• Journal of Korean Traditional Oncology
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• v.24 no.1
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• pp.1-9
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• 2019

Objective: The purpose of this study is to report the clinical effectiveness of advanced non-small cell lung cancer (NSCLC) with Samchilchoongcho-Jung (HAD-B1) in conjunction with Alectinib. Methods: The patient was diagnosed with Anaplastic lymphoma kinase (ALK) mutated (2+) non-small cell lung cancer adenocarcinoma stage IV, suffering from edema of lower extremities, dyspnea, pleural effusion, general weakness, insomnia. The patient being treated with Alectinib was treated with Samchilchoongcho-Jung (HAD-B1) for disease control and symptom management. The clinical outcomes were measured by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Numeral rating scale (NRS) and Eastern Cooperative Oncology Group (ECOG). Results: After treatment, dyspnea and edema of lower extremities was relieved from NRS 7 to 5, and 6 to 1 respectively. And ECOG score of the patient was improved from grade 3 to 2. During and after treatment, we didn't find any severe toxicities on laboratory findings. Conclusion: This case study suggests that Samchilchoongcho-Jung (HAD-B1) may improve symptom relief and life quality of NSCLC patient in conjunction with Alectinib.

• Journal of Korean Traditional Oncology
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• v.24 no.1
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• pp.19-28
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• 2019

Objective : The purpose of this study is to report and observe effects of Integrative Cancer Treatment (ICT) on metastatic breast cancer patient. Method : A left breast cancer patient diagnosed with recurrence on liver and bones April 2018. The patient had received paclitaxel chemotherapy for two months and discontinued it because of tumor progression and side effects. The patient has been treated with ICT since March 2018 and has been taking capecitabine since October 2018. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA15-3). The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA15-3), liver function test (AST, ALT), Eastern Cooperative Oncology Group performance status (ECOG PS), and numeric rating scales (NRS). Results : After the ICT, tumor size was partially decreased accompanying by reducing the levels of tumor markers. Major clinical symptoms induced by paclitaxel chemotherapy were improved. There were no severe adverse events induced by ICT based on National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0. Conclusion : This case suggests that ICT may have synergistic effect for the treatment of metastatic breast cancer patient in conjunction with capecitabine.

• Journal of Korean Traditional Oncology
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• v.23 no.2
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• pp.27-33
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• 2018

Objective: The purpose of this study is to report the therapeutic possibility of a primary peritoneal carcinoma (PPC) patient with Traditional Korean Medicine (TKM). Methods: A 37 years old female patient diagnosed with PPC suffered from operation site pain, neck pain, nausea, headache and fatigue after undergoing operation and chemotherapy (Paclitaxel/Carboplain). The patient was treated with acupuncture, pharmacoacupuncture, moxibution and herbal medicine. Laboratory study and National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0 were used to evaluate the safety and adverse events of treatments. The performance status was measured by Eastern Cooperative Oncology Group (ECOG) scale. Results: After treatments, cancer did not show any progression. Related symptoms such as postoperative pain, nausea, fatigue and quality of life have improved. Conclusion: This case study implies that TKM may have therapeutic possibility in treating PPC patient.

• Journal of Korean Traditional Oncology
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• v.23 no.2
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• pp.35-41
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• 2018

Objective: The purpose of this study is to report a metastatic adrenocortical carcinoma patient treated with wheel balanced cancer therapy (WBCT) regimen. Methods: A 52-year-old female patient diagnosed and incised with metastatic adrenocortical carcinoma visited the East West Cancer Center (EWCC) on Sep. 1st, 2018 for WBCT. The patient was treated with WBCT for an approximately 2 months, from Sep. 1st to Nov. 9th. Computed tomography (CT) was used to follow-up the tumor site. Laboratory analysis and National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0 were used to evaluate the safety of WBCT. Results: The surgical beds after surgery (Lt. Laparoscopic adrenalectomy) were maintained without recurrence at follow up chest CT, and related symptoms and quality of life (QOL) were improved during the WBCT. Conclusion: This case study suggests that WBCT may help to improve QOL of adrenocortical carcinoma patient.

• Journal of Microbiology and Biotechnology
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• v.31 no.10
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• pp.1420-1429
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• 2021

The safety of the probiotic strain Q180, which exerts postprandial lipid-lowering effects, was bioinformatically and phenotypically evaluated. The genome of strain Q180 was completely sequenced, and single circular chromosome of 3,197,263 bp without any plasmid was generated. Phylogenetic and related analyses using16S rRNA gene and whole-genome sequences revealed that strain Q180 is a member of Lactiplantibacillus (Lp., formerly Lactobacillus) plantarum. Antimicrobial resistance (AMR) genes were bioinformatically analyzed using all Lp. plantarum genomes available in GenBank, which showed that AMR genes are present differently depending on Lp. plantarum strains. Bioinformatic analysis demonstrated that some mobile genetic elements such as prophages and insertion sequences were identified in the genome of strain Q180, but because they did not contain harmful genes such as AMR genes and virulence factor (VF)- and toxin-related genes, it was suggested that there is no transferability of harmful genes. The minimum inhibition concentrations of seven tested antibiotics suggested by the European Food Safety Authority guidelines were slightly lower than or equal to the microbiological cut-off values for Lp. plantarum. Strain Q180 did not show hemolytic and gelatinase activities and biogenic amine-producing ability. Taken together, this study demonstrated the safety of strain Q180 in terms of absence of AMR genes and VF- and toxin-related genes as a probiotic strain.

