• Journal of Marine Bioscience and Biotechnology
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• v.1 no.3
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• pp.156-162
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• 2006

The halophilic enterobacteria, Enterobacteria cancerogenus, was isolated from the intestines of the fusiform fish (Trachurus japonicus) to yield a protein-like material termed PLM-f74. PLM-f74 was characterized by strong inhibition ratios to angiogenesis (82.8% at the concentration of $18.5{\mu}g/mL$) and elevated antioxidative capacities with low toxicity. The PLM-f74 is a glycoprotein comprised of saccharides and amino acids. PLM-f74 inhibited non-activated U937 monocytic cell adhesion to HUVECs activated with IL-$1{\beta}$ by 78.0%, and the adherence of U937 cells treated with the PLM-f74 and stimulated with IL-$1{\beta}$ to unstimulated HUVECs decreased by 102%. When both cell types were pretreated with PLM-f74, the adhesion of U937 cells to IL-$1{\beta}$ stimulated HUVECs was completely suppressed by 121% at a concentration of 18.5 ug/mL. PLM-f74 blocked signal pathways from VEGFR2, PI3K, ${\beta}$-catenin and VE-cadherin to NF-kB based on western bolt analysis. And also inhibited IL-1-stimulated HUVEC expression of the adhesion molecules, ICAM-1 by 40%, VCAM-1 by 60%, and E-selectin by 70% at the same concentration noted above. New anti-angiogenic and anti-cell adhesion materials showing elevated antioxidative capacities and non-toxicity may be expected from these results.

• Journal of Microbiology and Biotechnology
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• v.16 no.10
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• pp.1544-1553
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• 2006

The halophilic enterobacteria, Enterobacteria cancerogenus, was isolated from the intestines of the fusiform fish (Trachurus japonicus) to yield a protein-like material termed PLM-f74. PLM-f74 was characterized by strong inhibition ratios to angiogenesis (82.8% at the concentration of $18.5{\mu}g/ml$) and elevated antioxidative capacities with low toxicity. The PLM-f74 is a glycoprotein comprised of saccharides and amino acids. PLM-f74 inhibited cell adhesion that non-activated U937 monocytic cell adhesion to HUVECs activated with $IL-1{\beta}$ by 78.0%, and the adherence of U937 cells treated with the PLM-f74 and stimulated with $IL-1{\beta}$ to unstimulated HUVECs decreased by 102%. When both cell types were pretreated with PLM-f74, the adhesion of U937 cells to $IL-1{\beta}$-stimulated HUVECs was completely suppressed by 121% at a concentration of $18.5{\mu}g/ml$. PLM-f74 blocked signal pathways from VEGFR2, PI3K, ${\beta}$-catenin, and VE-cadherin to NF-kB, based on western bolt analysis. It also inhibited IL-l-stimulated HUVEC expression of the adhesion molecules, ICAM-l by 40%, VCAM-l by 60%, and E-selectin by 70% at the same concentration noted above. New anti-angiogenic and anti-cell adhesion materials showing elevated antioxidative capacities, and non-toxicity may be expected from these results.

• The Journal of Engineering Geology
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• v.33 no.1
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• pp.151-167
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• 2023

This study compares the revised method in loose saturated sandy ground where the LNG storage tank will be installed with an evaluation method by one-dimensional effective stress analysis using the UBC3D-PLM model. Various laboratory and field tests were conducted to establish the parameters necessary for evaluation. The revised liquefaction evaluation method using the seismic response analysis result and N value from standard penetration testing evaluated the possibility of liquefaction as high, but assessment using effective stress analysis, which can consider various liquefaction resistance factors, found the site to be somewhat stable against liquefaction. One-dimensional finite element analysis using UBC3D-PLM modeling facilitated easier assessment of stability against liquefaction than the other methods and minimized the area required for reinforcement against liquefaction. In addition, it is expected that two-and three-dimensional numerical analysis considering the foundation of the LNG storage tank can identify the seismic design and behavior when liquefaction occurs.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.10a
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• pp.655-656
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• 2006

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2009.06a
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• pp.1055-1056
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• 2009

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.06a
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• pp.905-906
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• 2008

• Korean Journal of Computational Design and Engineering
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• v.17 no.4
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• pp.294-302
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• 2012

