• Title/Summary/Keyword: Parameter Studies

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Assessment of covariate-effect of sleeping behavior on heart rate variability during a clinical trial (임상시험 중 수면행위가 심박변이도에 미치는 영향 분석)

  • Lee, Jeon;Oh, Dal-Seok;Lee, Hae-Jung;Choi, Sun-Mi;Kim, Jong-Yeol
    • Korean Journal of Oriental Medicine
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    • v.13 no.3
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    • pp.97-103
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    • 2007
  • The object of this study is to evaluate confounding effect of sleeping behavior on heart rate variability (HRV) in healthy volunteers during a randomized clinical trial. From 6 healthy volunteer, we acquired circadian electrocardiography(ECG) with a Holter monitoring device(DigiTrak Plus, Philips). The compatible analytical program, Zymed, was used for calculation of RR intervals of 24h ECG signal. Then, we generated HRV signals and calculated 9 HRV parameters in time domain and frequency domain for every 30 minute with Matlab 6.x software. We also encoded participants' activities as follows; stable condition(1), sleeping behavior(2), eating behavior(3), and undefined condition(4). Using SPSS 12.0, we tested if there was any difference between HRV parameters of day-time and night-time and between those of a subject in stable condition and in sleeping behavior. As a result, one of the most important parameter-LF/HF ratio, which indicates the autonomic balance between sympathetic and parasympathetic nervous systems, as same the other parameters, showed large inter-individual variations in circadian profiles. And, the mean LF/HF ratio of each participant was different between in stable condition and in sleeping behavior (p<.05). Consequently, the effect of sleeping behavior must be considered when one or more of HRV parameters, especially LF/HF ratio, are used as assessment index in clinical studies.

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Adsorption Equilibrium, Kinetic and Thermodynamic Param (활성탄을 이용한 Acid Green 27의 흡착평형, 동역학 및 열역학 파라미터의 연구)

  • Lee, Jong Jib
    • Korean Chemical Engineering Research
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    • v.55 no.4
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    • pp.514-519
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    • 2017
  • Adsorption characteristics of acid green 27 dye using activated carbon were investigated as function of adsorbent dose, pH, initial concentration, contact time and temperature. Freundlich isotherm explained adsorption of acid green 27 dye very well and Freundlich separation factors (1/n=0.293~0.387) were found that this process could be employed as effective treatment method. Kinetic studies showed that the kinetic data were well described by the pseudo second-order kinetic model. Pseudo second rate constant ($k_2$) decreased with the increase in initial acid green 27 concentration. Activation energy (10.457 kJ/mol) and enthalpy (79.946 kJ/mol) indicated that adsorption process was physisorption and endothermic. Since Gibbs free energy decreased with increasing temperature, spontaneity of adsorption reaction increased with increasing temperature in the temperature range of 298 K~318 K.

Dynamic Response Analysis of Slender Marine Structures under Vessel Motion and Regular Waves (파랑 및 부유체 운동을 고려한 세장해양구조물의 동적 거동 해석)

  • Chung Son Ryu;Michael Isaacson
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.10 no.2
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    • pp.64-72
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    • 1998
  • Dynamic response analysis is carried out for slender marine structures such as tensioned risers and tethers of tension leg platform, which are subjected to floating vessel motions as well as environmental forces arising from ocean waves. A mumerical analysis procedure is developed by using finite element model of the structural member. Dynamic analses are performed in the time domain for regular waves. Parameter studies are carried out to highlight the effects of surface vessel motions on the lateral dynamics of the structures. Example results of displacements, bending stresses are compared for various in water depth, environmental condition and vessel motion. Some instability conditions of the structures due to time-varying tension by vessel heave motion are discussed through the example analyses. As the results, the interaction between vessel surge and heave motions amplifies the total structural response of a riser. In the case of a tether, the effect of vessel heave motion during heavy storm is seemed to be quite significant to lateral response of the structure.

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An Experimental Study on Depositional Parameters of Cohesive Sediments in Semi-closed Bay (준 폐만 점착성 퇴적물의 퇴적매개변수 산정에 관한 실험적 연구)

  • Jung, Eui-Taek;Kim, Yong-Muk;Kim, Dong-Ho;Hwang, Kyu-Nam
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.24 no.3
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    • pp.159-165
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    • 2012
  • In this study, a series of deposition tests have been performed using an annular flume and depositional parameters of natural cohesive sediments have been estimated domestically for the first time. The natural cohesive sediments for deposition tests have been collected from Kwangyang Bay and total 18 deposition tests have been carried out on different bed shear stress respectively but with the same initial concentration. Test results for natural cohesive sediments of Kwangyang bay show that minimum bed shear stress ${\tau}_{bmin}$, standard deviation ${\sigma}_1$, and time scale parameter $({\tau}_b^*-1)_{50}$ are $0.11N/m^2$, 0.68 and 0.85, respectively. Through the comparison with results of previous studies for other sediments, the results of this study are shown to be good enough to verify.

