• 대한한방소아과학회지
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• 제19권2호
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• pp.99-114
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• 2005

Objectives: This study was aimed to find out the anti-stress and protective-memory effect of Quibitanggagam(QBT) on stress of rats Methods : This experimental study was conducted with elevated plus maze test, passive avoidance test, morris water maze test, and consequently density of AchE reactivity in the CA1 of hippocampus to research the learning and memory of rats affected by restraint stress, Results: Passive avoidance test revealed that time latency of retention test for QBT+Stress group significantly decreased on 2, 3rd day. Morris water maze revealed that acqusitive ability of QBT+Stress group significantly improved on 2, 3rd day and retentive ability of QBT+Stress group was significantly improved on 7th day. Elevated plus maze test revealed that latency in open arm of QBT+Stress group significantly decreased and locomotor activity(number of entered arm) of QBT+Stress group was significantly increased. The values of density of AchE stained nuclei in the CA1 of hippocampus QBT+Stress group was significantly increased compared with SAL+Stress group. Conclusion : According to the above results, it is concluded that QBT will be useful as a remedy against stress disease and improving memory.

• 한국식품영양과학회지
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• 제39권11호
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• pp.1691-1694
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• 2010

본 실험에서는 발효더덕을 제조한 후 발효더덕의 건망증에 대한 효과를 scoplamnine으로 유도된 건망증 모델을 이용하여 수동회피시험(passive avoidance test)과 Morris 수중미로시험(Morris water maze test)을 이용하여 행동학적 변화를 통하여 발효더덕의 기억력 개선 능력 여부를 확인하고자 하였다. 더덕 및 발효더덕 추출물 167, 333, 667 mg/kg을 경구투여 한 결과 발효더덕 추출물의 333 mg/kg 및 667 mg/kg 그룹에서 각각 $120.9{\pm}15.3$초 및 $140.7{\pm}18.0$초에 대하여 통계적으로 유의성 있게 latency time이 증가하였으며, 특히 333 mg/kg의 용량에서 대조군의 85% 수준으로 회복하는 것을 확인하였다. 또한, Morris water maze test를 실시에서도 더덕 및 발효더덕 추출물 처리군에서는 scopolamine에 의한 기억 손상이 개선되어 대조군의 escape latency 수준으로 회복되었다. 이상의 결과 발효더덕 추출물의 경구섭취는 scopolamine으로 유도된 기억력 감퇴 동물모델에서 기억력 개선 및 인지능력을 향상시킬 수 있다고 생각되며, 효과의 기전 및 효능성분을 확인 연구가 진행되어야 할 것으로 생각된다.

• Toxicological Research
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• 제17권
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• pp.257-261
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• 2001

Recently, a traditional medicine called Gouteng-san, which consists of eleven herbs, was reported to be effective in treating vascular dementia with a double-blind, placebo-controlled study. Gout-eng-san is also used for patients with vascular dementia in combination with Si-Wu-Tang. The effect of Gouteng-san and Si-Wu-Tang on deficit of learning behavior was investigated using step-down passive avoidance task in mice. Hot-water extract of Gouteng-san (1.5 and 6 g/kg, p.o.) significantly prolonged the step-down latency shortened by scopolamine. The extract of Uncaria hook (150 mg/kg, p.o.), one of the component herb of Gouteng-san, significantly prevented the decrease in the latency after scopolamine. Hot-water extract of Si-Wu-Tang (1.5 and 6 g/kg of dried herbs, p.o.) prevented dose-dependently scopola-mine-induced disruption qf learning behavior. Si-Wu-Tang also prevented the ischemia-induced deficit of learning behavior. Both hot water extract of peony and angelica (1.5 g/kg, p.o.), which are component herbs qf Si-Wu-Tang, prevented the scopolamine-induced learning behavior deficit. Scopolamine (10 uM) suppressed long-term potentiation (LTP) of population spike in the CA1 region of the rat hippocampal slices. Peoniflorin (0.1~ 1uM) extracted from paeony root significantly ameliorated scopolamine-induced inhibition of LTR These results suggest that improvement of deficit of learning behavior by Gouteng-san and Si-Wu-Tang is mediated by direct and/or indirect activation of the cholinergic system in the brain.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1984년도 학술대회지
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• pp.97-105
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• 1984

