• 한국문헌정보학회지
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• 제46권1호
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• pp.183-200
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• 2012

학교도서관 학부모 자원봉사자들의 봉사활동과 만족도를 파악하기 위하여 안양 과천지역 34개교 초등학교 자원봉사자를 대상으로 개인적 배경, 봉사활동 경험, 봉사교육, 대인관계, 만족도 등에 관한 조사를 수행하고 분석하였다. 2011년 11월 2주간 수행된 설문조사에 524명이 응답하였으며(응답률 60.6%), 데이터는 기술적 통계, t검증, 분산분석, 상관관계로 분석하였다. 학부모 자원봉사자는 여성, 36-40세, 대졸이 가장 많고, 봉사기간은 7-12개월, 최근 6개월간 봉사빈도는 6회 미만, 봉사시간은 6시간 이하가 많다. 74.0%가 사전교육을 받았으며, 50.9%가 계속교육 경험이 있다. 봉사활동에 관한 전체 만족도는 5점 척도에 3.64점이다. 만족도 분석 결과, 성별, 학력, 봉사활동과 계속교육 수준에 따른 만족도의 차이가 통계적으로 유의한 것으로 나타났으며, 여성, 고학력, 봉사 경력이 많을수록 만족도가 높다. 대인관계 요인과 만족도의 관계는 정적 상관관계가 있으며, 동료 봉사자와의 관계가 원만할수록 만족도가 높다. 분석 결과에 기초하여, 봉사활동의 효과와 만족도 향상을 위한 자원봉사자 관리방안을 제언하였다.

• 한국임상약학회지
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• 제10권1호
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• pp.19-24
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• 2000

The effect of cimetidine on the pbarmacokinetic parameters of cyclosporine (intravenous administration) were determined in 6 healthy volunteers (22-48 years old, 48-62 kg) by cross-over design. Cyclosporine and cyclosporine metabolites in whole blood were analysed by fluororescence polarization immunoassay (TDx-FLX). The blood concentrations of cyclosporine After pretreatment with cimetidine (200 mg bid, for 3days) were increased significantly at 8-12 hrs compared to the control (p<0.05). The ratios of blood concentrations of cyclosporine metabolites (M1, M17) to parent drug were decreased significantly at 8-12 hrs (p<0.05). Total body clearance (CL) was also decreased significantly (p<0.05), and area under the curve $(AUC,\%)$ was increased but not significant.

• Journal of Ginseng Research
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• 제37권4호
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• pp.451-456
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• 2013

Compound K is a major metabolite of ginsenoside Rb1, which has various pharmacological activities in vivo and in vitro. However, previous studies have focused on the pharmacokinetics of a single metabolite or the parent compound and have not described the pharmacokinetics of both compounds in humans. To investigate the pharmacokinetics of ginsenoside Rb1 and compound K, we performed an open-label, single-oral dose pharmacokinetic study using Korean Red Ginseng extract. We enrolled 10 healthy Korean male volunteers in this study. Serial blood samples were collected during 36 h after Korean Red Ginseng extract administration to determine plasma concentrations of ginsenoside Rb1 and compound K. The mean maximum plasma concentration of compound K was $8.35{\pm}3.19$ ng/mL, which was significantly higher than that of ginsenoside Rb1 ($3.94{\pm}1.97$ ng/mL). The half-life of compound K was 7 times shorter than that of ginsenoside Rb1. These results suggest that the pharmacokinetics, especially absorption, of compound K are not influenced by the pharmacokinetics of its parent compound, except the time to reach the maximum plasma concentration The delayed absorption of compound K support the evidence that the intestinal microflora play an important role in the transformation of ginsenoside Rb1 to compound K.

• Biomolecules & Therapeutics
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• 제4권3호
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• pp.251-256
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• 1996

The metabolism of carbinoxamine, 2-[(4-chlorophenyl)-2-pyridinyl-methoxy]-N, N-dimethylethaneamine, was studied in adult male volunteers after an oral dose of 15 mg. Solvent extracts of urine obtained with or without enzyme hydrolysis were analyzed by gas chromatography-mass spectrometry after derivatization with MSTFA/TMSCl (N-methyl-N-trimethylsilyltrifluoroacetamide/trimethyl chlorosilane). The structures of metabolites were determined based on the electron impact (EI) and chemical ionization (CI) mass spectra. Nonconjugated metabolites identified in the urine were carbinoxamine, nor-carbinoxamine, and bits-nor-carbinoxamine. Parent drug, nor-carbinoxamine, and bits-nor-carbinoxamine were also detected as conjugated forms. These metabolites observed in human urine were different from those previously reported in the rat. Urinary excretions of carbinoxamine were reached to maxima in 4 hours after drug administration with 4.9%-8.1% and 2.5-4.2% of the dose excreted during 24 h as carbinoxamine and its glucuronide, respectively.

