• 한국수정란이식학회지
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• 제16권3호
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• pp.245-250
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• 2001

This study was performed to evaluate whether vitrification method using ethyle glycol and eletron microscopic (EM) grid could be used far the cryopreservation of human oocytes in ART program. Surplus oocytes were obtained from consented IVF patients. These surplus human oocytes were frozen with our vitrification method, Oocytes were exposed to 1.5M ethylene glycol (EG) in DPBS far 2,5 minutes, followed by 5.5M EG plus 1.0M Sucrose in DPBS for 20 seconds. Then oocytes were transferred onto the EM grid and the grid was plunged into LN2 for storage. For thawing, oocytes containing EM grid were sequentially transferred in 1.0M, 0.5M, 0.25M, 0.125M and 0 M sucrose in DPBS solution at the intervals of 2.5 minutes. Thawed and survived oocytes were provided for ICSI. Embryos from vitrified oocytes were transferred to uterus of the patient on 4 to 5 days after ovulation in natural cycles of on 15 to 17 day of hormone replacement cycles. A total of 370 oocytes from 26 patients were thawed and 159 (43.0%) of them survived. One hundred thirty four oocytes (84.3%) were fertilized normally and 126 pre-embryos were transferred to 26 patients, resulting in 5 clinical pregnancies. The pregnancy rate per transfer was 19.2% and implantation rate was 4.0%. Among the five pregnant, 4 patients delivered 4 healthy babies and the one patient was 32-week ongoing pregnancy. From this results, vitrification using ethylene glycol as cryoprotectant and EM grid is a rapid and simple method that can be effectively applied for the cryopreservation of human oocytes in ART program.

• Archives of Plastic Surgery
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• 제41권6호
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• pp.716-721
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• 2014

Background The aim of this study was to review the recipient vessels used in our cases of facial reanimation with free functional muscle transfer and to identify patient variables that may predict when the facial vessels are absent. From this we present a protocol for vessel selection in cases when the facial artery and/or vein are absent. Methods Patients were identified from November 2006 to October 2013. Data was collected on patient demographics, facial palsy aetiology, history of previous facial surgery/trauma and flap/recipient vessels used. A standard operative approach was adopted and performed by a single surgeon. Results Eighty-seven eligible patients were identified for inclusion amongst which 98 hemifaces were operated upon. The facial artery and vein were the most commonly used recipient vessels (90% and 83% of patients, respectively). Commonly used alternative vessels were the transverse facial vein and superficial temporal artery. Those with congenital facial palsy were significantly more likely to lack a suitable facial vein (P=0.03) and those with a history of previous facial surgery or trauma were significantly more likely to have an absent facial artery and vein (P<0.05). Conclusions Our algorithm can help to guide vessel selection cases of facial reanimation with free functional muscle transfer. Amongst patients with congenital facial palsy or in those with a previous history of facial surgery or trauma, the facial vessels are more likely to be absent and so the surgeon should then look towards the transverse facial vein and superficial temporal artery as alternative recipient structures.

• 한국화재소방학회논문지
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• 제19권4호
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• pp.47-56
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• 2005

비응급상황에 대한 제한적인 구급요청의 거절 및 환자 등의 이송거부로 인한 법적 분쟁으로부터 당해 구급대원을 보호하고 이에 대한 절차를 엄격히 하여 응급환자를 보호하기 위하여 $\ulcorner$구조대 및 구급대 편성$\cdot$운영에 관한 규칙$\lrcorner$이 개정되었다. 이에 대하여 본 논문은 구급대원의 이송거절 거부에 따라 발생할 수 있는 법적 책임으로 응급의료거부죄의 구성요건 해당성을 고찰하고 부작위에 의한 형사책임 및 환자에게 발생한 손해에 대한 국가배상책임의 발생가능성에 대하여 연구하였다. 구급대원을 법적 책임으로부터 보호하기 위해 개정된 규칙의 준수에 있어서 유의해야 할 점과 외국의 판례들을 고려하여 법원의 태도를 살펴보았다. 결론적으로는 구급대원의 법적인 보호를 위해 지도의사의 의료지도 확보 및 적법한 절차를 따라 문서화된 서식을 충실히 기록함으로써 구급대원의 의무에 대한 충실한 이행 및 환자의 동의를 확보하여 이송거절 및 거부에 대한 정당성을 확보하는 것이 중요함을 강조하였다.

• 대한치과보철학회지
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• 제61권4호
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• pp.268-274
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• 2023

본 증례는 요양병원에 입원치료 중인 환자에서 치과에 내원하기 힘든 점과 의치 분실이 많은 점을 고려하여 내원 횟수를 감소시키고 재제작이 쉬운 CAD-CAM 총의치를 제작하였다. 환자가 적응한 기존 임시의치의 형태 및 수직고경, 악간관계를 최종의치 제작에 반영하기 위해 기존 임시의치를 스캔하고 프린팅한 개인트레이로 폐구인상을 채득하였다. UTS CAD를 이용하여 디지털 안궁이전하고 CAD 소프트웨어에서 치아배열 후 상하악 총의치를 단일 구조의 디스크로 의치상과 인공치를 한번에 절삭하여 제작하였다.

