• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8595-8601
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• 2014

Background: miR-200a expression is frequently altered in numerous cancers. The aim of the present study was to determine the role of microRNA-200a in advanced ovarian carcinomas. Materials and Methods: We measured miR-200a expression in 72 matched normal ovarian tissues and advanced ovarian carcinomas, and also two ovarian carcinoma cell lines (SKOV3 and SKOV3.ip1 - the latter being more invasive and metastatic than the parental SKOV3) by stem-loop real-time RT-PCR based on TaqMan microRNA assay using U6 as a reference. Levels of miR-200a expression were compared by disease stage, tumor grade, histology, and lymph node involvement. To evaluate the role of microRNA-200a, cell proliferation and invasion of SKOV-3 and SKOV-3.ip1 were analyzed with miR-200a inhibitor/mimic transfected cells. Results: Of 72 paired samples, 65 cancer tissues overexpressed microRNA-200a greater than two fold in comparison with matched normal epithelium. Specifically, patients with lymph node metastasis showed significant elevation. The level correlated with clinicopathological features, including high tumor grade, late disease stage, most notably with lymph node metastasis, but not with tumor histology. In addition, SKOV-3.ip1 cells also overexpressed miR-200a compared with SKOV-3, and miR-200a inhibitor transfected SKOV-3.ip1 cells showed significant reduction in cellular proliferation and invasion, while a miR-200a mimic stimulated the opposite behavior. Conclusions: We provide definitive evidence that miR-200a is up-regulated in a significant proportion of advanced ovarian carcinomas, and that elevated miR-200a expression facilitates tumor progression. Our findings support the notion that miR-200a is an onco-microRNA for ovarian cancer, and elevation is a useful potential diagnostic indicator. This study also provides a solid basis for further functional analysis of miR-200a in advanced ovarian cancer.

• Journal of Preventive Medicine and Public Health
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• v.53 no.5
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• pp.323-331
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• 2020

Objectives: This study aimed to determine the prevalence and correlates of sexual intercourse among junior secondary and high school students in Indonesia from the 2015 Global School-based Health Survey (GSHS). Methods: The survey was conducted among 11 110 students from 75 schools in Indonesia using a self-administered questionnaire. Univariate and multivariate analyses were conducted to explore associations between sexual intercourse and socio-demographic variables, substance use, mental distress, and protective factors. Results: Overall, 5.3% of students reported having ever had sex (6.9% of boys and 3.8% of girls). Of students who engaged in sexual intercourse, 72.7% of boys and 90.3% of girls had an early sexual debut (before reaching the age of 15) and around 60% had multiple sex partners. Sexual intercourse was associated with gender, school grade, smoking, alcohol consumption, drug use, suicidal ideation, truancy, peer support, and parental supervision. Conclusions: These findings indicate a pressing need to develop more comprehensive sexual health education in the national curriculum. An effective strategy should also address other risky behaviours.

• Human Ecology Research
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• v.51 no.4
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• pp.439-454
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• 2013

The purpose of this study is to explore Korean divorced mothers' experiences of noncustodial fathers' involvement in children's lives after divorce and co-parenting relationships. The data were collected from 17 mothers who were divorced between the years of 2004 and 2009, and were raising at least one minor child. Data were analyzed based on the inductive data analysis method. Divorced mothers' experiences of noncustodial fathers' involvement in children's lives after divorce were categorized in three ways: a satisfactory on-going relationship, a dissatisfactory on-going relationship, and a discontinued relationship. The results show that a few mothers were satisfied with the degree of the fathers' involvement in the children's lives 1) if the fathers were interested in their children and responsive to their children, and 2) if the fathers paid either child support or provided some financial supports for their children based on the fathers' financial abilities. However, the majority of the mothers were dissatisfied with the degree of the fathers' involvement in the children's lives. While some of the mothers maintained a relationship with the children's fathers despite their dissatisfaction, others discontinued the relationship. Regarding the co-parenting relationship after divorce, the relationships with the fathers were classified as either cooperative relationships or uncooperative relationships. The majority of the mothers experienced difficulties establishing cooperative co-parenting relationships with the fathers, but three mothers had cooperative relationships. The reasons for these uncooperative relationships were: uncooperative fathers, uncooperative mothers, or ambiguous communication regarding parenting after divorce. These findings suggest parenting education for divorced parents.