• Bulletin of the Korean Chemical Society
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• 제19권2호
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• pp.194-196
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• 1998

The metabolism of dromostanolone (2α-methyl-5α- androstan-17β-ol-3-one) was studied in three adult volunteers after oral dose of 20 mg. Solvent extracts of urine obtained after enzyme hydrolysis were derivatized with MSTFA/TMCS and MSTFA/TMIS. The structures of intact drug and its metabolites were determined by gas chromatography/mass spectrometry (GC/MS) in electron impact (EI) mode. The major metabolite (2α-methyl-5α- androstan-3α-ol-17-one), its 3β-epimer, parent compound, and several hydroxylated metabolites including intact drug were detected by comparing total ion chromatograms of control urine with that of the administered sample. Two epimers of 2α-methyl-5α- androstan-3,17β-diol were detected using selected ion monitoring. The maximum excretion of dromostanolone and 2α-methyl-5α- androstan-3α-ol-17-one was reached in 6.2-15 hr. The half-life of intact dromostanolone was 5.3 hr. About 3.0% of the administered amount was found to be excreted within 95 hr as unchanged form.

• Journal of Pharmaceutical Investigation
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• 제38권5호
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• pp.343-348
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• 2008

The bioequivalence of two cyclosporine A (CyA) 100 mg soft capsules (Chong Kun Dang's $Cipol-N^{(R)}$ as the test drug; Korea Novartis' Sandimmun $Neoral^{(R)}$ as the reference drug) was assessed in healthy male Korean volunteers after oral administration of 200 mg CyA according to a randomized crossover design. The whole blood samples were analyzed for the determination of parent CyA in the blood by using a validated HPLC/diode array detector method. The mean $AUC_t$ values for reference and test products were $4095.3{\pm}1397.2$ and $3958.3{\pm}1138.2\;ng{\cdot}hr/mL$, respectively. The mean $C_{max}$ values were $1135.9{\pm}293.2\;ng/mL$ for the reference product, and $985.0{\pm}207.9\;ng/mL$ for the test product. $T_{max}$ was $1.6{\pm}0.4\;hr$ for the reference and $1.8{\pm}0.5\;hr$ for the test product. The differences of $AUC_t$, $C_{max}$ and $T_{max}$ were -3.35, -13.28 and +10.63%, respectively. The point estimates and 90% confidence intervals for $AUC_t$ and $C_{max}$ were 0.981 (0.9171 to 1.0514) and 0.876 (0.8229 to 0.9336), respectively. Based on the pharmacokinetic and statistical data, we conclude that these two products are bioequivalent and can be considered interchangeable in the medical practice.

• 대한간호
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• 제28권3호
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• pp.83-93
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• 1989

This study analysed marital comflicts, related factors, and adjustments to those conflicts described by urban Korean women. The purpose was to discover directions for resolution that would enhance the helpfulness of volunteers or prfessionals working with women in counselling settings. The investigator interviewed 20 married women, all mothers and housewives living in Seoul, attending marriage encounter programs and the Lifeline telephone counselling service. An interview schedule using six open-ended questiona guided the data colleciton which took place between May 31 and December 29, 1988. Content analysis of the data revealed, in order of reported frequency, the following areas of conflict: relationships between husband wife, relationships with children, relationships between the wife and her mother-in-Law, unsatisfied sexual needs, the husband's extra marital relationships, lack of self actualization and finacial matters. Analysis of the data suggested the following factors were related to the conflicts: reasons for marriage, traditional views about marriage and divorce including to accept a marriage arranged by the parents, the husband's traditonal attitude toward the sex role of the wife, the husband's patriarchical authoritarianism, and his attitude toward the wife;s empolyment outside the home. The women thought these conflicts severely affected their relationships within the famaily, particularly with their children. Literature suggests links with such poor parent-child-family relationships and adolescent or young people's social problems. Volunteers or professionals working with married women in counselling situation need to be conscious of the possibility of these conflict during assessment, and direct their guidance toward such conflict resolution. The researcher makes several suggestions which include the need for the husband to give emotional supports to his wife, to recognize the worth of housework, to share the work of the home, to fine ways to enhance the wife's self-actualization and to ease dreary housework routines by prviding modern appliances.

