International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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The Effect of Vespa simillima Extracts on Long-Term Memory and MK-801-Induced Learning Disability in Mice

  • Fujiwara, Yumiko (Department of Agro-Bioscience, Faculty of Agriculture, Iwate University) ;
  • Kobayashi, Haruo (Department of Veterinary Medicine, Faculty of Agriculture, Iwate University) ;
  • Kawai, Shigenao (Department of Applied Biochemistry, Faculty of Agriculture, Iwate University) ;
  • Suzuki, Koichi (Department of Agro-Bioscience, Faculty of Agriculture, Iwate University)
  • Published : 2007.09.30
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Abstract

Extracts of adult worker bodies of Vespa simillima in 2 % NaCl or acidified methanol were administered orally to mice for 70 days. Following this period, memory at one-day and one-month periods, and the effects on scopolamine-induced amnesia were examined using a step-through passive avoidance task. Changes in MK-801-induced disability after 8 days of training, and in memory one month after the trial were also assessed. Mice treated with the 2% NaCl extract showed significant improvement in memory in the behavioral tests one month after the trial, whereas mice receiving the extract in acidified methanol, did not differ from the controls in any trial. The results inidicate that Vespa simillima contains substances acting favorably on the cerebral functions of mammals.

Keywords

References

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