• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.417-420
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• 2008

The requirement for durability of concrete is increasing recently as a large-scale concrete structure is built. For this reason, the concern about high-durable concrete is being high. Recently, metakaoline to be profitable in economical aspect as well as to have strength and durability of level similar to silica fume is evaluated highly as new admixture. In this study, the scaling, the drying shrinkage, the chloride resistance and the air-void structure are compared for both metakaolin and silica fume concrete. According to the results, the replacement of metakaoline improved the resistance of chloride penetration, freezing and thawing in concrete. On the other hand, as metakaolin was replaced to 10%, it was similar level with OPC in the property of scaling. It was showed that replacement of only metakaoline was similar with OPC in the drying shrinkage. However, MS5 reduced the drying shrinkage about 10%. In conclusion, replacement of the metakaoline 10% is the most excellent performance in terms of durability of concrete.

• The korean journal of orthodontics
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• v.47 no.4
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• pp.238-247
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• 2017

Objective: The aim of this study was to compare recycled and unused orthodontic miniscrews to determine the feasibility of reuse. The comparisons included both miniscrews with machined surfaces (MS), and those with etched surfaces (ES). Methods: Retrieved MS and ES were further divided into three subgroups according to the assigned recycling procedure: group A, air-water spray; group B, mechanical cleaning; and group C, mechanical and chemical cleaning. Unused screws were used as controls. Scanning electron microscopy, energy-dispersive X-ray spectrometry, insertion time and maximum insertion torque measurements in artificial bone, and biological responses in the form of periotest values (PTV), bone-implant contact ratio (BIC), and bone volume ratio (BV) were assessed. Results: Morphological changes after recycling mainly occurred at the screw tip, and the cortical bone penetration success rate of recycled screws was lower than that of unused screws. Retrieved ES needed more thorough cleaning than retrieved MS to produce a surface composition similar to that of unused screws. There were no significant differences in PTV or BIC between recycled and unused screws, while the BV of the former was significantly lower than that of the latter (p < 0.05). Conclusions: These results indicate that reuse of recycled orthodontic miniscrews may not be feasible from the biomechanical aspect.

• 한국지구물리탐사학회:학술대회논문집
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• 2006.06a
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• pp.291-296
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• 2006

The aspect of wave propagation around cavity was investigated for the exact inversion of crosshole tomography data in order to understand the possibility of the existence of underground cavity. We found that the adequate frequency range for the tunnel investigation was about 2kHz to 5kHz, and the grid space was set up to 1/10 length of wavelength. The propagation of the seismic wave near the cavity may go through or detour the cavity according to the seismic velocity of inside of cavity. The detouring wave propagates with the seismic velocity of mother rock in spite of the velocity of inside of cavity. The smaller the velocity difference between the mother rock and cavity, the more frequent penetration of the seismic wave through the cavity was appeared.

• The Journal of Engineering Geology
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• v.8 no.1
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• pp.25-34
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• 1998

It is not easy to understand exact soil properties, because soil is nonhomogeneous and anisotropic. There are raany inefficient cases in aspect of time and economy in site survey. So this study tried to analyze the correlation of cone resistance and seismic velocity in order to present an efficient method in ground investigation. A cone penetrometer is frequently used to investigate soil properties, which are especially fit to investigate coastal soft ground. A portable cone penetrometer was used in this research. A portable cone penetrometer has an advantage in investigating the state of soil swiftly and is convenient to manipulate. Also, seismic prospecting is one of the most PoPular methods among geophysical prospecting methods in the estimation of ground properties and its usage is continuously increasing in the survey of soft ground Cone resistance makes a regular group according to stratum in each depth. The results of seismic prospecting show a tendency to have a certain coherence according to the boundary of straturft Therefore, cone resistance and seisrnic prospecting have considerable relations that rnay irnprnve the efficiency of ground investigation.

