• 대한한방내과학회지
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• 제25권4호
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• pp.391-400
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• 2004

Tremor is a rhythmic and involuntary muscular contraction characterized by oscillations of a part of the body. Tremor is a symptom of many disorders, including Parkinson's disease, essential tremor, orthostatic tremor, cerebellar disease, peripheral neuropathy and alcohol withdrawal. The appropriate treatment of tremor depends on accurate diagnosis of it's cause. Some tremors respond to treatment of underlying conditions. Senile tremor and Parkinson's tremor are more common in aged people. Yanghyulgupung-tang is effective herbal medication in blood deficiency-type senile tremor. Four cases of senile tremor and Parkinson's tremor are reported. All four patient were treated with Yanghyulgupungtang-gamibang and improvement was seen in all four.

• 대한한방내과학회지
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• 제38권2호
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• pp.103-109
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• 2017

Objective: To describe the effects of traditional Korean medicine (TKM) on a patient diagnosed with Parkinson's disease. Methods: The patient was treated with Korean medicine, including pharmacopuncture, acupuncture, and Chungpajunsin-bang. The Unified Parkinson's Disease Rating Scale (UPDRS) and modified Hoehn and Yahr staging (H-Y stage) were used to measure changes in amplitude and improvements in the patient's symptoms. Results: After treatment with the Korean medicine, according to the UPDRS and H-Y stage assessments, the patient's tremor improved, with the tremor amplitude decreasing from 30 cm to 5 cm. Conclusions: We suggest that TKM could be effective in reducing tremor in Parkinson's disease.

• 대한의용생체공학회:의공학회지
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• 제36권4호
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• pp.103-108
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• 2015

Discrimination of Parkinson's disease (PD) from Essential tremor (ET) is often misdiagnosed in clinical practice. Since tremor is time-varying signal, and dominant and harmonic frequencies are shown in tremor only with moderate or severe symptom, there are some limitations to use frequency related features. Moreover, patients with PD or ET can suffer from both resting tremor and postural tremor. In this study, 28 patients with PD and 17 patients with ET were enrolled. Tremor was measured with accelerations on the more affected hand during resting and postural conditions. The ratio of root mean square (RMS) of resting tremor to RMS of postural tremor, the mean coefficients of autocorrelation function (ACF), and the mean of differences of two adjacent coefficients of ACF at resting and postural were calculated and compared between PD and ET. The performance showed 98% accuracy with support vector machine and leave-one-out cross validation. In addition, the method accurately differentiated the patients with tremor-dominant PD from patients with ET, with 100% accuracy. Therefore, the developed algorithm can assist clinicians in diagnosing and categorizing patients with tremor, especially, patients with mild symptom or the early stage of a disease, for proper treatment.

• 한국인터넷방송통신학회논문지
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• 제19권6호
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• pp.145-152
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• 2019

파킨슨병은 3대 노인성 질환 중 하나로 인구 고령화에 따라 전 세계적으로 발병률이 증가하고 있으며, 질병이 진행될수록 시간적·경제적인 비용이 높아지기 때문에 병의 진행정도를 파악하는 것과 초기에 진단해내는 것이 매우 중요하다. 본 논문에서는 스마트폰을 이용하여 파킨슨병을 조기 진단(Pre-Screening)할 수 있는 방법을 제안하고자 하였다. 개발한 어플리케이션의 콘텐츠들은 탭핑(Tapping), 떨림(Tremor), 나선형 그리기(Spiral Drawing), 보행(Gait)으로 구성되어 있으며, 통합형 파킨슨병 평가척도(Unified Parkinson's Disease Rating Scale)의 Part III(운동성 검사)를 기반으로 하였다. 이를 활용하여 파킨슨병의 운동성 증상으로 알려져 있는 서동증(Bradykinesia), 진전(Tremor), 자세 불안정(Postural Instability)에 대한 정량적인 진단이 가능하며, 증상의 진행 정도에 대한 모니터링이 가능하다. 이러한 방법은 파킨슨병 진단 및 치료에 유용하게 사용될 수 있을 것으로 기대된다.

• 대한한방내과학회지
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• 제27권4호
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• pp.954-961
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• 2006

As society ages, the seriousness of Parkinson's disease in the elderly increases. This study was performed in order to evaluate the effect of Korean medical treatments on Parkinson's symptoms. An elderly patient was diagnosed with Parkinson's disease by clinical symptoms, which were resting tremor, pill-rolling tremor and mild bradykinesia. We treated her disease with Korean medical treatment, including herbal medicine and acupuncture therapy and excluding western medication. For the herbal medicine, Insamyangyeong-tang (人參養榮湯), Bobi-tang (補脾湯), Dokhwaljihwang-tang (獨活地黃湯) and Sipimijihwang-tang (十二味地黃湯) were primarily used. In result, the clinical symptoms, measured by unified Parkinson's disease rating scale (UPDRS) and modified Hoehn and Yahr stage (H-Y stage), of Parkinson's disease in this patient had improved after the Korean medical treatment. This study suggests that Korean medical treatments can be applicable to improve symptoms in patients with Parkinson's disease.