• 간호행정학회지
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• 제13권1호
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• pp.5-16
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• 2007

Purpose: This study is to verify the validity and reliability of classified items and criteria of the patient classification system(PCS) based on Park's definition of nursing intensity. Methods: An expert group of 8 persons verified the content validity of the tools. The 1817 inpatients at a tertiary hospital in Seoul, Korea were classified into 4 groups according to two tools for verifying concurrent validity and interraters' reliability. These verifications were performed from September to October, 2004. Results: Nursing domains of the tools have been divided into 12 items: hygiene, nutrition, elimination, exercise & activity, education & counseling, emotional support, communication & consciousness, treatment & examination, medication, measurement & observation, coordination of multidisciplinary team, admission & discharge & transfer management. Content validity was verified by the content validity index(above 0.75 in all 12 areas). Interraters' reliability was no significant difference in the results of the patient classification between the two raters(A group 93.75%. B group 88.24%). Concurrent validity was also verified by the agreement of two tools(73.7%). Conclusion: These results showed that the reliability and validity of the PCS based on the nursing intensity were verified. These will use an data for nursing productivity in the future.

• 간호행정학회지
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• 제20권5호
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• pp.545-557
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• 2014

Purpose: The purpose of this study was to develop a patient classification system based on nursing care intensity for patients with acute stroke-related symptoms and verify its validity and reliability. Methods: Data were collected between November, 2013 and February, 2014. The verification for content validity of the patient classification system was conducted by a group of seven professionals. Both interrater reliability and concurrent validity were verified at stroke units in tertiary hospitals. Results: The intensive nursing care for acute stroke patients consisted of 14 classified domains and 56 classified contents by adding 'neurological assessment and observation' and 'respiratory care': 'hygiene', 'nutrition', 'elimination', 'mobility and exercise', 'education or counselling', 'emotional support', 'communication', 'treatment and examination', 'medication', 'assessment and observation', 'neurological assessment and observation', 'respiratory care', 'coordination between departments', and 'discharge or transfer care'. Each domain was classified into four levels such as Class I, Class II, Class III, and Class IV. Conclusion: The results show that this patient classification system has satisfactory validity for content and concurrent and verified reliability and can be used to accurately estimate the demand for nursing care for patients in stroke units.

• Molecules and Cells
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• 제39권2호
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• pp.77-86
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• 2016

Cancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes and tumor suppressor genes. Despite recent advances in high-throughput sequencing technologies and development of targeted therapies, novel cancer drug development is limited due to the high attrition rate from clinical studies. Patient-derived xenografts (PDX), which are established by the transfer of patient tumors into immunodeficient mice, serve as a platform for co-clinical trials by enabling the integration of clinical data, genomic profiles, and drug responsiveness data to determine precisely targeted therapies. PDX models retain many of the key characteristics of patients' tumors including histology, genomic signature, cellular heterogeneity, and drug responsiveness. These models can also be applied to the development of biomarkers for drug responsiveness and personalized drug selection. This review summarizes our current knowledge of this field, including methodologic aspects, applications in drug development, challenges and limitations, and utilization for precision cancer medicine.

• 대한전기학회논문지:시스템및제어부문D
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• 제54권3호
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• pp.206-214
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• 2005

In these days the virtual reality technology has been applied to treat such an anxiety disorders. And also a medical doctor can diagnose the patient in distance with the telemedicine system. In this thesis, an telemedicine assistant system for treatment of acrophobia using biomedical signals and virtual reality technique is proposed. I made two virtual reality simulations for treatment of acrophobia and telemedicine system for communication between doctor and patient using personal computer. Multimedia conference service, online questionary, signal transfer system are needed to configure such system. Virtual reality simulation system that composed of position sensor, head mount display, and audio system, is also included in this telemedicine system. I added virtual environment update system to this virtual reality telemedicine system for treatment of acrophobia. With this virtual environment update system, the doctors can change virtual reality simulation stage based on the status of each patient and symptom of phobia. We will apply this system to the acrophobia patient in distance and be able to offer better medical treatment for mental illness in near future.

• 대한한방부인과학회지
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• 제28권1호
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• pp.167-174
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• 2015

Objectives: This study is to evaluate the effect of KI06 acupuncture point in the first trimester vaginal bleeding of a threatened abortion patient. Methods: A patient of threatened abortion was treated consequently with KI06 acupuncture point, and the result was inspected and evaluated using sono. Results: After consequent 4 times KI06 acupuncture point treatments, amount and frequency of bleeding in a patient of threatened abortion decreased to 80%, 50%, 20%, 10%. after more treatment the first trimester vaginal bleeding was improved completely. Conclusions: Treatment of KI06 acupuncture point in a threatened abortion patient was effective and further study is needed.

• 한방재활의학과학회지
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• 제29권4호
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• pp.135-142
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• 2019

The objective of this study is to propose Korean Medicine treatment for recurrent limb weakness after Guillain-Barre syndrome (GBS) improvement by intraveinous immunoglobulin, and to report its effectiveness. Manual muscle test (MMT), Korean modified Bathel index (K-MBI), and tendon reflex were used to evaluate the patient. The patient was improved hip joint, knee joint, ankle joint MMT from grade 3-/3- to grade 5/5 and in the upper limb the patient can do big joint exercise but cannot do micromovement like writing or using cell phone. When discharge date the patient's wrist joint MMT grade is improved grade 5-/5- to grade 5/5. The K-MBI score is improved from 71 to 86 and there was a big change in walking and chair/bed transfer, there was no change in tendon reflex. This study suggests that Korean Medicine can be effective for patients who have recurrent limb weakness after GBS improvement.