• Pediatric Infection and Vaccine
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• v.21 no.2
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• pp.81-95
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• 2014

Purpose: Hematopoietic cell transplantation (HCT) recipients are vulnerable to invasive infection by Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae (Sp). This study was performed to evaluate immune responses after Hib and Sp vaccination in Korean pediatric HCT recipients. Methods: Patients were prospectively enrolled at Samsung Medical Center during 2009-2011. ELISA tests to detect anti-PRP IgG antibody and antibodies to Sp serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F were performed at the Center for Vaccine Evaluation and Study, Ewha Medical Research Institute. Results: Ten patients (two allogeneic, eight autologous recipients) with median age 5.4 years (range 2.7-12.2 years) were enrolled. Before Hib vaccination, 60% of patients' anti-PRP IgG titers were below $0.15{\mu}g/mL$. After vaccination, 100% of patients' anti-PRP IgG titers increased above $0.15{\mu}g/mL$ (cut-off value for detection) and $1.0{\mu}g/mL$ (cut-off value for seroprotection). For pneumococcus, in 2-5 year-old patients, pre-vaccination geometric mean concentrations (GMCs) of IgG for six serotypes (4, 6B, 9V, 14, 18C, and 23F) were below $0.35{\mu}g/mL$ and at 5 months post-vaccination GMCs of IgG for all seven serotypes increased to above $0.35{\mu}g/mL$. In patients older than 5 years, pre-vaccination GMCs of IgG for four serotypes (4, 9V, 14, and 23F) were below $0.35{\mu}g/mL$ and at 3 months post-vaccination GMCs of IgG for all seven serotypes increased to above $0.35{\mu}g/mL$. Conclusion: Most HCT recipients had low or no protective antibodies to Hib and Sp before vaccination, but showed good immune responses to protective levels after vaccination.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10a
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• pp.9-11
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• 1998

본 논문에서는 '그룹화된 패리티를 갖는 소수 라운드 로빈({{{{ { PRP}_{gp } }}}}:Prime Round Robiin with Grouped Parties)' 방식에 대한 기존의 조합 모델을 이용한 신뢰도 분석 시에 문제가 됐던 결함복구율을 고려하지 못한 모델링에 대해서 미르코프 모델을 이용한 신뢰도 모델링을 바탕으로 결함복구율을 고려한 신뢰도를 계산한다. 또한 산출된 신뢰도를 근거로 반최적화된(semi-optimal) 패리트 그룹 나누기 알고리즘을 도출하고 동시에 두 개의 결함에 대한 분석을 수행한다. 마르코프 모델을 이용한 신뢰도 모델링을 통해서 결함발생율만을 고려한 경우에 신뢰도가 기존의 조합 모델의 신뢰도와 거의 일치하고 결함발생율과 결함복구율을 동시에 고려한 경우에 신뢰도가 결함발생율만을 고려했을 경우보다 더높다는 것을 보인다. 반최적화된 패리티 그룹 나누기 알고리즘을 사용할 경우에, 동시에 두 개의 결함에 대한 분석을 통해서 약 30% 이상의 경우에 대해서 저장된 패리티 정보를 이용한 복구가 가능하다.

• Proceedings of the Korea Information Processing Society Conference
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• 2006.05a
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• pp.109-112
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• 2006

최근 대용량 추천시스템에 대한 필요성이 증가하고 있고, 특히 대규모 인터넷 쇼핑몰을 위한 개인화 추천 시스템 구조에 대한 관심이 높아지고 있다. 본 논문에서는 k-means 클러스터링과 순차 패턴 기법을 이용한 인터넷 쇼핑몰 상품 추천 시스템을 설계 및 구현한다. 사용자 정보의 일괄처리와 카테고리의 계층적 특성을 반영하면서 데이터 마이닝 기법을 활용하여 개인화된 추천 엔진을 대형 시스템에서 동작하도록 설계 하였다. 설계 구현한 시스템의 평가를 위해, 대형 쇼핑몰의 데이터를 이용하여 추천 예측 정확율(PRP: Predictive Recommend Precision), 추천 예측 재현율(PRR: Predictive Recommend Recall), 정확도 인수(PF1 : Predictive Factor One-measure)를 구하였다.

