• 대한두개안면성형외과학회지
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• 제15권2호
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• pp.98-101
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• 2014

Sj${\ddot{o}}$gren's syndrome is a chronic autoimmune exocrinopathy that destroys salivary and lacrimal gland tissue. We report an unusual case of this disease in a 54-year-old woman who presented with multiple and bilateral parotid cystic masses. The multiple, small, bead-like cysts were clearly evident in the computed tomography sections in this patient, a visible reminder that this may be the initial presentation in a patient with Sj${\ddot{o}}$gren's syndrome. As the case illustrates, Sj${\ddot{o}}$gren's syndrome should be included in the differential diagnosis of multiple and bilateral cystic parotid lesions.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제38권1호
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• pp.38-43
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• 2012

Introduction: The location of parotid gland tumors in the superficial or deep lobes can affect the time and difficulty of operations. Therefore, accurate preoperative evaluation of the tumor location is important for surgical outcomes. Materials and Methods: A total of 16 patients with parotid gland tumors and who underwent a parotidectomy between April 2003 and March 2011 were retrospectively reviewed in terms of demographic background, tumor location, surgical treatment, and treatment outcomes. Tumor location was estimated by four landmarks on contrast enhanced computerized tomography scans, which were Conn's arc, the facial nerve (FN) line, the Utrecht line, and the retromandibular vein. Tumor location was confirmed by relative position depending on the facial nerve during surgery. It was assumed positive since the tumor lies in the superficial lobe of the parotid gland, the sensitivity, specificity, positive predictive value, negative predictive value, and efficiency of each landmark were evaluated. Results: Our result revealed that the facial nerve line had a sensitivity of 83.3%, specificity of 100%, positive predictive value of 100%, negative predictive value of 71.4%, and efficiency of 87.5%. Some would be more efficient preoperative evaluation methods of the relationship of parotid gland tumors to the facial nerve than others. Conclusion: In our study, the FN line was found to be the most reliable analysis method.

• 대한영상의학회지
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• 제83권2호
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• pp.394-399
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• 2022

백혈병의 골수 외 재발이 발생할 수 있지만 이하선은 드문 재발 부위이다. 이하선을 포함하는 골수 외 재발은 다른 질환과 혼동될 수 있으며 종종 질환의 희귀성으로 인해 진단이 지연될 수 있다. 이에 저자들은 재발성 급성 림프아구성 백혈병 환자에서 이하선의 급성 림프아구성 백혈병의 골수 외 재발 사례와 영상 소견을 보고한다.

• 대한두경부종양학회지
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• 제36권2호
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• pp.21-25
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• 2020

Sebaceous carcinoma is a relatively rare and aggressive malignant tumor. Periocular area (especially eyelid) is the most common lesion to occur, and the most common extraocular lesion is the parotid gland. Because the lesion also mimic other benign inflammatory diseases, this leads to delayed diagnosis or misdiagnosis. Here, we report a 58-year-old male patient who presented with a non-tender painless left parotid mass after wide excision of sebaceous carcinoma in the left eyelid two years ago. When he was diagnosed with sebaceous carcinoma of left eyelid, there was a small left parotid tumor on the computed tomography. But no further examination and treatment were performed. Two years later, physical examination revealed growing parotid tumor and multiple neck nodes on the left side. After radical parotidectomy and neck dissection, histological examination showed a sebaceous carcinoma and neck node metastasis. Considering the aggressiveness of sebaceous carcinoma, further evaluation for parotid glands should be considered when sebaceous carcinoma of the eyelid was discovered. Postoperative chemoradiotherapy was performed for disease control. Follow up after two years, and computed tomography showed no sign of recurrence.

• Archives of Plastic Surgery
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• 제44권5호
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• pp.439-443
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• 2017

Kimura disease is a rare idiopathic chronic inflammatory disorder. It typically presents in the head and neck area, whereas bilateral involvement is unusual. Its diagnosis requires it to be differentiated from other inflammatory diseases and from head and neck tumors. Treatment methods include conservative management, steroid administration, radiotherapy, and surgery; however, no single treatment of choice has been established. Herein, we report an unusual presentation of Kimura disease with bilateral parotid involvement. This case was treated by surgical excision.

