• Mass Spectrometry Letters
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• 제15권1호
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• pp.49-53
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• 2024

Ceramide is a lipid in which sphingoid bases and fatty acids are linked by amide bonds. As a marker of skin disease in the human stratum corneum, its disease-causing and therapeutic effects have been partially confirmed, and it is therefore an important element in commercially available cosmetic formulations. However, structural diversity caused by differences in the chain length, number, and location of hydroxyl groups makes quality control difficult. In this study, a method was established to separate different ceramide species using reversed-phase LC-MS/MS and thus enable qualitative evaluation. Separation of four standards was achieved within a short retention time, and the accuracy and sensitivity of the method were demonstrated by the low limit of detection (LOD) calculated based on the calibration curve showing linearity, with R² > 0.994. After verification of reproducibility and reliability through intra- and inter-day analyses, the efficiency of the method was confirmed through analysis of commercial cosmetic raw materials.

• 대한한방내과학회지
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• 제37권1호
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• pp.77-89
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• 2016

Objectives: The aim of this study was to develop a standard instrument of pattern identification and evaluation for chemotherapy-induced peripheral neuropathy (CIPN).Methods: The advisory committee for this study was organized by 12 professors of traditional Korean medicine from the Korean Association of Traditional Oncology. The items and structure of the instrument were designed based on a review of previous publications. We revised the instrument in consultation with the advisory committee and received additional advice via email.Results: We divided the symptoms and signs of CIPN into four pattern identifications: wind arthralgia (風痺), cold arthralgia (寒痺), dampness arthralgia (濕痺), and arthralgia of the deficiency type (虛痺). We obtained the mean weights to reflect the standard deviations from each symptom of the four pattern identifications, which were scored on a 5-point scale by the advisor committee. After we obtained the answers to discrimination between variable symptoms (變症) and ordinary symptoms (素症) from the 12 experts, we gained the final weight from the combination of the ratio of pattern identification to the number of total answers of the advisory committee and the mean weight.Conclusions: The Instrument on Pattern Identification and Evaluation for CIPN was developed through a discussion between 12 experts. There was a limitation that the validity and reliability of this instrument have not been proven. However, the significance of this study was that it is the first Instrument on Pattern Identification and Evaluation aimed at assessing CIPN in traditional Korean medicine.

• 대한한방내과학회지
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• 제37권1호
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• pp.26-46
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• 2016

Objectives: The purpose of this study was to present the clinical guidelines and traditional Korean medicines for gastric cancer.Results: Gastric cancer is the second most common cancer in Korea. Recent studies have reported that applying integrative Oriental and Western medicine can suppress the tumor, improve the survival, the immune system, and the quality of life in gastric cancer. However, there still is no unified protocol for gastric cancer treatment, which produces difficulty in clinical applications. In Korea, a “Synopsis on the Clinical Practice Guidelines of Gastric Cancer” was published by the Korean Journal of Gastroenterology in 2014. In China, Oriental medicine clinical practice guidelines were published for the first time in 2014. The present author proposed “Clinical Practice Guidelines of Korean Medicine for Gastric Cancer” in 2014, but there is a need for more advanced guidelines with reference to the aforementioned Oriental and Western guidelines. This study will be helpful for understanding and building systems for integrative gastric cancer treatment.Conclusions: Further studies on integrative gastric cancer treatment are needed to improve the survival of gastric cancer patients and build the clinical practice guidelines for gastric cancer.

• 센서학회지
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• 제20권2호
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• pp.131-136
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• 2011

In this study, a compact wireless vibration measurement system was developed using a 3-axial accelerometer in order to evaluate the vibration stimulation system. A low power microprocessor chip integrated with 2.4 GHz RF transceiver was used for the wireless data communication. To evaluate the system, the frequencies and accelerations from the vibration stimulation system were measured using an LVDT sensor and a vibration measurement system. The average frequency difference by the measurement system was less than 0.1 Hz, and the standard deviation of frequencies estimated by the LVDT sensor and the accelerometer was below 0.08 Hz. The developed system was applied to access a vibration stimulation system for the future study. The average acceleration difference of the central and peripheral point of the stimulation system was less than 0.0005 g(1 g=9.8 $m/s^2$), and the standard deviation of the acceleration was below 0.004 g, which shows the usefulness of the wireless vibration measurement system.

