• BMB Reports
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• v.38 no.2
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• pp.167-176
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• 2005

Nuclear factor-E2-related factor 2 (Nrf2) is known as a key regulator of ARE-mediated gene expression and the induction of Phase II detoxifying enzymes and antioxidant enzymes, which is also a common property of many chemopreventive agents. In the present study, we investigated the regulatory role of different chemopreventive agents including sulforaphane (SUL), allyl isothiocyanate (AITC), indole-3-carbinol (I3C), and parthenolide (PTL), in the expression and degradation of Nrf2 and the induction of the antioxidant enzyme HO-1. SUL strongly induced Nrf2 protein expression and ARE-mediated transcription activation, retarded degradation of Nrf2 through inhibiting Keap1, and thereby activating the transcriptional expression of HO-1. AITC was also a potent inducer of Nrf2 protein expression, ARE-reporter gene and HO-1 but had little effect on delaying the degradation of Nrf2 protein. Although PTL and I3C could induce ARE reporter gene expression and Nrf2 to some extent, they were not as potent as SUL and AITC. However, PTL dramatically induced the HO-1 expression, which was comparable to SUL, while I3C had no effect. In addition, when treated with SUL and PTL, inhibition of proteasome by MG132 did not cause additional accumulation of Nrf2, suggesting the involvement of other degradation mechanism(s) in the presence of these compounds such as SUL and PTL. In summary, the results of our current study indicated that different chemopreventive compounds have different regulatory properties on the accumulation and degradation of Nrf2 as well as the induction of cellular antioxidant enzyme HO-1.

• Radiation Oncology Journal
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• v.31 no.4
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• pp.177-184
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• 2013

Purpose: The aim of this study was to analyze the patterns of care and treatment outcomes in patients with primary thyroid lymphoma (PTL) in a single institution. Materials and Methods: Medical records of 29 patients with PTL treated between April 1994 and February 2012 were retrospectively reviewed. Diagnosis was confirmed by biopsy (n = 17) or thyroidectomy (n = 12). Treatment modality and outcome were analyzed according to lymphoma grade. Results: The median follow-up was 43.2 months (range, 3.8 to 220.8 months). The median age at diagnosis was 57 years (range, 21 to 83 years) and 24 (82.8%) patients were female. Twenty-five (86.2%) patients had PTL with stage IEA and IIEA. There were 8 (27.6%) patients with mucosa-associated lymphoid tissue (MALT) lymphoma and the remaining patients had high-grade lymphoma. Patients were treated with surgery (n = 2), chemotherapy (n = 7), radiotherapy (n = 3) alone, or a combination of these methods (n = 17). Treatment modalities evolved over time and a combination of modalities was preferred, especially for the treatment of high-grade lymphoma in recent years. There was no death or relapse among MALT lymphoma patients. Among high-grade lymphoma patients, 5-year overall survival (OS) and 5-year progression-free survival (PFS) were 75.6% and 73.9%, respectively. Complete remission after initial treatment was the only significant prognostic factor for OS (p = 0.037) and PFS (p = 0.003). Conclusion: Patients with PTL showed a favorable outcome, especially with MALT lymphoma. Radiotherapy alone for MALT lymphoma and chemotherapy followed by radiotherapy for high-grade lymphoma can be effective treatment options for PTL.

• Applied Chemistry for Engineering
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• v.32 no.3
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• pp.332-339
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• 2021

Recently, due to concerns about the depletion of fossil fuels and the emission of greenhouse gases, the importance of hydrogen energy technology, which is a clean energy source that does not emit greenhouse gases, is being emphasized. Water electrolysis technology is a green hydrogen technology that obtains hydrogen by electrolyzing water and is attracting attention as one of the ultimate clean future energy resources. In this study, the surface properties of the porous transport layer (PTL), one of the cell components of the proton exchange membrane water electrolysis (PEMWE), were controlled using a sandpaper to reduce overvoltage and increase performance and stability. The surfaces of PTL were sanded using sandpapers of 400, 180, and 100 grit, and then all samples were finally treated with the sandpaper of 1000 grit. The prepared PTL was analyzed for the degree of hydrophilicity by measuring the water contact angle, and the surface shape was observed through SEM analysis. In order to analyze the electrochemical characteristics, I-V performance curves and impedance measurements were conducted.

