• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5993-5999
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• 2015

Background: Molecular testing for human papillomavirus (HPV) is the most objective and reproducible of all cervical cancer screening tests and also less demanding in terms of training and quality assurance. However, there is an impending need for cost effective molecular HPV testing methods with sampling ease, easy storage measures and minimum turn around times suitable for a low resource setting. Objective : Our aim was to evaluate the feasibility of using a fast transfer analysis (FTA) mini elute cartridge for cervical sampling to identify high risk HPV by real time PCR and to compare molecular HPV testing and Pap cytology testing to predict histologically confirmed cervical precancer (CIN 2+ lesions) in a cervical cancer prevention program. Materials and Methods: This was conducted as a pilot study (n=200) on women sampled using FTA mini elute cartridges, genotyped by two different real time PCR assays, detecting 13 high risk HPV (HR HPV) species, including HPV16 along with its physical DNA status. Results obtained from each of the tests were compared and analysed using suitable statistical tests. Results: With FTA mini elute cartridge samples HR HPV positivity was seen in 48/200 (24%). Of these, presence of HPV 16 DNA was observed in 28/48 (58.3%) women. High risk HPV was positive in 20% (37/185) of women with benign cytology and 73.3% (11/15) of women with abnormal cytology findings. A very significant correlation (${\chi}^2=22.090$ ; p=0.000) was observed between cytology and HR HPV findings showing an increasing trend of HR HPV prevalence in 50% (1/2) of LSIL, 75% (3/4) of HSIL and 100% (3/3) of SCC. Of the CIN 2+ lesions identified by histopathology, 88.9% (8/9) had HR HPV. A significant association (${\chi}^2=11.223$ ; p=0.001) of HR HPV and histopathologically confirmed CIN 2+ lesions was found. Sensitivity of the two tests were comparable but specificity of Pap testing was better (90.7% vs 70.4%) to predict histopathologically diagnosed cervical precancers. Conclusions: The current study explored the feasibility of using a FTA mini elute cartridge for cervical sampling for the first time in India as a part of a community based cervical cancer prevention program. We suggest that FTA based sampling is suitable and feasible for real time based HPV testing. Molecular HR HPV testing can be more sensitive and useful to identify high risk women requiring Pap testing which is more specific to detect histologically confirmed cervical precancer.

• Journal of Chest Surgery
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• 제27권9호
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• pp.723-731
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• 1994

We have modified the isolated perfused working rabbit lung model [IPWL] by perfusing the isolated lung with a hollow fiber membrane deoxygenator.For assessment the stored lung was ventilated with FIO2 0.4 and perfused with 37$^{\circ}$C deoxygenated circulating blood at a rate 5ml/kg/min for several hours until lung failure.We chose to compare our developing solution which contained low potassium and pentastarch with the modified Euro-Collins solution .Experiments were divided into four groups[n=6] based on the type of flushing preservation solution and preservation time.The flushed lungs were then preserved into same solution at 8~10$^{\circ}$C with 100% O2 inflated condition for 1 or 20 hours.These following results were obtained.The IPWL model requires only one animal per experiment and allows for the continuous assessment of aerodynamic performance. This should therefore be used as screening test in lung preservation.One hour preservation groups, there were no significant difference in recovery rates of PaO2, PAP and Paw. Survival time in the one hour preservation groups were very significant long in the Group II[LPPS, p<0.01]. Twenty hours preservation groups, there were no significant difference in the recovery rates of PAP and Paw between Group III[m-ECS] and Group IV[NS], but PaO2 was significantly worse at onset of reperfusion in Group III when compared with Group IV [p<0.05]. And also survival time in the 20 hours preservation groups were significant long in the Group IV [p<0.05].

• 지역사회간호학회지
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• 제21권1호
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• pp.43-52
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• 2010

Purpose: The aim of this study was to compare health promotion behavior in middle-aged rural residents by cancer screening participation. Methods: Data were collected from 508 rural residents during the period from April 6 to June 6, 2009 using structured questionnaires, and analyzed using SPSS/WIN 12.0. Results: The cancer screening rate was 50.2%. The rate was significantly different according to sex, educational level, marital status, private insurance, family cancer history, smoking, drinking, perceived health status, and health concern. Men showed the highest screening rate in gastroscopy for stomach cancer, and women in pap smear test for cervical cancer. Pap smear test for cervical cancer showed the highest regular screening rate (4.3%). The average score of health promotion behavior was $2.65{\pm}0.35$. Health promotion behavior was significantly different according to cancer screening participation, health responsibility, stress management, and self actualization. Conclusions: These results suggested that there may be differences in health promotion behavior among middle-aged rural residents according to their cancer screening participation. A further study is necessary to find effective interventions for the non-cancer screening group.

