• Molecules and Cells
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• v.40 no.6
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• pp.386-392
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• 2017

Periodontal ligament stem cells (PDLSCs) are multipotent stem cells derived from periodontium and have mesenchymal stem cell (MSC)-like characteristics. Recently, the perivascular region was recognized as the developmental origin of MSCs, which suggests the in vivo angiogenic potential of PDLSCs. In this study, we investigated whether PDLSCs could be a potential source of perivascular cells, which could contribute to in vivo angiogenesis. PDLSCs exhibited typical MSC-like characteristics such as the expression pattern of surface markers (CD29, CD44, CD73, and CD105) and differentiation potentials (osteogenic and adipogenic differentiation). Moreover, PDLSCs expressed perivascular cell markers such as NG2, ${\alpha}-smooth$ muscle actin, platelet-derived growth factor receptor ${\beta}$, and CD146. We conducted an in vivo Matrigel plug assay to confirm the in vivo angiogenic potential of PDLSCs. We could not observe significant vessel-like structures with PDLSCs alone or human umbilical vein endothelial cells (HUVECs) alone at day 7 after injection. However, when PDLSCs and HUVECs were co-injected, there were vessel-like structures containing red blood cells in the lumens, which suggested that anastomosis occurred between newly formed vessels and host circulatory system. To block the $SDF-1{\alpha}$ and CXCR4 axis between PDLSCs and HUVECs, AMD3100, a CXCR4 antagonist, was added into the Matrigel plug. After day 3 and day 7 after injection, there were no significant vessel-like structures. In conclusion, we demonstrated the perivascular characteristics of PDLSCs and their contribution to in vivo angiogenesis, which might imply potential application of PDLSCs into the neovascularization of tissue engineering and vascular diseases.

• Archives of Reconstructive Microsurgery
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• v.6 no.1
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• pp.73-79
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• 1997

Complete denervation after severe brachial plexus injury make significant muscle atrophy with loss of proper function. It is much helpful to reconstruct the essential function of the elbow flexion movement in patient with total loss of elbow flexion motion after brachial plexus lesion which was not recovered with nerve surgery or long term conservative treatment from onset. In whole arm type brachial plexus injury, if there were no response to neurotization or neglected from injury, the volume of the denervated muscle is significantely reduced month by month. About 18 months most of the muscle fibers change to fibrous tissues and markedly atrophied irreversibly, further waiting is no more meaningful from that period. Authors performed 14 cases of functioning gracilis muscle transfer from 1981 to 1995 with microneurovascular technique, neuromusculocutaneous free flaps were performed for reconstruction of lost elbow flexion function. Average follow-up period was 5 years and 6 months. We used couple of intercostal nerves as a recipient nerve which were anastomosed to muscular nerve from obturator nerve in all cases. Recipient vessels were three deep brachial artery and eleven brachial artery which were anastomosed to medial femoral circumflex artery with end to end or end to side fashion. Average resting length of the transplanted gracilis were 24 cm. We can get average 54 degree flexion range of elbow with fair muscle power from flail elbow. There were one case of muscle necrosis with lately developed thrombosis of microvascular anastomosed site which comes from insufficient recipient arterial condition, 3 cases of partial marginal necrosis of distal skin of the transplanted part which were not significant problem with spontaneously solved with time goes by gracilis muscle has constant neurovascular pattern with relatively easy harvesting donor with minimal donor morbidity. Especially it has similar length and shape with biceps brachii muscle of upper arm and longer nerve pedicle which can neurorrhaphy with intercostal nerve without nerve graft if sufficient mobilization of the nerves from both sides of gracilis and intercostal region. Authors can propose gracilis muscle transplantation with intercostal nerves neurotization is helpful method with minimal donor morbidity for neglected brachial plexus palsy patients.

• Korean Journal of Food Science and Technology
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• v.38 no.3
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• pp.385-391
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• 2006

Physicochemical properties of hydroxypropylated waxy rice starches were investigated to reduce steeping-time of yukwa (Korean oil-puffed rice snack) processing. Swelling power of hydroxypropylated waxy rice starch increased at relatively higher temperature $(60^{\circ}C)$ than native waxy rice starch $(70^{\circ}C)$. Solubility of hydroxypropylated waxy rice starches increased with increasing propylene oxide content. Pasting temperature $(66.3-66.9^{\circ}C)$ and peak viscosity (216-232 RVU) of hydroxypropylated waxy rice starch were higher than those of native starch (179 RVU) and increased with increasing propylene oxide content. DSC thermal transitions of hydroxypropylated waxy rice starches shifted toward higher temperature. Amylopectin melting enthalpy of hydroxypropylated waxy rice starch (8.4-9.2 J/g) was similar to native starch (9.0 J/g). X-ray diffraction patterns of native and hydroxypropylated waxy rice starches showed typical A-type pattern with no significant differences between them, suggesting hydroxypropylation only affected amorphous region. Results suggest hydroxypropylated waxy rice starch is not applicable for yukwa due to low puffing efficiency and dark color.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6267-6272
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• 2015