• Journal of Families and Better Life
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• v.29 no.6
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• pp.153-167
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• 2011

This study analyzed changes in postpartum depression in mothers from one month after childbirth to the first year using panel data collected overtime, in an effort to determine the relationship between the amount of change and child-rearing system variables. The subjects were 1097 mothers who belonged to both the lower and upper $30^{th}$ percentile groups in the depression change distribution of the 2008 Korean Children Panel Study (PSKC), a large, population-based study conducted by the Korea Institute of Childcare and Education. The data were analyzed by t-tests, $x^2$ tests, partial correlation coefficient analyses and regression analyses. The results are summarized as follows: First, the mothers' postpartum depression showed a significant increase during the first year as opposed to the first month after birth. Second, after controlling for socio-demographical variables of the mothers, the changes related to depression showed a positive relationship with child-rearing stress, and the child's emotional temperament, but showed a negative relationship with the mother's self-esteem, the child's birth order, and the father's participation in child-rearing activities. Third, variables having a significant effect on changes in postpartum depression were the mother's self-esteem and child-rearing stress, the child's age in months, and social support. Variables pertaining to the mother's characteristics variables had a more powerful effect than other child-rearing system variable categories. The results suggest the necessity to develop a parental education program or a mother-child health service in consideration of the variables that affect mothers, as determined in this study, in an effort to prevent postpartum depression.

• Human Ecology Research
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• v.58 no.4
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• pp.539-560
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• 2020

This study presents work-family multiple-role planning by female university students as a new approach to worklife balance. Accordingly, this study examines university years as a key time frame during which students establish their career paths. This study integrates the social cognitive career theory and the planned behavior theory to design and evaluate a model that explains the work-family multiple-role planning process; in addition, it develops an optimal model to predict the intentions of female university students in work-family multiple-role planning. This study has conducted a structural survey with 500 female university students. After inspecting the data, the responses of 435 participants were used in the data analysis (SEM) with SPSS 21.0 and AMOS 21.0. The findings include the following. First, suitability of predictive model presents a satisfying fit. The major factors in this study's model (parental support, subjective norms, attitudes toward multiple-role planning, career decision self-efficacy, and outcome expectations) are verified as direct and indirect predictors of the work-family multiple-role planning intent of female university students. Second, the strongest predictive factor for the work-family multiple-role planning intent is the social environment factor (subjective norms), indicating that the influence of social pressure on intent is relatively large. The predictive model formulated under this study's integrated theoretical framework supplements existing research that focused on attitudes toward multiple-role planning as well as provides a more profound theoretical foundation on which work-family multiple-role planning behaviors can be better understood.

• Korean Journal of Community Nutrition
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• v.23 no.3
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• pp.216-225
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• 2018

Objectives: This study was conducted to investigate the associations between obesity and the children's Nutrition Quotient (NQ) and to further examine the relationships between NQ and mini dietary assessment (MDA) of their parents. Methods: The subjects were 355 children aged 3 to 5 years and their parents in Dongducheon. We collected parental-reported NQ questionnaires for children and MDA of parents. Anthropometric measurements, height, weight and BMI by BIA were measured in children. Overweight and obesity were determined according to age- and sex-specific BMI percentile from the 2007 Korean national growth chart. Statistical analyses consisted of the chi-squared test, ANOVA, partial correlations and logistic regression analysis adjustments for parents BMI. Results: Approximately 20.8% of preschool children were classified as overweight or obese. Underweight children showed a significantly higher score for balance than overweight children. The NQ of the children was $61.9{\pm}11.6$, and NQ scores and their parents' MDA did not exhibit any significant differences according to degree of obesity. After adjusting for parent's BMI, children's BMI was significantly correlated with balance and moderation among NQ factors. Parent's MDA showed significant correlation with their children's NQ, balance, diversity, moderation, regularity, practice and NQ grade, except for diversity of father. Additionally, NQ grade had a significantly increased (150.1%) odds ratio (OR) of being overweight (95% CI 1.008-2.234). Conclusions: These results show that NQ for children is influenced by their parents' MDA and BMI. Furthermore, our findings support the association between overweight prevention and improvement of NQ grade among preschool children.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.553-564
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• 2019