• Korean Journal of Social Welfare Studies
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• v.44 no.3
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• pp.113-145
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• 2013

This research is a phenomenological case study to find about the process of becoming alcohol dependence among women, with a lifetime contextual point of view. The first phenomenon which participants experience within their lifetime was 'incomplete relationship'. This was a trigger to become alcohol dependence. The researchers whom participated in this research focused on the first alcohol intake. The first drink has been given a unique meaning as 'characteristic symbol system'. While the participants were choosing alcohol, dailiness, a continuum of daily life emerged. With dailiness aspect, alcohol dependence goes through a process of 'invasion or penetration'. Through these processes alcohol dependent experience among women became 'meaninglessness and mirage'. According to these results undertone to approach women alcohol dependence was able to be deducted.

• Proceedings of the Korean Geotechical Society Conference
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• 2004.03b
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• pp.453-460
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• 2004

To prevent penetration of rainwater into the landfill site is the main purpose of the final cover in landfill sites. Conventional designs of landfill covers uses geotextiles such as geomembrane and GCL, and clay liners to lower the permeability of final covers of landfill sites. However, differential settlement and the variation of temperature in landfill sites cause the development of cracks or structural damage inside the final cover and it is also difficult to obtain clay - the main material of the compacted clay liner in Korea. Thus the former final cover system that suggests geomembrane and GCL or compacted clay liner has several limitations. Therefore, an alternative method is necessary and one of them is the application of SRSL(self-Recovering Sustainable Liner) material. SRSL is two different layers consist of individual materials that react with each other and form precipitates, and with this process lowers the permeability of the landfill final cover. SRSL generally is made up of two layers, so that when a internal crack occurs the reactants of the two layers migrate towards the crack and heal it by forming another liner. In this study the applicability of SRSL material for landfill final cover was examined by performing; (1) jar test to verify the formation of precipitate in the mixture of each reactants, (2) falling head test considering the field stress in order to confirm the decrease of permeability or prove that the hydraulic condctivity is lower than the regulations, (3) compression tests to judge weather if the strength satisfies the restricts for landfills, (4) freeze/thaw test to check the applicability of SRSL for domestic climate. In addition, the application of waste materials in the environmental and economical aspect was inspected, and finally the possibility of secondary contamination due to the waste materials was examined by performing elution tests.

• Advances in Traditional Medicine
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• v.1 no.1
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• pp.8-27
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• 2000

Components of extracellular matrix and the matrix-degrading enzymes are some of the key regulators of tumor metastasis and angiogenesis. Hyaluronic acid (HA), a matrix glycosaminoglycan, is known to promote tumor adhesion and migration, and its small fragments are angiogenic. Until now, we have compared levels of hyaluronidase, an enzyme that degrade HA, in normal adult prostate, benign prostate hyperplasia and prostate cancer tissues and in conditioned media from epithelial explant cultures, using a substrate (HA)-gel assay and ELISA-like assay (Kim et al., unpublished results). The present review described an overall characterization of hyaluronidases and its application to human diseases. The hyaluronidases are a family of enzymes that have, until recently, deed thorough explication. The substrate for these enzymes, hyaluronan, is becoming increasingly important, recognized now as a major participant in basic processes such as cell motility, wound healing, embryogenesis, and implicated in cancer progression. And in those lower life forms that torment human beings, hyaluronidase is associated with mechanisms of entry and spread, e.g. as a virulence factor for bacteria, for tissue dissection in gas gangrene, as a means of treponema spread in syphilis, and for penetration of skin and gut by nematode parasites. Hyaluronidase also comprises a component of the venom of a wide variety of organisms, including bees, wasps, hornets, spiders, scorpions, sh, snakes and lizards. Of particular interest is the homology between some of these venom hyaluronidases and the enzyme found in the plasma membrane of mammalian spermatozoa, attesting to the ancient nature of the conserved sequence, a 36% identity in a 300 amino acid stretch of the enzyme protein. Clearly, hyaluronidase is of biological interest, being involved in the pathophysiology of so many important' human disorders. Greater effort should be made in studying this family of enzymes that have, until recently, been overlooked. Also, oriental medical application of the hyaluronidase will be discussed with respect to inhibition and suppression of inflammation and malignacy.

