are significantly up-regulated in the colonic mucosal epithelia of young people group, which include ATP synthase beta chain, electron transfer flavoprotein alpha-subunit, catalase, glutathione peroxidase 1, annexin A2 and heat shock cognate 71 kDa protein, etc.; There are nineteen proteins which are significantly up-regulated in the colonic mucosal epithelia of aged people group, which include far upstream element-binding protein 1, nucleoside diphosphate kinase B, protein disulfide-isomerase precursor and VDAC-2, etc.. The identified differential proteins appear to be involved in metabolism, energy generation, chaperone, antioxidation, signal transduction, protein folding and apoptosis. The data will help to understand the molecular mechanisms of human colon epithelial aging.

• BMB Reports
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• v.42 no.8
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• pp.486-492
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• 2009

OsDREB1D, a special DREB (dehydration responsive element binding protein) homologous gene, whose transcripts cannot be detected in rice (Oryza sativa L), either with or without stress treatments, was amplified from the rice genome DNA. The yeast one-hybrid assay revealed that OsDREB1D was able to form a complex with the dehydration responsive element/C-repeat motif. It can also bind with a sequence of LTRE (low temperature responsive element). To analyze the function of OsDREB1D, the gene was transformed and over-expressed in Arabidopsis thaliana cv. Columbia. Results indicated that the over-expression of OsDREB1D conferred cold and high-salt tolerance in transgenic plants, and that transgenic plants were also insensitive to ABA (abscisic acid). From these data, we deduced that this OsDREB1D gene functions similarly as other DREB transcription factors. The expression of OsDREB1D in rice may be controlled by a special mechanism for the redundancy of function.

• Structural Engineering and Mechanics
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• v.59 no.2
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• pp.261-275
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• 2016

Effect of silica fume on fresh properties, compressive strength at 28 days and fracture behavior of fly ash concrete composite were studied in this paper. Test results indicated that the fluidity and flowability of fly ash concrete composites decreased and fly ash concrete composite are more cohesive and appear to be sticky with the addition of silica fume. Addition of silica fume was very effective in improving the compressive strength at 28 days of fly ash concrete composite, and the compressive strength of fly ash concrete composite has a trend of increase with the increase of silica fume content. Results also indicated that all the fracture parameters of effective crack length, fracture toughness, fracture energy, the critical crack opening displacement and the maximum crack opening displacement of fly ash concrete composite decreased with the addition of silica fume. When the content of silica fume increased from 3% to 12%, these fracture parameters decreased gradually with the increase of silica fume content. Furthermore, silica fume had great effect on the relational curves of the three-point bending beam specimen. As the silica fume content increased from 3% to 12%, the areas surrounded by the three relational curves and the axes were becoming smaller and smaller, which indicated that the capability of concrete composite containing fly ash to resist crack propagation was becoming weaker and weaker.

• Molecules and Cells
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• v.40 no.1
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• pp.45-53
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• 2017

Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer. A number of studies have focused on the hypermethylation of a single Wnt antagonist and its role in regulating the activation of signaling. However, how the Wnt antagonists interacted to regulate the signaling pathway has not been reported. In the present study, we systematically investigated the methylation of some Wnt antagonist genes (SFRP2, SFRP4, SFRP5, DKK1, DKK2, and APC) and their regulatory role in carcinogenesis. We found that aberrant promoter methylation of SFRP2, SFRP4, DKK1, and DKK2 was significantly increased in gastric cancer. Moreover, concurrent hypermethylation of SFRP2 and DKK2 was observed in gastric cancer and this was significantly associated with increased expression of ${\beta}-catenin$, indicating that the joint inactivation of these two genes promoted the activation of the Wnt signaling pathway. Further analysis using a multivariate Cox proportional hazards model showed that DKK2 methylation was an independent prognostic factor for poor overall survival, and the predictive value was markedly enhanced when the combined methylation status of SFRP2 and DKK2 was considered. In addition, the methylation level of SFRP4 and DKK2 was correlated with the patient's age and tumor differentiation, respectively. In conclusion, epigenetic silencing of Wnt antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 could be a potential marker for a prognosis of poor overall survival.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.879-881
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• 2010

For the rapid development of society, such as small family, one-people family is following. The traditional family is being changed, so the older stay home alone. That makes it more and more. Staying home alone, the older's health and safety are worth considering by us. With the rapid development of RFIDRadio Frequency Identification) technology, its applications have extended to all areas of our lifes. RFIDRadio Frequency Identification) has became a major topic of concern in multi-industry. With the high-speed economic growth and the development of science, medicine, the old people's life expectancy is increasing slightly. So it is necessary to design a protective system for the older's safety. In this thesis, self-care system is made by using RFID(Radio Frequency Identification) technology to authenticate an user and using TTS(test to speech) to convert character information to voice information and also using infrared radiation technology to protect home effectively, and using e-blood pressure monitors to examination the older's bodies.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.10
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• pp.1630-1639
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• 2019

