• Tuberculosis and Respiratory Diseases
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• 제65권6호
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• pp.487-494
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• 2008

연구배경: p53 유전자의 돌연변이가 모든 조직형의 폐암에서 가장 흔한 유전적 이상으로 알려져 있다. 이전의 연구에도 불구하고, 폐암 조직에서 p53 단백질의 과발현과 생존과의 관계에 대해서는 아직도 논란이 있다. 본 연구의 목적은 수술로 절제한 병리학적 병기 1기인 비소세포폐암 환자에서 p53 단백질 과발현과 관련된 임상적 특징을 평가하고, p53 단백질 과발현과 예후와의 관계를 평가하는 것이다. 방 법: 본 연구는 삼성서울병원에서 2003년 1월부터 2004년 6월까지 폐암으로 치료 받은 환자 중 병리학적 병기 제 1기의 비소세포폐암 환자를 대상으로 한 후향적 연구이다. 폐암 환자의 종양 조직을 이용하여 p53 단백질에 대한 면역조직화학 염색이 시행되었다. 성별, 연령, 흡연력, 조직형 및 병기 등의 임상적 특징들에 따른 p53 과발 현 여부를 단변량 및 다변량 분석으로 평가하였다. 한편, p53의 과발현 여부에 따른 DFS, DSS 및 OS은 Kaplan-Meier 방법으로 평가하였고, 군간 비교는 log-rank test를 이용하였다 결 과: 125명의 연구 대상 환자에서 p53 면역 염색양성 종양 세포 빈도의 중앙값은 10%였다. 편평세포암에서 p53 과발현(${\geq}10%$)의 빈도가 66%로 선암의 38%보다 통계적으로 유의하게 증가되어 있었다(p=0.002). 병리학적 병기가 IB인 경우 p53 과발현의 빈도가 59%로 IA의 38%보다 증가되어 있었다(p=0.024). 흡연의 기간은 p53이 과발현 된 경우(27년)에 그렇지 않은 경우(20년)보다 통계적으로 유의하게 길었다(p=0.032). 25갑년 이상의 흡연력도 p53이 과발현 된 경우(58%)에 그렇지 않은 경우(38%)보다 더 흔하게 관찰되었다(p=0.024). 다변량 분석에서 p53 과발현과 관련된 인자는 편평세포암의 조직형뿐인 것으로 평가 되었다(p=0.002). 한편, p53 과발현 여부에 따른 DFS, DSS 및 OS의 차이는 없었으며, 편평세포암과 선암의 세부 군 분석에서도 생존의 차이는 없었다. 결 론: 수술로 절제한 제 1기 비소세포폐암 조직에서 면역조직화학 염색으로 평가한 p53 과발현은 조직형, 병기 및 흡연력과 관련이 있었고, 다변량 분석에서 조직형만이 p53 과발현과 관련된 독립적 인자였다. 하지만, p53 과발현과 환자의 생존과는 관련이 없었다.

• 대한치과교정학회지
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• 제22권3호
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• pp.703-713
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• 1992

Researches in pathologic entities and syndromes that describe temporomandibular joint (TMJ) or TMJ-related pain and dysfunction, have been hampered by confusion and conflict over the pathogenesis of myofascial and joint pain, the character and causes of joint noises, and the lack of scientific methods. Investigators have more recently correlated clinical diagnosis and arthrographic and surgical findings to demonstrate 'internal derangements' of the TMJ. It is thought that the structural and functional changes characteristic of internal derangements constitute the principal pathologic entity of the TMJ. Cephalometric data from a group of 34 subjects with documented functional changes in the TMJ were compared with those of a group of 35 subjects from a control sample. The results were as follows: 1. Comparison of a group which shows Class I relationship, there was a tendency to show clock-wise rotation of mandible and linguoversion of upper and lower anterior teeth in the experimental sample. 2. Excluding the vertical relationship, there was a tendency to show low values of the lingual surface slope of the upper central incisor and high values of the interincisor angle in the experimental sample.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8101-8105
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• 2014