• 한국콘텐츠학회논문지
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• 제21권12호
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• pp.1-12
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• 2021

특정 연구 분야에 대한 전문성을 가진 연구자를 찾기 위해서는 객관적인 전문가 판별 방법이 필요하다. 기존에는 전문가 판별을 위해 인용 그래프 기반의 판별 기법과 수식 기반의 판별 기법이 존재한다. 본 논문에서는 기존 수식 기반 판별에서 고려하지 못하였던 다양한 특성들을 반영한 효율적인 전문가 판별 기법을 제안한다. 연구자의 전문성을 판별하기 위해 품질, 생산성, 기여도, 최신성, 정확성, 지속성을 고려한 전문성 지수를 제안한다. 또한, 학술 검색 사이트만의 특성을 반영하기 위해 소셜 인용 수를 추가로 고려한다. 다양한 학술 사이트 기반의 논문 수집 및 성능 평가 결과를 제시하고 제안하는 기법의 타당성과 실현성을 입증한다.

• Tuberculosis and Respiratory Diseases
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• 제39권2호
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• pp.186-193
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• 1992

호흡곤란을 호소한 2명의 젊은 남자에서 개흉폐조직 검사로 폐호산구성육아종으로 확진후 문헌 고찰과 함께 보고하는 바이다.

• 대한불안의학회지
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• 제2권1호
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• pp.50-55
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• 2006

Objectives : In the psychiatry, structured interview is very important tool to be used in epidemiological or psychopharmacological studies. However, investigators often find that the administration of comprehensive diagnostic interviews is time-consuming and expensive to be used in clinical or research settings. Considering these points, Sheehan and his colleagues developed MINI (Mini International Neuropsychiatric Interview) to meet the need for a brief, reliable, and valid structured diagnostic interview for psychiatric disorders. The MINI has been translated into many languages and used in many countries. Therefore, we translated the MINI into Korean and determined its validity in this study. Methods : Twohundred seventy patients and normal subjects participated in the validation of the MINI versus an expert's professional opinion. Schizophrenia and other psychotic disorders, mood disorders including major depressive disorder and bipolar disorder, anxiety disorders including panic and other phobic disorders, and alcohol dependence were included in this study. The validity was obtained by examination whether MINI based diagnoses were compatible with diagnoses by expert psychiatrists. Results : The range of Kappa values was 0.22 (somatoform disorder) to 0.93 (bipolar disorder - past). Overall agreement between MINI and expert's diagnoses were good. The Kappa values for anxiety disorders seemed to be higher than those for other disorders. Conclusion : The MINI Korean version has the good validity. It also has potential applications as a diagnostic tool for psychiatric disorders.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2007년도 춘계학술발표회
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• pp.43-44
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• 2007

• 대한전기학회:학술대회논문집
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• 대한전기학회 1995년도 하계학술대회 논문집 C
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• pp.1235-1238
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• 1995

Electrical property of polymeric insulating plays a key role in the trend of making power apparatus high voltage, and reliability and safety of apparatus in the long term depend on it. There is a recent trend of applying polymeric material to insulating material for outdoor, and particularly it is expected that it may be used partly as a pin insulator. Using as an alternate of insulating material for outdoor, however, it has still many problems to be solved in the field of material such as resistances of environment and tracking. It has been given attention to that the silicon rubbers and the epoxy have recently been used. but the the reliability in the viewpoint of material property becomes an issue. The polymeric materials such as EPDM, Epoxy and PVC have also been used as an insulating materials for outdoor. In this point of view, we studied each tracking phenomenon with test material such as rubber for pin, PVC for powercable used as an insulating material for outdoor, and Epoxy etc. The characteristics of anti tracking shows EPDM>Epoxy>PVC in order in the results. We also know that there is an close relationship between properties of tracking and thermegravimetry.

• 한국농공학회논문집
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• 제56권4호
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• pp.21-28
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• 2014

In this study, evaluated ware the strength and durability of the vegetated water purification channel concrete to which recycled aggregates, hawang-toh and jute were applied. Box-Behnken method of response surface analysis in statistics was applied to the experimental design. Experimental variables are as follows, recycled coarse aggregates, hawang-toh, blast-furnace slag and jute fiber. In the experiment, conducted were the tests of compressive strength, chloride ion penetration, abrasion resistance and impact resistance the replacement rate effects of the recycled aggregates, blast-furnace slag and hwang-toh on the performance of vegetated water purification channel concrete were analyzed by using the response surface analysis method on the basis of the experimental results. In addition, an optimum mixing ratio of vegetated water purification channel concrete was determined by using the experimental results. The optimum mixing ratio was determined to be in 10.0% recycled coarse aggregates, 60.0% blast-furnace slag, 10.1% hwang-toh and 0.16% jute fiber. The compressive strength, chloride ion penetration, abrasion rate, and impact number of fracture test results of the optimum mixing ratio were 24.1 MPa, 999 coulombs, 10.30 g/mm3, and 20 number, respectively.