• Biomolecules & Therapeutics
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• v.32 no.1
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• pp.146-153
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• 2024

The LEPR (leptin receptor) genotype is associated with obesity. Gut microbiome composition differs between obese and non-obese adults. However, the impact of LEPR genotype on gut microbiome composition in humans has not yet been studied. In this study, the association between LEPR single nucleotide polymorphism (rs1173100, rs1137101, and rs790419) and the gut microbiome composition in 65 non-obese Korean adults was investigated. Leptin, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels were also measured in all participants. Mean ± SD (standard deviation) of age, body mass index, and leptin hormone levels of participants was 35.2 ± 8.1 years, 21.4 ± 1.8 kg/m², and 7989.1 ± 6687.4 pg/mL, respectively. Gut microbiome analysis was performed at the phylum level by 16S rRNA sequencing. Among the 11 phyla detected, only one showed significantly different relative abundances between LEPR genotypes. The relative abundance of Candidatus Saccharibacteria was higher in the G/A genotype group than in the G/G genotype group for the rs1137101 single nucleotide polymorphism (p=0.0322). Participant characteristics, including body mass index, leptin levels, and other lipid levels, were similar between the rs1137101 G/G and G/A genotypes. In addition, the relative abundances of Fusobacteria and Tenericutes showed significant positive relationship with plasma leptin concentrations (p=0.0036 and p=0.0000, respectively). In conclusion, LEPR genotype and gut microbiome may be associated even in normal-weight Korean adults. However, further studies with a greater number of obese adults are needed to confirm whether LEPR genotype is related to gut microbiome composition.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.4 no.1
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• pp.133-146
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• 1997

The objective of this study was to clarify whether there are any differences between normal and over-weight adults in their perceived weight, health status, health conception and health promoting behavior. The sample consisted of 238 normal weight and 106 over-weight(11% above on the Body Index Scale) adults, more than 20 years-old, who live in Seoul metropolitan. One participant per household was selected for conveneience. The findings from this study are summarized below. 1) Among 106 overweight adults, 30 were above 20% on the Body Index Scale and 11 were above 30%. Twenty-one(19.8%) of the overweight group and 34(14.4%) of the normal weight group had one disease, and there were 30(28.3%) in the overweight group and 46(19.6%) in the normal weight group where one of the family members had a disease, but these differences were not statistically significant. The average monthly family income for the overweight group was \2,220,000 compared to \2,070,000 for the normal weight group, and this difference was statistically significant. The age range for the whole group was between 20 and 74(mean=35.6 for total, 39.4 for overweight and 34.0 for normal weight group). Again significant difference was found. Occupations were salaryman(57.6%), teacher(7.4%), student(5.4%) and others(27.3%). Fifty-six salaryman(70.0%) from the overweight group and 92(52.0%) from the normal group did not consitute a statistically significant different. For the educational status, 90(87.5%) of the overweight adults and 222(93.7%) of the normal weight group finished high school or more educational courses, and there was significant statistical difference. Ninety-two(86.8%) of the overweights and 156(65.5%) of the normal weight group were married, and again significant statistical difference was found. 2) A test for difference in health characteristics between the two weight groups indicated that two groups did not show statistical differences in their perceived health status, health conception or health promoting behavior. That is, the overweight group also perceive their health status as good as the normal group, and regard 'Health' as a state that enables them to carry out social roles and functions rather than as the traditional concept of health as no disease or no symptoms. Both group showed slightly high level of health promoting behavior. To determine if no statistical difference might be related to the overweight group's failure of perceive themselves as overweight, the perceived and objective overweight status were compared by the Pearson Correlation Analysis, and a strong corelationship was found(r=.76, p=.000). That is, if participants perceived themselves as overweighted, they thought and replied to be got more weight comparing to the other person who are in same age and sex. However, 43(18.1%) of the normal group perceived themselves as being overweight and 28(26.4%) of the overweight group thought they were of normal weight. Even though the overweight group employed in this study perceived themselves as being overweight, they regarded themselves as healthy as those in the normal weight group. It was shown that there was no statistical difference between the two groups in health conception, health status and health promoting behavior. 3) Perceived health conception was shown to be significantly related to health promoting behavior(r=.20, p=.004 for whole group ; r=.27, p=.009 for overweight group ; and r=.21, p=.001 for normal group). It means that in both group the higher perceived health conception level, the more frequent health promoting behavior. And, perceived health status was also shown to be significantly related to health promoting behavior(r=.16, p=.000) as a whole and especially for overweight group(r=.24, p=.018), but no significant relationship for normal group(r=.08, p=.620). 4) By means of multiple regression analysis, health conception, perceived health status, age, sex and marital status provided predicted 15.18% on health promoting behavior.

