• Journal of Biomedical Engineering Research
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• v.43 no.5
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• pp.331-340
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• 2022

Early afterdepolarization (EAD), a significant cause of fatal ventricular arrhythmias including Torsade de Pointes (TdP) in long QT syndromes, is a depolarizing afterpotential at the plateau or repolarization phase in action potential (AP) profile early before completing one pace. AP duration prolongation is related to EAD but is not necessarily accounted for EAD. Several computational studies suggested EAD can form from an abnormality in the late plateau and/or repolarization phase of AP shape. In this sense, we hypothesized the slope during repolarization has the characteristics to predict TdP risk, mainly focusing on the maximum slope during repolarization (dVm/dt_{max_repol}). This study aimed to predict the sensitivity of dVm/dt_{max_repol} to ion channel conductances as a TdP risk metric through a population simulation considering multiple effects of simultaneous reduction in six ion channel conductances of g_NaL, g_Kr, g_Ks, g_to, g_K1, and g_CaL. Additionally, we verified the availability of dVm/dt_{max_repol} for TdP risk prediction through the correlation analysis with qNet, the representative TdP metric. We performed the population simulations based on the methodology of Gemmel et al. using the human ventricular myocyte model of Dutta et al. Among the sixion channel conductances, dVm/dt_{max_repol} and qNet responded most sensitively to the change in g_Kr, followed by g_NaL. Furthermore, dVm/dt_{max_repol} showed a statistically significant high negative correlation with qNet. The dVm/dt_{max_repol} values were significantly different according to three TdP risk levels of high, intermediate, and low by qNet (p<0.001). In conclusion, we suggested dVm/dt_{max_repol} as a new biomarker metric for TdP risk assessment.

• Journal of Convergence for Information Technology
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• v.11 no.5
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• pp.111-117
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• 2021

With the rapid development of advanced science and technology including the 4th industrial revolution, the future battlefield environment is evolving at a rapid pace. In order to actively respond to issues such as reduction of military resources and shortening of service period, and to emphasize the realization of human-centered values, the Ministry of National Defense is re-establishing the role of the Army in accordance with the defense reform and is promoting the Warrior Platform, a next-generation individual combat system. In this paper, we intend to present the optimal warrior platform architecture suitable for the Korean Army by realizing the concept of future ground operations and analyzing overseas cases. We analyze the essential abilities required of individual combatants and the abilities required for each unit type, and specifically presents a plan for integration and linkage of warrior platform equipment. We also propose an efficient business promotion direction by presenting the data flow and power connection diagram between the devices that need integration and interworking.

• International Journal of Computer Science & Network Security
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• v.22 no.5
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• pp.31-38
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• 2022

The article highlights the educational potential of information and communication technologies in the study of philological disciplines in higher education institutions. The study aims to analyze the didactic potential of ICT in the study of philological disciplines, as well as to check the scientific hypothesis that the use of ICT in HEIs in the study of philological disciplines will intensify and enhance the effectiveness of the learning process. To confirm the validity of the hypothesis, experimental testing was carried out and the results are illustrated in the article. The above-mentioned goal of the study determined the use of theoretical and empirical methods: analysis, synthesis, generalization, and systematization of pedagogical and scientific-methodological literature to clarify the state of research problem development and to identify pedagogical foundations on which the process of ICT use is based, comparison and prediction; questioning and testing of educational process participants to understand the effectiveness of ICT use in their training in HEIs. The research results showed positive changes in all analyzed criteria in the experimental group, which is due to the introduction of additional ICT tools into the educational process of the mentioned group. The scientific novelty of the study consists in highlighting the main characteristics and didactic functions of ICT in the learning process of philological students; in covering the classification of ICT, ICT tools, and typology of training sessions using ICT in the study of philological disciplines. In the conclusion it is summarized that the introduction of modern ICT in the educational process allows intensifying the learning process, implementation of a variety of ideas, increases the pace of classes and material assimilation, influencing the motivation for learning, increases the amount of independent work of students.