• Journal of Oral Medicine and Pain
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• v.20 no.1
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• pp.7-18
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• 1995

The Purpose of this article is to describe the biochemical properties and biological functions of several salivary proteins that possess the unusual properties of inhibiting spontaneous and secondary precipitation of calcium phosphate. This function is very important since human salivary secretion is supersaturated with respect to calcium phosphate. Biological function of statherin, proline rich protein (PRP) and histidine rich protein (HRP) is to inhibit precipitation of calcium phosphate in salivary glands, in the oral fluids, and onto tooth surfaces. The resulting supersaturated state of the salivary secretions contributes a protective and reparative environment which is important for the integrity of the tooth. Beneficial consequences of salivary supersaturation with respect to calcium phosphate are selectively expressed in the oral cavity- that is, protection is provided for the dental enamel-while undesirable consequences, for example, precipitation of calcium phosphates in the salivary glands and onto the teeth do not occur. Purification and structural characteristics of these proteins as well as clinical significance of functions of each protein will be discussed.

• Korean Journal of Pharmacognosy
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• v.33 no.2 s.129
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• pp.120-123
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• 2002

The possibility of Galla Rhois(GR) water extract as an antithrombotic agent was investigated. The effect of GR on platelet aggregation in human platelet-rich plasma(PRP) induced by collagen and ADP in vitro and coagulation parameters in a pathological model induced by endotoxin and hydrocortisone acetate(HA) in vivo were examined. In platelet aggregation assay, GR extract significantly inhibited platelet aggregation induced by collagen and ADP in a dose-dependent manner. GR extract significantly increased the number of platelet and shortened prothrombin time(PT) and activated thromboplastin time(APTT) as compared with the control in pathological model induced by endotoxin and HA. Also, GR extract significantly increased fibrinogen level as compared with the control in a pathological model induced HA. These results suggest that GR may be a promising antithrombotic agent.

• Journal of Food Hygiene and Safety
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• v.9 no.1
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• pp.23-30
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• 1994

When three systems commonly used for screening(washed platelets suspended in uffer containing Ca2+, washed platelets in buffer without Ca2+and platelet rich plasma) are compared by studying the anti-aggregating capacity of garlic extract, platelet rich plasma was the least sensitive system. The most sensitive assay system, based on the IC50s of garlic extract and 2 other platelet aggregation-inhibiting agents(vitamin K3 and propranolol), was the platelet preparation without Ca2+in the suspension buffer. This system was confirmed as the most sensitive during subsequent investigation of garlic extract's capacity to inhibit platelet ATP release. These results suggest that applying the system with washed platelet without Ca2+is most effective to screen for the anti-affregating capacity of natural food.

• Proceedings of the KIEE Conference
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• 2015.07a
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• pp.221-222
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• 2015

디지털 변전소를 위해 IEC61850 국제 표준 프로토콜을 적용한 보호계전기(IED), 게이트웨이, HMI등이 필드에서 사용되고 있고, 전체 디지털 변전소를 위한 병합장치(Merging Unit: MU)등도 실제 운영되고 있다. 디지털 변전소는 기존 변전소를 효과적으로 운영하기 위해 필요한 높은 수준의 가용성과 전송능력이 필요하다. IEC TC 57 WG10은 디지털 변전소를 위한 이중화 사양으로 IEC SG65C WG15의 IEC62439-3/4 고속 절체 네트워크 운영 프로토콜(Highly Available Seamless Redundancy: HSR),(Parallel Redundancy Protocol: PRP)들을 추천하고 있다. 본 논문에서는 프로세스 버스의 병합장치(MU)로부터 계측된 전류와 전압을 고속 이더넷을 통해 샘플 계측값(Sampled Measured Values: SMV)을 전송받고, 고정밀 IEEE1588v2 PTP(Precision Time Protocol) 시각동기를 하며, 스테이션 레벨에서 MMS와 GOOSE 통신을 하는 계전기와 성능에 대한 것이다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.4
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• pp.12-28
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• 2015

Objective : The purpose of this study is to analyse research trend on alopecia including androgenetic alopecia, alopecia areata, etc.Methods : We searched Pubmed, CNKI and OASIS on the title "alopecia" in recent 5 years.Results : We found 23 studies on Pubmed, 20 on CNKI, and 3 on OASIS about treatments of alopecia. The subjects of them were about 5α-reductase inhibitor, Minoxidil, steroids, immunosuppression, laser therapy, PRP, microneedling, stem cell, herbal medicine, integrative medicine, external treatments and syndrome differentiation.Conclusions : In recent studies in western medicine were about combination therapy or safety and presented validities and superiorities about new treatments. Integrative medicine, external treatment and researches about patients' characteristics were reported in TCM. Korean medicine has advantages of considering whole body and phychological problems.