• Journal of Korea Society of Waste Management
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• v.35 no.8
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• pp.770-776
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• 2018

This study measured the energy recovery rate of each municipal waste incineration facility according to the revised energy recovery rate estimation method, which targeted four municipal waste incineration facilities (Unit No. 7). The results calculated by the measuring instruments were used for each factor to estimate the recovery rate, and the available potential of available energy was examined by analyzing the energy production and valid consumption. As a result of the low heating value, 2,540 kcal/kg was calculated on average when the LHVw formula was applied, which is approximately 116 kcal/kg higher than the average design standard of 2,424 kcal/kg. The energy recovery rate was calculated as 96.9% on average based on production and 67.5% based on effective consumption, and the analysis shows that approximately 29.4% energy can be used.

• Journal of Korea Society of Waste Management
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• v.35 no.7
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• pp.660-669
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• 2018

Domestic automotive shredder residue (ASR) recycling facilities must comply with 60% of the energy recovery criteria calculated by the waste control act, based on resource circulation of electrical and electronic equipment and vehicles. The method of calculating energy recovery criteria was newly enacted on November 6, 2017, and it has been judged that it is necessary to consider applicability. In this study, the energy recovery efficiency of 7 units was calculated by past and present calculation methods. Furthermore, this study attempts to find applicability and a method of increasing the energy recovery efficiency by taking advantage of available potentials. An analysis of the calculation results showed that the average values calculated by past methods, present methods, and the method that includes available potentials are 76.35%, 70.68%, and 78.24%, respectively. Therefore, the new calculation method for energy recovery efficiency is also applicable to domestic automotive shredder residue recycling facilities.

• Korean Journal of Head & Neck Oncology
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• v.37 no.2
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• pp.33-41
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• 2021

Background/Objectives: Extra-nodal extension (ENE) is one of the strongest prognosticators in oral cancers. Here we tried to evaluate clinicopathological factors associated with the presence of ENE. Materials & Methods: We retrospectively analyzed clinical information of 120 patients who diagnosed with oral cancer and received curative surgery at our hospital from Mar 2012 to Apr 2020. We comparatively analyzed clinicopathological factors associated with the presence of lymph node (LN) metastasis and ENE, respectively. Results: Variable factors of primary tumor characteristics such as lymphovascular invasion, perineural invasion, largest diameter of tumor, depth of invasion and maximum standardized uptake value were significantly associated with the presence of cervical LN metastasis. The largest diameter of tumor was statistically significant also in multivariate analysis for predicting the LN metastasis. Meanwhile, the association between primary tumor characteristics and the presence of ENE were not statistically significant except the primary tumor size. Importantly, factors associated with LN characteristics including the maximum diameter and number of metastatic LNs were significantly associated with ENE. Conclusion: In this study, several factors affecting cervical LN metastasis and ENE in oral cancer patients were identified. The ENE seems to be influenced by the status of the metastatic LNs, such as the number of metastatic LNs, rather than the characteristics of the primary tumor itself.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.11
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• pp.1463-1470
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• 2021

With the development of ICT technology, a monitoring system to check the status of an object to be managed in real time in various industrial fields is widely used. Existing monitoring systems implemented individual systems according to monitoring targets, but recently, monitoring systems have been implemented using open sources such as Prometheus and Grafana. When using Prometheus and Grafana, many parts become more convenient compared to the existing monitoring system development method, but there are still problems. In this paper, to solve this problem, we propose an integrated monitoring system that supports Prometheus and Grafana. The proposed system is a detailed module that collects, stores, visualizes, and manages data to be monitored, and each module is implemented so that roles can be divided and existing problems can be solved. The proposed system can conveniently manage and monitor monitoring targets stored in heterogeneous databases, and create dashboards through simple operation.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.2
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• pp.75-82
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• 2022

Nondestructive method to predict buckling load for the propellant tank of launch vehicle should be evaluated. Vibration correlation technique can predict the global buckling load of unstiffened cylindrical structure with geometric initial imperfection using correlation of natural frequency and compressive load from compressive test below the buckling load. In this study, vibration and buckling tests of a thin metal unstiffened propellant tank model subjected to internal pressure and compressive loads were performed and the test results were used for VCT to predict global buckling load. For the vibration test of thin structure, non-contact excitation method using a speaker was used. The response was measured with piezoelectric polymer(PVDF) sensor. Prediction results of VCT were compared with the measured buckling load in the test and the nondestructive global buckling load prediction method was verified.