• 전기학회논문지
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• 제60권1호
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• pp.167-173
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• 2011

Most of the terminologies used in medical domain is not intended to be applied directly in clinical setting but is developed to integrate the terms by defining the reference terminology or concept relations between the terms. Therefore, it is needed to develop the subsets of the terminology which classify categories properly for the purpose of use and extract and organize terms with high utility based on the classified categories in order to utilize the clinical terms conveniently as well as efficiently. Moreover, it is also necessary to develop and upgrade the terminology constantly to meet user's new demand by changing or correcting the system. This study has developed a mapping tool that allows accurate expression and interpretation of clinical terms used for medical records in electronic medical records system and can furthermore secure semantic interoperability among the terms used in the medical information model and generate common terms as well. The system is designed to execute both 1:1 and N:M mapping between the concepts of terms at a time and search for and compare various terms at a time, too. Also, in order to enhance work consistency and work reliability between the task performers, it allows work in parallel and the observation of work processes. Since it is developed with Java, it adds new terms in the form of plug-in to be used. It also reinforce database access security with Remote Method Invocation (RMI). This research still has tasks to be done such as complementing and refining and also establishing management procedures for registered data. However, it will be effectively used to reduce the time and expenses to generate terms in each of the medical institutions and improve the quality of medicine by providing consistent concepts and representative terms for the terminologies used for medical records and inducing proper selection of the terms according to their meaning.

• 전기전자학회논문지
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• 제21권1호
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• pp.100-103
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• 2017

움직임 추정기는 동영상 압축에서 가장 많은 연산량을 차지하는 연산으로, 처리 속도를 맞추기 위해 다수의 단위 연산기를 병렬로 사용하는 경우가 많다. 단위 연산기를 많이 사용할수록 처리 속도가 빨라지지만 하드웨어 면적도 커지기 때문에 단위 연산기의 개수를 최적화하는 것이 중요하다. HEVC(high efficiency video coding)의 경우 연산량을 줄이고 성능을 높이기 위해서 다단계 움직임 추정 기법을 주로 사용하는데, 각 단계마다 탐색점의 개수 및 위치가 다르기 때문에 단위 연산기의 사용률이 항상 100%가 되지 않으며 단위 연산기의 개수에 따라 사용률이 크게 달라진다. 본 논문에서는 단위 연산기의 사용률과 연산 사이클을 계산하여 주어진 움직임 추정 기법에 최적화된 단위 연산기 개수를 찾아 내는 방법을 제안한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제27권1호
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• pp.31-38
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• 2016

Pharmacotherapy is considered the first line therapy in attention-deficit hyperactivity disorder (ADHD). Many patients also choose complementary medicine such as dietary supplements. Omega-3 has shown some efficacy for improving ADHD symptoms in several studies. The goal of this review is to integrate the previous research findings on omega-3 and understand the issues worth considering in the treatment of ADHD. The terms "attention deficit disorder with hyperactivity", "omega-3", and "dietary supplements" were searched on PubMed, Cochrane, and Google scholar. The search was further limited to clinical trials, reviews, and meta-analyses. Trials that examined treatments for ADHD, used randomized design, and placebo-controlled trials were included. Eighteen clinical trials with a total of 1,141 participants were included in this review. Fifteen trials had parallel designs, comparing an omega-3/6 polyunsaturated fatty acid (PUFAs) or a combination of both to a placebo and three compared omega-3/6 PUFAs to a placebo and psycho-stimulants. Seven of the included trials showed significant improvements in groups receiving omega-3/6 PUFAs compared to placebo groups, however, 11 trials showed no significant differences. Evidence that PUFAs supplementation provides benefits for ADHD was yet limited. Mixed results were due to selection variability criteria, variability of supplementation, and short follow-up intervals.

• Journal of Gastric Cancer
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• 제12권2호
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• pp.73-80
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• 2012

Purpose: The specific aim of this study is to unravel a DNA copy number alterations, and to search for novel genes that are associated with the development of Korean gastric cancer. Materials and Methods: We investigated a DNA copy number changes in 23 gastric adenocarcinomas by array-comparative genomic hybridization and quantitative real-time polymerase chain reaction analyses. Besides, the expression of UQCRFS1, which shows amplification in array-CGH, was examined in 186 gastric cancer tissues by an immunohistochemistry, and in 9 gastric cancer cell lines, as well as 24 gastric cancer tissues by immunoblotting. Results: We found common gains at 48 different loci, and a common loss at 19 different loci. Amplification of UQCRFS1 gene at 19q12 was found in 5 (21.7%) of the 23 gastric cancers in an array-comparative genomic hybridization and DNA copy number were increased in 5 (20.0%) out of the 25 gastric cancer in quantitative real-time polymerase chain reaction. In immunohistochemistry, the overexpression of the protein was detected in 105 (56.5%) out of the 186 gastric cancer tissues. Statistically, there was no significant relationship between the overexpression of UQCRFS1 and clinicopathologic parameters (P>0.05). In parallel, the overexpression of UQCRFS1 protein was confirmed in 6 (66.7%) of the 9 gastric cancer cell lines, and 12 (50.0%) of the 24 gastric cancer tissues by immunoblotting. Conclusions: These results suggest that the overexpression of UQCRFS1 gene may contribute to the development and/or progression of gastric cancer, and further supported that mitochondrial change may serve as a potential cancer biomarker.