• Land and Housing Review
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• v.13 no.2
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• pp.91-115
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• 2022

This study examines changes in business survival rates in a gentrified commercial district by comparing early movers with late entrants. Using the Hongik University Commerical District, or Hongdae, as a case study, we adopt discrete-time survival analysis to compare survival rates between businesses established before 2000 (early movers) and ones established after 2000 (late arrivers). We compare the business survival patterns in a gentrified commercial district (experimental group) to non-gentrified commercial districts (control group) in Mapogu. We examine a survival-rate difference between early movers and late arrivers by different industrial categories. We finally examine a survival-rate gap between franchise and non-franchised businesses. The results show that the early movers have lower survival rates than the late arrivers in the gentrified Hongdae area, whereas there is no significant difference in survival rates between the early movers and the late arrivers in Mapogu. The early movers in daily-life-supporting businesses in Mapogu have even higher survival rates than the late-arrivers. In addition, franchised businesses have higher survival rates than non-franchised stores both in Hongdae and Mapogu. The results provide statistical and comprehensive evidence of the displacement of early movers at a more rapid pace in gentrified areas than non-gentrified aveas, which has been an anecdotal narrative.

• Archives of Plastic Surgery
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• v.49 no.2
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• pp.266-274
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• 2022

Background Many authors have researched ways to optimize fat grafting by looking for a technique that offers safe and long-term fat survival rate. To date, there is no standardized protocol. We designed a "hydraulic system technique" optimizing the relationship among the quantity of injected fat, operative time, and material cost to establish fat volume cutoffs for a single procedure. Methods Thirty-six patients underwent fat grafting surgery and were organized into three groups according to material used: standard, "1-track," and "2-tracks" systems. The amount of harvested and grafted fat as well as material used for each procedure was collected. Operating times were recorded and statistical analysis was performed to establish the relationship with the amount of treated fat. Results In 15 cases the standard system was used (mean treated fat 72 [30-100] mL, mean cost 4.23 ± 0.27 euros), in 11 cases the "1-track" system (mean treated fat 183.3 [120-280] mL, mean cost 7.63 ± 0.6 euros), and in 10 cases the "2-tracks" one (mean treated fat 311[220-550] mL, mean cost 12.47 ± 1 euros). The mean time difference between the standard system and the "1-track" system is statistically significant starting from three fat syringes (90 mL) in 17.66 versus 6.87 minutes. The difference between the "1-track" system and "2-tracks" system becomes statistically significant from 240 mL of fat in 15 minutes ("1-track") versus 9.3 minutes for the "2-tracks" system. Conclusion Data analysis would indicate the use of the standard system, "1-track," and "2-tracks" to treat an amount of fat < 90 mL of fat, 90 ÷ 240 mL of fat, and ≥ 240 mL of fat, respectively.

• Journal of the Korea Society for Simulation
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• v.19 no.4
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• pp.291-299
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• 2010

As recent advances in science, technology and performance requirements of the weapons system are getting highly diversified and complex, the performance requirements also get stringent and strict. Moreover, the weapons system should be intimately connected with other systems such as watchdog system, command and control system, C4I system, etc. However, a tremendous amount of time, cost and risk being spent to acquire new weapons system, and not being diminished compared to the rapid pace of its development speed. Defense Modeling and Simulation(M&S) comes into the spotlight as an alternative to overcoming these difficulties as well as constraints. In this paper, we propose the development process of virtual test framework based on the synthetic environment as a tool to analyze the effectiveness of the weapons system of underwater engagement model. To prove the proposed concept, we develop the test-bed of virtual test using Delta3D simulation engine, which is open source S/W. We also design the High Level Architecture and Real-time Infrastructure(HLA/RTI) based Federation for the interoperation with heterogeneous simulators. The significance of the study entails (1)the rapid and easy development of simulation tools that are customized for the Korean Theater of War; (2)the federation of environmental entities and the moving equations of the combat entities to manifest a realistic simulation.

• Journal of the Daesoon Academy of Sciences
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• v.33
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• pp.351-379
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• 2019

In this paper, the approach to 'Place' and 'Experience' typically adopted by anthropogeographers will be reconsidered in light of the Taoist perspective to these phenomena. In order to develop the discussion more specifically, this exploration will be based on Jeff Malpas's philosophical theories rather than geography, and the Lao-Zhuang (Laozi and Zhuangzi) perspective will also come into pace as place and experience are examined. In this paper, I have divided place and space on the basis of their dictionary meanings and have reconsidered each via Malpas and Lao-Zhuang views. I then discuss place in terms of 'Place' and 'Place experience.' Experience is what Malpas emphasizes as having Place in regards to place. Through this, I check the placing of place and examined the characteristics of place, while comparing the views mentioned in Lao-Zhuang with those of Malpas and considered their meanings. In this study, I look at why a place should be a place, what experience in a place means, and what view and position Lao-Zhuang Thought has on this matters. Place is a meaningful subject for both the East and the West. Based on this work, I hope that Asian place theory can emerge anew.

