Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Single Dose Toxicity Study of Hwangiaegongjinbo, an Invigorator, in Mice and Rats

마우스 및 랫드에서 자양강장제 황제공진보의 단회투여독성시험

  • 이정남 (가천의과대학원 외과) ;
  • 박창신 (인하대학교 의과대학, 약리학교실) ;
  • 김홍표 (인하대학교 의과대학, 약리학교실) ;
  • 황성연 ((주)한국의과학연구소) ;
  • 정운계 (인하대학교 의과대학, 약리학교실)
  • Published : 2002.03.01
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Abstract

The single dose toxicity of Hwangiaegongjinbo, an invigorator developed by Korea Medical Science Institute was evaluated in ICR mice and Sprague-Dawley rats. The aqueous solution of freeze-dried powder of Hwangiaegongjinbo or its original solution was once administrated orally to both sexes of mice and rats at dose of 2000 mg/kg, the recommended upper limit dose for acute toxicity. Water was administered to another group as control. after single adminstration, sign of toxicity were observed every hour for the first 6 hours and every day for 14 days. Neither sign그cant toxic sign nor death was observed during the observation period. In addition, no pathological changes were noticed in macroscopic examination at necropsy in those treated group. These results indicated that $LD_{50}$ of Hwangiaegongjinbo is greater than 2000 mg/kg in ICR mice and Sprague-Dawley rats.

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