• Korean Journal of Veterinary Research
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• 제22권1호
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• pp.31-36
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• 1982

This study was taken to clarify the clinical signs and macroscopical lesions of pigs naturally infected with hog cholera. The clinical and macroscopical observation on the natural cases of hog cholera and experimental cases inoculated with ALD Virus and isolated virus strains were carried out. The results obtained are as follow; In clinical inspection of the natural cases, diarrhea (73.1%) blotching of ear (50.0%), staggering (42.3%), erythema of skin (40.0%), constipation (38.5%), conjunctivitis (32.7%) and dyspnea (30.8%) were observed. Dyspnea, constipation and erythema of skin were observed mainly in the experimental cases, however, staggering and conjunctivitis in pigs infected with ALD virus were found and convulsion and hemorrhage of skin of pigs infected with isolated virus were seen, respectively. The gross lesions of natural cases were hemorrhage of lymph node (82.5%), enteritis and hemorrhage of large intestine (65.0%), splenic infarction (57.5%), pneumonia (55.0%), gastritis and hemorrhage (52.5%), cardiac hemorrhage (40.0%) and renal petechiation (37.5%), while in the experimental cases, hemorrhage of lymph node, pneumonia, gastritis and hemorrhage, enteritis and hemorrhage of laryge intestine and splenic infarction were seen mainly.

• Toxicological Research
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• 제18권1호
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• pp.73-77
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• 2002

The single dose toxicity of Hwangiaegongjinbo, an invigorator developed by Korea Medical Science Institute was evaluated in ICR mice and Sprague-Dawley rats. The aqueous solution of freeze-dried powder of Hwangiaegongjinbo or its original solution was once administrated orally to both sexes of mice and rats at dose of 2000 mg/kg, the recommended upper limit dose for acute toxicity. Water was administered to another group as control. after single adminstration, sign of toxicity were observed every hour for the first 6 hours and every day for 14 days. Neither sign그cant toxic sign nor death was observed during the observation period. In addition, no pathological changes were noticed in macroscopic examination at necropsy in those treated group. These results indicated that $LD_{50}$ of Hwangiaegongjinbo is greater than 2000 mg/kg in ICR mice and Sprague-Dawley rats.

• Korean Journal of Pharmacognosy
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• 제39권4호
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• pp.352-356
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• 2008

Acute toxicity of standardized extract of Salvia miltiorrhiza Bunge was examined using male and female ICR mice. Mice were treated with standardized extract the intragastrically at 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. At the doses used, no mortality or abnormal clinical signs in animals were shown during at the observation period. Also there was no difference in net body weight gain, gross pathological findings at the terminal sacrifice among the groups mice treated with different doses of the test substance. The results suggested that acute oral toxicity of standardized extract of S. miltiorrhiza in mice is very low at the conditions employed in this study.

• Journal of Veterinary Clinics
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• 제16권2호
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• pp.492-496
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• 1999

A 3-year old male Maltese, which had enlarged and ballooned superficial lymph-nodes, was admitted to the Veterinary Teaching Hospital, College of Veterinary Medicine, Kyung-pook National University. Radiographic findings indicated cranial mediastinal mass, interstitial pneumonitis, conspicuous splenomegaly and liver enlargement. The patient showed anorexia, depression and anemia. It was autopsied following its death 2 days after admittance. There were copious hemoperitoneum, lymphomatous mass in the spleen, torsion of the mesenterium and stenosis of the duodenum. On the microscopic observation, there was the increase of the amount of lymphocytic cytoplasm and numbers of nucleus-devided lymphocytes followed by their diffused infiltration in lymph nodule. Based on the physical, histological and pathological findings, this case was diagnosed as a multicentric form of lymphosarcoma.

• Journal of Korean Medical classics
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• 제22권4호
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• pp.255-259
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• 2009

The origin of "Fire" in Traditional Chinese Medicine is summed up based on observation and knowledge of natural fire, followed by abstract thinking, of which the outcomes are best symbolized in the character Fire[火]. Because it is an abstract concept, it is hard to give a single and strict definition. Naturally, it would be necessary to analyze and illustrate the origin of 'Fire' from different angles such as broad definition, multi-definition, levels, classifications and effects. The concept of 'Fire' has four meanings in the aspect of the broad definition: first, natural fire; second, the physiological conception of fire; third, the medical conception of fire; fourth, general concept related to fire. In Traditional Chinese Medicine, fire mainly indicates physiologic fire, pathological fire, the fire in the six kinds of natural climate and the fire as one of the properties and the flavors of herbs.