• 한국비블리아학회지
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• 제23권2호
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• pp.69-86
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• 2012

사서교사와 학부모의 협력 관계는 학교도서관의 학습 공동체적 성격과 경영의 확대 측면에서 매우 중요한 경영 요소이다. 이러한 협력 관계는 학생의 스트레스와 위험요소를 완화함으로써 학생의 자아 탄력성을 활성화하는데 기여한다. 본 연구에서는 10명의 현직 사서교사를 대상으로 학부모와의 협력 관계를 통한 학생지도 사례를 분석하고, 관계 형성에 어떠한 공식 또는 비공식 커뮤니케이션 채널을 활용하고 있는지 알아보았다. 분석 결과 사서교사는 학부모와의 협력이 필요하다고 인식하고 있으며, 학생의 생활지도, 진로지도, 독서상담 및 담임교사와 학부모 간의 갈등 조정 등의 경험이 있는 것으로 나타났다. 그리고 사서교사와 학부모의 공식 커뮤니케이션은 학교도서관운영위원회와 같은 제도적인 협의체 보다는 함께 참여하는 독서프로그램인 것으로 나타났다. 또한 사서교사는 학교도서관에서 이루어지는 학부모 모임이나 연수를 통해서 학부모와 비공식적으로 만나고 있다. 학부모를 위해서 학교도서관이 제공하는 정기 프로그램은 독서관련 행사와 연수이며, 주요 홍보 수단은 가정통신문과 학교홈페이지인 것으로 나타났다. 사서교사와 학부모가 협력을 통해서 학생의 자아 탄력성 강화에 기여하기 위해서는 학교도서관운영위원회에 학부모를 참여시킴으로써 공식적인 커뮤니케이션 채널을 확보해야 한다. 그리고 학부모의 도서관 운영 참여를 단순한 일손 돕기 보다는 책 읽어주기, 도서관 이용 안내, 사서교사의 도서관 활용수업 보조, 교수매체 제작 등으로 확대하는 것이 바람직하다.

• 한국임상약학회지
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• 제3권1호
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• pp.79-88
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• 1993

Bioequivalence(BE) test of commercially available sustained release tablets of diltiazem hydrochloride(DTZ) was performed to give some guidelines to BE test in korea in case of which drugs with low oral bioavaiiability(BA) due to substantial first-pass hepatic loss form pharmacologically active metabolites. In such cases, the pharmacologic activity after oral administration is greater than anticipated from BA data, based on chemical assay of drug alone. Therefore, this paper explores the use and meaning of area under the plasma concentration-time(AUC) data of parent and its metabolites to access BA if sustained release tablets. Normal healthy male volunteers(n=14) were randomly divided into 2 groups, and sustained release reference$(Herbesser^{(R)})$ and test$(Herben^{(R)})$ tablets of DTZ-30mg were given orally by balanced two-period cross-over dosing schedule. The plasma concentration of DTZ and and its active metabolite, desacetyldiitiazem(DAD), were determined by high performance liquid chromatography, and, $AUC_{DTZ},\;AUC_{DAD},\;AUC_{DTZ+DAD},\;C_{max}\;and\;T_{max}$ obtained. Analysis of varlance(ANOVA) showed that $AUC_{DTZ}\;and\;C_{max}$ passed the standard $(\alpha=0.05,\;1-\beta\geq0.8,\;\Delta\leq0.2)$ of BE test of korea, but $AUC_{DAD}$ was not satisfied from the standpoint of power. On the other hand, $AUC_{DTZ\midDAD}$ may be more avaliable than $AUC_{DAD}$ from the standpoint of statistics and pharmacologic equivalence.

• 한국문헌정보학회지
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• 제58권3호
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• pp.265-286
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• 2024

본 연구는 경상북도교육청 도서관의 인문·사회적 가치 실현과 급변하는 미래사회 환경에 대응하기 위한 비전 및 정책 방안을 마련하고자 한다. 이에 7개 평가항목을 도출하고 19개 평가지표를 선정하여 그 간의 계획추진 성과와 중요도 진단을 통해 시사점을 도출하였다. 주요 시사점으로, 계획추진 정도와 중요도 수준에 대한 인식이 대부분 높게 나타났다. 그러나 공동보존서고 설치 및 운영 항목, 청·장년층을 대상으로 한 취·창업 지원 프로그램, 학부모 자원봉사자 활성화 항목 등은 추진 정도와 중요도가 모두 낮게 나타났다. 이를 바탕으로 정책과제는 4대 추진전략 아래 10개 정책과제, 28개 실행과제를 제안하였다.