• Journal of Life Science
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• v.25 no.8
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• pp.947-952
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• 2015

Prostate apoptosis response-4 (Par-4) was originally identified in androgen-independent prostate cancer cells undergoing apoptosis. Par-4 is ubiquitously expressed in normal cells and tissues, but it is downregulated in several types of cancers. Par-4 is a 38 kDa tumor suppressor protein encoded by the PARW gene. Par-4 promotes apoptosis in a variety of cancerous cells, but not in normal cells. In this review, we focused on the structure, expression and function of Par-4 in apoptotic signaling pathway. Functional domains of Par-4 include two nuclear localization sequences (NLS), a leucine zipper (LZ) domain, a nuclear export sequence (NES) and selective for apoptosis in cancer cell (SAC) domain. Many studies have underlined the importance of Par-4 in preventing cancer development. The activity of Par-4 is differently regulated by localization of intracellular and extracellular Par-4. Intracellular Par-4 inhibits Akt- and NF-κB-mediated cell survival pathways and downregulates Bcl-2 expression. Extracellular Par-4 activates the extrinsic apoptotic pathway by binding to cell surface receptor GRP78, a stress response protein that is in the endoplasmic reticulum (ER). Endogenous Par-4 sensitizes cancer cells to various apoptotic stimuli, while exogenous Par-4 enhances SAC domain-dependent apoptosis in cancer cells, but not normal cells. Therefore, Par-4 is an attractive target for cancer therapy.

• Nuclear Engineering and Technology
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• v.55 no.12
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• pp.4382-4394
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• 2023

Passive auto-catalytic recombiners (PARs) are widely used to mitigate a hydrogen hazard. The first step to evaluate the hydrogen safety by PARs is to obtain qualified test data of the PARs for validation of their analytical model. SPARC PAR tests SP8 and SP9 were conducted to evaluate the hydrogen recombination characteristics of a honeycomb-shaped catalyst PAR. To obtain the hydrogen recombination rate from the PAR test data, two methods, Method-1 and Method-2, introduced by the THAI project, were applied. Since a large gradient of hydrogen concentration developed during hydrogen injection can cause a large error in the hydrogen mass obtained by integrating the measured hydrogen concentrations, a gate was installed at the PAR inlet to homogenize hydrogen in the test vessel before the PAR operation in the tests. A computational fluid dynamics (CFD) code with a PAR model was also applied to evaluate the characteristics of the PAR recombination according to the PAR inlet conditions, and the results were compared with those from Method-1 and Method-2. It was confirmed that the recombination rates from Method-1 require a correction factor to be compatible with results from Method-2 and the CFD simulation in the case of the SPARC-PAR tests.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.10 s.101
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• pp.995-1002
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• 2005

An orthogonal frequency division multiplexing(OFDM) system has the problem of the peak-to-average power ratio(PAR). In general, in order to obtain optimal PAR reduction using the partial transmitted sequence(PTS), the total search for the number of sub-blocks and the rotation factors must be accomplished. As the number of sub-blocks and rotation factors increases, PAR reduction improves, such that complexity increases exponentially and the process delay occurs simultaneously. Therefore a technique that reduces PAR, which is almost close to optimal, and the amount of calculation is desired. In this paper a new method using genetic algorithm(GA), which is widely used to search for a point that is globally optimal in many problems, is proposed to search for a rotation factor that reduces simultaneously both the PAR and the amount of calculation, such that the complexity of calculation and the process time are reduced at the same time, Comparison is performed between the proposed method and the various techniques developed previously. The superiority of proposed method is presented by demonstrating the reduction of complexity while a similar PAR reduction is obtained.