• 대한두경부종양학회지
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• 제17권1호
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• pp.26-31
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• 2001

Background: Primary malignant lymphoma of the parotid gland is a rare disease and defined as any malignant lymphoma that first manifests in the parotid gland, regardless of the subsequent stage of the diseases, whether it arises in the parenchyma or intraglandular lymph nodes. This study was performed to review the clinicopathological characteristics of primary parotid lymphoma and identify its optimal treatment modality. Materials and Methods: Six cases with parotid mass as first presentation of malignant lymphoma between 1988 and 2000, were studied on the basis of clinical features, diagnostic tools, treatment modality, treatment outcomes, and clinical stage by Ann Arbor Criteria. All were microscopically reevaluated and classified by NCI working formulation. Results: All patients were males and mean age was 36.7 years (2-66 years). Rapid growing non-tender mass was presented in all the cases and cervical lymphnodes were palpated in 4 cases. However, there was not any evidence of concurrent autoimmune disease such as Sjogren's syndrom or Rheumatoid arthritis. One case was confirmed by surgical specimen after superficial parotidectomy, 2 by excisional biopsy, and 3 by incisional biopsy. The stage of disease by NCI working formulation was IE in 1 patient, IIE in 4 and IV in 1. All were classified into non-Hodgkin' lymphoma, of which there were 5 cases of B-cell type and 1 case of T-cell type. There were 3 diffuse large cell lymphomas, 1 Burkitt lymphoma, 1 MALT lymphoma and 1 T-lymphoblastic lymphoma. Three cases were treated by chemotherapy only, 2 by radiotherapy only and 1 by chemo-radiotherapy. One case with Burkitt lymphoma was died from the disease and one case was lost to follow-up. The others are alive with no evidence of recurrence. Conclusions: Although primary parotid lymphoma is rare and difficult to diagnose preoperatively, most were detected in early stage and showed a relatively good response to the chemotherapy or radiotherapy like other types of extranodal malignant lymphoma.

• Clinical and Experimental Pediatrics
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• 제56권10호
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• pp.451-455
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• 2013

Sialolithiasis is caused by the obstruction of a salivary gland or its excretory duct by the formation of calcareous concretions or sialoliths; this results in salivary ectasia and provokes subsequent dilation of the salivary gland. Sialolithiasis is relatively common, accounting for 30% of salivary diseases; however, it is rarely observed in childhood. This case report describes a 2-year-old male patient who complained of a painful swelling over the right cheek, and presented with palpable stones and pus discharge from the orifice of the right Stensen's duct. Computerized tomography of the neck confirmed the diagnosis, and the patient received intravenous empiric antibiotics combined with intraoral sialolithotomy. We also provide a review of the spectrum of concepts regarding the pathogenesis, diagnosis, and treatment of sialolithiasis.

• 대한두경부종양학회지
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• 제12권2호
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• pp.193-200
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• 1996

We performed a retrospective study to evaluate the effect of posterior approach to facial nerve in parotid surgery, being the standard procedure in our hospital, on postoperative facial palsy and to access the safety of this procedure in preserving the function of facial nerve. A series of 176 parotid surgeries from 172 patients from January 1989 to December 1994 was analyzed, of which, 2 Schwannomas, 4 Kimura's diseases, 6 preoperative facial palsies, and 4 intentional nerve resections for malignancy were excluded. Factors such as pathology of tumor, extent of surgery, location of tumor, size of tumor, frequency of surgery were reviewed to determine if any factor contributed to the developement of facial palsy postoperatively. Of 160 parotidectomies, postoperative facial palsy was found in 58(36.3%), being temporary in 35(35. 6%), recovered within 12 months after surgery and permanent in 1(0.6%). Facial palsy occured in 47(35.7%) of 128 benign tumors, 42(89.5%) recovered completely within 6 months and in 11(34.4%) of 32 malignant tumors, 6(54.5%) within 6 months. Among the factors analyzed, postoperative facial palsy was found to be common in the tumors of deep lobe(p<0.02) and in total or neartotal parotidectomies(p<0.08). In our study, the factors of the location of tumor and extent of surgery would be contributable to developement of postoperative facial palsy and the surgical technique using posterior approach to the facial nerve may be a simple and safe surgical procedure for identification and preservation of facial nerve in parotid surgery.