• 대한후두음성언어의학회지
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• 제13권1호
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• pp.23-27
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• 2002

The purpose of the study is to examine differences in subglottic air pressure as a function of phonetic context. The phonetic contexts consisted of $/i:{p^h}i:{p^h}i:/,/{p^h}i:{p^h}i:/, and /{p^h}{p^h}/$. The aerodynamic and phonatory parameters are investigated in 20 female normal adults. All measurements are taken and analysed using Aerophone II voice function analyzer. The aerodynamic parameters are Peak Air Pressure(PAP) and Mean Air Pressure(MAP), and the phonatory parameters are Phonatory Flow Rate(PFR) Maximum SPL(MSPL), Phonatory SPL(PSPL), Phonatory Power (PP), Phonatory Efficiency(PE), and Phonatory $Resistance^*$ 10-5(PR). A one-way ANOVA revealed the following results. First, the aerodynamic parameters are not significantly different. Second, Peak Air Pressure(PAP) and Mean Air Pressure(MAP), as well as the phonatory parameters such as Phonatory Flow Rate(PFR) Maximum SPL(MSPL), Phonatory SPL(PSPL), and Phonatory Efficiency(PE) were significantly different. Therefore, it is advised that clinicians use only aerodynamic parameters but phonatory parameters when using Aerophone II.

• 여성건강간호학회지
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• 제9권1호
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• pp.28-38
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• 2003

The purpose of this study was to explore the experience of Pap smear screening of menopausal women in W city using a phenomenological methodology. The participants were 5 focus groups consisting of 37 menopausal women. They were selected using snowball sampling method. The data were collected through focus group interviews. Data were recorded and analyzed by Colazzi's method. Significant statements were extracted from the data resulting in 20 themes. These themes formed 12 clusters and 5 categories. The essential themes of the experience of cervical cancer screening emerged as : "unpleasant feelings during procedure", "ambivalent feelings about results", "be guided to seek health", "shrink from interaction with health professionals", "at ease about cervical cancer". The results indicated that cervical cancer prevention strategies for menopausal women need to be based on deep under standing of the personal experiences of Pap smear screening. In conclusion, it is suggested that more specified strategies are needed for menopausal women to encourage them to have regular screening.

• 한국환경농학회지
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• 제6권1호
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• pp.61-66
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• 1987

수종(數種)의 과채류(果菜類)에 대(對)한 농약(農藥)의 잔류량(殘留量)을 조사(調査)한 결과(結果)는 다음과 같다. 1. 채소류(菜蔬類)(무우, 배추, 오이, 도마토)에서의 MEP, Malathion이 검출(檢出)빈도가 비교적 높았으며, Parathion, Captan은 전시료(全試料)에서 부검출(不檢出)되었으며 검출(檢出)된 농약(農藥)의 잔류량(殘留量)도 낮은 수준(水準)으로서 허용기준(許容基準)의 $\frac{1}{3}{\sim}\frac{1}{66}$이었다. 2. 과실류(果實類)(포도, 복숭아)에서는 MEP, PAP, Parathion의 검출(檢出)빈도가 높았고 Diazinon, Captan은 전시료(全試料)에서 부검출(不檢出)되었다. 검출(檢出)된 농약잔류량(農藥殘留量)은 극히 낮은 수준(水準)으로서 허용기준(許容基準)의 $\frac{1}{8}{\sim}\frac{1}{500}$이었다. 3. 국내생산(國內生産) 과채류중(果菜類中)의 농약잔류량(農藥殘留量)은 국내외(國內外)의 잔류허용기준(殘留許容基準)에 훨씬 미달(未達)되는 수준(水準)이었으며 그 잔류량(殘留量)도 세정(洗淨)이나 조리과정(調理過程)에서 상당한 량(量)이 제거(除去)될 것으로 생각되므로 실제로 인체에 섭취(攝取)되는 잔류농약(殘留農藥)의 량(量)은 적을 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5023-5029
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• 2013

