• 제목/요약/키워드: PLNA

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Assessment of autoimmunogenic potential of autoimmune disease inducing chmecals using the popliteal lymph node assay

  • Kim, Hyung-Soo;Juno H. Eom;Kim, Jin-Ho;Chung, Seung-Tae;Park, Jae-Hyun;Kang, Sun-Kyung;Kim, Dong-Sub
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.113-113
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    • 2001
  • The popliteal lymph node assay (PLNA) was proposed to predict autoimmunogenic potential of xenobiotics. This study was conducted to establish the popliteal lymph node assay(PLNA) and to investigate the measurement of lymphocyte subsets can be utilized as an additional parameter in PLNA.(omitted)

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Investigation of autoimmunogenic potential of GX-12, a New anti-HIV DNA Vaccine, by popliteal lymph node assay and autoantibody induction

  • Kang, Kyung-Koo;Park, Min-Seul;Baik, Dae-Hyun;Lee, Dong-Sup;Park, Jae-Hun;Ahn, Byoung-Ok;Kim, Won-Bae
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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    • pp.178-179
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    • 2002
  • GX-12 is a naked DNA vaccine developed by Dong-A Pharmaceutical Company, Green Cross Company and Genexine for the treatment of HIV infection. GX-12 consists of four separate plasmids. This study was performed to investigate the autoimmunogenic potential of GX-12 using primary and secondary PLNA method, and to examine the induction of autoantibodies in mice immunized with GX-12.(omitted)

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