• The Journal of Dong Guk Oriental Medicine
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• v.8 no.2
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• pp.25-46
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• 2000

Pain can be evaluated by experimental methods and clinical methods, but due to subjective characteristics of pain, clinical methods are generally used. The clinical pain measurement tools are divided into unidimensional and multidimensional assessment tools. The former include Visual Analogue Scale, Verbal Rating Scale, Numerical Rating Scale, Pain Faces Scale, and Poker Chip Tool and the latter include McGill Pain Questionnaire, MMPI, Pain Behavior Scale, Pain disability index, and Pain Rating Scale. Unidimensional pain scales mainly measure the intensity of pain on the basis of the patient's self report and their simple construction and ease of use enable the invesgator to assess acute pain. Multidimensional pain scales are used to evaluate subjective, psychological and behavioral aspects of pain and because of its comprehensive and confidential properties they are applied to chronic pain. Patient's linguistic and cognitive abilities are major factors to restrain accurate assessment of pain. Although behavioral patterns and vital sign are inferior to self-report in the measurement of pain, they can be useful indexes in those situations. When deciding on a pain-assessment tool, the investigator must determine which aspect of pain he or she wishes to evaluate on the characteristics of the group of patients, their backgrounds, and their communication skills. Making the proper choice will facilitate the acquisition of meaningful data and the formulation of valid conclusions.

• The Korean Journal of Pain
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• v.19 no.2
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• pp.213-217
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• 2006

Although various treatments for complex regional pain syndrome (CRPS) have been proposed, no well recognized treatment for CRPS has been established. Herein, a case using barbiturate coma therapy for the refractory pain management of a 24-year-old male patient, who suffered from constant stabbing and burning pain, with severe touch allodynia in the left upper extremity following blunt trauma on his forearm is described. Interventional treatments, including permanent spinal cord stimulation and large doses of oral medications, were performed. However, the pain could not be controlled, which lead to frequent emergency room treatment for about 1 month prior to his therapy. He then underwent barbiturate coma therapy due to the uncontrollable pain, with repeated sedation therapy due to his outrageous behavior. His pain became increasingly tolerable and the allodynia was markedly decreased after 5 days of coma therapy.

• The Korean Journal of Pain
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• v.19 no.1
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• pp.17-21
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• 2006

Background: Cyclic guanosine monophosphate (cGMP) plays an important role in the modulation of nociception. Although local sildenafil produces antinociception, by increasing cGMP through the inhibition of phosphodiesterase 5, the effect of spinal sildenafil has not been determined. The authors evaluated the effects of intrathecal sildenafil on the nociceptive behavior evoked by formalin injection and thermal stimulation. Methods: Lumbar intrathecal catheters were implanted into rats, with formalin and Hot-Box tests used as nociceptive models. The formalin-induced nociceptive behavior (flinching response) and withdrawal latency to radiant heat were measured, and the general behaviors also observed. Results: The intrathecal administration of sildenafil produced dose-dependent suppression of the flinches in both phases in the formalin test, and increased the withdrawal latency in the Hot-Box test. No abnormal behaviors were noted. Conclusions: Sildenafil, an inhibitor of phosphodiesterase 5, is active against the nociceptive state evoked in the spinal cord by formalin and thermal stimulations. Accordingly, spinal sildenafil may be useful in the management of pain.

• Journal of Korean Academy of Nursing
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• v.25 no.2
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• pp.341-350
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• 1995

A quasi-experimental study was conducted to examine the effect of ice pack application to post cardiac surgery toddlers before C-tube removal. Twenty toddlers aged 13 months to 24 months, who were admitted to the hospital for open heart surgery during the period from July, 1993 to October, 1993 were randomly assigned to the experimental or control group. An ice pack was applied to the C-tube insertion site for 8 minutes before C-tube removal for the experimental group. The children were videotaped during the procedure to assess pain behavior and crying time. The score on the Modified Behavioral Pain Scale(MBPS), crying time, and vital signs were measured to determine the effect of ice pack application. The data were analyzed using Mann-Whitney U test, Paired t-test, and Pearson correlation coefficient. The result of the study are as follows : 1. There was a significant difference between the experimental group and the control group in pain behavior (U=17.0, p=.01). 2. There was no significant difference between the two groups in crying time. 3. There was a significant difference between the two groups in heart rate (U=24.5, p=.05). 4. There was a significant difference between the two groups in systolic blood pressure (U=24.0, p=.05) 5. There was a significant difference between the two groups in diastolic blood pressure (U=23.0, p=.04). 6. There was no significant difference between the two groups in respiration rate. 7. Pain behavior was significantly correlated with heart rate, systolic blood pressure, and crying time (r=.50, .54 and .59, p<.05). The result showed that the ice pack application was effective to reduce pain related to C-tube removal for the toddlers. From the study, it is recommended that the effectiveness of the cold ap-plication to children undergoing different painful procedures be examined to determine the most effective length of cold application to reduce pain in children.