• Journal of Genetic Medicine
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• 제7권2호
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• pp.119-124
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• 2010

약 7,000 여개의 단일유전자질환이 보고되어 있지만 보고된 질환의 절반도 아직 원인 유전자가 밝혀지지 못한 상황이다. 그리고 기존에 밝혀진 원인 유전자의 돌연변이형들은 대부분 단백질을 코딩하는 부위의 돌연변이에 의하여 발생하고 있어서 인간 유전체에서 단백질을 코딩하는 엑손 부위만을 선별적으로 분리하여 염기서열을 분석하는 엑솜 염기서열 분석 방법은 희귀한 유전질환의 신규 원인 유전자 발굴을 위한 매우 효과적인 유전 분석법이 될 것이다. 엑솜은 전체 유전체의 약 1.5% 정도를 차지하고 있어서 매우 경제적으로 분석이 가능하다. 그리고 엑솜 염기서열 분석 방법은 엑솜 부위를 선별하는 기술과 대용량 염기서열 분석기술로 수행된다. Freeman-Sheldon 증후군의 원인 유전자를 엑솜 염기서열 분석 방법으로 발굴한 이후로 단일유전자질환의 원인 유전자 발굴을 위한 표준 분석법으로 엑솜 염기서열 분석방법이 사용되고 있다. 향후에는 엑솜 염기서열 분석 방법이 다양한 복합질병의 유전분석에도 활용되어 개인 맞춤의학의 실현을 앞당기는데 크게 기여할 것으로 기대된다.

• 컴퓨터교육학회논문지
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• 제21권6호
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• pp.39-47
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• 2018

이 연구는 사다리타기 게임에서 등장하는 사다리 모양에 따른 이산구조를 순열과 조합적 사고, 알고리즘적 구현을 통하여 최소생성사다리를 생성하는 방법과 컴퓨팅 사고력과의 관련성을 탐구하는 내용을 다루었다. 먼저 연구자는 사다리 모양의 세로판과 가로판의 조합에 따라서 생성되는 순열 중에서 역순열에 대응하는 사다리(최소생성사다리)를 필터링 기법과 새로 개선한 알고리즘을 고안하여 Mathematica 프로젝트로 진행하였다. 그 결과 최소생성사다리를 생성원(generator)으로 하는 새로운 그래프를 Mathematica로 창출하여 YC그래프라 이름 붙였으며 그에 대한 속성을 조사하였다. YC그래프는 이전 차원의 그래프를 내포하는 재귀적 구조와 다층 구조를 가졌으며 간선대칭의 특징을 보여주었다. 또한 계산복잡도가 증가함에 따라 세로판 5개, 가로판 10개 사다리부터 층별로 최소생성사다리를 생성하도록 탐색 공간을 분할하는 알고리즘을 적용하였다. 이 과정에서 자료의 시각화, 추상화 및 병렬처리 알고리즘 구현을 통한 컴퓨팅 사고력이 새로운 YC그래프의 창출 및 구조 분석에 기여한 것으로 나타났다.

• 디지털융복합연구
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• 제16권11호
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• pp.237-253
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• 2018

급변하는 환경 속에서 기업은 동적역량이 중요한 요소로 등장하고 빅 데이터의 활용은 비즈니스의 새로운 핵심가치로 부각되고 있으나 기업이 빅 데이터를 활용함에 있어 성과를 창출할 수 있는 기업의 주요자원 및 역량에 대한 연구는 미미한 실정이다. 본 연구에서는 빅 데이터 활용의도에 영향을 주는 중소기업의 동적역량과 기업가지향성에 대해 분석하였다. 실증분석을 위해 국내 연구개발을 수반하는 중소기업 364개를 대상으로 설문조사를 실시하여 동적역량이 기업가지향성을 경유하여 빅 데이터 활용의도에 미치는 영향에 대해 SPSS Win Ver.22.0와 PROCESS macro v3.0을 이용하여 병렬다중 매개분석을 수행하였다. 가설검증결과 동적역량은 빅 데이터 활용의도에 정의 영향을 미쳤으며, 기업가지향성은 부분적으로 빅 데이터 활용의도에 정의 영향을 미치는 것으로 나타났다. 본 연구를 통해 인공지능과도 연계된 빅 데이터의 활용의 결정요인으로 중소기업의 핵심자원인 동적역량과 기업가지향성에 영향력과 이해도를 높이고 중소기업 경영관리에 도움을 주고자 한다.