• Bulletin of the Korean Chemical Society
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• v.18 no.4
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• pp.369-373
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• 1997

When 1H NMR spectra of pyridine, 4-amino-, 4-methyl-, and 4-cyanopyridine coordinated to the paramagnetic polyoxometalate, [SiW11CoⅡO39]6- in D2O are compared, both α- and β-proton peaks are shifted upfield as the basicity of the ligand decreases. The isotropic shifts are separated into contact and pseudocontact contributions by assuming that the contact shifts are proportional to the isotropic shifts of the same ligands coordinated to [SiW11NiⅡO39]6-. This separation reveals that the shift variations with the axial ligand basicity are dominated by changes in the magnetic anisotropy (pseudocontact shift) of [SiW11CoⅡ(ptl)O39]6- (ptl=pyridine-type ligand). The magnitude of the magnetic anisotropy in a series of pyridine-type ligands increases linearly as the pKa of their conjugate acids decreases.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.30 no.1 s.244
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• pp.66-75
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• 2006

Nonlinear response structural optimization using equivalent static loads (NROESL) has been proposed. Nonlinear response optimization is solved by sequential linear response optimization with equivalent static loads which are generated from the nonlinear responses and linear stiffness matrix. The linear stiffness matrix should be obtained in NROESL, and this process can be fairly difficult for some applications. Proportional transformation of loads (PTL) is proposed to overcome the difficulties. Equivalent static loads are obtained by PTL. It is the same as NROESL except for the process of calculating equivalent static loads. PTL is developed for large-scale probems. First, linear and nonlinear responses are evaluated from linear and nonlinear analyses, respectively. At a DOF of the finite element method, the ratio of the two responses is calculated and an equivalent static load is made by multiplying the ratio and the loads for linear analysis. Therefore, the mumber of the equivalent static loads is as many as that of DOF's and an equivalent static load is used with the reponse for the corresponding DOF in the optimization process. All the equivalent static loads are used as multiple loading conditions during linear response optimization. The process iterates until it converges. Examples are solved by using the proposed method and the results are compared with conventional methods.

• Journal of the Microelectronics and Packaging Society
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• v.17 no.3
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• pp.43-49
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• 2010

Direct printing technology is an attractive metallization method, which has become immerging as "Green technology" to the conventional photolithography, on account of low cost, simple process and environment-friendliness. In order to commercialize the printed electronics in industry, it is essential to evaluate the electrical properties of conductive circuits using direct printing technology. In this contribution, we focused on the electrical characteristics of inkjet-printed circuits. A Cu nanoink was inkjet-printed onto a Bisaleimide triazine(BT) substrate with parallel transmission line(PTL) and coplanar waveguide(CPW) type, then was sintered at $250^{\circ}C$ for 30 min. We calculated the resistivity of printed circuits through direct current resistance by the measurement of I-V curve: the resistivity was approximately 0.558 ${\mu}{\Omega}{\cdot}cm$ which is about 3.3 times that of bulk Cu. Cascade's probe system in the frequency range from 0 to 30 GHz were employed to measure the Scattering parameter(S-parameter) with or without a gap between the substrate and the probe station chuck. The result of measured S-parameter showed that all printed circuits had over 5 dB of return loss in the entire frequency range. In the curve of insertion loss, $S_{21}$, showed that the PTL type circuits had better transmission of radio frequency (RF) than CPW type.