• 음성과학
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• 제8권3호
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• pp.173-184
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• 2001

The purpose of this study was to examine the effects of manipulating loudness and pitch in terms of speech intelligibility and voice of a patient with Parkinson's Disease. The subject, who was diagnosed as a patient with Parkinson's disease 11 years ago, demonstrated a severely breath voice with low intensity. The accuracy of articulation in consonants was intelligible only at the single word level, and the overall intelligibility in continuous speech was low. The results showed that the subject's articulation accuracy and speech intelligibility was significantly improved after having loudness and pitch training. Habitual Fo, Jitter, Shimmer, Fo tremor, Amp tremor were decreased after training. In addition, the value of HNR also increased after training. It was shown that the changes of these acoustic parameters were closely related to the decrease of breathiness in Parkinson's voice, and this decrease of breathiness affected speech intelligibility considerably. Based on the experimental results, it was claimed that the vocal training by manipulating the loudness and pitch could be highly effective in improving the voice quality and speech intelligibility in Parkinson's Disease.

• 동의신경정신과학회지
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• 제18권3호
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• pp.165-180
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• 2007

Parkinson's disease is a common neurodegenerative disorder charaterized by distal resting tremor, rigidity, and bradykinesia, and asymmetric onset. The patient was 38-year-old man who had Parkinson's disease diagnosed and complained resting and postural tremor, rigidity, bradykinesia and so on. He was treated by oriental medicine with acupuncture, herb medication, physical therapy, kinesitherapy and Korean psychotherapy; Eejeong-byunki, Jiun-goron. After treatment the symptoms of Parkinson' disease was reduced, but the patient was deconditioned through several seizures. This result suggested that the oriental medical therapy is recommanded for Parkinson's disease. But, the relation of Parkinson's disease and seizure should be studied.

• 한국운동역학회지
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• 제30권1호
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• pp.83-91
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• 2020

Objective: The study aimed to develop a functional performance index that evaluates the functional performance of Parkinson's patients, i.e., to integrate biomechanical measurements of walking, balance, muscle strength and tremor, and to use multiple linear regression with stepwise methods to identify the most suitable predictors for the progression of disease. Method: A total of 60 subjects were tested for sub-variables of four factors: walking, balance, isometric strength and hand tremors. Potential independet variables were extracted through correlation analysis of the sub-variables and dependent variables, Hoehn & Yahr scale. And then, a stepwise multiple regression analysis using the potential independent variables was performed to identify predictor of Hoehn & Yahr scale. Results: First, the results of the study showed that physical composition and gait had a relatively more correlated with the progression of the disease, compared to balance and hand tremor. Second, Parkinson's functional performance is characterized by dynamic pattern of walking, such as foot clearance and turning angle (TA) of walking, and a high-explained regression model is completed. Conclusion: The study emphasized the importance of walking variables and body composition in minor pathological features compared to Parkinson's patient's balancing ability and hand tremor. Specifically, it revealed that dynamic walking patterns functionally characterize patients. The results are worth considering when assessing functional performance related to the progression of the disease at the site.

• 사상체질의학회지
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• 제14권3호
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• pp.153-159
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• 2002

Parkinson's disease(PD) is characterized by chronic progress of mesencephalic dopaminergic neuronal death. Diagnostic criteria for PD require at least two of three motor sign: tremor, rigidity, or bradykinesia. Levodopa and the dopamine agonists are considerd first-line drug therapy. In the book ‘dongyi soose bowon(東醫壽世保元)’, Soyangin Gihwangbeakho-tang(地黃白虎湯) is used at Soyangin Interior-overheated-disease. This case is patient who is 69 years old lady, suffered by the tremor of jaw and a slight rigidity, bradykinesia etc. This patient was classified as Soyangin by features, somatotype and emotional patterns. She improved in the tremor of jaw and others with Gihwangbeakho-tang for 67days. The result revealed that Soyangin-Gihwangbeakho-tang was effected on the tremor of jaw and others with Parkinson's disease patient.

• Annals of Clinical Neurophysiology
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• 제8권2호
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• pp.135-145
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• 2006

Background: Parkinson's disease is movement disorder due to dopaminergic deficiency. It has been noted that cognitive dysfunction also presented on Parkinson's disease patients. But, it is not clear whether such a cognitive dysfunction was a dopaminergic dysfunction or cholinergic dysfunction. Using linear and non-linear analyses, we analysed the effect of cognitive and motor symptom on EEG change. Methods: EEGs were recorded from patients with Parkinson's disease and essential tremor, and normal controls during rest. We calculated the power spectrum, correlation dimension and Lyapunov exponent by using 'Complexity'program. The power spectrum, correlation dimension, and Lyapunov exponent were compared between Parkinson's disease patients and essential tremor patients. Results: Theta power was increased in Parkinson's disease patient group. Correlation dimension was increased in Parkinson's disease patients. Positive correlation was noted between MMSE and correlation dimension, and negative correlation was noted between MMSE and Lyapunov exponent. Lyapunov exponent was decreased in Parkinson's disease patient. Conclusions: We conclude that the state of Parkinson's disease patient is characterized by increased correlation dimension and decreased Lyapunov exponent.