• Imaging Science in Dentistry
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• 제42권1호
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• pp.41-45
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• 2012

Hyperdontia or supernumerary teeth without associated syndrome is a rare phenomenon, as supernumerary teeth are usually associated with cleft lip and palate or other syndromes such as Gardner's syndrome, cleidocranial dysplasia, and so on. Five patients with supernumerary teeth visited our department. They had no familial history or other pathology, certain treatment protocols was modified due to the presence of supernumerary teeth. Non-syndromic supernumerary teeth, if asymptomatic, need to have periodical radiographic observation. If they showed no variation as they impacted in the jaw, careful examination is necessary because they may develop into pathological status such as dentigerous cysts. The importance of a precise clinical history and radiographic examination for patients with multiple supernumerary teeth should be emphasized.

• Korean Journal of Pharmacognosy
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• 제17권2호
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• pp.148-152
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• 1986

The preventive effect of Sosiho-Tang extract administered concurrently with methionine on hepatotoxicity induced by carbon tetrachoride (20% $CCl_4$ in olive oil, 5 ml/kg) in rats was studied. S-GOT values were decreased significantly by the concurrent administration of Sosiho-Tang extract 100 mg/kg with methionine 100 mg/kg and also Sosiho-Tang 200 mg/kg with methionine 100 mg/kg. S-GPT values were decreased remarkably by the concurrent administration of Sosiho-Tang extract 200 mg/kg with methionine 100 mg/kg. In histological observations, the pattern of the contrast group indicated the marked necrosis of the parenchymatous cells around the centrilobular area and the fatty changes of the hepatic cells around the midzonal area, but the concurrent administration of Sosiho-Tang extract 200 mg/kg and methionine 100 mg/kg revealed better improvements than their respective single administration in all pathological aspects.

• Journal of Veterinary Clinics
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• 제18권4호
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• pp.478-481
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• 2001

A Patient (Korean native cow, 4 years old, 300 kg, female), with chief complaint of anorexia for long period was admitted to the Chungnam national University Veterinary Medical Teaching Hospital. At necropsy findings, hard masses of necrotic fat were located in the omentum, rectum, kidney, colon, heart and thoracic cavity, respectively. The yellowish changes also were observed in liver, spleen and lung, respectively. In histopathological findings, fatty accumulation was observed by microscopic observation in each organ of fatty masses. Hamatological analysis revealed the low levels of Hb, PCV and neutrophil. Blood chemical analysis indicated the high concentration of Cholestelol and Triglyceride. That patient was diagnosed as typical case of lipomatosis by clinical, blood, blood chemical and pathological examinations.

• Korean Journal of Veterinary Research
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• 제37권3호
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• pp.601-606
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• 1997

Mulberry heart disease was associated with vitamin E and selenium deficiency of pigs. Anatomical findings of this disease were hydropericadium, extensive patchy hemorrhage of epicardium, endocardium, and discoloration of dark red color of myocardium. In histological findings were characterized by acute myocardial degeneration, extensive hemorrhage, fibrinoid degeneration of arterioles, PAS positive material deposition of arterioles and capillary thrombosis. In affected herds, feed and serum tocopherol and selenium concentration were less than normal values.

• Clinical Endoscopy
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• 제51권6호
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• pp.591-595
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• 2018

Intussusception after colonoscopy is an unusual complication. A MEDLINE search revealed only 7 reported cases. We present a report of a 28-year-old man who developed abdominal pain several hours after routine colonoscopy and in whom computed tomography (CT) revealed colocolic intussusception. We postulate that this condition is iatrogenic and induced by suctioning of gas on withdrawal of the colonoscope. A common observation among the reported cases was abdominal pain several hours after colonoscopy and right-sided intussusception. All cases had colonoscopy reaching the right side of the colon. Treatment for adult intussusception remains controversial with regard to reduction versus resection, especially given the high association with a pathological cause and malignancy. Among the 8 reported cases, only the current case did not require surgery. A combination of benign colonoscopy, CT, and the clinical picture should provide sufficient information to initially choose a more conservative treatment approach.