• Transactions of the Korean hydrogen and new energy society
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• v.32 no.6
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• pp.442-454
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• 2021

The porous transport layer (PTL) is essential to effectively remove oxygen and hydrogen gas from the electrode surface at high current density operation conditions. In this study, the effect of PTL with different characteristics such as pore size, pore gradient, interfacial coating was investigated by multi-layered sintered mesh. A water electrolysis single cell of active area of the 34.56 cm² was constructed, and IV performance and impedance analysis were conducted in the range of 0 to 2.0 A/cm². It was confirmed that the multi-layered sintered mesh PTL, which have an average pore size of 25 to 57 ㎛ and a larger pore gradient, removed bubbles effectively and thus seemed to improve IV performance. Also, it was confirmed that the catalytic metals such as Ni, NiMo coating on the PTL reduced activation overpotential, but increased mass transport overpotential.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.250-251
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• 2007

산업용 조사장치로 전자빔은 활용도가 매우 높고, 대부분의 장치는 국내에서 제작이 어려울 뿐만 아니라 외국의존도 높다. 현재 미국, 일본, 러시아, 캐나다 등을 중심으로 약 1500 기의 전자빔 조사 설비가 산업용 및 연구용으로 설치되어 있는데, 이 중 많은 설비가 공동이용 연구시설 또는 상업적인 전자빔 조사서비스 시설로 운영되고 있다. 산업적으로 이용하기 위하여 철원물리기술연구소에 설치될 전자빔 조사 시설을 위한 전자빔 가속기를 개발 중이다. 곡물 살충 및 발아억제, 식품 저장, 위생용품 살균, 의약품 및 의료용구 살균, 전력반도체 생산 등의 분야에 전자빔 조사 설비를 응용할 수 있다. 본 논문에서는 산업용 조사 설비의 전원장치로 사용되는 펄스 모듈레이터의 설계, 제작 및 실험내용을 보이고자 한다.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.40 no.6
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• pp.447-458
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• 2003

A high speed multiplier is essential basic building block for digital signal processors today. Typically iterative algorithms in Signal processing applications are realized which need a large number of multiply, add and accumulate operations. This paper describes a macro block of a parallel structured multiplier which has adopted a 32$\times$32-b regularly structured tree (RST). To improve the speed of the tree part, modified partial product generation method has been devised at architecture level. This reduces the 4 levels of compression stage to 3 levels, and propagation delay in Wallace tree structure by utilizing 4-2 compressor as well. Furthermore, this enables tree part to be combined with four modular block to construct a CSA tree (carry save adder tree). Therefore, combined with four modular block to construct a CSA tree (carry save adder tree). Therefore, multiplier architecture can be regularly laid out with same modules composed of Booth selectors, compressors and Modified Partial Product Generators (MPPG). At the circuit level new Booth selector with less transistors and encoder are proposed. The reduction in the number of transistors in Booth selector has a greater impact on the total transistor count. The transistor count of designed selector is 9 using PTL(Pass Transistor Logic). This reduces the transistor count by 50% as compared with that of the conventional one. The designed multiplier in 0.25${\mu}{\textrm}{m}$ technology, 2.5V, 1-poly and 5-metal CMOS process is simulated by Hspice and Epic. Delay is 4.2㎱ and average power consumes 1.81㎽/MHz. This result is far better than conventional multiplier with equal or better than the best one published.

• Journal of the Korean GEO-environmental Society
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• v.9 no.6
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• pp.61-70
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• 2008

In this study, undrained triaxial (CU) tests were performed on low-plastic silt of Nakdong River in order to investigate the undrained shear behavior of low-plastic silt. In experimental results, the deviator stress showed the hardening behavior after reaching its yield stress like the tendency of common sand, and the pore water pressure was gradually decreased to critical state after the maximum value. In the effective stress paths, regardless of consolidation stress or overconsolidation ratios, both a critical state line (CSL) and a phase transformation line (PTL) exist in the effective stress path that is similar to the case of sand. The behavior of low-plastic silt was predicted by the Modified Cam-Clay (MCC) model, the Jordan and the Elman-jordan model that is artificial neural network model. According to predicted results, the overall undrained shear behavior of low-plastic silt could not be predicted with the MCC model, but the Jordan and Elman-Jordan model showed well-matched experiment results.