• Current Research on Agriculture and Life Sciences
• /
• 제31권4호
• /
• pp.272-279
• /
• 2013

사과 중 triazole계 살균제 flusilazole 및 myclobutanil의 생물학적 반감기와 출하전 잔류허용기준을 산출하기 위해 안전사용기준에 근거한 기준량과 3배량의 약제를 살포하고 그 잔류량을 조사하였다. 시험기간 중 두 농약의 잔류량은 각각의 MRL 이하로 나타났으며, 사과 중 생물학적 반감기는 flusilazole의 경우 기준량 처리구에서 6.7일, 3배량 처리구에서 6.2일로 나타났다. 반면에 myclobutanil의 반감기는 기준량 처리구에서 13.3일, 3배량 처리구에서 24.8일로 나타나 flusilazole보다 더 긴 반감기를 가지는 것으로 조사되었다. First order kinetics에 근거한 감소지수식을 이용하여 산출된 각 농약의 감소상수는 flusilazole에 대하여 0.0513, myclobutanil에 대하여 0.0244이었으며, 산출된 감소상수들을 이용하여 출하 전 잔류허용기준(PHRL)을 계산한 결과, 안전사용기준을 준수한 농약살포를 가정하였을 때 flusilazole은 수확 일주일 전 0.43 mg/kg, myclobutanil은 같은 시기 0.59 mg/kg 이하로 잔류하면 수확 시 잔류농도가 MRL 이하로 잔류할 것으로 예측된다.

• Biomolecules & Therapeutics
• /
• 제4권4호
• /
• pp.349-353
• /
• 1996

The present study examined pharmacokinetic profiles of KBP31705-Cl27 and KBP30603-901, new platinum coordination complexes synthesized as anticancer candidates, in comparison with two well-known platinum-containing anticancer agents, cisplatin and carboplatin in rats. Under sodium pentobarbital anesthesia of male Sprague-Dawley rats, urinary bladder, and femoral artery and vein were catheterized for urine collection, blood sampling and drug injection, respectively Following i.v. administration of cisplatin (2 mg/kg), KBP31705-C127 (2 mg/kg), carboplatin (20 mg/kg) or KBP30603-901 (20 mg/kg), blood samples were collected at 2, 4, 6, 8, 10, 15, 20, 30, 45, 60 and 120 minutes. Urine samples were collected at 1-hr interval for 4 hr. Platinum concentrations in plasma and urine were measured using an inductively coupled plasmamass spectrometer. The plasma concentration-time curves were biphasic for all drugs during the time period studied. Compared with cisplatin, KBP31705-C127 showed similar decay patters in the alpha- and betaphases with slightly lower plasma concentrations. Urinary platinum excretion for cisplatin and KBP31705-C 127 was 56 and 52% of the administered dose in 4 hr, respectively. With regard to carboplatin and KBP 30603-901, a similar decay pattern was also observed in the alpha-phase. The half life of KBP30603-901 in the beta-phase, however, was much longer than that of carboplatin, which was consistent with the urinary excretion results that 46 and 59% of the administered dose were excreted in the urine in 4hr, respectively. The results suggest that platinum coordination complexes are primarily excreted via the renal route and KBP30603-901 can elicit longer duration of action due to slower renal excretion compared to carboplatin.

• Animal Systematics, Evolution and Diversity
• /
• 제7권1호
• /
• pp.65-72
• /
• 1991

LeucoPhenga속에 속하는 초파리 L. maculata. L. concilia. L. orientalis 및 L. quinqµemaculiPennis를 대상으로 수용성 단백질을 전기영동법으로 분석하여 이 들 종간의 유연관계를 밝히고자 하였다. SDS-PAGE로 분석한 4종간의 전기영동상을 densitometer로 scanning한 결 과 band 양상이 L. maculata와 L. concilia가 유사했고, L.quinquemaculiPennis 는 이들 3종과 다른 양상을 보였다. TDE에 의한 4종간의 유전적 거리는 L. maculata와 L.concilia;가 0.393으로 가장 가까운 유연관계를 나타냈으며, L. maculata와 L.quinquemaculipennis가 0.496로 유연관계가 가장 멀었다. TDE의 유전적 거리의 지수를 근거로 UPGMA법 으로 분석한 결과 L. maculata와 L. concilia가 1차적으로 cluster 되었고 여기에 L. orientalis. L. quinquemaculiPennis순으로 cluster 되었다. 이 결과는 L.quinquemaculipennis가 다른 3종과는 유연관계가 멀고 나머지 3종 가운데서는 L. maculata와 L. concilia간의 유연관계가 더 가까운 것으로 생각된다.