• Journal of Korean Academy of Nursing
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• v.28 no.2
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• pp.303-318
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• 1998

Cutaneous stimulation and distraction are independent nursing interventions used in various painful conditions, which is explained by gate control theory. This study was aimed at identifying the effect of cutaneous stimulation, distraction and combination of cutaneous stimulation and distraction on the reduction of intravenous injection pain levels of chemotherapy patients. Repeated measurement post test research design was used for one group. Fifty-three cancer patients who received intravenous chemotherapy regulary in outpatient injection rooms of D medical center and Y medical center in Taegu were studied from June 23, 1997 to July 12, 1997. First the intravenous injection pain level of the control period was measured. Second, the intravenous injection pain level of the experimental period using cutaneous stimulation was measured. Third, the intravenous injection pain level of the experimental period using distraction was messured. Fourth, the intravenous injection pain level of the experimental period using a combination of cutaneous stimulation and distraction was measured. The instruments used for this study were a visual analogue pain scale as subjective pain measurement and an objective pain behavior checklist. Analysis of data was done by use of repeated measure ANOVA, bonferni, t-test, and F-test. The results of this study were summerized as follows : 1) The first hypothesis that the subjective pain score of intraveneous injection pain in the experimental period with cutaneous stimulation will be lower than in the control period was rejected. 2) The second hypothesis that the objective pain behavior score of intravenous injection pain in the experimental period with cutaneous stimulation will be lower than in the control period was accepted(F=24.23, p=0.0001, Bornferni p<.05). 3) The third hypothesis that the subjective pain score of intraveneous injection pain in the experimental period with distraction will be lower than in the control period was rejected. 4) The fourth hypothesis that the objective pain score of intravenous injection pain in the experimental period with distraction will be lower than in the control period was accepted(F=24.23, p=0.0001, Bornferni p<.05). 5) The fifth hypothesis that the subjective pain score of intravenous injection pain in the experimental period with combination of cutaneous stimulation and distraction will be lower than in the control period was accepted(F=3.04, p=0.031, Bonferni p<.05). 6) The sixth hypothesis that the objective pain score of intravenous injection pain in the experimental period with combination of cutaneous stimulation and distraction will be lower than in the control period was accepted(F=24.23, p=0.0001, Bonferni p<.05).

• Annals of Clinical Neurophysiology
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• v.14 no.1
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• pp.1-6
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• 2012

Low back pain is a common clinical condition with heterogeneous causes and challenges to manage. High prevalence and numerous assessments result in an enormous socioeconomic burden. Clinician must conduct efficient and stepwise evaluation process to rule out serious spinal pathology, neurologic involvement, and identify risk factors for chronicity. The process can be achieved through the focused history taking and physical examination. Certain factors related to serious spinal pathology include age (>50 years), trauma, unexplained fever, recent urinary or skin infection, unrelenting night or rest pain, unexplained weight loss, osteoporosis, immunosuppression, steroid use, and widespread neurological symptoms. In non-specific low back pain, diagnostic imaging and laboratory studies are often unnecessary and can disturb an appropriate management. For the management of acute low back pain, patient education and medication such as acetaminophen, non-steroidal anti-inflammatory drugs, and muscle relaxants are recommended. For chronic low back pain, behavior therapy, back exercise, and spinal manipulation are beneficial. The evidence based approach could improve success rate of management, result in prevention of acute low back pain from being chronic intractable pain.

• The Korean Journal of Pain
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• v.34 no.2
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• pp.165-175
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• 2021

Background: Management of pain from open wounds is a growing unmet healthcare need. However, the models available to study pain from wounds or to develop analgesics for the patients suffering from them have primarily relied on incisional models. Here, we present the first characterized and validated model of open wound pain. Methods: Unilateral full-skin excisional punch biopsy wounds on rat hind paws were evaluated for evoked pain using withdrawal responses to mechanical and thermal stimulation, and spontaneous pain was measured using hind paw weight distribution and guarding behavior. Evaluations were done before wounding (baseline) and 2-96 hours post-wounding. The model was validated by testing the effects of buprenorphine and carprofen. Results: Pain responses to all tests increased within 2 hours post-wounding and were sustained for at least 4 days. Buprenorphine caused a reversal of all four pain responses at 1 and 4 hours post-treatment compared to 0.9% saline (P < 0.001). Carprofen decreased the pain response to thermal stimulation at 1 (P ≤ 0.049) and 4 hours (P < 0.011) post-treatment compared to 0.9% saline, but not to mechanical stimulation. Conclusions: This is the first well-characterized and validated model of pain from open wounds and will allow study of the pathophysiology of pain in open wounds and the development of wound-specific analgesics.