Background: Extra nodal lymphoma (ENL) constitutes about 33 % of all non-Hodgkin's lymphoma. 18-28% develops in the head and neck region. A multimodality treatment with multi-agent chemotherapy (CT) and radiotherapy (RT) is considered optimum. Materials and Methods: We retrieved the treatment charts of patients of HNENL treated in our institute from 2001-2012. The charts were reviewed and the demographic, treatment details and outcome of HNENL patients were retrieved using predesigned pro-forma. Results: We retrieved data of 75consecutive patients HNENL. Median age was 47years (Range: 8-76 years). Of the 75 patients 51 were male and 24 were female. 55patients were evaluable. The patient and tumor characteristics are summarized in Table 1. All patients were staged comprehensively with contrast enhanced computed tomography of head, neck, thorax, abdomen, pelvis and bone marrow aspiration and biopsy 66 patients received a combination multi-agent CT with CHOP being the commonest regimen. 42 patients received 4 or lesser number of cycles of chemotherapy whereas 24received more than 4 cycles chemotherapy. Post radiotherapy, 41 out of 42 patients had a complete response at 3 months. Only 21patients had a complete response after chemotherapy. All patients received radiation (mostly involved field radiation) as a part of the treatment. The median radiation dose was 45 Gray (Range: 36 Gray-50 Gray). The radiation was planned by 2D fluoro simulation based technique in 37cases and by 3 Dimensional conformal radiation therapy (3DCRT) in 36 cases. Two patients were planned by the intensity modulated radiation therapy (IMRT) technique. IMRT was planned for one thyroid and one nasal cavity primary. 5 patients experienced relapse after a median follow up of 19 months. The median survival was not reached. The estimated two and three year survival were 92.9% (95%CI- 68.6- 95.35) and 88% (95%CI- 60.82 - 92.66) respectively. Univariate analysis revealed higher stage and poorer baseline performance status to be significantly associated with worse progression free survival. 5 patients progressed (relapse or primary disease progression) after treatment. Of the 5 patients, two patients were primary orbital NHL, two patients had NHL nasal cavity and one was NHL thyroid. Conclusions: Combined modality treatment in HNENL confers excellent disease control with acceptable side effects.

• Korean journal of applied entomology
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• v.32 no.3
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• pp.307-316
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• 1993

The potential of using GIS in analyzing pest surveillance data was explored. The Spatial Analysis System (SPANS) was used to construct a spatial data base to study pest distributions using pest surveillance data collected from 152 stations in South Korea. The annual spatIal distributions of the striped rice borer(SRB), Chdo suppressalis, showed that high densities started to expand in the early 1980s, reaching a peak in 1988. The pattern change appears to be related to cultivation of japonica and indica-japonica hybrid varieties in South Korea. Japo7l!ca varieties have longer duration resulting in the SRB haVlng more time to mature and hibernate in wmter. The locus of SRB spread appears to be located in the mid-west region near lri, Chun~ Buk Province. High brown planthopper (BPH) populations in South Korea are often related to the early immigration and temperature. The simulated distribution of PPH densities in September using these two factors was compared with the actual distribution obtained using 1990 data. The two density maps corresponded closely excepL for differences in the south eastern valley. By overlaying the simulated map layer with the elevation and rice area maps, more specific BPH risk zones could be identified.

• Economic and Environmental Geology
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• v.24 no.4
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• pp.447-463
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• 1991

Petrological and chemical studies of Precambrian dikes in the southern Lake Superior region were conducted with the objects of evaluating magma source and constraining models for the paleo-tectonic environment. Forty-six samples were analyzed for major, trace, and rare earth elements. Chemical data of the studied dikes are typical of continental tholeiites and showing iron-enrichment fractionation trend. With wallrock contamination carefully evaluated, a series of tectonic discriminating methods utilizing immobile trace elements indicate that the source magma was a high-Ti tholeiitic basalt similar to present-day T-type MORB. Effect of chemical contamination from wallrock assimilation accmulates with increasing differentiation. Evolved rocks show LREE enriched patterns and have enhanced levels of LIL elements (e.g., Rb, K, Ba, Th), but low levels of high field strength elements (e.g., Nb, P, Ti) with respect to their neighboring elements. It is suggested from this study that this enrichment possibly due to a combination of a feature inherited from the subcontinental lithosphere and crustal contamination. Geochemical signatures of these rocks are distinctively different from those of arc-related volcanics. Comparisons with chemistries of modern magmas show a pattern of overlap between Within-plate and ocean-floor characteristics, and chemical signatures of these rocks favor a model of intrusion into a crustal environment undergoing lithospheric attenuation.