Background: Although mucinous adenocarcinoma has been recognized for a long time, whether it is associated with a poorer prognosis in colorectal cancer patients is still controversial. Many studies put emphasis on mucinous adenocarcinoma containing mucin component ${\geq}50%$. Only a few studies have analyzed cases with a mucin component <50%. Objectives: This study aimed to analyze the prognostic value of different mucin component proportions in patients with stage III rectal cancer. Materials and Methods: Clinical, pathological and follow-up data of 136 patients with the stage III rectal cancer were collected. Every variable was analyzed by univariate analysis, then multivariate analysis and survival analysis were further performed. Results: Univariate analysis showed pathologic T stage, lymphovascular invasion, and histological subtype were statistically significant for DFS. Pathologic T stage was significant for OS. Histological subtype and lymphovascular invasion were independent prognostic factors in multivariate analysis for DFS, and histological subtype was the only independent prognostic factor for OS. Survival curves showed the survival time of mucinous adenocarcinoma (MUC) was shorter than non-MUC (adenocarcinomas with a mucin component <50% and without mucin component). Conclusions: Histological subtype (tumor with different mucin component) was an independent prognostic factor for both DFS and OS. Patients with MUC had a worse prognosis than their non-MUC counterparts with stage III rectal carcinoma.

• 동의생리병리학회지
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• 제32권4호
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• pp.211-216
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• 2018

Generally, clause 273 of Shanghan-lun was called as a principle of Taeeum-byung and was regarded that it contains essential substances of Taeeum-byung. In this study, I compared the text of diverse woodblock-printed versions, the opinions of many annotators, and other clauses of Shanghan-lun which related with clause 273 in pathologic view points. As results, "the symptoms become worsen by purgative medicine" of remained version is more reasonable rather than "diarrhea become worsen" of Song version, in the side of pathologic interpretation of Taeeum-byung and to understand the reason of mistreatment. In addition, the symptoms of "an intermittent and autonomous abdominal cramp" and "feeling hard on sub-chest region" should be recognized as transformed symptoms by mistreatment of purgative medicine. Thus, diarrhea cannot be accepted as a peculiar symptom of Taeeum-byung, but should be regarded as a possible symptom transformed from Taeeum-byung or its preceding diseases by purgative medicine.

• Journal of Chest Surgery
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• 제31권3호
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• pp.319-323
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• 1998

흉선의 유암종은 매우 드문 종격동 종양으로, 1972년에 Rosai와 Higa에 의해 기술되었다. 흉선의 유암종은 Kultschizky 세포에서 생기는 종양으로 생각되어지며, 흉선종과 다른 종양으로 간주되어 왔다. 흉선의 유암종의 병리학적인 진단으로 병리학적, 면역조직화학적, 전자현미경적 소견을 이용한다. 유암종의 50% 정도에서는 내분비 질환을 가진다. 재발과 흉곽외 전이가 특징적이다. 발견당시나 재발의 경우에 외과적인 절제가 가장 효과적이라고 생각된다. 그러나 방사선 치료나 항암치료의 역할은 분명하지 않다. 저자들은 수술 및 병리학적으로 증명된 57세 남자의 흉선 유암종 1예를 경험하였기에 간단한 문헌 고찰과 함게 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2871-2877
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• 2015

Background: Urothelial carcinoma (UC) is a malignant neoplasm that most commonly occurs in the urinary bladder. The primary aim of this study was to evaluate the clinicopathologic features, recurrence and progression in patients with bladder urothelial cancer. Materials and Methods: The medical records of patients diagnosed with UC in the state pathology laboratory between January 2006 and July 2014 were retrospectively included. Carcinomas were categorized according to age, gender, histologic grade, tumor configuration, pathologic staging, recurrence status, and progression. Results: A total of 125 (113 men, 12 women) patients were examined. The mean age was 65.9 years and the male-to-female urothelial cancer incidence ratio was 9.4:1. Low-grade UCs were observed in 85 (68%) and high-grade in 40 (32%). A papillary tumor pattern was observed in 67.2% of the UCs. Cases were classified with the following pathological grades: 34 (27.2%) cases of pTa, 70 (56%) of pT1, and 21 (16.8%) of pT2. Recurrence occurred in 27 (21.6%) patients. Ten progressed to a higher stage (pT1 to pT2), and three cases to higher grade (low to high). We also analyzed the results separately for 70 (56%) patients 65 years of age and older. Conclusions: With early detection and diagnosis of precursor lesions in older patients, by methods such as standard urologic evaluation, urinary cytology, ultrasound scanning and contrast urography, and cystoscopy, in addition to coordinated efforts between pathologists and urologists, early diagnosis may reduce the morbidity and mortality of patients with urothelial carcinoma.