Background: To evaluate knowledge about screening tests and tests without proven screening value in a Greek Breast Unit population undergoing benign vacuum-assisted breast biopsy (VABB). Materials and Methods: This study included 81 patients. Three knowledge-oriented items (recommended or not, screening frequency, age of onset) were assessed. Regarding screening tests two levels of knowledge were evaluated: i). crude knowledge (CK), i.e. knowledge that the test is recommended and ii). advanced knowledge (AK), i.e. correct response to all three knowledge-oriented items. Solely CK was evaluated for tests without proven screening value. Risk factors for lack of knowledge were assessed with multivariate logistic regression. A second questionnaire was administered 18 months after VABB to assess its impact on the performance of tests. Results: Concerning screening tests considerable lack of AK was noted (mammogram, 60.5%; Pap smear, 59.3%; fecal occult blood testing, 93.8%; sigmoidoscopy, 95.1%). Similarly lack of CK was documented regarding tests without proven screening value (breast self-examination, 92.6%; breast MRI, 60.5%; abdominal ultrasound, 71.6%; barium meal, 48.1%; urine analysis, 90.1%; chest X-Ray, 69.1%; electrocardiogram, 74.1%; cardiac ultrasound, 75.3%). Risk factors for lack of AK were: place of residence (mammogram), age (Pap smear), personal income (sigmoidoscopy); risk factors for lack of CK included number of offspring (breast MRI, chest X-Ray), BMI (abdominal ultrasound), marital status (urine analysis), current smoking status (electrocardiogram). VABB's only effect was improvement in mammogram rates. Conclusions: A considerable lack of knowledge concerning screening tests and misperceptions regarding those without proven value was documented.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 제14회 신호처리 합동 학술대회 논문집
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• pp.609-612
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• 2001

An adaptive sub-optimal method using a preset threshold for combining partial transmit sequence (PTS) of an orthogonal frequency division multiplexing (OFDM) signal is presented. The results show that adaptive sub-optimal method reduces the 0.1% PAP by 3.4dB, while iterative flipping method reduces it by 3dB and PTS reduce it by 4.1dB. The complexity of adaptive sub-optimal method is 2.4% of that of PTS method for M=8.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.927-932
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• 2015

Background: Breast and cervical cancers are the most common causes of cancer mortality among women in India, but actually they are largely preventable diseases. Although early detection is the only way to reduce morbidity and mortality, there are limited data on breast and cervical cancer knowledge, safe practices and attitudes of teachers in India. The purpose of this study is to assess the level of awareness and impact of awareness programs in adoption of safe practices in prevention and early detection. Materials and Methods: This assessment was part of a pink chain campaign on cancer awareness. During cancer awareness events in 2011 at various women colleges in different parts in India, a pre-test related to cervical cancer and breast cancer was followed by an awareness program. Post-tests using the same questionnaire were conducted at the end of the interactive session, at 6 months and 1 year. Results: A total of 156 out of 182 teachers participated in the study (overall response rate was 85.7 %). Mean age of the study population was 42.4 years (range- 28-59 yrs). There was a significant increase in level of knowledge regarding cervical and breast cancer at 6 months and this was sustained at 1 year. Adoption of breast self examination (BSE) was significantly more frequent in comparison to CBE, mammography and the Pap test. Magazines and newspapers were sources for knowledge regarding screening tests for breast cancer in more than 60% of teachers where as more than 75% were educated by doctors regarding the Pap test. Post awareness at 6 months and 1 year, there was a significant change in alcohol and smoking habits. Major reasons for not doing screening test were found to be ignorance (50%), lethargic attitude (44.8%) and lack of time (34.6%). Conclusions: Level of knowledge of breast cancer risk factors, symptoms and screening methods was high as compared to cervical cancer. There was a significant increase in level of knowledge regarding cervical and breast cancer at 6 months and this was sustained at 1 year. Adoption of BSE was significantly greater in comparison to CBE, mammography and the Pap test. To inculcate safe practices in lifestyle of people, awareness programmes such as pink chain campaign should be conducted more widely and frequently.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.579-583
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• 2015

This study was conducted on female patients with different gynecological problems attending the gynecology out-patient departments of two tertiary care hospitals in Peshawar city of Khyber Pakhtunkhwa, Pakistan between August 2012 and October 2013. The 200 patients had an age range of 21-65 years. Smears were taken with cervical brushes and preserved in preservative medium and processed for manual liquid based cytology (MLBC) for Pap staining. Out of 200 collected samples, 30 samples were found inadequate on cytology. Of the remaining 170 samples, 164 (96.47%) were normal, 5 (2.94%) were of atypical squamous cells of unknown significance (ASCUS) and 1 (0.6%) was of high grade squamous intraepithelial lesion (HSIL). On PCR all the samples were positive for beta globin gene fragment including those reported inadequate on cytology. Out of the 5 ASCUS samples, 2 samples were positive for HPV, one each for HPV 16 and HPV 18, and the rest of the 3 samples were negative for HPV DNA. The 1 sample of HSIL was positive for HPV 16 on PCR. Out of 164 normal samples on cytology, only 1 sample was HPV 16 positive. So overall, 4 (2%) out of 200 samples were positive for HPV DNA, where 3 were HPV 16 (1.5%), and 1 was HPV 18 (0.5%) positive, and thus the ratio of infection with of HPV 16 to HPV 18 was 3:1 in the general population. In conclusion, PCR based HPV detection is a more sensitive method for screening of HPV infection than cytology as sample inadequacy does not affect the results. However, it can be combined with cytology methods in a HPV positive female to achieve the maximum results.