• 복식문화연구
• /
• 제17권6호
• /
• pp.1009-1020
• /
• 2009

This study aims to express the androgynous image via shirts as a fashion item. Shirts are widely worn as a fashion item regardless of sex and age, with growing importance as a casual outer, with the increase in leisure activities driven by the recent implementation of the 5-Day Work Week system in Korea. As for the theoretical background, the study was reviewed previous studies of books, thesis, a series of publication, and the Internet sites on this topic. Through a careful analysis of these previous studies, it designed and made shirts that inspired by androgynous image. Conclusions of this study are as follows: First, the study found that meanings of symbolism in clothing continue to change, not fixed at all, depending on historic and cultural environments, and so does symbolism for femininity and masculinity of clothing. Second, shirts are widely worn as a fashion item regardless of sex and age, with growing importance as a casual outer, with the increase in leisure activities driven by the recent implementation of the 5-Day Work Week system in Korea. Third, two patters were used for the work in this study in order to emphasize its form, along with mono color white and stripe patterns. For materials, cotton and blend as a most basic material for a shirt were used with unique variations in the form. Fourth, decorative details or trimming such as ribbon tying methods, shirring, attaching in layers, and irregular pleading widely used for women's wear were applied, and silhouettes with strong drape feelings were used to add feminine feature to men' shirts, in an effort to propose a fashion design of the androgynous look. Fifth, clothes proposed in this study are different from feminine clothing item blouse, because they are androgynous shirts mixing masculinity and femininity. Stiff pads were used in collars and cuffs characteristics of men's traditional shirts to maintain masculinity of a shirt, and design was developed by adding feminine decorative elements, which is different from women's blouse.

• 대한약침학회지
• /
• 제10권2호통권23호
• /
• pp.5-18
• /
• 2007

Objectives : The purpose of this study was to obtain an objective differentiating method for various types of Panax ginseng: ginseng, cultivated wild ginseng, and natural wild ginseng which are distinctive according to their growing environment. Methods : The roots, stem, and leaves of several types of ginseng were collected and comparative analysis of proteome was conducted on each part using 2-DE and the results examined. Results : 1. Proteome images of the respective parts within the samples showed spot-matching in most cases, suggesting that they are genetically identical panax ginseng. 2. Similar distribution patters were seen within the different parts of the Panax ginseng: ginseng, Chinese cultivated wild ginseng, and the 5 and 10 years old Korean cultivated wild ginseng. 3. For a quantitative evaluation of spots showing differences among the samples, 102 spots from the roots, 109 spots from the stems, and 132 spots form the leaves which showed a difference were selected and centrifugal identification was conducted. 4. Peculiar proteins from each respective part of the Panax ginseng were identified and the top 20 spots with significant differences were selected and analyzed in order to provide a differentiation rate among the samples. The accuracy rate ranged between 23.0-38.8%. 5. Differentiation rate of the top 10 spots with significant differences showed a 50-85% accuracy rate, and the differentiation rate was especially high for the stem of Chinese cultivated wild ginseng and Korean cultivated wild ginseng.

• 한국산업보건학회지
• /
• 제29권3호
• /
• pp.343-350
• /
• 2019

Objectives: This study aims to identify whether ventilation conditions and their effectiveness can be significantly improved in an experimental chamber by increasing the mixing factor (K-Factor). Methods: In a chamber with a volume of $1m^3$, air velocity was measured at six different points with four roof fans in the upper part of the chamber being operated in order. The impact of the ventilation conditions was analyzed when the flow rates were increasing and the first inlet of the chamber was either open or closed. Smoke patterns were also observed at four corner points where ventilation was limited. Kruskal Wallis and Mann-Whitney tests were performed to compare air velocities measured in the chamber. Results: The air velocities measured at only the third point increased significantly from $0.03{\pm}0.03m/s$ (door open) and $0.05{\pm}0.06m/s$ (door closed) with two fans, $0.08{\pm}0.08m/s$ with three fans, and $0.09{\pm}0.09m/s$ with four fans operating (p<0.05). However, air velocities at the four corner points did not significantly increase. Smoke patters also showed that the open inlet of the chamber had no effect on improvement of ventilation conditions and effectiveness. Conclusions: In this study, the air velocities at six points in the chamber did not significantly increase despite the increase in the mixing factor and flow rates of ventilation in the controlled environment. Therefore, the inflow of outdoor air throughout an open inlet and installation of a forced ventilation system can potentially increase the indoor air velocity and improve ventilation condition without an increase in the mixing factor.