• Journal of Korean Dental Science
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• v.7 no.1
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• pp.6-15
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• 2014

Purpose: The purpose of this retrospective study is to investigate the degree of coincidence between the peer assessment rating (PAR) index and American Board of Orthodontics objective grading system (ABO-OGS) in the assessment of orthodontic treatment outcomes of Class I malocclusion cases. Materials and Methods: The sample consisted of 26 Class I patients. The PAR index was used for evaluation of pre-(T0) and posttreatment (T1) casts, and the ABO-OGS for assessment of T1 casts. If there was a reduction in PAR scores from T0 to T1 of more than 30%, the label 'PAR+' was given to the case, and if not, it was labeled 'PAR-'. If the ABO-OGS was less than 27, the label 'OGS+' was given to the case and if not, it was labeled 'OGS-'. 'A PAR-only qualified group' (PAR+), 'ABO-OGS-only qualified group' (OGS+), 'both indices qualified group' (PAR+/OGS+), and 'both indices disqualified group' (PAR-/OGS-) were compared with a Wilcoxon rank-sum test, sensitivity/specifi city test and Spearman's correlation test. Result: PAR scores for T0, T1, and percentage reduction were 21.1, 6.4, and 65.9%, respectively, and 35.4 for ABOOGS. The distribution of the 'PAR+/OGS+', 'PAR+', and 'PAR-/OGS-' group was 19.3%, 76.9%, and 3.8%, respectively. The T0-PAR, T1-PAR and PAR point reductions for the 'PAR+' group were significantly higher than those of 'PAR+/OGS+' groups (23.1 vs. 15.6; 6.7 vs. 4.6; and 16.5 vs. 11.0; all P<0.05). However, the PAR-percentage reduction and treatment duration between the two groups were not statistically different (70.0% vs. 67.0%, P=0.4325; 24.1 months vs. 25.0 months, P=0.4057). The T1-ABO-OGS score for 'PAR+' group was significantly higher than that of the 'PAR+/OGS+' groups (38.2 vs. 24.0, P<0.001). Conclusion: Since the fraction of the 'PAR+/OGS+' group was less than 20% and there was no significant correlation between PAR-percentage reduction and T1-ABO-OGS, development of a new index system for the accurate evaluation of treatment outcome is needed.

• Korean Journal of Remote Sensing
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• v.32 no.3
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• pp.253-262
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• 2016

Here, we estimated daily Photosynthetically Available Radiation (PAR) from Geostationary Ocean Colour Imager (GOCI) and compared it with daily PAR derived from polar-orbiting MODIS images. GOCI-based PAR was also validated with in-situ measurements from ocean research station, Socheongcho. GOCI PAR showed similar patterns with in-situ measurements for both the clear-sky and cloudy day, whereas MODIS PAR showed irregular patterns at cloudy conditions in some areas where PAR could not be derived due to the clouds of sunglint. GOCI PAR had shown a constant difference with the in-situ measurements, which was corrected using the in-situ measurements obtained on the days of clear-sky conditions at Socheongcho station. After the corrections, GOCI PAR showed a good agreement excepting on the days with so thick cloud that the sensor was optically saturated. This study revealed that GOCI can estimate effectively the daily PAR with its advantages of acquiring data more frequently, eight times a day at an hourly interval in daytime, than other polar orbit ocean colour satellites, which can reduce the uncertainties induced by the existence and movement of the cloud and insufficient images to map the daily PAR at the seas around Korean peninsula.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.4
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• pp.422-430
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• 2018

The inappropriate and widespread use of quinolones in humans and animals may cause accelerated emergence and spread of antimicrobial-resistant determinants. In this study, we investigated quinolone resistance mechanisms in a total of 65 nalidixic acid-resistant E. coli isolated from swine rectal swabs (N=40) and clinical specimens (N=25). Antimicrobial susceptibilities were determined by the disk diffusion method. PCR and DNA sequencing were performed for investigations of genes and mutations associated with quinolone resistance. In our study, 62 of 65 nalidixic acid-resistant E. coli harbored mutations in gyrA, parC, and/or parE genes; of the 65 isolates, 62 (95.4%) had mutations in the gyrA gene, 35 (53.8%) had mutations in the parC gene, 7 (10.8%) had mutations in the parE gene. The 35 isolates harbored mutations in two genes, gyrA and parC. Plasmid-mediated quinolone resistance (PMQR) determinants were investigated in the 65 isolates. Thirteen of 65 nalidixic acid-resistant E. coli contained the qnrS gene and 10 of those isolates had mutations in the gyrA, parC, and/or parE genes. We confirmed that an important mechanism of quinolone resistance in E. coli isolated from human and swine involves chromosomal mutations in the gyrA, parC, and/or parE genes with increasing use of quinolone for treatment or additives.