• Toxicological Research
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• v.12 no.2
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• pp.289-293
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• 1996

Our previous studies demonstrated that quinone (menadione) is cytotoxic to rat platelets. In an attempt to assess the relative contributions of redox cycling and/or arylation in quinone-induced cytotoxicity, we have studied three quinones with different mechanisms: 2, 3-dimethoxy-1, 4-naphthoquinone (DMNQ; pure redox cycler), menadione (both redox cycler and arylator), and 1, 4-benzoquinone (pure arylator). The order of redox cycling capacity in platelet rich plasma (PRP) isolated from rats was menadione>DMNQ>1, 4-benzoquonone, which was consistent with the previous studies using isolated hepatocytes. 1, 4-Benzoquinone was more toxic to rat platelets than menadione, while DMNQ did not cause cell death at all. Lactate dehydrogenase inhibition studies revealed that 1, 4-benzoquinone inhibited significantly in a time-dependent manner, while menadione and DMNQ did not at all. These results suggested that arylation by quinone compounds might play a critical role in quinone-induced cytotoxicity in rat platelets.

• Journal of Society of Preventive Korean Medicine
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• v.3 no.1
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• pp.125-145
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• 1999

The effects of Wang-ttum, Magnetic Water, Magnetic field and Sibjeondaebotang on hemodynamics in sleep deprivation were studied. The results as follows; 1. In case of Wang-ttum operated group, significant changes were observed at 12 p.m., 2 a.m., 4 a.m. in maximum blood pressure for the first and second overnight stay and at 2 a.m. for the third and, respectively, average blood pressure at 12 p.m., 2 a.m. for the 1st and 2nd overnight stay, minimum blood pressure at 10 p.m.. 12 p.m.. 2 a.m. for the 1st overnight stay and at 10 p.m., 12 p.m. for the 2nd and at 12 p.m. for the 3rd, pulse rate at 12 p.m., 2 a.m., 4 a.m., 6 a.m., for 1st and 2nd and at 2 a.m., 4 a.m. for the 3rd and 4th, TP-KS at 12 p.m., 2 a.m., 4 a.m., 6 a.m. for the 1st and 2nd and at 2 a.m., 4 a.m., 6 a.m. for the 3rd, PRP at 10 p.m., 12 p.m., 2 a.m., 4 a.m., 6 a.m. for the 1st and 2nd and at 12 p.m., 2 a.m., 4 a.m. for the 3rd and at 2 a.m., 4 a.m. for the 4th, TPR at 10 p.m., 12 p.m., 2 a.m., 4 a.m., 6 a.m. from 1st to 4th overnight stay. 2. In case of taking magnetic water group, significant changes were observed at 2 a.m., 4 a.m. in pulse rate for the 1st overnight stay and, respectively, PRP at 2 a.m. for the 1st, TRP at 10 p.m., 12 p.m., 2 a.m., 4 a.m., 6 a.m. for the 1st and 4th. 3. In case of attaching magnet group, TPR was significantly observed at 10 p.m. for the 1st overnight stay. 4. In case of medicating Sibjeondaebotang group, significant changes were observed at 10 p.m., 12 p.m., 2 a.m., 4 a.m., 6 a.m. in maximum blood pressure for the 1st and 2nd overnight stay and at 12 p.m., 2 a.m., 4 a.m., 6 a.m. for the 3rd and at 2 a.m., 4 a.m., 6 a.m. for the 4th and, respectively, average blood pressure at 10 p.m., 12 p.m. for the 1st and 2nd and at 10 p.m. for the 3rd and 4th, minimum blood pressure at 10 p.m., 12 p.m. from 1st to 4th, pulse rate at 2 a.m., 4 a.m., 6 a.m. from 1st to 3rd and at 2 a.m., 4 a.m. for the 4th, TP-KS at 10 p.m., 12 p.m., 2 a.m., 4a.m., 6 a.m. for the 1st and at 10 p.m., 2 a.m., 4 a.m., 6 a.m. for the 2nd and at 2 a.m., 4 a.m., 6 a.m. for the 3rd and at 6 a.m. for the 4th, PRP at 12 p.m., 2 a.m., 4 a.m., 6 a.m. for the 1st and at 10 p.m., 12 p.m., 2 a.m., 4 a.m., 6 a.m. for the 2nd and 3rd and at 12 p.m., 2 a.m., 4 a.m., 6 a.m. for the 4th, TPR at 10 p.m., 12 p.m., 2 a.m., 4 a.m., 6 a.m. from 1st to 4th. As mentioned obove, the effects of Wangttum and Sibjeondaebotang on hemodynamics in sleep deprivation were observed both the impulse of SIM-YANG and mutual function of QI-HYOL. The effects of Magnetic water and Magnetic field were observed the side of mutual function of QI-HYOL.