• Journal of Animal Science and Technology
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• v.54 no.5
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• pp.337-340
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• 2012

The genetic connectedness between herds is an essential requirement to make robust across-herd estimation of the breeding values of the animals. In this study, genetic connectedness between herds was evaluated by a connectedness rating method. A total of 24,971 records of days to 90 kg (D90KG) of the pigs on performance testing programs collected from six herds (labeled from 'A' to 'F') of Duroc breed along with pedigree information comprising 456,697 families were used. Results showed that a total of eight boars were used for semen exchange programs among participant farms. Herds 'A' through 'E' were found strongly connected among them. But 'F' herd was genetically connected strongly only with 'A' herd. The highest average connectedness rating was 91.7% between 'A' herd and 'C' herd. The lowest average connectedness rating was 65.1% between 'D' and 'F'. The concept of a single genetic group comprising six Duroc herds studied is meaningful due to high connectedness rates among them. Therefore, with this high genetic ties between participant Duroc farms, the more accurate genetic evaluation would be possible.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.6
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• pp.1449-1461
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• 2013

In this study, We analyzed whether the quality of marine leisure sports experience have effects on participants satisfaction, immersion and 5motive for reparticipation. We also investigated effect of participants' pre-experience of participating race on satisfaction, immersion and motive for reparticipation. Sense of freedom and social interaction appeared to affect satisfaction of participants significantly, but the sense of control did not. Sense of freedom had effect on immersion, whereas sense of control and social interaction had no effect on immersion. Significant relationship between motive for reparticiaption and participants' satisfaction and immersion was observed. Interaction effect between participant's satisfaction and was significant. Immersion mediates relation between reparticiaption and participants' satisfaction, participants experienced yahct race before showed more effect of satisfaction on motive for reparticiaption than participants with no race experience, who showed no significant effect of satisfaction on motive for reparticiaption. Immersion have effect on motive for reparicipation in both groups, but effect size was greater in the group with race experience. Thus, satisfaction and immersion of participants who have pre-experience of participating race showed greater effect on reparticipation than who haven't.

• Journal of Korean Medicine Rehabilitation
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• v.23 no.4
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• pp.185-194
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• 2013

Objectives The aim of this study was to evaluate the efficacy and safety of micro current taping therapy (MTT) on patients with chronic low back pain (CLBP). Methods We included 50 participants who met the inclusion criteria and 5 participants dropped out during the sessions due to the following reasons: 3 participants were personal reasons, 1 participant was taking medication, 1 participant was fore arm fracture. We attached "I" shaped 40 cm, 2 tapes along the erector muscles of the spine starting from both iliac crest and another "I" shaped 30 cm, 1 tape on the painful site horizontally. This procedure was done 8 times and participants visited a total of 9 times including a final visit for evaluation. We measured visual analog scale (VAS), range of motion (ROM) and schober's test on every visit. Participants completed a questionnaire of oswestry disability index (ODI) and Beck's depression inventory (BDI) on the first and last visits. Results In VAS for pain intensity and bothersomeness, there were significant decreases after 1st, 6th treatments. In range of extension, there was significant increase after 3rd treatment at first. In range of flexion, there was significant increase after 2nd treatment at first. In range of left flexion, there was significant increase after 4th treatment at first. In range of right flexion, there was significant increase after 3rd treatment at first. in schober's test, there was significant increase after 2nd treatment at first. In VAS, ROM, schober's test, BDI, ODI, there were significant improvement after all treatments had done. Conclusions There was a significant effect of MTT on CLBP. And there was no adverse effect.