• 대기
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• 제29권1호
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• pp.75-86
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• 2019

In this paper, we introduce a novel Climate & Environment Database System (CEDS). The CEDS is developed by the National Institute of Meteorological Sciences (NIMS) to provide easy and efficient user interfaces and storage management of climate model data, so improves work efficiency. In uploading the data/files, the CEDS provides an option to automatically operate the international standard data conversion (CMORization) and the quality assurance (QA) processes for submission of CMIP6 variable data. This option increases the system performance, removes the user mistakes, and increases the level of reliability as it eliminates user operation for the CMORization and QA processes. The uploaded raw files are saved in a NAS storage and the Cassandra database stores the metadata that will be used for efficient data access and storage management. The Metadata is automatically generated when uploading a file, or by the user inputs. With the Metadata, the CEDS supports effective storage management by categorizing data/files. This effective storage management allows easy and fast data access with a higher level of data reliability when requesting with the simple search words by a novice. Moreover, the CEDS supports parallel and distributed computing for increasing overall system performance and balancing the load. This supports the high level of availability as multiple users can use it at the same time with fast system-response. Additionally, it deduplicates redundant data and reduces storage space.

• 동의생리병리학회지
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• 제34권6호
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• pp.309-318
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• 2020

Besides respiratory infection, COVID-19 has many neurological symptoms not only loss of smell and taste but also fatigue and brain fog. But it is a challenge to treat the neurological symptoms especially of anosmia and ageusia. In order to search for the therapeutic methods, the geographical diversity and pathological mechanisms of the COVID-19 and two symptoms were investigated from the latest clinical studies. Because the environmental conditions of the monsoon climate zone of East Asia and the Mediterranean and Oceanic climate zone of Italy, Britain, United States and tropical Brazil are different, each of diverse etiology and internal milieu should be considered differently in the treatment. SARS-CoV-2 exhibits the dampness-like characteristics and the olfactory and gustatory disorders are particularly more common than other flu or cold. and it tends to show features of damaging the lung qi of olfaction and heart-spleen qi of gustation. The mechanisms of olfactory and gustatory loss are various according to precursory, inflammatory, non-inflammatory and sequelar forms, so the therapeutic method should be designed for each period and pathology. If the process of inflammation arises from nasal and respiratory, olfactory epithelium to the central nervous structure by way of blood brain barrier, the treatment should be corresponded with the stage and depth of pathogen place. And if the olfactory loss is asymptomatic or in the initial stage, it can be applied intranasal topical scent therapy to relieve temporary locking of qi movement, but maybe also used in parallel together with herbs of relieving dampness toxin latent in the lung parenchyma.

• Journal of Dental Anesthesia and Pain Medicine
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• 제21권6호
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• pp.527-545
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• 2021

The aim of this systematic review was to determine the success rate of nitrous oxide-oxygen procedural sedation (NOIS) in dentistry. A systematic digital search was conducted for publications or reports of randomized controlled trials evaluating the clinical performance of NOIS. Abstracts of research papers were screened for suitability, and full-text articles were obtained for those who met the inclusion and exclusion criteria accordingly. The quality of the studies was assessed using the revised Cochrane risk-of-bias tool (RoB 2). A total of 19 articles (eight randomized clinical trials with parallel intervention groups and 11 crossover trials), published between May 1988 and August 2019, were finally selected for this review. The studies followed 1293 patients reporting NOIS success rates, with a cumulative mean value of 94.9% (95% CI: 88.8-98.9%). Thirteen trials were conducted on pediatric populations (1098 patients), and the remaining six were conducted on adults (195 patients), with cumulative efficacy rates of 91.9% (95% CI: 82.5-98.1%) and 99.9% (95% CI: 97.7-100.0%), respectively. The difference was statistically significant (P = 0.002). Completion of treatment and Section IV of the Houpt scale were the most used efficacy criteria. Within the limitations of this systematic review, the present study provides important information on the efficacy rate of NOIS. However, further well-designed and well-documented clinical trials are required and there is a need to develop guidelines for standardization of criteria and definition of success in procedural sedation. Currently, completion of treatment is the most used parameter in clinical practice, though many others also do exist at the same time. To maximize NOIS efficacy, clinicians should strictly consider appropriate indications for the procedure.