Objective: Sixty Pengbo semi-wool sheep ewes (approximately 1.5-years-old; $31.33{\pm}0.43kg$) were randomly assigned to two groups, either grazing (G) or dry lot feeding (D), to examine the effects of traditional daily grazing and dry lot feeding on performance and blood metabolites during the cold season in Tibetan Plateau. Methods: The ewes in the G group were grazed continuously each day and housed in one shed each evening, while the ewes in the D group were housed in another shed all day. All animals were fed 400 g/d of commercial concentrate, and grass hay was available freely throughout the experimental period. Results: Compared with the G group, the ewes in the D group had higher (p<0.05) live weight and weight gain. The D group ewes had greater (p<0.05) numbers of white blood cells and platelets, while they had lower (p<0.05) platelet-large cell ratios, cholesterol, high-density lipoprotein cholesterol and glutathione peroxidase, as compared with the G group ewes. Additionally, three serum metabolites, abscisic acid, xanthoxin and 3,4-dihydroxy-5-polypren, were upregulated (p<0.05) in the G group in comparison with the D group. Conclusion: In conclusion, a dry lot feeding regime during the winter and spring period will increase the productivity of sheep and improve blood physiological and biochemical profiles.

• Animal Bioscience
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• v.35 no.7
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• pp.975-988
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• 2022

Objective: In this study, we aimed to identify long non-coding RNAs (lncRNAs) that play important roles in starvation stress, analyze their functions, and discover potential molecular targets to alleviate starvation stress to provide a theoretical reference for subsequent in-depth research. Methods: We generated a piglet starvation stress animal model. Nine Yorkshire weaned piglets were randomly divided into a long-term starvation stress group (starved for 72 h), short-term starvation stress group (starved for 48 h), and the control group. LncRNA libraries were constructed using high-throughput sequencing of piglet ileums. Results: We obtained 11,792 lncRNAs, among which, 2,500 lncRNAs were novel. In total, 509 differentially expressed (DE)lncRNAs were identified in this study. Target genes of DElncRNAs were predicted via cis and trans interactions, and functional and pathway analyses were performed. Gene ontology functions and Kyoto encyclopedia of genes and genomes analysis revealed that lncRNA-targeted genes mainly participated in metabolic pathways, cellular processes, immune system processes, digestive systems, and transport activities. To reveal the mechanism underlying starvation stress, the interaction network between lncRNAs and their targets was constructed based on 26 DElncRNAs and 72 DEmRNAs. We performed an interaction network analysis of 121 DElncRNA-DEmRNA pairs with a Pearson correlation coefficient greater than 0.99. Conclusion: We found that MSTRG.19894.13, MSTRG.16726.3, and MSTRG.12176.1 might play important roles in starvation stress. This study not only generated a library of enriched lncRNAs in piglets, but its outcomes also provide a strong foundation to screen key lncRNAs involved in starvation stress and a reference for subsequent in-depth research.

• Nuclear Engineering and Technology
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• v.55 no.4
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• pp.1332-1341
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• 2023

Beam position measurement system can not only provide the beam position monitoring, but also be used for global orbit correction to reduce beam loss risk and maximize acceptance. The Beam Position Monitors (BPM) are installed along the synchrotron to acquire beam position with the front-end electronics and data acquisition system (DAQ). To realize high precision orbit measurement in the main heavy ion synchrotron and cooling storage ring of heavy-ion research facility in Lanzhou (HIRFL-CSRm), a series of alignment and calibration work has been implemented on the BPM and its DAQ system. This paper analyzed the tests performed in the laboratory as well as with beam based on the developed algorithms and hardware. Several filtering algorithms were designed and implemented on the acquired BPM raw data, then the beam position and resolution were calculated and analyzed. The results show that the position precision was significantly improved from more than 100 ㎛ to about 50 ㎛ by implementing the new designed filtering algorithm. According to the analyzation of the measurement results and upcoming physical requirements, further upgrade scheme for the BPM DAQ system of CSRm based on field programmable gate array (FPGA) technology was proposed and discussed.

• Structural Engineering and Mechanics
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• v.90 no.4
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• pp.325-343
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• 2024

Triple-tower double-cable suspension bridges have increased confinement stiffness imposed by the main cable on the middle tower, which has bright application prospects. However, vertical bending and torsional vibrations of the double-cable and the girder are coupled in such bridges due to the hangers. In particular, the bending vibration of the towers in the longitudinal direction and torsional vibrations about the vertical axis influence the vertical bending and torsional vibrations of the stiffening girders, respectively. The conventional analytical algorithm for assessing the dynamic features of the suspension bridge is not directly applicable to this type of bridge. This study attempts to mitigate this problem by introducing an analytical algorithm for solving the triple-tower double-cable suspension bridge's natural frequencies and mode shapes. D'Alembert's principle is employed to construct the differential equations of the vertical bending and torsional vibrations of the stiffening girder continuum in each span. Vibrations of stiffening girders in each span are interrelated via the vibrations of the main cables and the bridge towers. On this basis, the natural frequencies and mode shapes are derived by separating variables. The proposed algorithm is then applied to an engineering example. The natural frequencies and mode shapes of vertical bending and torsional vibrations derived by the analytical algorithm agreed well with calculations via the finite element method. The fundamental frequency of vertical bending and first- and second-order torsion frequencies of double-cable suspension bridges are much higher than those of single-cable suspension bridges. The analytical algorithm has high computational efficiency and calculation accuracy, which can provide a reference for selecting appropriate structural parameters to meet the requirements of dynamics during the preliminary design.