• Korean Journal of Cognitive Science
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• v.22 no.3
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• pp.255-270
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• 2011

The purpose of this study was to examine the effects of nonspecific and specific cue on decision making during situation awareness. Participants were 36 male college students who were randomly assigned to one of three groups: (1) nonspecific situation awareness, (2) specific situation awareness, and (3) a control group. Every participant was in the level 3-4.5 according to American National Tennis Level Program. Participants were asked to watch tennis single defence, single offence, double defence rally and when the screen stops, they were required to push the button(left, middle, or right) appropriate for the ball's direction to return as soon as possible. The experiment was designed to be analyzed for group(3)${\times}$condition(3)${\times}$area(7) using three-way ANOVA. The dependent variables were reaction time, accuracy rate, and amplitude and latency of P300. The result showed that the latency of the nonspecific situation awareness group and the specific situation awareness group was shorter and their amplitudes were higher than the control group. Fz, Cz, Pz were prominent among areas, and the single defence condition was more prominent than the single offence and the double defence condition. As a result of the study, it can be suggested that the information about situation awareness provided beforehand directly affects the brain's information processing. In addition, it shows that ERP can be a useful index for studying situation awareness.

• Industry Promotion Research
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• v.5 no.2
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• pp.41-50
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• 2020

WIn Korea, the rapid rise of elderly population and dementia prevalence resulting from the unprecedently rapid aging in the world is being emerged as a serious social issue. Caring the elderly with dementia is a different way from a general life and is a world which new cultural existential relationships are interlaced from the relationship viewpoint. From this aspect, the psychological matter of family caring a demented elderly needs to be studied for existential understanding in depth and fundamentally. This study focused on in-depth understanding and description of the stress phenomena experienced by family caregivers with a demented elderly based on Giorgi's method among phenomenological research methods and using existential group counseling techniques. Total 8 sessions of existential group counseling were conducted. This study drew out the outcomes(emotional stress, psychosocial stress, time-dependent stress) of participants' self-awareness experiences by applying 4 steps of Giorgi's phenomenological research methodology based on the Existential Philosophy to participant's intensive statements about stress of family caring a demented elderly drawn out of the existential group counselling sessions. It is hoped that understanding the pain of the supporters who cannot express their own pains through the research results and their self-help group counseling activities will become active, contributing to the health of our society which is about to enter post-aged society.

• Journal of Distribution Science
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• v.13 no.5
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• pp.61-70
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• 2015