In order to understand the difficulties and overcoming effort in teachers of Employer-Supported Child-Care Center in the attitude of parents, this study explored seven teachers of Soie Child-Care Center that operated for 18 hours a day, 365 days a year. Seven teachers were interviewed and the data were analyzed utilizing content analysis. The results of the study came out that Teachers experience difficulties such as parents' non-regulations, excessive use, excessive individual demands, excessive sensitivity in case of safety accidents, the connection of parental rank to the classroom, excessive service demands. In order to overcome this problem, participants used methods such as identifying sensitive parts of parents, seeking advice, objectifying situations, and enhancing professionalism. This will be basic data for the expanding operation of Employer-Supported Child-Care Center and the development of programs to support teachers.

• Journal of Digital Convergence
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• v.19 no.6
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• pp.373-385
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• 2021

In this study, the Korea Youth Policy Institute applied a self-registering model to verify the patterns of parental stress, multicultural youth psychological maladjustment, and interdependence between three factors by using five-point-time data tracked from middle school to high school. According to the analysis, First, Parent' stress at the time of the five surveys had a significant positive effect on the psychological maladjustment and the risk of academic interruption of multicultural adolescents at that point. Second, the psychological maladaptation of multicultural adolescents at the time of the previous five surveys had a significant positive effect on the risk of academic interruption at that point. Based on these analysis results, various support measures were proposed to cope with the stress of multicultural youth parents, and policy alternatives were proposed to prevent the risk of academic interruption by reducing the psychological maladjustment of multicultural youth.

• The Journal of the Convergence on Culture Technology
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• v.8 no.2
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• pp.23-28
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• 2022

This paper analyzed the influence of employment, human resource development, and labor practices on the corporate performance. Data were collected from the Korea Labor Institute's workplace panel survey(WPS) from 2017, and the analysis used 2,868 companies. This study employed operating profit as a corporate performance. Employment included open recruitment of new employees, evaluation of NCS job competency, and implementation of core human resources acquisition program. Human resource development consisted of incumbent training, job competency improvement evaluation, management program for low performer, emoloyee's career plan, and HRD using job analysis. Labor practices included guarantees for parental leave, guarantees for maternity leave, and support for childcare facilities. The analysis method used binominal logistic regression analysis for two groups of operating profit surplus and deficit companies. As a result of the analysis, it was possible to confirm the influence of employment, human resource development, and labor practices on performance. And the implications of employment, human resource development, and labor practices to improve corporate performance were discussed.

• Journal of Korean Critical Care Nursing
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• v.15 no.3
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• pp.101-114
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• 2022

Purpose : This study aimed to identify post-traumatic stress disorder (PTSD) and burnout experienced by healthcare providers who cared for patients with Coronavirus Disease 2019 (COVID-19) and their influencing factors. Methods : Data were collected from 135 healthcare providers who cared for patients with COVID-19 in a tertiary general hospital from June 8 to September 2, 2021, using a questionnaire. Descriptive statistics, Mann-Whitney U test, Kruskal-Wallis test, t-test, ANOVA and Scheffe's test, Pearson's correlation coefficients, and multiple regression were used for analysis using SPSS/WIN 27.0. Results : Participants' average PTSD score was 9.31 ± 11.80, and 8.9% were in the high-risk group. Participants' average burnout score was 51.77±21.28, and 62.2% were at high risk. PTSD scores differed significantly according to participants' age, education, job, position, and current workplace. Burnout scores differed significantly according to their age, gender, marital status, parental status, and education. There was positive correlation between participants' PTSD and burnout. The factors influencing participants' PTSD were term of self-isolation and age (R²=.09). There were no significant influencing factors on participants' burnout. Conclusion : This study reconfirmed that healthcare providers who cared for patients with COVID-19 experienced both PTSD and burnout, suggesting that interventions are needed such as regular pre-training or simulation training and establishing a support system.