Process mining is a useful methodology that can be used for extracting user patterns in log files in order to discover efficient or inefficient processes in organizations. In general, it is used to find and reduce differences between pre-defined processes and actually executed processes in an organization. In this paper, we propose a method to improve processes in PDM/PLM systems based on process mining. In order to improve and detect the inefficient processes, we gathered event logs from PDM/PLM systems and derived process models using several process mining techniques such as ${\alpha}$-algorithm mining, heuristics mining, and fuzzy miner. By comparing original process models with process mining results, it is possible to detect differences between predefined processes and real ones; thereby we can build improved process models for future application.

• CDE review
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• v.13 no.1
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• pp.14-19
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• 2007

PLM과 ERP의 정보 및 프로세스 통합은 개개의 기여도 함보다는 훨씬 큰 종합적인 이익을 가져오기 위하여 조직 전반에 걸쳐서 사용자들의 생산성을 제고한다. 그러나 이러한 이익을 얻기 위하여 정보는 조직을 통하여 자유로운 흐름이 있어야 한다. 이러한 통합의 범위를 결정하는 것은 복잡한 작업이 될 수 있다. 반드시 고려되어야 할 인자로는 다음과 같다. - 데이터 및 포로세스 소유권 - 정보의 마스터 출처 정의 - 필요한 통합 수준 - 제품 설계 및 생산의 두 영역에 걸쳐있는 프로세스를 어떻게 관리할 것인가? - 공통된 용어를 사용 각 회사에서 PLM과 ERP를 통합하는 최상의 방법을 결정할 때, 필요로 하는 것에 우선권을 두어야 한다. 즉, 희망하는 것 보다는 비즈니스상 요구되는 사항에 대한 것이다. 개발, 초기적용, 진행중인 유지보수를 포함하여 소유총비용(total cost of ownership)을 계산한다. PLM-ERP 통합은 데이터 통합 그 이상의 작업임을 명심하여야 한다. 이익을 최대화하기 위하여 제품과 관련된 정보, 프로세스. 조직 및 구성원의 광범위한 범위를 포함하여야 한다. 기업의 진취적인 노력에도 불구하구, 경영진의 지원은 성공에 결정적이다. 고심하고 있는 경영진이나 문제들을 인정하고 있는 사람들은 제품개발 프로세스 내에서 PLM과 ERP 통합의 필요성, 솔루션 및 이익에 대하여 필요한 교육을 제공받는 것을 필요로 하고 있다. 더욱이 그들은 성공을 보장하는 통합, 지침제공, 후원 및 자원의 사전 행동하는 지지자가 되기를 희망한다.

• Korean Journal of Computational Design and Engineering
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• v.10 no.2
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• pp.77-88
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• 2005

This paper introduces a project for the development of an F-125 machine using 3D PLM systems including 3D CAD, CAM, CAE, PDM, and DMU systems. Here, the F-125 machine is a formula racing car equipped with a 125cc motorcycle engine. A development process and computer-integrated environment was established using 3D PLM systems on the conceptual basis of concurrent and virtual engineering. A DMU model for a full vehicle was built using CATIA V.5 and used to check interference between parts and to simulate assembly process. This DMU-based approach enables to find and fix manufacturing problems in the early design stage. All development activities have been done by the graduate and undergraduate students of the automotive engineering department of Kookmin University. Through the project, the students could acquire knowledge about car development process and 3D PLM systems in automotive industry.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2008.04a
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• pp.253-258
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• 2008

PLM(Product Lifecycle Management) is one of innovative manufacturing paradigms which leverages e-business technologies to allow a company's product content to be developed and integrated with all company business process through the extended enterprise. In these days, most construction companies also make an effort to enhance their systems for creating, sharing and managing information to improve business efficiency through entire lifecycle of project execution. Because of different needs, business process and diverse engineering activities such as design, structural analysis, installing simulation, documents and data managements, a new paradigm for construction companies is needed to manage and share the entire workflow, and information in total project lifecycle. In this paper, we conducted user requirement and business process analysis of the construction to design architecture of C-PLM(Construction Project Lifecycle management) and implement a prototype of C-PLM systems based on commercial PDM system.