Fundamental Studies of Gas-jet Assisted Radio Frequency Glow Discharge Atomic Absorption Spectrometry (원자흡수법에 의한 Gas-Jet Assisted RF 글로우방전 시스템의 특성 연구)

  • Choi, Seong-Kyu;Kim, Hyo-Jin
    • Analytical Science and Technology
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    • v.8 no.1
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    • pp.69-77
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    • 1995
  • The instrumentation and operating characteristics of a gas-jet assisted radio frequency glow discharge atomic absorption spectrometry(RF-GDAAS) are studied. The roles of discharge power, pressure as well as gas flow rate on the sample loss rate and absorbance are described in this paper. Results show that the optimum discharge conditions depend on pressure and discharge power as well as on the gas flow rate. The gas flow rate plays as an important parameter in RF-GDAAS. Absorbance increases as the gas flow rate increase up to 600ml/min., and the optimum absorbance is obtained at the pressure of 3 mbar. The absorbance increases when the discharge power increases as expected, however, the instability of the system due to the heat might be the trade off factor. The linear calibration curves of Ni and Cr in stainless steel(BAS 461-468) and brass (KSS 1121-1126) are obtained with RF-GDAAS.

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Effect of Oncostatin M on Proliferation and Matrix Synthesis of Dermal Fibroblasts (Oncostatin M이 피부섬유모세포의 증식과 기질생성에 미치는 영향)

  • Chun, Kyung Wook;Lim, Hyung Woo;Han, Seung-Kyu;Kim, Woo Kyung
    • Archives of Plastic Surgery
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    • v.35 no.2
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    • pp.115-120
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    • 2008
  • Purpose: Oncostatin M(OSM) is a multifunctional cytokine that belongs to the interleukin(IL)-6 family. Although there have been a number of studies that focused on the role and mechanism of OSM in various organs and tissues, there are few reports on its effect on wound healing. The final purpose of this project is to evaluate the effect of OSM on wound healing. This pilot study was designed to investigate the effect of OSM on proliferation and matrix synthesis of human dermal fibroblasts, which are the major components of the wound healing. Methods: Excess skin that was obtained from patients who underwent skin grafts, was used for this study. From this material, fibroblasts were isolated and cultured. The cultured fibroblasts were treated with one of four concentrations of OSM. The OSM concentrations used were 0, 50, 100, and 200 ng/ml, respectively. After the OSM treatment, cell proliferation was determined by the MTT assay, collagen synthesis by the C1CP method, GAG levels by the Blyscan Dye method. The parameter levels of each group were compared. Results: OSM treatment increased all the components tested in the study. In particular, cell proliferation, GAG synthesis demonstrated statistically significant increases(p<0.05 in the Mann-Whitney U-test). The highest increase in all the components was obtained at a 100 ng/ml concentration of OSM.Conclusion: The results of the present study indicate that OSM stimulates proliferation and matrix synthesis of human dermal fibroblast and the optimal concentration for wound healing is 100 ng/mL.

Numerical Study of Non-Newtonian Flow Characteristics in Sudden Contraction-Expansion Channel (급축소-확대관에서 비뉴턴유체의 유동 특성에 관한 수치적 연구)

  • Kim, Hyung Min
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.37 no.6
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    • pp.591-597
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    • 2013
  • Because most existing non-Newtonian models are not suitable for application to the lattice Boltzmann method, theoretical and numerical studies in this regard remain challenging. In this study, the hydrokinetic (HK) model was modified and applied to a 3D sudden contraction-expansion channel flow, and the characteristics of the HK model flow were evaluated to generate non-trivial predictions in three-dimensional strong shear flows. The HK model is very efficient for application to the lattice Boltzmann method because it utilizes the shear rate and relaxation time. However, the simulation would be unstable in a high shear flow field because the local relaxation time sharply decreases with an increase in the shear rate in a strong shear flow field. In the HK model, it may become necessary to truncate the relaxation time and non-dimensional parameter to obtain stable numerical results.

