• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2009.10a
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• pp.239-240
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• 2009

Vessels stability problems need to resolve the nonlinear mathematical models of rolling motion. For nonlinear systems subjected to random excitations, there are very few special cases can obtain the exact solutions. In this paper, the specific differential equations of rolling motion for intact ship considering the restoring and damping moment have researched firstly. Then the partial stochastic linearization method is applied to study the response statistics of nonlinear ship rolling motion in beam seas. The ship rolling nonlinear stochastic differential equation is then solved approximately by keeping the equivalent damping coefficient as a parameter and nonlinear response of the ship is determined in the frequency domain by a linear analysis method finally.

• Industrial Engineering and Management Systems
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• v.2 no.1
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• pp.55-62
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• 2003

This paper deals with the difficulties involved in analyzing and designing a management system to reduce the risks and improve the productivity of new product development. In this paper, a method is described to analyze user information and determine product specifications based on a stimulus-response model, the conjoint measurement of users needs, and product characteristics deployment. The proposed method can analyze the effect of a partial price on the contribution ratio based on the order of preference of product profiles through a smaller number of product profiles. The strengths and weaknesses of this method are examined as the method is applied to the case study of a mobile computer intended for personal use.

• Proceedings of the Korea Water Resources Association Conference
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• 2000.05a
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• pp.1-2
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• 2000

This paper introduces the equivalent frequency response method (EFRM) into runoff analysis. This EFRM originally had been developed to analyze dynamic behavior of nonlinear elements such as threshold and saturation in control engineering. Many runoff models are described by nonlinear ordinary or partial differential equations. This paper presents that these nonlinear differential equations can be converted into semi-linear ones based on EFRM. The word of “a semi-linear equation” means that the coefficients of derived equations depend on average rainfall

• The Plant Pathology Journal
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• v.38 no.2
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• pp.146-158
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• 2022

Changes in physiological and biochemical patterns in lucerne plants caused by the presence of 'Candidatus Phytoplasma australasia', which is one of the significant pathogens causing yield losses in lucerne plants, were investigated. Significant differences were evident in total chlorophyll, chlorophyll a, chlorophyll b, and protein amounts between 'Ca. Phytoplasma australasia'-positive and negative lucerne plants. Stress-related metabolites such as phenol, malondialdehyde, and proline accumulations in 'Ca. Phytoplasma australasia'-positive plants were remarkably higher than those of phytoplasma-negative plants. As a response to disease attack, phytoplasma-positive plants exhibited higher antioxidant enzymes (peroxidase and catalase) and nonenzymatic metabolite responses such as jasmonic and salicylic acids. We state that partial disease responses were revealed for the first time to breed resistant lucerne lines infected by 'Ca. Phytoplasma australasia'.

• Coupled systems mechanics
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• v.11 no.6
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• pp.485-504
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• 2022

This paper presents nonlinear oscillations of a carbon nanotube reinforced composite beam subjected to lateral harmonic load with damping effect based on the modified couple stress theory. As reinforcing phase, three different types of single walled carbon nanotubes distribution are considered through the thickness in polymeric matrix. The non-linear strain-displacement relationship is considered in the von Kármán nonlinearity. The governing nonlinear dynamic equation is derived with using of Hamilton's principle.The Galerkin's decomposition technique is utilized to discretize the governing nonlinear partial differential equation to nonlinear ordinary differential equation and then is solved by using of multiple time scale method. The frequency response equation and the forced vibration response of the system are obtained. Effects of patterns of reinforcement, volume fraction, excitation force and the length scale parameter on the nonlinear responses of the carbon nanotube reinforced composite beam are investigated.

• Journal of Yeungnam Medical Science
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• v.39 no.1
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• pp.62-66
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• 2022

Immune checkpoint inhibitor (ICI)-associated adrenal insufficiency is rare but may become a serious adverse event in patients treated with ICIs. The present case report documents two cases of adrenal insufficiency developed during chemotherapy plus tislelizumab (百泽安, Baize'an; BeiGene Ltd.) therapy in patients with advanced gastric cancer. Adrenal insufficiency developed after 6 and 13 cycles of treatment and was well controlled with hydrocortisone. The patients also developed hypothyroidism, which was managed with levothyroxine. Two patients showed a partial response, and one patient out of two achieved a near-complete response, sustaining over 11 months. Increased awareness of ICI-related adrenal insufficiency is crucial for early detection and prompt management of patients treated with ICIs.