• Radiation Oncology Journal
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• 제4권1호
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• pp.21-27
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• 1986

이하선 악성종양의 치료는 근치적 수술이 주된 치료법으로 알려져 왔으나 이하선이 해부학적으로 주위의 근육, 골조직, 혈관, 신경등과 밀접하게 부착되어 있어 피막 및 주위 조직의 침윤이 있거나 조직학적으로 high grade tumor, 임파절 전이가 있는 경우 등에서 광범위한 근치적 수술로도 종양을 완전히 제거하기가 어렵고 수술 후 국소재발이 빈번한 것으로 알려져 있다. 수술만으로는 국소재발율이 상당히 높은 데도 북구하고 이 종양이 방사선치료에 반응하지 않는 것으로 잘못 인식되어져와서 수술후 방사선치료를 시행해 오지 않다가 근래에 와서 수술후 방사선치료가 실시되었고 수술만 시행한 경우에서보다 국소재발율이 현저히 감소한 것으로 보고되고 있어 현재는 방사선치료가 치료 결과를 향상시키는 중요한 치료방법으로 인식되고 있다. 이에 저자들은 1970년 1월부터 1982년 12월 사이 연세대학교 의과대학 연세암센터, 치료방사선과에서 이하선암으로 치료를 받은 31예를 대상으로 후향적 추적조사를 통하여 치료방법과 치료실패 양상을 분석하여 향후 치료방법의 실정과 치료 결과의 향상을 위하여 본 연구를 실시하였다.

• Journal of Oral Medicine and Pain
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• 제37권2호
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• pp.81-91
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• 2012

타액이 대부분의 구강 내 질환에 영향을 주는 것으로 알려져 있다. 반대로, 여러 전신적 조건이 타액의 흐름에 영향을 줄 수 있으며 이는 구강 건조증을 야기할 수 있는데, 특히 사회심리적 스트레스는 타액의 부족과 구강 건조증의 병인으로 큰 역할을 할 수 있다. 많은 연구에서 자율신경계 반응에 의한 스트레스의 타액선에의 거시적 효과에 중점을 두어왔다. 본 연구에서는 구속 스트레스 조건 하에서 백서(Rat) 이하선에서 clusterin의 변화를 관찰하였다. 연구를 위해, 10마리의 백서를 이용, 3그룹으로 구분하였다. 1) 그룹 1: 대조군으로 rat 2마리 2) 그룹 2 : 실험대조군으로 2마리를 두어 2시간 동안 restraint cone을 사용하여 구속스트레스를 부여 3)그룹 3 : 실험군으로 6마리를 두어 매일 2시간씩 restraint cone을 사용하여 구속 스트레스를 부여 백서는 스트레스 부여 후 즉시(그룹 2) 희생하거나 24, 48, 72 시간 후 희생하여 이하선을 절취하였다. Western blotting과 면역조직화학검사를 시행하여 다음과 같은 결과를 얻었다. 1. 백서의 이하선에서 clusterin이 약간 증가하였고 구속 스트레스 부여 직후 타액선관에서 명확하게 관찰되었다. 2. 백서의 이하선에서 clusterin은 구속 24시간, 48시간 후에 매우 감소되었으며, 타액선관에서도 소량 관찰되었다. 3. 백서의 이하선에서 clusterin은 구속 72시간 후 현저하게 증가되었으며, 역시 타액선관에 밀집하여 증가되었다.