Fatigue Behavior of STS316L Weldments and Degradation Characteristic Evaluation by Ultrasonic Test (STS316L 용접부의 피로거동 및 초음파시험에 의한 열화특성 평가)

  • Nam, Ki-Woo;Park, So-Soon;Ahn, Seok-Hwan;Do, Jae-Yoon;Park, In-Duck
    • Journal of the Korean Society for Nondestructive Testing
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    • v.23 no.2
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    • pp.156-164
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    • 2003
  • STS316L had been used as the structural material for energy environmental facilities, because austenite stainless steels like 316L have superior mechanical properties of which toughness, ductility, corrosion resistant and etc. However, those welded structures are receiving severe damage due to increasing of the aged degradation. Most studies until now have been carried out against fatigue behaviors of weldments, and were not well studied on nondestructive evaluation methods. In this study, the fatigue crack propagation behavior of STS316L weldment usually used for vessels of the nuclear power plant was investigated. Also, the degradation characteristics of 316L stainless steel weldments were evaluated by the ultrasonic parameter such as ultrasonic velocity, attenuation factor and time-frequency analysis. The results of this study can be used as a basic data for the prediction of the fatigue crack life of weldments structures without disjointing or stopping service of structures in service.

Availability Assessment of Meteorological Drought Index for Agricultural Drought Estimation in Ungauged Area of Agricultural Drought Parameter (농업가뭄인자 미계측 지역의 농업가뭄 추정을 위한 기상학적 가뭄지수의 활용성 평가)

  • Park, Min Woo;Kim, Sun Joo;Kwon, Hyung Joong;Kim, Phil Shik;Kang, Seung Mook;Lee, Jae Hyuk
    • Journal of The Korean Society of Agricultural Engineers
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    • v.59 no.5
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    • pp.127-136
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    • 2017
  • The object of this study was to assess availability of meteorological drought index for agricultural dorught estimation in ungauged area of agricultural drought parameters which are reservoir water level and soil moisture. The IADI (Integrated Agricultural Drought Index) and the SPI (Standard Precipitation Index), which are the criteria for determining agricultural drought and meteorological drought, were calculated and compared. For this purpose, the droughts that occurred in the Baeksan reservoir in Gimje and the Edong reservoir in Suwon were evaluated by using the IADI and SPI drought indecies. In addition, we compared and analyzed the depth of drought based on the two drought indices. Evaluations derived form the IADI and SPI showed that the standard precipitation index tended to indicate the occurrence of drought earlier than the integrated agricultural drought index. However, the integrated agricultural drought index was better than the standard precipitation index at evaluating the severity of drought during the period of irrigation. The relationship between these two drought indices seems to be useful for decision making in the case of drought, and it is considered that more studies are needed to examine the applicability of these drought indexes.

Visual Analysis for Detection and Quantification of Pseudomonas cichorii Disease Severity in Tomato Plants

  • Rajendran, Dhinesh Kumar;Park, Eunsoo;Nagendran, Rajalingam;Hung, Nguyen Bao;Cho, Byoung-Kwan;Kim, Kyung-Hwan;Lee, Yong Hoon
    • The Plant Pathology Journal
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    • v.32 no.4
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    • pp.300-310
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    • 2016
  • Pathogen infection in plants induces complex responses ranging from gene expression to metabolic processes in infected plants. In spite of many studies on biotic stress-related changes in host plants, little is known about the metabolic and phenotypic responses of the host plants to Pseudomonas cichorii infection based on image-based analysis. To investigate alterations in tomato plants according to disease severity, we inoculated plants with different cell densities of P. cichorii using dipping and syringe infiltration methods. High-dose inocula (${\geq}10^6cfu/ml$) induced evident necrotic lesions within one day that corresponded to bacterial growth in the infected tissues. Among the chlorophyll fluorescence parameters analyzed, changes in quantum yield of PSII (${\Phi}PSII$) and non-photochemical quenching (NPQ) preceded the appearance of visible symptoms, but maximum quantum efficiency of PSII ($F_v/F_m$) was altered well after symptom development. Visible/near infrared and chlorophyll fluorescence hyperspectral images detected changes before symptom appearance at low-density inoculation. The results of this study indicate that the P. cichorii infection severity can be detected by chlorophyll fluorescence assay and hyperspectral images prior to the onset of visible symptoms, indicating the feasibility of early detection of diseases. However, to detect disease development by hyperspectral imaging, more detailed protocols and analyses are necessary. Taken together, change in chlorophyll fluorescence is a good parameter for early detection of P. cichorii infection in tomato plants. In addition, image-based visualization of infection severity before visual damage appearance will contribute to effective management of plant diseases.