• Journal of Navigation and Port Research
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• v.29 no.8 s.104
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• pp.755-761
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• 2005

In this paper, we propose a high-speed adaptive PTS method which eliminates high PAR (Peak-to-Average Power Ratio) and we compare the proposed method with other conventional methods. In addition, we have designed a combined type SLM-PTS scheme to reduce PAR and evaluate the performance. The system used for evaluating PAR performance can be constructed as COFDM (Coded Orthogonal Frequency Division Multiplexing) applying ETD(Enhabced Time Diversity)-Turbo coding scheme. All the analyses in this paper are focused on the system characteristics according to IFFT's point and modulation method and the performance evaluation are based on the PAR reduction rates. As a result, the SLM-PTS combination method reveals good PAR reduction rate and remarkable reduction in the amount of calculations. Especially, in the case of combine-3 scheme, we can achieve approximately $3.7\~3.9$ dB PAR reduction on a basis of 10-5 BER level. Moreover, we can eliminate the side information in COFDM system because of its adaptive characteristics in evaluating PAR reduction rate, so that the additional errors can be omitted.

• Journal of Advanced Navigation Technology
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• v.10 no.1
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• pp.20-25
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• 2006

In these days, OFDM(Orthogonal Frequency Division Multiplexing) is adopted to support high-speed data communication based on multi-path RF channel, but it has some weak point. One of those is that it has a higher PAR(peak-to-average power ratio) compared with single-carrier method. If some PAR of the transmitted signal is high, nonlinear amplitude distortion has occurred when it pass through the HPA(high power amplifier). There is a solution to prevent nonlinear distortion using higher peak power HPA, but it makes inefficiency and a cost problem. In this paper, we choose the SLM(Selected Mapping) scheme, which transmit the lowest PAR signal after OFDM symbol mapping, in various schemes reducing PAR for OFDM system. And we derived the performances of SLM method in fading channel through computer simulations.

• BMB Reports
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• v.45 no.11
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• pp.595-603
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• 2012

Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy.

• Journal of Microbiology and Biotechnology
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• v.20 no.12
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• pp.1735-1743
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• 2010

The full-length genes gyrB (2,415 bp), parC (2,277 bp), and parE (1,896 bp) in Edwardsiella tarda were cloned by PCR with degenerate primers based on the sequence of the respective quinolone resistance-determining region (QRDR), followed by elongation of 5' and 3' ends using cassette ligation-mediated PCR (CLMP). Analysis of the cloned genes revealed open reading frames (ORFs) encoding proteins of 804 (GyrB), 758 (ParC), and 631 (ParE) amino acids with conserved gyrase/topoisomerase features and motifs important for enzymatic function. The ORFs were preceded by putative promoters, ribosome binding sites, and inverted repeats with the potential to form cruciform structures for binding of DNA-binding proteins. When comparing the deduced amino acid sequences of E. tarda GyrB, ParC, and ParE with those of the corresponding proteins in other bacteria, they were found to be most closely related to Escherichia coli GyrB (87.6% identity), Klebsiella pneumoniae ParC (78.8% identity), and Salmonella Typhimurium ParE (89.5% identity), respectively. The two topoisomerase genes, parC and parE, were found to be contiguous on the E. tarda chromosome. All 18 quinolone-resistant isolates obtained from Korea thus far did not contain subunit alternations apart from a substitution in GyrA (Ser83$\rightarrow$Arg). However, an alteration in the QRDR of ParC (Ser84$\rightarrow$Ile) following an amino acid substitution in GyrA (Asp87$\rightarrow$Gly) was detected in E. tarda mutants selected in vitro at $8{\mu}g/ml$ ciprofloxacin (CIP). A mutant with a GyrB (Ser464$\rightarrow$Leu) and GyrA (Asp87$\rightarrow$Gly) substitution did not show a significant increase in the minimum inhibitory concentration (MIC) of CIP. None of the in vitro mutants exhibited mutations in parE. Thus, gyrA and parC should be considered to be the primary and secondary targets, respectively, of quinolones in E. tarda.