• Structural Engineering and Mechanics
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• v.85 no.4
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• pp.545-562
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• 2023

In this work, superharmonic and subharmonic resonance of rotating stiffened FGM truncated conical shells exposed to harmonic excitation in a thermal environment is investigated. Utilizing classical shell theory considering Coriolis acceleration and the centrifugal force, the governing equations are extracted. Non-linear model is formulated employing the von Kármán non-linear relations. In this study, to model the stiffener effects the smeared stiffened technique is utilized. The non-linear partial differential equations are discretized into non-linear ordinary differential equations by applying Galerkin's method. The method of multiple scales is utilized to examine the non-linear superharmonic and subharmonic resonances behavior of the conical shells. In this regard, the effects of the rotating speed of the shell on the frequency response plot are investigated. Also, the effects of different semi-vertex angles, force amplitude, volume-fraction index, and temperature variations on the frequency-response graph are examined for different rotating speeds of the stiffened FGM truncated conical shells.

• Asia pacific journal of information systems
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• v.33 no.3
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• pp.603-623
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• 2023

While prior work has conducted individuals' password security behavior, there is a relatively neglect to examine individuals' affect and feelings of password fatigue in password change context. Therefore, this study explicated individuals' affective response to the feelings of password fatigue by drawing on several theoretical lens. Survey data collected from 267 users were used to test the model using partial least square analysis. This study found that feelings of password fatigue positively affected the negative password fatigue-induced affect, and also both the feelings of password fatigue and the negative password fatigue-induced affect were negatively related to attitude toward changing passwords, which in turn, leads to the intention to change passwords. Furthermore, this study found that shadow work recognition negatively moderated the relationship between attitude and behavioral intention. This study could offer a new theoretical perspective to understand an individual's security behavior and provide empirical evidences for practitioners in charge of IT security in organizations.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2401-2406
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• 2013

From January 1, 2008 to March 31, 2010, 101 patients with stage II-III breast cancer were enrolled in this study and subjected to an anthracycline-based neoadjuvant chemotherapy regimen with or without docetaxel. Surgery was performed after 2-6 cycles of chemotherapy, and the clinical response was determined by pathological and histochemical assessments. The clinical response rate, as indicated by complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD), were 6.9, 52.5, 36.6, and 4.0%, respectively. A multivariable correlation analysis indicated that the overall clinical response rate correlated with the number of metastatic lymph nodes, number of chemotherapy cycles, and vessel invasion status. Importantly, the CR rate was only associated with the number of chemotherapy cycles. Nonparametric tests failed to detect a correlation between HER2 or Topo $II{\alpha}$ status and clinical response to neoadjuvant chemotherapy in these patients. When they were stratified by HER2 or HR status, for HER2-positive patients the CR rate was associated with vessel invasion and Topo $II{\alpha}$ status. Based on our findings, we propose that HR, HER-2 and Topo $II{\alpha}$ are not putative predictive biomarkers of chemotherapy outcome for breast cancer patients. Topo $II{\alpha}$ expression level was only inversely correlated with CR rate among HR-positive patients. Importantly, the achievement of CR was largely related to the number of chemotherapy cycles.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.17 no.1
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• pp.31-36
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• 2014

Purpose: Infliximab (IFX) is considered safe and effective for the treatment of ulcerative colitis (UC) in both adults and children. The aim of this study was to evaluate the short- and long-term clinical course of IFX in Korean children with UC. Methods: Pediatric patients with UC who had received IFX infusions between November 2007 and May 2013 at Samsung Medical Center were retrospectively investigated. The clinical efficacy of IFX treatment was evaluated at 8 weeks (short term) and 54 weeks (long term) after the initiation of IFX treatment using the Pediatric Ulcerative Colitis Activity Index (PUCAI). The degree of response to IFX treatment was defined as complete response (PUCAI score=0), partial response (decrement of PUCAI score${\geq}20$ points), and non-response (decrement of PUCAI score <20 points). Adverse events associated with IFX treatment were also investigated. Results: Eleven pediatric patients with moderate to severe UC had received IFX. The remission rate after IFX treatment was 46% (5/11) and 82% (9/11) at 8 weeks and 54 weeks after IFX treatment, respectively. All patients who were steroid-dependent before treatment with IFX achieved remission at 54 weeks and were able to stop treatment with corticosteroids, while all steroid-refractory patients failed to achieve remission at 54 weeks after treatment with IFX. Conclusion: Response to IFX treatment after 8 weeks may predict a favorable long-term response to IFX treatment in Korean pediatric UC patients.