• Economic and Environmental Geology
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• v.28 no.4
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• pp.395-404
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• 1995

The geologic structure of the Cheju volcanic island has been investigated by analyzing the gravity and magnetic data. Bouguer gravity map shows apparent circular low anomalies at the central volacanic edifice, and the maximum difference of the anomaly values on the island appears to be 30 mgal. The subsurface structure of the island is modeled by three-dimensional depth inversion of gravity data by assuming the model consists of a stacked grid of rectangular prisms of volcanic rocks bounded below by basement rocks. The gravity modeling reveals that the interface between upper volvanic rocks and underlying basement warps downward under Mt. Halla with the maximum depth of 5 km. Magnetic data involve aeromagnetic and surface magnetic survey data. Both magnetic anomaly maps show characteristic features which resemble the typical pattern of total magnetic anomalies caused by a magnetic body magnetized in the direction of the geomagnetic field in the middle latitude region, though details of two maps are somewhat different. The reduced-to-pole magnetic anomaly maps reveal that main magnetic sources in the island are rift zones and the Halla volcanic edifice. The apparent magnetic boundaries inferred by the method of Cordell and Grauch (1985) are relatively well matched with known geologic boundaries such as that of Pyosunri basalt and Sihungri basalt which form the latest erupted masses. Inversion of aeromagnetic data was conducted with two variables: depth and susceptibility. The inversion results show high susceptibility bodies in rift zones along the long axis of the island, and at the central volcano. Depths to the basement are 1.5~3 km under the major axis, 1~1.5 km under the lava plateau and culminates at about 5 km under Mt. Halla. The prominent anomalies showing N-S trending appear in the eastern part of both gravity and magnetic maps. It is speculated that this trend may be associated with an undefined fault developed across the rift zones.

• Journal of the Economic Geographical Society of Korea
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• v.22 no.4
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• pp.458-471
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• 2019

DMSP-OLS nighttime satellite imagery could be used to derive the sum of lights (SOL) and built-up area, and the two indices have been widely employed to make the estimation of socio-economic variables and the dynamics of urban developments. Considering it, this research investigated the spatiotemporal patterns of economic growth and urbanized area in Jilin Province, China, using DMSP-OLS data for a time span between 1992 and 2012. This study found the SOLs of both the province and most cities to tend to grow during the period. While SOL-weighted centroids' means moved towards northwestern direction, urban-area centroids' means followed the trend of south-eastern migration. These directional patterns could be associated with the Northeast Revitalization Plan of Chinese governments. Nonetheless, a future study will need to consider SNPP VIIRS DNB imagery in order to overcome temporal limitation of DMSP-OLS data. In addition, it is also necessary to estimate socio-economic indices, e.g., growth regional domestic product, using a regression model developed with correlation relationship between economic statistics ad SOL.

• Journal of the Economic Geographical Society of Korea
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• v.22 no.4
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• pp.488-512
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• 2019

This study examines the 'Asia Decoupling' hypothesis, focusing on changes in trade patterns between regions and countries, based on the latest value added trade statistics. As an analytical tool, indicators that can directly measure the degree of distribution of actual value added were used. Main findings are: Firstly, creating potential at regional level which used to be the growth engine of East Asia until the mid-2000s declined sharply after the global financial crisis. Secondly, in the development pattern of the value added distribution network, no positive change has been detected in the give-out or gain capacity of emerging countries that can generate future growth in East Asia through GVC development. Lastly, China's value added contributing capacity, as different from the hub countries in other regions such as US and Germany, has declined significantly since the mid 2000s, while its capability to benefit greatly increased, and the gain potential of advanced group countries in competition with China is decreasing. We suggest the establishment of intra-regional economic cooperation mechanism including all countries in East Asia for expanding the value creating capacity in the region.

• Journal of Environmental Health Sciences
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• v.41 no.3
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• pp.182-190
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• 2015

Objectives: To introduce a protocol of Mobi-kids study which was aimed to examine an association between radiofrequency (RF) radiation exposure by mobile phone use and brain tumor risk in children and adolescents. Methods: The Mobi-kids study was a multinational matched case control study using a standardized protocol with the number of subjects targeted about 1,000 cases and 2,000 controls aged 10 to 24. In Mobi-Kids Korea, the source population was restricted to Seoul, Incheon, and Gyeonggi-do province. Eligible cases of primary brain tumor (glioma, meningioma, and others) were diagnosed from January 2012 to June 2015. Eligible controls were appendicitis patients operated during the study period. Two controls were matched on age, gender, and study region for 1 case. Information about pattern and history of mobile phone use and other covariates were obtained by face to face interview by trained interviewer. The Mobi-kids study has been involved in Mobi-expo as a validation study about mobile phone use, XGridmaster to localize tumor in the brain for RF energy calculation, and histological review for validation of diagnosis. Results: The Mobi-kids was the first and largest study in children and adolescents to estimate risk of brain tumor in association with the RF energy absorption in the brain estimated by mobile phone use. Forty-six-cases and 54 controls were collected as of September 2014 in Korea. Conclusions: The meaningful results of the study were expected because of the largest sample size, high validity of EMF exposure assessment as well as the susceptible study populationof children and adolescents.