홍삼 추출물이 스트레스에 노출된 생쥐의 행동에 미치는 영향을 다음과 같은 실험을 통하여 연구하였다. 1. 줄타기 테스트와 같은 강제적 운동 2. 매달리기와 같은 스트레스에 노출된 생쥐의 기억력의 감퇴 및 직장 체온의 변화 3. 매달리기와 같은 만성적 스트레스에 노출된 생쥐의 성행동능과 학습행동능 4. 매달리기와 같은 만성적 스트레스에 노출된 성숙한 암컷쥐의 성주기 변화 5. $40{\%}$의 알콜을 투여한 후 rotar-rod및 step-through테스트를 통한 운동자율능과 수동성 시도 기피반응 홍삼의 투여는 경구투여 방법을 택하였다. 1. 강제적 운동을 시키기 전에 인삼을 투여하면, 강제적 운동수행능이 증가되었다. 2주동안 하루에 1회 강제적 운동을 시킨 후 바로 인삼을 투여하면. 생쥐의 강제적 운동수행능의 감소가 억제되었다. 2. 4일동안 하루에 1회 스트레스에 노출시킨 후 인삼을 경구 투여하면 step-through와 step-down 테스트에 대한 수동성 기피반응의 쇠퇴를 지연시켰으며, 직장온도의 감소를 억제하였다. 3 인삼투여는 성능력의 감퇴와 수동성 기피반응 수행능의 감퇴를 개선하였고. 수동성 기피반응의 쇠퇴를 지연시켰다. 인삼의 투여는 스트레스에 노출된 후 하루에 한번씩 2주동안 투여하였다. 4. 인삼투여로 스트레스에 의한 성주기의 파괴와 직장온도가 감소되는 것이 방지되었다. 5. 인삼투여로 알콜유발성 운동실조와 기억의 습득 및 회복의 저해가 보호되었다.

• International Journal of Industrial Entomology and Biomaterials
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• 제15권1호
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• pp.39-45
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• 2007

Extracts of adult worker bodies of Vespa simillima in 2 % NaCl or acidified methanol were administered orally to mice for 70 days. Following this period, memory at one-day and one-month periods, and the effects on scopolamine-induced amnesia were examined using a step-through passive avoidance task. Changes in MK-801-induced disability after 8 days of training, and in memory one month after the trial were also assessed. Mice treated with the 2% NaCl extract showed significant improvement in memory in the behavioral tests one month after the trial, whereas mice receiving the extract in acidified methanol, did not differ from the controls in any trial. The results inidicate that Vespa simillima contains substances acting favorably on the cerebral functions of mammals.

• 생약학회지
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• 제47권4호
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• pp.319-326
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• 2016

We investigated the effect of Selaginella tamariscina extract on the learning and memory impairments in scopolamine-induced (5 mg/kg, i.p.) dementia rats. Rats treated with oral tacrin (20 mg/kg, p.o.) as positive control group and S. tamariscina extract 100, 200mg/kg, p. o. (SME 100, SME 200) as experimental group had significantly reduced scopolamine-induced memory deficits in the passive avoidance test. The acetylcholine content were paralleled the results of the behavior experiment. The acetylcholine contents of the experimental groups (SME 200 group) was higher than that of control group. We also evaluated expression of VAchT, vesicular acetylcholine transporter. SME was significantly increased VAchT expression on hippocampus of scopolamine-induced dementia rats. We suggest that S. tamariscina might exert a significantly neuro-protective effect on cognitive impairment.