• 대한불안의학회지
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• 제9권2호
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• pp.113-120
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• 2013

Objectives : The aim of this study was to investigate clinical meaning of hallucination among patients with posttraumatic stress disorder (PTSD). Methods : PTSD patients with hallucination (n=50) were selected and matched with the PTSD patients without hallucination (n=50) by age and sex. The patients were evaluated in two different aspects, pathologic aspects which can develop after traumatic event, and positive/adaptive aspects which are concerned in positive psychology. In addition to these, temperament and character features between two groups were also evaluated using the Temperament and Character Inventory (TCI). Results : Except for the total score of DES (Dissociative Experience Scale) and the score of re-experience subscale of CAPS (Clinician Administered PTSD Scale), clinical characteristics did not show any significant difference between the two groups. Among the comparison of seven higher dimensions in TCI profiles, only Self-transcendence showed significant difference between the two groups. Conclusion : The two groups did not show significant differences in pathologic aspects except for factors that may contribute to development of hallucination. Furthermore, authors could not find any differences in positive/adaptive aspects.

• Parasites, Hosts and Diseases
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• 제35권2호
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• pp.135-138
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• 1997

이 연구는 가시입이형흡충 감염에 의한 초기 장병변을 관찰하기 위하여 수행되었다. 감염 1일부터 7일까지 가시입이형흡충은 십이지장과 공장의 융모간극 최하부에서 관찰되었다 괴낭유충 1.000개와 5.000개 감염군 사이에 병변의 정도 차이는 인정되지 않았다. 충체 둘레에 있는 융모 기질에 가벼운 부종과 염증세포침윤이 있었다. 감염 4일에 선와는 경도의 과증식을 보였으며 융모는 중등도고 위축된 소견을 보였나 장병변은 충체 주위에 국한되었으며 광범위하게 확산되지 않았다. 따라서 장병변은 가시입흡충의 장상피세포에 대한 기계적으로 손상으로 인하여 야기되었나고 생각된다.

• 한국콘텐츠학회논문지
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• 제10권5호
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• pp.259-266
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• 2010

Clostridium difficile 연관 설사증은 항생제 관련 병원 감염 설사에 매우 중요하며, 최근 병원 내 C. difficile 감염 발생률은 계속 증가해왔다. 본 연구에서는 2005년 1월부터 2008년 12월까지 대변 총 1,329 검체를 검사 하여, C. difficile 발생률과 감염 특성을 분석하였다. 전체 1,329 검체 중 독소 A/B검사(EIA)양성 반응을 나타낸 검체는 총283건이었다. 4년간 평균 양성률은 21.2%였으며, 연령 분포에서는 70세 이상에서 가장 높았다. 내시경 소견에서 PMC 57.7%, 정상 소견 19.5%였으며, 조직학적 소견에서는 PMC26.8%, AAC 52.2% 였다. C. difficile 은 PMC 와 관련이 있으나, 내시경 검사 및 조직 검사 소견에서는 정상에서 PMC 까지 다양하게 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.1037-1041
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• 2013

Background: Prognostication of breast cancer using clinico-pathologic variables, although useful, remains imperfect. Recent research has focused on finding new markers of prognosis using gene expression profiling. Panels of proteins assessed by immunohistochemistry might also be useful in this regard. This study focused on Bcl-2 protein expression in triple-negative (TNBC) and non- triple-negative breast cancer (non-TNBC) with correlation to clinico-pathologic variables. Materials and methods: We analyzed Bcl-2 expression in 77 women with primary breast carcinoma divided into two groups; triple-negative and non- triple-negative according to expression of estrogen (ER), progesterone (PR) and human epidermal growth factor receptors (Her2/neu). Bcl-2 expression was assessed in relation to age, histo-pathological subtype, grade, nodal status and tumor size. Results: Bcl-2 was expressed in 74% of triple-negative breast cancers and 70% of non- triple-negative cancers. In TNBC, expression was significantly correlated with invasive ductal subtype, while in non-TNBC it was significantly correlated with age and negative nodal status. In both groups higher Bcl-2 expression associated with favourable prognostic factors in breast cancer, but no significant statistical correlations were found. Conclusions: Frequency of Bcl-2 expression does not differ between TNBC and non-TNBC, but different prognostic factors correlate with Bcl-2 in the two cases.