• Proceedings of the Korean Society of Tobacco Science Conference
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• 1997.10a
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• pp.79-90
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• 1997

The world-wide cigarette market is becoming increasingly regulated. This involves restrictions on the freedom to advertise, restrictions on where people can smoke, and in some ways of most importance, limits on cigarette smoke deliveries. In particular, in an increasingly large number of countries maximum tar legislation is being enacted. In many cases, such as the European Union, this type of legislation is progressive and over time it is entirely conceivable that maximum permitted tar deliveries will be reduced to as low as 5 mg, possibly with additional restrictions on smoke nicotine deliveries. In addition, the pace of change is increasing as more and more countries embark on tar reduction programmes. The key challenge facing the cigarette industry is to manage these changes in such a way which ensures that product acceptability is maintained at as high a level as is possible in these circumstances. There are a number of ways of achieving this involving filter ventilation, modifying blends and using different filter constructions The real innovation comes when combining these in a way that gives the most acceptable balance of all these competing variables as far as the smoker is concerned. Undoubtedly, the nature of the filter is of crucial importance in designing the most acceptable low tar products, and this paper will discuss some of the filter types which are currently in use in the various low tar markets around the world. Also, some thoughts about the future in terms of new filter developments will be presented.

• 한국체육학회지인문사회과학편
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• v.54 no.1
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• pp.47-55
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• 2015

This study is to examine the current situation of Korean sports culture and seek its pointing spot and alternatives to its advancement. First, out of the current situation of Korean sports culture, that of school physical education, even though it is the most significant basis for sports culture, is riddled with so many contradictions that the pace of its change is very slow. Only when the elite sport is normally operated and well coordinated, can it have the value of existence as a stable field. The mass sports have been determined to have insufficient self-reliance of sport facilities, sport programs and instructor management since the national policy for physical education has been focused on the elite sports. Second, internalization of "Winning First Policy" as a pointing spot of sports culture has been found to be an production of the value system with not only a very passive tendency caused by political changes. Accordingly, the concept of sports-culturism has been introduced as a new pointing spot of sports culture and then it has been emphasized that the sports-culturism is the awareness of sports advancement. Third, in terms of finding any alternatives to sports culture, enacting a school physical education promotion law has a very significant meaning as its advancement method. Next, the immorality of and match-fixing by sport organizations and the umpire's bad call have been mentioned as major problems to the elite sport, and also the alternative to each field has been set. Last, it has been assented with emphasis that Law of Sports for All should be enacted for the public sports to have any significance of the times.

• Journal of The Korean Association For Science Education
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• v.43 no.3
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• pp.295-306
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• 2023

In this study, we explored science teachers' perceptions of adaptive practice in terms of importance and practice. For this purpose, an adaptive practice questionnaire was developed targeting secondary science teachers, and the responses of 128 science teachers were analyzed. The results of this study were as follows: First, the science teachers responded that all 17 items regarding adaptive practice were important. In particular, items related to 'addition of examples', 'adjustment of the level/range of concepts', and 'encouragement of student participation' showed high importance and performance levels. Second, the results of the IPA concerning adaptive practice showed that the items needing intensive improvement due to high importance but low performance were 'encouraging students' self-directed learning' and 'monitoring and responding to individual differences'. The science teachers identified a lack of time and uniform curriculum as the reasons for the low level of practice despite the high importance of these items. Third, regarding the IPA of the adaptive practice items, the items located in the fourth area, an excessive area, concerned 'pace control', 'modifying activities', and 'metaphor use'. More specifically, considering that 'metaphor use' was the only item with a higher level of performance than importance, it is necessary to reconsider whether problems are caused by excessive use. Fourth, analyzing the responses regarding the reasons for the difference in importance and performance revealed that the factors related to teachers included teachers' lack of knowledge or ability, and the tendency to implement as planned. As for student factors, an excessive number of students, differences in the levels of students, and a tendency to prefer classes centered on entrance exams were identified. As environmental factors, a uniform curriculum, conditions for experiments, evaluation systems, and external demands were mentioned. Finally, the implications of the results of this study for science education were discussed.