• Knowledge Management Research
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• v.21 no.3
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• pp.105-121
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• 2020

With regard to the development of new drugs, what is most important for a Korean Biotech, where no global sales network has been established, is decision-making related to out-licensing of new drugs. The probability of success for each clinical phase is different, and the licensing amount and its royalty vary depending on which clinical phase the licensing contract is made. Due to the nature of such a licensing contract and Biotech's weak financial status, it is a very important decision-making issue for a Biotech to determine when to license out to a Big Pharma. This study defined a model called 'optimal timing for out-licensing of new drugs' and the results were derived from the decision tree analysis. As a case study, we applied to a Biotech in Korea, which is conducting FDA global clinical trials for a first-in-class new drug. Assuming that the market size and expected market penetration rate of the target disease are known, it has been shown that out-licensing after phase 1 or phase 2 of clinical trials is a best alternative that maximizes Biotech's profits. This study can provide a conceptual framework for the use of management science methodologies in pharmaceutical fields, thus laying the foundation for knowledge and research on out-licensing of new drugs.

• Journal of the Korean Geotechnical Society
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• v.38 no.3
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• pp.35-42
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• 2022

The N-value from the Standard Penetration Test (SPT), which is one of the representative in-situ test, is an important index that provides basic geological information and the depth of the bearing layer for the design of geotechnical structures. In the aspect of time and cost-effectiveness, there is a need to carry out a representative sampling test. However, the various variability and uncertainty are existing in the soil layer, so it is difficult to grasp the characteristics of the entire field from the limited test results. Thus the spatial interpolation techniques such as Kriging and IDW (inverse distance weighted) have been used for predicting unknown point from existing data. Recently, in order to increase the accuracy of interpolation results, studies that combine the geotechnics and deep learning method have been conducted. In this study, based on the SPT results of about 22,000 holes of ground survey, a comparative study was conducted to predict the depth of the bearing layer using deep learning methods and IDW. The average error among the prediction results of the bearing layer of each analysis model was 3.01 m for IDW, 3.22 m and 2.46 m for fully connected network and PointNet, respectively. The standard deviation was 3.99 for IDW, 3.95 and 3.54 for fully connected network and PointNet. As a result, the point net deep learing algorithm showed improved results compared to IDW and other deep learning method.

• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.1
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• pp.33-42
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• 2014

Purpose: I-131 scan using High Energy (HE) collimator is generally used. While, Medium Energy (ME) collimator is not suggested to use in result of an excessive septal penetration effects, it is used to improve the sensitivities of count rate on lower dose of I-131. This research aims to evaluate I-131 SPECT/CT image quality using by HE and ME collimator and also find out the possibility of ME collimator clinical application. Materials and Methods: ME and HE collimator are substituted as Siemens symbia T16 SPECT/CT, using I-131 point source and NEMA NU-2 IQ phantom. Single Energy Window (SEW) and Triple Energy Windows (TEW) are applied for image acquisition and images with CTAC and Scatter correction application or not, applied different number of iteration and sub set are reconstructed by IR method, flash 3D. By analysis of acquired image, the comparison on sensitivities, contrast, noise and aspect ratio of two collimators are able to be evaluated. Results: ME Collimator is ahead of HE collimator in terms of sensitivity (ME collimator: 188.18 cps/MBq, HE collimator: 46.31 cps/MBq). For contrast, reconstruction image used by HE collimator with TEW, 16 subset 8 iteration applied CTAC is shown the highest contrast (TCQI=190.64). In same condition, ME collimator has lower contrast than HE collimator (TCQI=66.05). The lowest aspect ratio for ME collimator and HE collimator are 1.065 with SEW, CTAC (+) and 1.024 with TEW, CTAC (+) respectively. Conclusion: Selecting a proper collimator is important factor for image quality. This research finding tells that HE collimator, which is generally used for I-131 scan emitted high energy ${\gamma}$-ray is the most recommendable collimator for image quality. However, ME collimator is also applicable in condition of lower dose, lower sensitive if utilizing energy window, matrix size, IR parameter, CTAC and scatter correction appropriately.