• Korean Journal of Health Education and Promotion
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• v.22 no.4
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• pp.245-256
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• 2005

The purpose of this study is to research the situation and related knowledge and behavior of Korean beauty artists on their musculoskeletal disorders and the factors on them. It was researched by questionnaire from March 1 to May 31, 2003, and the subjects were 984 of beauty artists who were working as hair designers, skin care specialists, and make-up artists over 1 year in big cities including Seoul, Daegu, Busan and Gwangju. The analyzation was done by frequency, percentage, $x^2-test$, t-test. The results can be summarized as follows; 1. As for their degree of pain according to part of their body, the highest was shoulder as 88.3%, and next were neck(cervical region) as 83.2%, waist as 77.6%, and wrist(hand) as 71.8%, in order. 2. The level of knowledge on the muscloskeletal disorder was 65.6 points on the basis 100points. As for their level of protective behavior and knowledge on the disorders of musculoskeletal system according to their educational experience, the higher educational level they had the higher knowledge level they showed, as 42.6% of 'high', 30.4% of 'medium', and 27.0% of low; and as for degree of performing the protective behavior, they showed the higher protective behavior level when they had the higher educational level. 3. As for their level of knowledge on disorders of musculoskeletal system according to their general uniqueness as beauty artists, they showed statistical significance on the field of their marriage status, educational degree, specialized field, and numbers of customers they manage; and as for the degree of their protective behavior, they showed statistical significance in the field of age, marriage status, specialized field, and rank in their jobs. 4. The level of protecting behavior on the muscloskeletal disorder was 57.4 points on the basis 100points. As for their degree of pain on each part of their body according to their protective behavior and knowledge on musculoskeletal system, it had statistical significance on their elbows and hips, and the less pain they showed when the higher knowledge they had; it had statistical significance on their neck(cervical region), shoulders, backs, waists, knees and ankles(feet) according their protective behavior, and the less pain they showed when the higher level of protective behavior they did.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.489-494
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• 2016

Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its role in modulating NPP has not been reported yet. This study aims at uncovering the role of procaine in NPP. Rats were pretreated with procaine by intrathecal injection. Then NPP rat model was induced by sciatic nerve chronic compression injury (CCI) and behavior tests were performed to analyze the pain behaviors upon mechanical, thermal and cold stimulations. Spinal expression of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) was detected by qRT-PCR and western blot. JAK2 was also overexpressed in procaine treated model rats for behavior tests. Results showed that procaine pretreatment improved the pain behaviors of model rats upon mechanical, thermal and cold stimulations, with the best effect occurring on the $15^{th}$ day post model construction (p<0.05). Procaine also inhibited JAK2 and STAT3 expression in both mRNA (p<0.05) and protein levels. Overexpression of JAK2 increased STAT3 level and reversed the improvement effects of procaine in pain behaviors (p<0.01). These findings indicate that procaine is capable of attenuating NPP, suggesting procaine is a potential therapeutic strategy for treating NPP. Its role may be associated with the inhibition on JAK2/STAT3 signaling.

• Journal of muscle and joint health
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• v.14 no.1
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• pp.33-41
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• 2007

Purpose: The purpose of the study was to identify the pain patterns and factors affecting low back pain in middle-aged women with backache. Method: A descriptive research design was utilized. The participants were middle-aged women who visited to two back pain clinics in Wonju from October, 2006 through February, 2007. A total of 195 low back pain patients agreed to participate in this study, and data from 177 were analyzed. Data were collected using a questionnaire which included a modified short-form Korean pain rating scale, demographic factors, factors related to low back pain and health behavior. Descriptive statistics and multiple regression analysis was utilized in the analysis. Results: The mean score for low back pain was relatively low(M=21.57, SD=11.44). Among pain patterns, scores for dull pain were the highest of all the dimensions. In the regression analysis, significant factors affecting low back pain were found to be age, level of education, religion, BMI, experience of pregnancy, delivery type and exercise. These variables explained 24.8% of variance in low back pain(F=3.79, p<.001). Conclusion: These results suggest that nurses need for assessment and intervention to take into consideration pain patterns as well as factors affecting middle-age women with backache.