• 자동차안전학회지
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• 제14권3호
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• pp.60-64
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• 2022

In the automotive industry, the development of automobiles to meet safety requirements is becoming increasingly complex. This is because quality evaluation agencies in each country are continually strengthening new safety standards for vehicles. Among these various requirements, collision safety must be satisfied by controlling airbags, seat belts, etc., and can be defined as post-crash safety. Apart from this safety system, the Advanced Driver Assistance Systems (ADAS) use advanced detection sensors, GPS, communication, and video equipment to detect the hazard and notify driver before the collision. However, research to improve passenger safety in case of an accident by using the sensor of active safety represented by ADAS in the existing passive safety is limited to the level that utilizes the sudden braking level of the FCA (Forward Collision-avoidance Assist) system. Therefore, this study aims to develop logic that can improve passenger protection in case of an accident by using ADAS information and driving information secured before a collision. The proposed logic was constructed based on LSTM deep learning techniques and trained using crash test data.

• 대한본초학회지
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• 제29권6호
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• pp.103-109
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• 2014

Objectives : The purpose of this study aimed to investigate that dieckol - isolated from Ecklonia cava - supplementation can improve cognitive ability in mice. Methods : 48-male mice(6 weeks old) were divided into four groups; High-Dieckol group(n=12), Low-Dieckol group(n=12), Placebo group(n=12), Control group(n=12) and they were administered orally 5 days per week for 4 weeks at the same time. We performed Morris water maze test, Passive avoidance test, Blood serotonin analysis. And there was examined on neurogenesis in dentate gyrus of hippocampus using 5-bromo-2'-deoxyuridine (BrdU) to label proliferating cells. Results : The results are as follows; As a Morris water maze results, Trial duration was significantly decreased in high dieckol group comparing to placebo group and control group. Distance to target was significantly decreased in high dieckol group and low dieckol group comparing to placebo group and control group. Mean speed was significantly low in high dieckol group comparing to low dieckol group, placebo group and control group. As a Passive avoidance test results, latency time was significantly long in high dieckol group comparing to low dieckol group, placebo group and control group. BrdU cell count was significantly high in high dieckol group comparing to low dieckol group, placebo group and control group. Conclusions : As a conclusion, it is considered that dieckol supplementation might improve learning and cognitive ability.

• 동의신경정신과학회지
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• 제22권2호
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• pp.85-105
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• 2011

Objectives : The purpose of this study was to characterize the neuroprotective effects and anxiolytic-like effects of Gongjin-dan and Polygala japonica, Polygala tenuifolia, Acorus gramineus mixed pills(G.J.D-P.P.A.). Methods : The neuroprotective effects of G.J.D-P.P.A. determined by the passive avoidance and Y-maze tasks and Morris water maze task, and the anxiolytic-like effects of the G.J.D-P.P.A. using an elevated plus-maze(EPM) in mice. Results : Drug-induced amnesia was induced by treating animals with scopolamine(1 mg/kg, i.p.). A single G.J.D-P.P.A.(400 and 800 mg/kg) administration significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks(P < 0.05) and also reduced escape-latency on the Morris water maze task(P < 0.05). The administration of GJD-PPA(400 and 800 mg/kg) significantly increased the percentage of time spent in open arms and entries into the open arms of the EPM compared with saline-treated control group(P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with saline-treated control group. Conclusions : These results suggest that GJD-PPA dramatically possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and promotes the anxiolytic-like activity in mice.

• Preventive Nutrition and Food Science
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• 제20권2호
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• pp.126-132
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• 2015

This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine- induced memory impairment in rats. GW were fermented by the lactic acid bacterium Bifidobacterium bifidum (FGWB), followed by Lactobacillus sakei LI033 (FGWBL). To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally injected into rats 30 min before the behavioral tests. Step-through latencies of rats treated with primary fermented extracts (300 mg/kg, FGWB) and secondary fermented extracts (300 mg/kg, FGWBL) were significantly longer than those of rats treated with GW (300 mg/kg) in the retention trial of the multiple trial passive avoidance test. In the Morris water maze task, FGWBL significantly shortened escape latencies in training trials. Furthermore, swimming times within the target zone during the probe trial with FGWBL were significantly higher than the GW and FGWB treatments. In addition, acetylcholinesterase activities were lower in the brains of scopolamine-treated rats treated with FGWBL. These results suggest that FGWBL could be useful to enhance learning memory and cognitive function via cholinergic dysfunction.