Purpose - This study investigates whether the effectiveness of self trait-advertisement versus communion-focused advertisement on product evaluations depends on a type of pride felt as ambient emotion. It also explores whether the mediating roles of cognitive and affective response to the effect of the advertisement type on product evaluation are moderated by types of pride such as hubristic pride or authentic pride. Research Design, Data, and Methodology - This research uses a restaurant service as the experimental object and employs a 2 (pride type: hubristic pride vs. authentic pride) × 2 (advertisement type: self trait-focused advertisement versus communion-focused advertisement) between-subjects design, with cognitive response and affective response as within-subject. Each experimental group consisted of 40 undergraduate students assigned to participate in the experiment. One questionnaire from the authentic pride and self-trait focused advertisement group and two questionnaires from the hubristic pride and communion-focused advertisement group were removed due to answer errors, resulting in a participant number of 157. The author conducts a 2 (pride type: hubristic pride vs. authentic pride) × 2 (advertisement type: self trait-focused advertisement versus communion-focused advertisement) ANOVA on advertised product evaluations, and to better understand the interaction effects, also conducts separate analysis of the hubristic and the authentic pride groups. Additionally, the study conducts mediated moderation analysis to check the mediation role difference of the cognitive response and the affective response to each advertisement on the interaction effects on product evaluations between the hubristic and the authentic pride groups. Results - The findings indicate that participants in the hubristic pride group more positively evaluate the product in self-trait focused advertisement, whereas participants in the authentic pride group more positively evaluate the product in communion-focused advertisements. In addition, the mediating role of cognitive response on the positive interaction effect of advertisement type and pride type on product evaluation is partially moderated by the pride type. However, the mediating role of affective response on the positive interaction effect of advertisement type and pride type on the product evaluation is not moderated by the pride type. Conclusions - The results of this study contribute to advertisement theory development by exploring interaction effects of ambient pride type and advertisement type on product evaluation, as well as to the theory of consumer behavior by exploring how pride type moderates the mediating roles of cognitive response on the positive interaction effect of advertisement type and pride type on product evaluation. From the perspective of the current research, advertisers should research what kinds of events consumers have experienced to increase the effectiveness of their advertisements, and use self-trait advertisements when consumers are grouped under ambient hubristic pride, and use communion-focused advertisements when consumers are grouped under ambient authentic pride. However, future research is necessary to discover the reasons why the mediating role of affective response to advertisements in the interaction effects of pride type and advertisement type on product evaluation is not moderated by pride type.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.5
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• pp.423-431
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• 2021

Purpose: To assess the effect of combination probiotic Saccharomyces boulardii CNCM-I 3799 and Bacillus subtilis CU-1 in outpatient management of acute watery diarrhea in children. Methods: A randomized double-blind placebo-controlled study was conducted in 180 participants aged six months to five years with acute mild to moderate diarrhea. All were enrolled from six centers across India and centrally randomized to receive S. boulardii CNCM-I 3799 and B. subtilis CU-1 or a placebo along with oral rehydration salts and zinc supplementation. Each participant was followed up for three months to assess recurrence of diarrhea. Results: The mean duration of diarrhea in the probiotic and placebo groups were 54.16 hours and 59.48 hours, respectively. The difference in the duration of diarrhea in those administered with probiotic or placebo within 24 hours of diarrhea onset was 25.21 hours. Furthermore, the difference in duration of diarrhea was 13.84 hours (p<0.05) for participants who were administered with probiotics within 48 hours. There were no significant differences in the stool frequencies between the two arms. After three months, 15% in the probiotic group and 18.5% in the placebo group reported episodes of diarrhea. The mean duration of diarrhea was considerably lower in the probiotic group, 31.02 hours versus 48 hours in placebo (p=0.017). Conclusion: S. boulardii CNCM-I 3799 and B. subtilis CU-1 combination was effective in reducing the duration of diarrhea when administered within 48 hours of diarrhea onset. Similarly, it reduced recurrence of diarrhea and its intensity in the subsequent three months.

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.303-316
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• 2021

This study is aimed at verifying the effects of an ETC(Expressive Therapies Continuum)-based group art therapy program on reducing parental anxiety in first-grade elementary school students' mothers. An ETC program was composed based on the therapeutic factors of the ETC components. Seven mothers of first-grade students located in city A of Gyeonggi-do were selected as the subjects of the study. These mothers underwent 11 sessions of ETC-based group art therapy from April 18 to May 24, 2019, 1 to 2 times a week for 70 to 90 minutes. In order to verify the effectiveness of this research program, scores from pre- and post-parental anxiety scales were analyzed using SPSS 24.0 program. Results demonstrated that first, mothers' parental anxiety was significantly reduced after the ETC program participation. Second, changes in ETC component use throughout the program positively influenced reductions in parental anxiety. In conclusion, each participant experienced the opportunity to self-explore and self-understand at all levels of ETC with their preferred art medium, thereby lowering parenting anxiety. It is meaningful that through the ETC-based art therapy program, the client can be self-aware of his or her problem, and the client can decide the direction that is beneficial to them through voluntary media selection. In addition, it is meaningful that the ETC group art therapy is able to perform activities tailored to each individual.