• 한국컴퓨터정보학회논문지
• /
• 제25권6호
• /
• pp.65-72
• /
• 2020

오늘날 사물 인터넷은 우리에게 편의를 제공하기 위해 가정, 산업 현장 및 병원을 포함한 많은 장소에서 사용된다. 다양한 장치가 네트워크에 연결됨에 따라 많은 서비스들이 실시간 데이터 수집, 저장 및 분석을 통해 새로운 가치를 창출하고 있다. 이처럼 많은 분야에서 IoT 장치 내의 센서 및 통신 기능을 활용하는 서비스 및 애플리케이션을 개발하고 있다. 예시로 산업 분야에서 Samsung과 LG는 자사의 IoT 애플리케이션을 통해 가전과 IoT 기기를 연결하여 스마트 홈을 구축하는 서비스를 제공하며, 의료 및 건강 분야에서 Samsung과 Xioami와 같은 기업들은 피트니스 워치 및 앱을 통해 심전도를 확인하거나 운동량을 기록, 관리한다. 위 같은 사례에서 스마트 홈을 구축하는 서비스의 경우에 수집한 데이터를 통해 해당 가정의 생활 패턴이나 출퇴근 여부 등의 민감정보를 유출할 수 있다. 또한 의료 데이터로 사용하기 위해 측정한 데이터를 통해 개인 정보와 질병의 존재와 같은 민감정보를 유출할 수 있다. 따라서 이를 보호하기 위해 해당 논문이 제안하는 방법에 따라 데이터를 수집, 배포한다면 데이터를 제공하는 사용자의 개인 정보 보호에 위협을 막을 수 있다. 이를 해결하기 위해 최근에는 프라이버시 보호 데이터 처리에 차분 프라이버시(DP)가 채택되어왔다. 따라서 DP를 기반으로 스마트워치 플랫폼에서 건강 데이터를 안전하게 수집할 수 있는 방법을 제안하며, 이를 통해 위와 같이 다양한 분야에서 프라이버시를 보호하는 환경에서의 데이터 수집 및 배포를 가능케 할 수 있다.

• 한국수학교육학회지시리즈A:수학교육
• /
• 제58권2호
• /
• pp.161-185
• /
• 2019

이 연구에서는 중등 수학 교사와 예비교사들이 추론과 증명을 어떻게 이해하여 구성하는지를 탐색하였다. 연구 참여자들은 대부분 대수적인 증명을 시도하는데 이미 알고 있는 공식이나 식을 적용한 대수적 조작으로 답을 구하는 것에 그치며 주어진 문제에 내재된 수학적 구조를 통해 증명을 구성하지는 못하였다. 또한 참여자의 상당수가 대수적 식을 통한 증명만을 완전한 증명으로 판단하였으며 대부분은 기존에 접하지 못했던 새로운 문제유형에서 추론 및 증명구성을 완성하지 못하는 것으로 나타났다.

• 한국자기학회지
• /
• 제12권1호
• /
• pp.1-6
• /
• 2002

Sol-gel법을 이용하여 $Y_3$Fe$_{5-x}$Al$_{x}$O$_{12}$ (x = 0.0, 0.25, 0.50, 0.75, 1.0) 분말을 합성하였다. 열시차 중량 분석장치(TG-DTA), x선회절기, 시료진동 자화율 측정기(VSM) 및 Mossbauer 분광기를 이용하여 물질의 결정구조 및 자기적 성질을 연구하였다. $Y_3$Fe$_{5-x}$Al$_{x}$O$_{12}$ 의 결정구조는 cubic이며, 격자상수는 x = 0.0에서 1.0까지 치환되었을 때 12.381부터 12.304 $\AA$으로 선형적으로 감소함을 보였다. Mossbauer spectrum을 13K부터 600K가지 여러 온도에서 측정을 하였다. x=0일 때 Mossbauer spectrum은 2 set으로 잘 구분할 수 있지만 치환량이 증가함에 따라 바깥쪽 팔면체 자리의 선폭이 점점 넓어지는 것을 관측할 수 있다. 이러한 현상은 사면체 자리에 존재하는 Fe$^{3+}$ 과 $Al^{3+}$ 이온의 확률적 분포에 따른 것으로 해석된다.

• 한국환경성돌연변이발암원학회지
• /
• 제22권3호
• /
• pp.142-148
• /
• 2002

Although ionizing radiation (IR) has been used to treat the various human cancers, IR is cytotoxic not only to cancer cells but to the adjacent normal tissue. Since normal tissue complications are the limiting factor of cancer radiotherapy, one of the major concerns of IR therapy is to maximize the cancer cell killing and to minimize the toxic side effects on the adjacent normal tissue. As an attempt to develop a method to monitor the degree of radiation exposure to normal tissues during radiotherapy, we investigated the transcriptional responses of human peripheral blood lymphocytes (PBL) following IR using cDNA microarray chip containing 1,221 (1.2 K) known genes. Since conventional radiotherapy is delivered at about 24 h intervals at 180 to 300 cGy/day, we analyzed the transcriptional responses ex-vivo irradiated human PBL at 200 cGy for 24 h-period. We observed and report on 1) a group of genes transiently induced early after IR at 2 h, 2) of genes induced after IR at 6 h, 3) of genes induced after IR at 24 h and on 4) a group of genes whose expression patters were not changed after IR. Since Biological consequences of IR involve generation of various reactive oxygen species (ROS) and thus oxidative stress induced by the ROS is known to damage normal tissues during radiotherapy, we further tested the temporal expression profiles of genes involved in ROS modulation by RT-PCR. Specific changes of 6 antioxidant genes were identified in irradiated PBL among 9 genes tested. Our results suggest the potential of monitoring post-radiotherapy changes in temporal expression profiles of a specific set of genes as a measure of radiation effects on normal tissues. This type of approach should yield more useful information when validated in in vivo irradiated PBL from the cancer patients.